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Information on EC 3.4.24.22 - stromelysin 2
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- 3.4.24.22
- metalloproteinases
- mmp-9
- collagen
- metastasis
- timps
- endothelial
- stromelysin-1
- gelatinase
- cartilage
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basement
- keratinocytes
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zymography
- matrilysin
- diagnostics
- collagenase-1
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collagenolytic
- medicine
- sdc1
- metalloelastase
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Similar to stromelysin 1, but action on collagen types III, IV and V is weak
Synonyms
mmp-10, mmp10, stromelysin-2, matrix metalloproteinase-10, matrix metalloproteinase 10, stromelysin 2, transin 2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Matrix metalloproteinase 10
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Matrix metalloproteinase-10
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MMP-10
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Proteoglycanase 2
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Transformation-associated protein 34A
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Transin 2
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Transins, 2
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY
140610-48-6
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
tissue inhibitor of metalloproteinases 2
TIMP-2, conserved mechanism of inhibition, interactions and conformation analysis, and structural changes induced by complex formation with the enzyme's catalytic domain, detailed overview
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additional information
the endogenous tissue inhibitors of metalloproteinases (TIMPs) regulate proteolytic activity by binding tightly to the MMP active site. While each of the four TIMPs can inhibit most MMPs, binding data reveal tremendous heterogeneity in affinities of different TIMP/MMP pairs. Identification of a group of highly conserved contacts at the heart of MMP/TIMP complexes that define the conserved mechanism of inhibition, as well as a second category of diverse adventitious contacts at the periphery of the interfaces
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Spontaneous abortion is preceded by an altered serum concentration of matrix metalloproteinases.
Acquired Immunodeficiency Syndrome
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
Acute Kidney Injury
Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling.
Adenocarcinoma
Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients.
Adenocarcinoma
Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma.
Adenocarcinoma
Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism.
Adenocarcinoma of Lung
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Adenocarcinoma of Lung
Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells.
Adenocarcinoma of Lung
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Albuminuria
MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade.
Albuminuria
Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study.
Angiofibroma
Evaluation of MMP-1, MMP-10, TIMP-1, a-SMA e TGF-b1 in angiofibromas of tuberous sclerosis.
Aortic Aneurysm
Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.
Aortic Aneurysm, Abdominal
[Metalloproteases, vascular remodeling and atherothrombotic syndromes]
Aortic Valve Stenosis
A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis.
Arthritis
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
Arthritis
Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.
Arthritis
Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis research.
Arthritis, Psoriatic
Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients.
Arthritis, Rheumatoid
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.
Asthma
Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET.
Asthma
Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma.
Astrocytoma
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
Atherosclerosis
A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis.
Atherosclerosis
Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease.
Atherosclerosis
Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis.
Atherosclerosis
Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease.
Atherosclerosis
Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification.
Atherosclerosis
Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.
Atherosclerosis
Serum levels of matrix metalloproteinase-10 are associated with the severity of atherosclerosis in patients with chronic kidney disease.
Blister
Disturbances of the expression of metalloproteinases and their tissue inhibitors cause destruction of the basement membrane in pemphigoid.
Blister
Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines.
Bowen's Disease
MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.
Brain Ischemia
New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator.
Breast Neoplasms
Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node.
Breast Neoplasms
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress.
Breast Neoplasms
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Breast Neoplasms
O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR.
Breast Neoplasms
Plasma Level of MMP-10 May Be a Prognostic Marker in Early Stages of Breast Cancer.
Breast Neoplasms
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.
Breast Neoplasms
RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.
Carcinogenesis
Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3.
Carcinogenesis
Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
Carcinogenesis
Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.
Carcinogenesis
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
Carcinogenesis
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Carcinogenesis
Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors.
Carcinogenesis
Protein expression under sustained activation of signal transducer and activator of transcription-3 in diethylnitrosamine-induced rat liver carcinogenesis.
Carcinoma
AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression.
Carcinoma
Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10.
Carcinoma
Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization.
Carcinoma
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Carcinoma
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.
Carcinoma
Esophageal cancer: Matrix metalloproteinase 10 is associated with survival in patients with esophageal squamous cell carcinoma.
Carcinoma
Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas.
Carcinoma
Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity.
Carcinoma
Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma.
Carcinoma
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Carcinoma
Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.
Carcinoma
Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation.
Carcinoma
Metalloproteinases and their inhibitors: Influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas.
Carcinoma
MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.
Carcinoma
Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma.
Carcinoma
Regulation of extracellular matrix remodeling following transforming growth factor-beta1/epidermal growth factor-stimulated epithelial-mesenchymal transition in human premalignant keratinocytes.
Carcinoma
Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications.
Carcinoma
The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma.
Carcinoma
TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma.
Carcinoma
Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature.
Carcinoma, Hepatocellular
C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
Carcinoma, Hepatocellular
Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis.
Carcinoma, Hepatocellular
[RNA interference of HDAC7 expression in hepatocellular carcinoma.]
Carcinoma, Merkel Cell
Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.
Carcinoma, Non-Small-Cell Lung
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
Carcinoma, Non-Small-Cell Lung
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Carcinoma, Non-Small-Cell Lung
MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.
Carcinoma, Renal Cell
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Carcinoma, Squamous Cell
Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity.
Carcinoma, Squamous Cell
Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation.
Carcinoma, Squamous Cell
Protein Expression of Stromelysin-2 in Head and Neck Squamous Cell Carcinomas.
Carcinoma, Squamous Cell
Regulation of extracellular matrix remodeling following transforming growth factor-beta1/epidermal growth factor-stimulated epithelial-mesenchymal transition in human premalignant keratinocytes.
Carcinoma, Squamous Cell
TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma.
Carcinoma, Transitional Cell
Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma.
Carcinoma, Verrucous
Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity.
Cardiovascular Diseases
Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease.
Cardiovascular Diseases
Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis.
Carotid Artery Diseases
MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study.
Carotid Stenosis
Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study.
Cataract
Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy.
Cerebellar Ataxia
Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia.
Cerebral Infarction
Matrix metalloproteinase 10 gene polymorphism and atherothrombotic cerebral infarction risk in a Han Chinese population.
Cerebral Infarction
MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study.
Colitis
Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia.
Colitis
Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium.
Colitis, Ischemic
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Colitis, Ulcerative
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Colitis, Ulcerative
Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn's disease and regulate Th1/Th17 cell responses.
Colonic Neoplasms
Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients.
Coronary Disease
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease.
Crohn Disease
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Cystic Fibrosis
Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.
Dermatomyositis
Serum levels of soluble stromelysin-2 and interleukin-33 in patients with dermatomyositis and polymyositis.
Diabetes Mellitus, Type 1
Matrix metalloproteinase-10 and microvascular complications of type 1 diabetes: might vitamin D status be relevant?
Diabetes Mellitus, Type 2
MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade.
Diabetic Nephropathies
MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade.
Epidermolysis Bullosa Dystrophica
Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia.
Erythema
Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.
Esophageal Neoplasms
Esophageal cancer: Matrix metalloproteinase 10 is associated with survival in patients with esophageal squamous cell carcinoma.
Esophageal Neoplasms
MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer.
Esophageal Squamous Cell Carcinoma
AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression.
Esophageal Squamous Cell Carcinoma
Esophageal cancer: Matrix metalloproteinase 10 is associated with survival in patients with esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications.
Febrile Neutropenia
MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia.
Gastritis
Gentiopicroside ameliorates ethanol-induced gastritis via regulating MMP-10 and pERK1/2 signaling.
Gastritis
Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis.
Gastritis, Atrophic
Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR.
Gingival Overgrowth
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth.
Glaucoma
Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion.
Glioblastoma
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
Glioma
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
Granuloma
Expression kinetics of metalloproteinases and their tissue inhibitors in experimental murine pulmonary tuberculosis.
Head and Neck Neoplasms
Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.
HIV Infections
Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
Hypertension
Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease.
Hypertension, Pulmonary
Stromelysin-2 (MMP-10), a novel mediator of vascular remodeling underlying pulmonary hypertension associated with systemic sclerosis.
Idiopathic Pulmonary Fibrosis
Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction.
Infections
CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2).
Infections
Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis.
Infections
Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways.
Infections
Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase-1 and matrix metalloproteinase-10.
Infections
Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
Infections
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Infections
Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells.
Infections
Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.
Infections
Mayaro Virus Infects Human Chondrocytes and Induces the Expression of Arthritis-Related Genes Associated with Joint Degradation.
Infections
Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.
Infections
T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain.
Infections
T-cell production of matrix metalloproteinases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain.
Infections
VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.
Inflammatory Bowel Diseases
Increased expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: cross-sectional study.
Influenza, Human
Role of matrix metalloproteinases and their inhibitor in the development of early pulmonary fibrosis in mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus.
Ischemic Stroke
Matrix metalloproteinase 10 gene polymorphism and atherothrombotic cerebral infarction risk in a Han Chinese population.
Ischemic Stroke
MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes.
Ischemic Stroke
New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator.
Ischemic Stroke
Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction.
Joint Diseases
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
Keratoacanthoma
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas.
Kidney Failure, Chronic
MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade.
Kidney Neoplasms
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Leiomyoma
Extracellular matrix metalloproteinase expression in endometrial tissue after arterial embolization of myomas.
Lichen Planus, Oral
Immunohistochemical Expression of Stromelysin-2 (St-2) In Patients with Oral Lichen Planus and Its Clinical Significance.
Liver Diseases
Differential expression of matrix metalloproteinases in viral and non-viral chronic liver diseases.
Lung Neoplasms
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
Lung Neoplasms
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Lung Neoplasms
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Lung Neoplasms
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.
Lung Neoplasms
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Lung Neoplasms
MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.
Lupus Nephritis
Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study.
Lyme Disease
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Lyme Disease
Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.
Lymphatic Metastasis
Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.
Lymphoma
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Melanoma
Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.
Mouth Neoplasms
Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers.
Muscular Dystrophies
MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy.
Neoplasm Metastasis
C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma.
Neoplasm Metastasis
Circulating osteopontin per tumor volume as a prognostic biomarker for resectable intrahepatic cholangiocarcinoma.
Neoplasm Metastasis
Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.
Neoplasm Metastasis
Functional significance of secreted Frizzled-related protein 1 in metastatic renal cell carcinomas.
Neoplasm Metastasis
Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases.
Neoplasm Metastasis
Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase-1 and matrix metalloproteinase-10.
Neoplasm Metastasis
Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis.
Neoplasm Metastasis
Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.
Neoplasm Metastasis
Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis.
Neoplasm Metastasis
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.
Neoplasm Metastasis
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Neoplasm Metastasis
Metalloproteinases and their inhibitors: Influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas.
Neoplasm Metastasis
p38-regulated FOXC1 stability is required for colorectal cancer metastasis.
Neoplasm Metastasis
Prognostic significance of stromelysin-3 and tissue inhibitor of matrix metalloproteinase-2 in esophageal cancer.
Neoplasm Metastasis
The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma.
Neoplasm Metastasis
Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma.
Neoplasm Metastasis
Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism.
Neoplasms
A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential.
Neoplasms
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
Neoplasms
CD16+ monocytes give rise to CD103+RALDH2+TCF4+ dendritic cells with unique transcriptional and immunological features.
Neoplasms
Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.
Neoplasms
Differential expression of matrilysin-1 (MMP-7), 92 kD gelatinase (MMP-9), and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer.
Neoplasms
Differential expression of matrix metalloproteinases and miRNAs in the metastasis of oral squamous cell carcinoma.
Neoplasms
Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls.
Neoplasms
Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck.
Neoplasms
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Neoplasms
Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10.
Neoplasms
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.
Neoplasms
Epithelial cells up-regulate matrix metalloproteinases in cells within the same mammary carcinoma that have undergone an epithelial-mesenchymal transition.
Neoplasms
Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity.
Neoplasms
Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma.
Neoplasms
Expression of matrix metalloproteinase-10 in non-metastatic prostate cancer: Correlation with an imbalance in cell proliferation and apoptosis.
Neoplasms
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Neoplasms
Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck.
Neoplasms
Expression of matrix metalloproteinases in supraglottic carcinoma and its clinical implication for estimating lymph node metastases.
Neoplasms
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
Neoplasms
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Neoplasms
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Neoplasms
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress.
Neoplasms
Gemcitabine Enhances Kras-MEK-Induced Matrix Metalloproteinase-10 Expression Via Histone Acetylation in Gemcitabine-Resistant Pancreatic Tumor-initiating Cells.
Neoplasms
Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases.
Neoplasms
Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases.
Neoplasms
Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis.
Neoplasms
IL-1?, IL-8, and Matrix Metalloproteinases-1, -2, and -10 Are Enriched upon Monocyte-Breast Cancer Cell Cocultivation in a Matrigel-Based Three-Dimensional System.
Neoplasms
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Neoplasms
Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma.
Neoplasms
Induction of matrix metalloproteinase gene expression in an endothelial cell line by direct interaction with malignant cells.
Neoplasms
Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation.
Neoplasms
Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.
Neoplasms
Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular elbow fracture.
Neoplasms
Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis.
Neoplasms
Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.
Neoplasms
Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database.
Neoplasms
Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.
Neoplasms
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Neoplasms
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
Neoplasms
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Neoplasms
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.
Neoplasms
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Neoplasms
Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors.
Neoplasms
Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.
Neoplasms
Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers.
Neoplasms
Metalloproteinases and their inhibitors: Influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas.
Neoplasms
MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.
Neoplasms
MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.
Neoplasms
Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma.
Neoplasms
Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.
Neoplasms
Plasma Level of MMP-10 May Be a Prognostic Marker in Early Stages of Breast Cancer.
Neoplasms
Prognostic significance of stromelysin-3 and tissue inhibitor of matrix metalloproteinase-2 in esophageal cancer.
Neoplasms
Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.
Neoplasms
Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells.
Neoplasms
Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction.
Neoplasms
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Neoplasms
Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines.
Neoplasms
Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.
Neoplasms
The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer.
Neoplasms
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas.
Neoplasms
TRIM21 Is Decreased in Colitis-associated Cancer and Negatively Regulates Epithelial Carcinogenesis.
Neoplasms
Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma.
Neoplasms
Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature.
Neoplasms, Squamous Cell
MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.
Neoplastic Cells, Circulating
Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.
Neurologic Manifestations
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients.
Neurologic Manifestations
Inflammatory leptomeningeal cytokines mediate delayed COVID-19 encephalopathy.
Obesity
Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity.
Oligodendroglioma
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
Osteochondrodysplasias
Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia.
Osteolysis
Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21.
Osteonecrosis
MMP2 and MMP10 Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population.
Osteosarcoma
Protective effects of acetaminophen on Ibuprofen-induced gastric mucosal damage in rats with associated suppression of matrix metalloproteinase.
Ovarian Neoplasms
Activation of the PKC Pathway Stimulates Ovarian Cancer Cell Proliferation, Migration, and Expression of MMP7 and MMP10.
Ovarian Neoplasms
Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.
Ovarian Neoplasms
MicroRNA-205 promotes cell invasion by repressing TCF21 in human ovarian cancer.
Ovarian Neoplasms
Tumor-associated macrophages promote invasion via Toll-like receptors signaling in patients with ovarian cancer.
Periodontitis
Bone biology-related gingival transcriptome in aging and periodontitis in non-human primates.
Periodontitis
MMP?REDOX/NO interplay in periodontitis and its inhibition with Satureja hortensis L. essential oil.
Peripheral Arterial Disease
Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease.
Pleural Effusion
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
Pleural Effusion, Malignant
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
Polymyositis
Serum levels of soluble stromelysin-2 and interleukin-33 in patients with dermatomyositis and polymyositis.
Porcine Reproductive and Respiratory Syndrome
Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis.
Pre-Eclampsia
Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function.
Pre-Eclampsia
Matrix metalloproteinase multiplex screening identifies increased MMP-2 urine concentrations in women predicted to develop preeclampsia.
Pressure Ulcer
Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines.
Prostatic Neoplasms
Expression of matrix metalloproteinase-10 in non-metastatic prostate cancer: Correlation with an imbalance in cell proliferation and apoptosis.
Proteinuria
Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
Pseudomonas Infections
Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.
Psoriasis
Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients.
Pulmonary Disease, Chronic Obstructive
Differential Expression of Tissue Repair Genes in the Pathogenesis of COPD.
Pyoderma Gangrenosum
Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum.
Renal Insufficiency
Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
Renal Insufficiency, Chronic
Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
Renal Insufficiency, Chronic
Serum levels of matrix metalloproteinase-10 are associated with the severity of atherosclerosis in patients with chronic kidney disease.
Respiratory Syncytial Virus Infections
Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells.
rna-directed dna polymerase deficiency
Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs).
Scleroderma, Systemic
Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta.
Scleroderma, Systemic
Stromelysin-2 (MMP-10), a novel mediator of vascular remodeling underlying pulmonary hypertension associated with systemic sclerosis.
Sepsis
Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.
Sepsis
Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis?
Sepsis
MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia.
Skin Neoplasms
Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck.
Skin Neoplasms
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Squamous Cell Carcinoma of Head and Neck
Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck.
Squamous Cell Carcinoma of Head and Neck
Metalloproteinases and their inhibitors: Influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
MMP-10/stromelysin-2 promotes invasion of head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Protein Expression of Stromelysin-2 in Head and Neck Squamous Cell Carcinomas.
Squamous Cell Carcinoma of Head and Neck
The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma.
Stomach Neoplasms
Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10.
Stomach Neoplasms
Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma.
Stomach Neoplasms
Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase-1 and matrix metalloproteinase-10.
Stomach Neoplasms
Loss of COP1 expression determines poor prognosisin patients with gastric cancer.
Stomach Neoplasms
Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.
Stomach Neoplasms
Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGS cells.
Stomach Neoplasms
Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.
Stroke
Inside the Thrombus: Association of Hemostatic Parameters With Outcomes in Large Vessel Stroke Patients.
Stroke
Matrix metalloproteinase 10 gene polymorphism and atherothrombotic cerebral infarction risk in a Han Chinese population.
Stroke
Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.
Stroke
MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes.
Stroke
New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator.
Stroke
proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke.
Stroke
Vascular MMP-9/TIMP-2 and Neuronal MMP-10 Up-Regulation in Human Brain after Stroke: A Combined Laser Microdissection and Protein Array Study.
stromelysin 2 deficiency
Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.
stromelysin 2 deficiency
Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification.
stromelysin 2 deficiency
Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity.
Thrombosis
Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis.
Thrombosis
Inside the Thrombus: Association of Hemostatic Parameters With Outcomes in Large Vessel Stroke Patients.
Tongue Neoplasms
Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases.
Triple Negative Breast Neoplasms
Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway.
Tuberculosis
1alpha,25-dihydroxyvitamin D inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection.
Tuberculosis
Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis.
Tuberous Sclerosis
Evaluation of MMP-1, MMP-10, TIMP-1, a-SMA e TGF-b1 in angiofibromas of tuberous sclerosis.
Urinary Bladder Neoplasms
Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3.
Urinary Bladder Neoplasms
Analytical validation of ONCURIA a multiplex bead-based immunoassay for the non-invasive bladder cancer detection.
Urinary Bladder Neoplasms
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.
Urinary Bladder Neoplasms
Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors.
Urinary Bladder Neoplasms
Prognostic Significance of Lymphocyte Infiltration and a Stromal Immunostaining of a Bladder Cancer Associated Diagnostic Panel in Urothelial Carcinoma.
Urinary Bladder Neoplasms
Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature.
Uterine Cervical Neoplasms
Gene identification by cDNA arrays in HPV-positive cervical cancer.
Uterine Cervical Neoplasms
[Global expression analysis in uterine cervical cancer: metabolic pathways and altered genes]
Varicose Ulcer
Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds.
Varicose Ulcer
Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines.
Varicose Veins
Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins.
Vascular Calcification
A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis.
Vascular Calcification
Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification.
Vascular Diseases
Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.
Virus Diseases
Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
matrix metalloproteinases (MMPs) play central roles in vertebrate tissue development, remodeling, and repair. The endogenous tissue inhibitors of metalloproteinases (TIMPs) regulate proteolytic activity by binding tightly to the MMP active site. While each of the four TIMPs can inhibit most MMPs, binding data reveal tremendous heterogeneity in affinities of different TIMP/MMP pairs
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified active human MMP-10 catalytic domain in complex with inhibitor protein TIMP-2, hanging drop vapor diffusion method, mixing of proteins in a 1:1.1 (mol/mol) ratio, 4.5-5.5 mg/ml protein in 20 mM Tris, pH 8.5 and 150 mM NaCl, are mixed with reservoir solution containing 0.1 M HEPES, pH 7.5, and 25% w/v PEG 2000 monomethyl ether, 1-2 weeks, X-ray diffraction structure determination and analysis at 2.1 A resolution, molecular replacement, comparison and analysis of the crystal structure of the human MMP-10/TIMP-1 complex, PDB ID 3V96
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme MMP-10 catalytic domain from Escherichia coli strain BL21 (DE3), by anion exchange chromatography and gel filtration
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of the enzyme catalytic domain in Escherichia coli strain BL21 (DE3)
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Batra, J.; Soares, A.; Mehner, C.; Radisky, E.
Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes
PLoS ONE
8
e75836
2013
Homo sapiens (P16035)
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Release 2023.1 (January 2023)
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