EC Number |
General Information |
Reference |
---|
3.4.24.22 | evolution |
despite their similar substrate specificities, the stromelysins show differential patterns of transcriptional regulation and tissue distribution that hint at distinct physiological functions in processes such as skeletal development, wound healing, and vascular remodeling |
734175 |
3.4.24.22 | evolution |
sequence comparisons of MMP-3 (EC 3.4.22.17) and MMP-10, high similarity |
-, 755661 |
3.4.24.22 | malfunction |
association between MMP-9, MMP-10, TIMP-1, and MMP-9/TIMP-1 ratios and parameters of sepsis severity, overview |
708234 |
3.4.24.22 | malfunction |
ectopic overexpression of MMP-10 promotes the invasion of head and neck squamous cell carcinoma cells, and knockdown of MMP-10 suppressed the invasion of head and neck squamous cell carcinoma cells |
718291 |
3.4.24.22 | malfunction |
in acute Pseudomonas aeruginosa infection, 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity), but lethality and morbidity in Mmp10-/- mice are not due to impaired bacterial clearance. Mmp10-/- mice die due to altered or excessive inflammation |
-, 754327 |
3.4.24.22 | malfunction |
MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. Contribution of MMP-10 to squamous cell cancer development in the FVB/NTg(KRT5-Nfkbia)3Rto mouse line, overview |
-, 708422 |
3.4.24.22 | malfunction |
MMP-10 plays a critical role in VEGF-induced angiogenesis, overview |
709245 |
3.4.24.22 | malfunction |
Mmp10 knockout mice show a significant reduction in lung tumor number and size after urethane exposure or genetic activation of oncogenic Kras |
718298 |
3.4.24.22 | malfunction |
oropharyngeal aspiration of long multiwalled carbon nanotubes (MWCNTs) (0.08 mg/mouse) by wild-type mice induces expression of Mmp10 mRNA, which is accompanied by a robust inflammatory response characterized by elevated expression of Tnfa, Il6, and Il1b. In Mmp10-/- mice, absence of MMP-10 leads to impaired pulmonary clearance of MWCNTs and reduced macrophage cell survival. Exposure of wild-type bone marrow-derived macrophages (BMDMs) and alveolar macrophages to MWCNTs caused a rapid, dose-dependent upregulation of Mmp10 mRNA expression, which was accompanied by expression of pro-inflammatory products (Il6 and Il1b). These products were further enhanced in Mmp10-/- macrophages, resulting in increased caspase-3-dependent cell death compared with wild-type cells. Absence of Mmp-10 confers sensitivity to apoptosis in BMDMs without an increase in endocytosis |
753928 |
3.4.24.22 | malfunction |
RNAi-mediated knockdown of Mmp10 leads to a loss of stem cell marker gene expression and inhibition of oncosphere growth, clonal expansion, and transformed growth in vitro. Enzyme Mmp10-deficient cultures show a severe defect in tumor initiation |
-, 735049 |