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Information on EC 3.4.21.78 - granzyme A
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3.4.21.78 granzyme ASpecify your search results
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- 3.4.21.78
- thrombospondin-1
- angiogenesis
- endothelial
- perforin
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killer
- granule
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angiogenic
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antiangiogenic
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cytolytic
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matricellular
- metastasis
- collagen
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microvessels
- t-cells
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microvascular
- integrins
- fibrosis
- fibronectin
- cd8
- tgf-beta1
- neovascularization
- fasl
- fgf-2
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corneal
- alphavbeta3
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exocytosis
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ctl-mediated
- factor-beta
- bfgf
- medicine
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caspase-independent
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angiogenesis-related
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granule-associated
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integrin-associated
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angiostatic
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proangiogenic
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metronomic
- properdin
- endostatin
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granulysin
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tregs
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lymphocyte-mediated
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lymphokine-activated
- ifn-gamma
- vegf-a
The enzyme appears in viruses and cellular organisms
Synonyms
tsp-1, granzyme a, h factor, gzm a, gzma/k, ctla3, ctl tryptase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Autocrine thymic lymphoma granzyme-like serine protease
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CTL tryptase
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CTLA3
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Cytotoxic T lymphocyte serine protease
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H factor
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Hanukkah factor
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HuTPS
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T-cell associated protease 1
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T-cell derived serine proteinase 1
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TSP-1
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY
143180-73-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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involvement of granzyme A in exacerbation and perpetuation of enteritis indicated, early increase of granzyme A in rats with experimentally induced ulcerative colitis shown
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
The role of TSP-1 on decidual macrophages involved in the susceptibility to unexplained recurrent spontaneous abortion.
Acquired Immunodeficiency Syndrome
Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.
Acute Chest Syndrome
Association of plasma CD40L with acute chest syndrome in sickle cell anemia.
Acute Kidney Injury
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Acute Kidney Injury
Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury.
Acute Kidney Injury
Reduction of natural killer and natural killer T cells is not protective in cisplatin-induced acute renal failure in mice.
Acute Lung Injury
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.
Adenocarcinoma
Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.
Adenocarcinoma
Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.
Adenocarcinoma
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Adenocarcinoma
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.
Adenocarcinoma
Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma.
Adenocarcinoma
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Adenocarcinoma
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
Adenocarcinoma
The effect of thrombospondin-1 and TGF-beta 1 on pancreatic cancer cell invasion.
Adenocarcinoma
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Adenocarcinoma
Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion.
Adenocarcinoma
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Adenocarcinoma
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Adenocarcinoma
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Adenocarcinoma
Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer.
Adenocarcinoma
[Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance.]
Adenocarcinoma
[Relationship between changes of serum concentrations of antiangiogenic factors and disease progression in patients of pancreatic carcinoma]
Adenocarcinoma of Lung
[Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance.]
Adenocarcinoma, Follicular
Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity.
Adenoma
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Airway Obstruction
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
Alzheimer Disease
Amyloid-? inhibits thrombospondin 1 release from cultured astrocytes: effects on synaptic protein expression.
Anemia, Hemolytic
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Anemia, Sickle Cell
Disturbance of plasma and platelet thrombospondin levels in sickle cell disease.
Anemia, Sickle Cell
Relationship of Thrombospondin 1 to von Willebrand Factor and ADAMTS-13 in Sickle Cell Disease Patients of Arab Ethnicity.
Aneurysm, Dissecting
Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients With Acute Aortic Dissection.
Aortic Aneurysm
Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix.
Arteriovenous Malformations
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Arthritis
Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis.
Arthritis
Granzyme A contributes to inflammatory arthritis through stimulation of osteoclastogenesis.
Arthritis, Experimental
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.
Arthritis, Rheumatoid
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).
Arthritis, Rheumatoid
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.
Arthritis, Rheumatoid
Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.
Arthritis, Rheumatoid
Tumor Necrosis Factor Inhibition Modulates Thrombospondin-1 Expression in Human Inflammatory Joint Disease through Altered NR4A2 Activity.
Asbestosis
Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS.
Asthma
Granule Cytotoxic Activity and Oxidative DNA Damage in Smoking and Nonsmoking Patients With Asthma.
Asthma
Increased angiogenic factors in exhaled breath condensate of children with severe asthma - New markers of disease progression?
Asthma
TIPE2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma.
Astrocytoma
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Astrocytoma
Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53.
Astrocytoma
Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.
Atherosclerosis
C3 and alternative pathway components are associated with an adverse lipoprotein subclass profile: The CODAM study.
Atherosclerosis
Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus.
Atherosclerosis
Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries.
Atherosclerosis
Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat.
Atherosclerosis
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Atherosclerosis
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Atherosclerosis
Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases.
Atherosclerosis
Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase.
Atherosclerosis
Thrombospondin-1 is elevated with both intimal hyperplasia and hypercholesterolemia.
Atherosclerosis
TSP-1 (Thrombospondin-1) Deficiency Protects ApoE-/- Mice Against Leptin-Induced Atherosclerosis.
Atherosclerosis
[The role of thrombospondin-1 in hypoxia-induced migration of human vascular smooth muscle cells]
Atypical Hemolytic Uremic Syndrome
A user's guide to the interactive Web database of factor H-associated hemolytic uremic syndrome.
Atypical Hemolytic Uremic Syndrome
Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach.
Atypical Hemolytic Uremic Syndrome
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Atypical Hemolytic Uremic Syndrome
Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome.
Atypical Hemolytic Uremic Syndrome
Postoperative thrombotic thrombocytopenic purpura in an infant: case report and literature review.
Atypical Hemolytic Uremic Syndrome
[Clinical characteristies of atypical hemolytie uremic syndrome associated with H factor antibody in children].
Brain Diseases
Granzyme A Participates in the Pathogenesis of Infection-Associated Acute Encephalopathy.
Brain Injuries
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Brain Injuries
Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes.
Brain Injuries, Traumatic
Plasma thrombospondin-1 and clinical outcomes in traumatic brain injury.
Brain Injuries, Traumatic
Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice.
Brain Injuries, Traumatic
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Brain Neoplasms
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Breast Neoplasms
ADAMTS1-mediated targeting of TSP-1 by PPAR? suppresses migration and invasion of breast cancer cells.
Breast Neoplasms
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Breast Neoplasms
Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis.
Breast Neoplasms
CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.
Breast Neoplasms
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Breast Neoplasms
Decrease of let-7f in low-dose metronomic Paclitaxel chemotherapy contributed to upregulation of thrombospondin-1 in breast cancer.
Breast Neoplasms
Differential proteomic analysis of late-stage and recurrent breast cancer from formalin-fixed paraffin-embedded tissues.
Breast Neoplasms
Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
Breast Neoplasms
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Breast Neoplasms
Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells.
Breast Neoplasms
Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
Breast Neoplasms
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
Breast Neoplasms
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.
Breast Neoplasms
Histopathology and clinical assessment correlate with the cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) receptor of thrombospondin-1 in breast tumors.
Breast Neoplasms
Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo.
Breast Neoplasms
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
Breast Neoplasms
Inhibition of breast cancer progression by an antibody to a thrombospondin-1 receptor.
Breast Neoplasms
Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab.
Breast Neoplasms
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Breast Neoplasms
Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis.
Breast Neoplasms
Role of urokinase plasminogen activator receptor in thrombospondin 1-mediated tumor cell invasion.
Breast Neoplasms
Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2.
Breast Neoplasms
Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer.
Breast Neoplasms
Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion.
Breast Neoplasms
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Breast Neoplasms
Thrombospondin-1 and transforming growth factor-beta l promote breast tumor cell invasion through up-regulation of the plasminogen/plasmin system.
Breast Neoplasms
Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Breast Neoplasms
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Breast Neoplasms
[The poor prognosis is correlated with the high expression of vascular endothelial growth factor (VEGF) and low expression of thrombospondin 1 (TSP-1) in patients with breast cancer].
Bronchopulmonary Dysplasia
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
Calcinosis
The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study.
Calciphylaxis
The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study.
Carcinogenesis
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Carcinogenesis
Further characterization of BC3H1 myogenic cells reveals lack of p53 activity and underexpression of several p53 regulated and extracellular matrix-associated gene products.
Carcinogenesis
Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo.
Carcinogenesis
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Carcinogenesis
Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.
Carcinogenesis
Microvessel density and regulators of angiogenesis in malignant and nonmalignant prostate tissue.
Carcinogenesis
The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma.
Carcinogenesis
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Carcinogenesis
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Carcinogenesis
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Carcinogenesis
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Carcinogenesis
Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.
Carcinogenesis
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Carcinogenesis
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Carcinogenesis
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Carcinoma
Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features.
Carcinoma
c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation.
Carcinoma
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1.
Carcinoma
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Carcinoma
Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.
Carcinoma
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Carcinoma
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Carcinoma
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.
Carcinoma
Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma.
Carcinoma
Extraction of RNA from archival tissues and measurement of thrombospondin-1 mRNA in normal, dysplastic, and malignant oral tissues.
Carcinoma
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
Carcinoma
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Carcinoma
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Carcinoma
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.
Carcinoma
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Carcinoma
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.
Carcinoma
pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines.
Carcinoma
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
Carcinoma
The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma.
Carcinoma
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Carcinoma
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Carcinoma
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.
Carcinoma
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Carcinoma
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Carcinoma
Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival.
Carcinoma
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Carcinoma
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Carcinoma
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Carcinoma
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Carcinoma
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Carcinoma
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
Carcinoma
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Carcinoma
Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas.
Carcinoma in Situ
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Carcinoma, Ductal
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Carcinoma, Ductal
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Carcinoma, Ductal
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Carcinoma, Hepatocellular
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Carcinoma, Hepatocellular
Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
Carcinoma, Intraductal, Noninfiltrating
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Carcinoma, Mucoepidermoid
Correlation between the expression of thrombospondin-1 and neovascularization in mucoepidermoid carcinoma.
Carcinoma, Mucoepidermoid
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
Carcinoma, Mucoepidermoid
[Correlation between the expression of thrombospondin-1 and the angiogenesis in mucoepidermoid carcinoma]
Carcinoma, Mucoepidermoid
[The expression of inhibitor-1 of DNA binding/differentiation-1 and thrombospondin-1 in mucoepidermoid carcinoma of different malignant degree]
Carcinoma, Non-Small-Cell Lung
Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Carcinoma, Papillary
Activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion.
Carcinoma, Papillary
Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) expression in thyroid papillary carcinoma cells.
Carcinoma, Renal Cell
pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines.
Carcinoma, Renal Cell
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Carcinoma, Squamous Cell
c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation.
Carcinoma, Squamous Cell
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Carcinoma, Squamous Cell
Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.
Carcinoma, Squamous Cell
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
Carcinoma, Squamous Cell
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Carcinoma, Squamous Cell
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Carcinoma, Squamous Cell
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.
Carcinoma, Squamous Cell
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
Carcinoma, Squamous Cell
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Carcinoma, Squamous Cell
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Carcinoma, Squamous Cell
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Carcinoma, Squamous Cell
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Carcinoma, Squamous Cell
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Cardiovascular Diseases
Association of Plasma Thrombospondin-1 Level with Cardiovascular Disease and Mortality in Hemodialysis Patients.
Cardiovascular Diseases
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Cardiovascular Diseases
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.
Cataract
Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation.
Cerebral Hemorrhage
Elevated cerebrospinal fluid levels of thrombospondin-1 correlate with adverse clinical outcome in patients with aneurysmal subarachnoid hemorrhage.
Cervical Intraepithelial Neoplasia
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Chikungunya Fever
RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.
Cholangiocarcinoma
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.
Cholera
The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration.
Choroidal Neovascularization
Production and accumulation of thrombospondin-1 in human retinal pigment epithelial cells.
Choroidal Neovascularization
Thrombospondin-1 expression in RPE and choroidal neovascular membranes.
Chronic Periodontitis
Targeting TSP-1 decreased periodontitis by attenuating extracellular matrix degradation and alveolar bone destruction.
Chronic Urticaria
Endostatin and Thrombospondin-1 levels are increased in the sera of patients with chronic spontaneous urticaria.
Colitis
Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model.
Colitis, Ulcerative
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
Colitis, Ulcerative
Association Between Response to Etrolizumab and Expression of Integrin ?E and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.
Colonic Neoplasms
Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.
Colonic Neoplasms
Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense?
Colonic Neoplasms
Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer.
Colonic Neoplasms
Mechanisms of Platelet-Stimulated Colon Cancer Invasion: Role of Clusterin and Thrombospondin-1 in Regulation of the P38MAPK-MMP-9 Pathway.
Colonic Neoplasms
Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer.
Colonic Neoplasms
Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.
Colonic Neoplasms
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
Colonic Neoplasms
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Colorectal Neoplasms
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
Colorectal Neoplasms
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Colorectal Neoplasms
Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma.
Colorectal Neoplasms
Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Colorectal Neoplasms
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Colorectal Neoplasms
Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.
Corneal Injuries
BMP-1 disrupts cell adhesion and enhances TGF-? activation through cleavage of the matricellular protein thrombospondin-1.
Corneal Neovascularization
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.
Corneal Neovascularization
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.
Corneal Neovascularization
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.
Corneal Neovascularization
Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression.
Corneal Neovascularization
Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis.
Corneal Neovascularization
Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.
Coronary Artery Disease
Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus.
COVID-19
Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.
Cowpox
Perforin is essential for control of ectromelia virus but not related poxviruses in mice.
Craniocerebral Trauma
Plasma thrombospondin-1 and clinical outcomes in traumatic brain injury.
Crohn Disease
CD47(Low) Status on CD4 Effectors Is Necessary for the Contraction/Resolution of the Immune Response in Humans and Mice.
Cysts
Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.
Dermatitis, Contact
The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions.
Dermatomyositis
Biomarker profiles of endothelial activation and dysfunction in rare systemic autoimmune diseases: implications for cardiovascular risk.
Diabetes Complications
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose.
Diabetes Complications
Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications.
Diabetes Mellitus
Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.
Diabetes Mellitus
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Diabetes Mellitus
Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.
Diabetes Mellitus, Type 1
Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates.
Diabetes Mellitus, Type 1
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Diabetes Mellitus, Type 1
Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No.
Diabetes Mellitus, Type 1
Granzyme A-deficiency breaks immune tolerance and promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
Diabetes Mellitus, Type 1
The use of granzyme A as a marker of heart transplant rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats.
Diabetic Angiopathies
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Diabetic Angiopathies
Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia.
Diabetic Cardiomyopathies
The role of thrombospondin-1-mediated TGF-?1 on collagen type III synthesis induced by high glucose.
Diabetic Nephropathies
Correlation of enhanced thrombospondin-1 expression, TGF-beta signalling and proteinuria in human type-2 diabetic nephropathy.
Diabetic Nephropathies
Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-beta1 dependent and TGF-beta1 independent pathways.
Diabetic Nephropathies
Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo.
Diabetic Neuropathies
Exercise and IGF-1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy.
Diabetic Retinopathy
Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes.
Diabetic Retinopathy
Thrombospondin-1 is produced by retinal glial cells and inhibits the growth of vascular endothelial cells.
Diabetic Retinopathy
[Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]
Diabetic Retinopathy
[The changes of TSP-1 expression in the retina of STZ-induced rat diabetic mellitus model with pioglitazone]
Diphtheria
Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells.
Diphtheria
Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells.
Down Syndrome
Identification of novel direct transcriptional targets of glucocorticoid receptor.
Dry Eye Syndromes
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.
Dry Eye Syndromes
Thrombospondin-1 as a Regulator of Corneal Inflammation and Lymphangiogenesis: Effects on Dry Eye Disease and Corneal Graft Immunology.
Dysentery
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.
Dysplastic Nevus Syndrome
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Ectromelia
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
Ectromelia
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Encephalomyelitis, Autoimmune, Experimental
Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes.
Endometrial Neoplasms
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Endometrial Neoplasms
microRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer.
Endometrial Neoplasms
Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Endometrial Neoplasms
Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis.
Endometriosis
Expression of vascular endothelial growth factor and thrombospondin-1 mRNA in patients with endometriosis.
Endometriosis
Influence of Ovarian Endometrioma on Expression of Steroid Receptor RNA Activator, Estrogen Receptors, Vascular Endothelial Growth Factor, and Thrombospondin 1 in the Surrounding Ovarian Tissues.
Endometriosis
microRNAs expression in endometriosis and their relation to angiogenic factors.
Endometriosis
[Expression of vascular endothelial growth factor and thrombospondin-1 in the ectopic and eutopic endometrium of women with endometriosis]
Epilepsies, Partial
A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model.
Epilepsy
Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.
Epiretinal Membrane
Thrombospondin-1 is produced by retinal glial cells and inhibits the growth of vascular endothelial cells.
Erectile Dysfunction
Expression changes of transforming growth factor-beta1 and thrombospondin-1 in cavernous tissues of diabetic rats.
Fatty Liver
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
Fibroadenoma
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Fibrosarcoma
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Fibrosarcoma
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
Fibrosarcoma
[Inhibition of fibrosarcoma growth in mice by antibody against B cell epitope on mouse Toll-like receptor-2 extracellular domain]
Fragile X Syndrome
Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model.
Ganglioneuroma
Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma.
Glaucoma
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Glioblastoma
Antisense-mediated reduction in thrombospondin-1 expression reduces cell motility in malignant glioma cells.
Glioblastoma
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Glioblastoma
Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus.
Glioblastoma
Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma.
Glioblastoma
Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.
Glioma
Antisense-mediated reduction in thrombospondin-1 expression reduces cell motility in malignant glioma cells.
Glioma
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Common Brain Tumors.
Glioma
Correlation between TSP-1, TGF-? and PPAR-? expression levels and glioma microvascular density.
Glioma
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Glioma
Cytotoxic CD4(+) T cells are correlated with better prognosis in Han Chinese grade II and grade III glioma subjects and are suppressed by PD-1 signaling.
Glioma
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Glioma
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Glioma
Participation of thrombospondin-1 in the activation of latent transforming growth factor-beta in malignant glioma cells.
Glioma
Quantification of thrombospondin-1 secretion and expression of alphavbeta3 and alpha3beta1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells.
Glomerulonephritis
Differential expression of thrombospondin and cellular fibronectin during remodeling in proliferative glomerulonephritis.
Glomerulonephritis
Expression and clinical significance of thrombospondin-1 and plasminogen activator inhibitor-1 in patients with mesangial proliferative glomerulonephritis.
Glomerulonephritis
PDE-5 inhibition impedes TSP-1 expression, TGF-beta activation and matrix accumulation in experimental glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach.
Graft vs Host Disease
Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease.
Granulomatosis with Polyangiitis
Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study.
granzyme a deficiency
Granzyme A-deficiency breaks immune tolerance and promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
granzyme a deficiency
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency promotes angiotensin-II induced aneurysm in mice.
granzyme a deficiency
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.
granzyme a deficiency
Sustained beta-cell dysfunction but normalized islet mass in aged thrombospondin-1 deficient mice.
granzyme a deficiency
Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix.
granzyme a deficiency
Thrombospondin-1 Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis.
granzyme a deficiency
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy via TGF-?1 activation in mice.
granzyme a deficiency
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
granzyme a deficiency
TSP-1 (Thrombospondin-1) Deficiency Protects ApoE-/- Mice Against Leptin-Induced Atherosclerosis.
granzyme a deficiency
TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis.
Heart Diseases
Investigation of thrombospondin-1 and transforming growth factor-? expression in the heart of aging mice.
Heart Failure
Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling.
Heart Failure
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure.
Hemangioma
Role of thrombospondin-1 and nuclear factor-kappa B signaling pathways in anti-angiogenesis of infantile hemangioma.
Hemangioma
[Expression and significance of the proteins in TSP-1 and NF-?B signal pathways of infantile capillary hemangioma].
Hemorrhagic Fever with Renal Syndrome
Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome.
Hepatitis C, Chronic
Gene expression of perforin and granzyme A in the liver in chronic hepatitis C: comparison with peripheral blood mononuclear cells.
Herpes Simplex
Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.
HIV Infections
Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infection.
HIV Infections
Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.
Hypercalcemia
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.
Hyperglycemia
Application of transcutaneous carbon dioxide improves capillary regression of skeletal muscle in hyperglycemia.
Hyperglycemia
The effect of cilostazol on expression of thrombospondin-1 in diabetic retinopathy.
Hyperglycemia
Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications.
Hypersensitivity
The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions.
Hypersensitivity
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Hypersensitivity
Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.
Hypertension
Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril.
Hypertension, Pulmonary
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
Hypotension
Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome.
Idiopathic Interstitial Pneumonias
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Idiopathic Pulmonary Fibrosis
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Immunoglobulin G4-Related Disease
Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease.
Immunoglobulin G4-Related Disease
Lesional CD4+ IFN-?+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis.
Infections
A novel and divergent role of granzyme A and B in resistance to helminth infection.
Infections
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection.
Infections
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.
Infections
Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius.
Infections
Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections.
Infections
Control of murine cytomegalovirus replication in salivary glands during acute infection is independent of the Fas ligand/Fas system.
Infections
Cutaneous leishmaniasis: co-ordinate expression of granzyme A and lymphokines by CD4+ T cells from susceptible mice.
Infections
Cytomegalovirus infection decreases expression of thrombospondin-1 and -2 in cultured human retinal glial cells: effects of antiviral agents.
Infections
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
Infections
Differential Activation of Human Monocytes and Lymphocytes by Distinct Strains of Trypanosoma cruzi.
Infections
Ex vivo rectal explant model reveals potential opposing roles of Natural Killer cells and Marginal Zone-like B cells in HIV-1 infection.
Infections
Expression of activation and cytotoxic molecules by peripheral blood lymphocytes of patients with paracoccidioidomycosis.
Infections
Expression of cytotoxicity-associated genes in Marek's disease virus-infected chickens.
Infections
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.
Infections
Expression of perforin, granzyme A and Fas ligand mRNA in caecal tissues upon Eimeria tenella infection of naïve and immune chickens.
Infections
Extracellular granzyme A in amniotic fluid is elevated in the presence of sterile intra-amniotic inflammation in preterm prelabor rupture of membranes.
Infections
Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease.
Infections
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
Infections
Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.
Infections
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Infections
HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
Infections
Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53.
Infections
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Infections
Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease.
Infections
Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis.
Infections
Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection.
Infections
Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.
Infections
RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.
Infections
Stable RNA interference of host thrombospondin-1 blocks Trypanosoma cruzi infection.
Infections
The kinetics of CD4+ and CD8+ T-cell gene expression correlate with protection in Atlantic salmon (Salmo salar L) vaccinated against infectious pancreatic necrosis.
Infections
Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection.
Infections
Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells.
Infections
Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.
Infections
Thrombospondin-1 Restricts Interleukin-36?-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.
Influenza, Human
Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses.
Influenza, Human
Examination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+M1 vaccine.
Influenza, Human
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection.
Intracranial Aneurysm
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Intracranial Hemorrhages
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Ischemic Stroke
Plasminogen deficiency causes reduced angiogenesis and behavioral recovery after stroke in mice.
Keratoacanthoma
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Leiomyoma
Expression of matricellular proteins in human uterine leiomyomas and normal myometrium.
Leiomyoma
Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.
Leishmaniasis, Cutaneous
Cutaneous leishmaniasis: co-ordinate expression of granzyme A and lymphokines by CD4+ T cells from susceptible mice.
Leishmaniasis, Cutaneous
Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis.
Leukemia
A secretable serine proteinase with highly restricted specificity from cytolytic T lymphocytes inactivates retrovirus-associated reverse transcriptase.
Leukemia
Adenovirus-mediated gene therapy with an antiangiogenic fragment of thrombospondin-1 inhibits human leukemia xenograft growth in nude mice.
Leukemia
All-trans retinoic acid induces Thrombospondin-1 expression in acute promyelocytic leukemia cells though down-regulation of its transcription repressor, c-MYC oncoprotein.
Leukemia
Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.
Leukemia
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A.
Leukemia
Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection.
Leukemia
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
Leukemia
Thrombospondin-1 (TSP-1) and TSP-1-derived heparin-binding peptides induce promyelocytic leukemia cell differentiation and apoptosis.
Leukemia
Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3.
Leukemia
Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells.
Leukemia, Promyelocytic, Acute
All-trans retinoic acid induces Thrombospondin-1 expression in acute promyelocytic leukemia cells though down-regulation of its transcription repressor, c-MYC oncoprotein.
Leukopenia
Decreased serum thrombospondin-1 and elevation of its autoantibody are associated with multiple exacerbated clinical manifestations in systemic lupus erythematosus.
Liver Cirrhosis
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
Liver Diseases
Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor ? signal activation and liver regeneration after hepatectomy in an experimental model.
Liver Diseases
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
Liver Failure, Acute
Thrombospondin-1 Exacerbates Acute Liver Failure and Hepatic Encephalopathy Pathology in Mice by Activating Transforming Growth Factor ?1.
Lung Diseases, Interstitial
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Lung Neoplasms
Adoptive immunotherapy of lung cancer with immobilized anti-TCRgammadelta antibody-expanded human gammadelta T-cells in peripheral blood.
Lung Neoplasms
Decreased Thrombospondin-1 and Bone Morphogenetic Protein-4 Serum Levels as Potential Indices of Advanced Stage Lung Cancer.
Lung Neoplasms
Identification and validation of novel circulating biomarkers for early diagnosis of lung cancer.
Lung Neoplasms
Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer.
Lung Neoplasms
Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.
Lung Neoplasms
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Lung Neoplasms
[Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance.]
Lupus Erythematosus, Systemic
Decreased serum thrombospondin-1 and elevation of its autoantibody are associated with multiple exacerbated clinical manifestations in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome.
Lymphatic Metastasis
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Lymphatic Metastasis
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Lymphatic Metastasis
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Lymphatic Metastasis
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
Lymphatic Metastasis
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Lymphatic Metastasis
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Lymphatic Metastasis
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Lymphatic Metastasis
[The poor prognosis is correlated with the high expression of vascular endothelial growth factor (VEGF) and low expression of thrombospondin 1 (TSP-1) in patients with breast cancer].
Lymphocytic Choriomeningitis
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
Lymphocytic Choriomeningitis
Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes.
Lymphocytic Choriomeningitis
Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.
Lymphoma
NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case.
Lymphoma
The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175.
Lymphoma, B-Cell
Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma.
Lymphoma, T-Cell, Cutaneous
Thrombospondin-1 promotes tumor progression in cutaneous T-cell lymphoma via CD47.
Lymphoproliferative Disorders
The clinicopathologic spectrum of cytotoxic lymphomas of the skin.
Macular Degeneration
Effect of Risk Alleles in CFH, C3, and VEGFA on the Response to Intravitreal Bevacizumab in Tunisian Patients with Neovascular Age-related Macular Degeneration.
Medulloblastoma
Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.
Melanoma
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
Melanoma
Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas.
Melanoma
Human microvascular endothelial cells adhere to thrombospondin-1 via an RGD/CSVTCG domain independent mechanism.
Melanoma
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
Melanoma
Interference of macrophage migration inhibitory factor expression in a mouse melanoma inhibits tumor establishment by up-regulating thrombospondin-1.
Melanoma
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.
Melanoma
Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma.
Melanoma
Novel application of adipose-derived mesenchymal stem cells via producing antiangiogenic factor TSP-1 in lung metastatic melanoma animal model.
Melanoma
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression.
Melanoma
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
Melanoma
Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model.
Melanoma
The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatment.
Melanoma
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Melanoma
Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth.
Melanoma, Experimental
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.
Meningioma
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Common Brain Tumors.
Meningitis
Escherichia coli K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis.
Mesothelioma
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Mesothelioma, Malignant
Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS.
Mesothelioma, Malignant
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Microscopic Polyangiitis
Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study.
Mucocutaneous Lymph Node Syndrome
[Predicting value of thrombospondin-2 for coronary artery dilatation in patients with Kawasaki disease].
Muscular Diseases
Role of thrombospondin 1 in macrophage inflammation in dysferlin myopathy.
Myocardial Infarction
A functional variant in the thrombospondin-1 gene and the risk of small for gestational age infants.
Myocardial Infarction
Association of Thrombospondin-1 (N700S) and Thrombospondin-4 (A387P) Gene Polymorphisms with the Incidence of Acute Myocardial Infarction in Egyptians.
Myocardial Infarction
Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling.
Myocardial Infarction
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Myocardial Infarction
Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population.
Myocardial Infarction
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Myocardial Ischemia
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Myositis
Immunohistochemical analysis of perforin and granzyme A in inflammatory myopathies.
Neoplasm Metastasis
Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance.
Neoplasm Metastasis
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Neoplasm Metastasis
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Neoplasm Metastasis
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
Neoplasm Metastasis
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1.
Neoplasm Metastasis
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Neoplasm Metastasis
Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein.
Neoplasm Metastasis
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Neoplasm Metastasis
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Neoplasm Metastasis
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
Neoplasm Metastasis
Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
Neoplasm Metastasis
IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.
Neoplasm Metastasis
Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
Neoplasm Metastasis
Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.
Neoplasm Metastasis
Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts.
Neoplasm Metastasis
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.
Neoplasm Metastasis
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Neoplasm Metastasis
Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGF?-1.
Neoplasm Metastasis
Postoperative administration of ketorolac averts morphine-induced angiogenesis and metastasis in triple-negative breast cancer.
Neoplasm Metastasis
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1.
Neoplasm Metastasis
Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2.
Neoplasm Metastasis
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
Neoplasm Metastasis
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Neoplasm Metastasis
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-?1 (TGF-?1).
Neoplasm Metastasis
Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer.
Neoplasm Metastasis
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Neoplasm Metastasis
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Neoplasm Metastasis
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Neoplasm Metastasis
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Neoplasm Metastasis
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Neoplasm Metastasis
Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.
Neoplasm Metastasis
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Neoplasm Metastasis
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Neoplasm Metastasis
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts.
Neoplasm Metastasis
Thrombospondin-2 inhibits tumor cell invasion through the modulation of MMP-9 and uPA in pancreatic cancer cells.
Neoplasm Metastasis
[The poor prognosis is correlated with the high expression of vascular endothelial growth factor (VEGF) and low expression of thrombospondin 1 (TSP-1) in patients with breast cancer].
Neoplasm Micrometastasis
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
Neoplasm Micrometastasis
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts.
Neoplasms
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Neoplasms
AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma.
Neoplasms
Aberrant Expression of Chemokine Receptor CCR4 in Human Gastric Cancer Contributes to Tumor-Induced Immunosuppression.
Neoplasms
Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates.
Neoplasms
Activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion.
Neoplasms
All-trans retinoic acid induces Thrombospondin-1 expression in acute promyelocytic leukemia cells though down-regulation of its transcription repressor, c-MYC oncoprotein.
Neoplasms
Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1.
Neoplasms
Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance.
Neoplasms
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Neoplasms
Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide.
Neoplasms
Anti-angiogenesis effect of 3'-sulfoquinovosyl-1'-monoacylglycerol via upregulation of thrombospondin 1.
Neoplasms
Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts.
Neoplasms
Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib.
Neoplasms
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
Neoplasms
Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors.
Neoplasms
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Neoplasms
Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma.
Neoplasms
Association of Oxytocin with Glucose Intolerance and Inflammation Biomarkers in Metabolic Syndrome Patients with and without Prediabetes.
Neoplasms
Association of platelet activation markers with cancer-associated venous thromboembolism.
Neoplasms
Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts.
Neoplasms
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
Neoplasms
c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.
Neoplasms
Carrageenan inhibits granzyme A-induced detachment of and interleukin-8 release from alveolar epithelial A549 cells.
Neoplasms
Cationic lipid gene transfer of an IL-2 transgene leads to activation of natural killer cells in a SCID mouse human tumor xenograft.
Neoplasms
CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix.
Neoplasms
CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo.
Neoplasms
Changes in thrombospondin-1 levels in the endothelial cells of the anterior pituitary during estrogen-induced prolactin-secreting pituitary tumors.
Neoplasms
Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression.
Neoplasms
Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma.
Neoplasms
Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma.
Neoplasms
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1.
Neoplasms
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion.
Neoplasms
Combination of metronomic administration and target delivery strategies to improve the anti-angiogenic and anti-tumor effects of triptolide.
Neoplasms
Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth.
Neoplasms
Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors.
Neoplasms
Correlation between pathological data and the RNA expression of p53 or p53-targeted genes in primary invasive ductal breast carcinomas: a preliminary study.
Neoplasms
Correlation between the expression of thrombospondin-1 and neovascularization in mucoepidermoid carcinoma.
Neoplasms
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Neoplasms
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection.
Neoplasms
Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.
Neoplasms
Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma.
Neoplasms
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A.
Neoplasms
Decrease in immune function and the role of mitogen-activated protein kinase (MAPK) overactivation in apoptosis during T lymphocytes activation induced by zearalenone, deoxynivalenol, and their combinations.
Neoplasms
Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors.
Neoplasms
Development of a Cancer Treatment with the Concomitant Use of Low-Intensity Ultrasound: Entering the Age of Simultaneous Diagnosis and Treatment.
Neoplasms
Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment.
Neoplasms
Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells.
Neoplasms
Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein.
Neoplasms
EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes.
Neoplasms
Effect of oral anticoagulant therapy on thrombospondin-1 and von Willebrand factor in patients with stable heart failure.
Neoplasms
Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer.
Neoplasms
Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
Neoplasms
Efficacy of schedule-dependent metronomic S-1 chemotherapy in human oral squamous cell carcinoma cells.
Neoplasms
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Neoplasms
Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation.
Neoplasms
Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women.
Neoplasms
Enhanced expression of thrombospondin-1 and hypovascularity in human cholangiocarcinoma.
Neoplasms
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Neoplasms
Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta.
Neoplasms
Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer.
Neoplasms
Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.
Neoplasms
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Neoplasms
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Neoplasms
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.
Neoplasms
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
Neoplasms
Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer.
Neoplasms
Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma.
Neoplasms
Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma.
Neoplasms
Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas.
Neoplasms
Extraction of RNA from archival tissues and measurement of thrombospondin-1 mRNA in normal, dysplastic, and malignant oral tissues.
Neoplasms
Fascin overexpression correlates with positive thrombospondin-1 and syndecan-1 expressions and a more aggressive clinical course in patients with gallbladder cancer.
Neoplasms
Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
Neoplasms
Functional Characterization of BK Virus-Specific CD4(+) T Cells with Cytotoxic Potential in Seropositive Adults.
Neoplasms
General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering.
Neoplasms
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Neoplasms
Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties.
Neoplasms
Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.
Neoplasms
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
Neoplasms
Halofuginone Inhibits Tumor Growth in the Polyoma Middle T Antigen Mouse via a Thrombospondin-1 Independent Mechanism.
Neoplasms
HBV-specific CD4+ cytotoxic T cells in hepatocellular carcinoma are less cytolytic toward tumor cells and suppress CD8+ T cell-mediated antitumor immunity.
Neoplasms
Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) expression in thyroid papillary carcinoma cells.
Neoplasms
Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.
Neoplasms
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
Neoplasms
Histopathology and clinical assessment correlate with the cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) receptor of thrombospondin-1 in breast tumors.
Neoplasms
Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo.
Neoplasms
Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53.
Neoplasms
Human eosinophils exert TNF-? and granzyme A-mediated tumoricidal activity toward colon carcinoma cells.
Neoplasms
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.
Neoplasms
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Neoplasms
Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour.
Neoplasms
IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.
Neoplasms
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Neoplasms
Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients.
Neoplasms
Immunosurveillance by Antiangiogenesis: Tumor Growth Arrest by T Cell-Derived Thrombospondin-1.
Neoplasms
Improved therapeutic responses for liposomal doxorubicin targeted via thrombospondin peptidomimetics versus untargeted doxorubicin.
Neoplasms
Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma.
Neoplasms
Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1.
Neoplasms
Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.
Neoplasms
Interference of macrophage migration inhibitory factor expression in a mouse melanoma inhibits tumor establishment by up-regulating thrombospondin-1.
Neoplasms
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice.
Neoplasms
Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma.
Neoplasms
Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts.
Neoplasms
Markers of angiogenesis in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study.
Neoplasms
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.
Neoplasms
Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma.
Neoplasms
Metronomic docetaxel chemotherapy inhibits angiogenesis and tumor growth in a gastric cancer model.
Neoplasms
Microencapsulation of low-passage poorly-differentiated human mucoepidermoid carcinoma cells by alginate microcapsules: in vitro profiling of angiogenesis-related molecules.
Neoplasms
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Neoplasms
Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis.
Neoplasms
Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice.
Neoplasms
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.
Neoplasms
Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells.
Neoplasms
Murine Thy-1+ dendritic epidermal T cell lines express granule-associated perforin and a family of granzyme molecules.
Neoplasms
Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma.
Neoplasms
Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer.
Neoplasms
Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.
Neoplasms
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Neoplasms
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Neoplasms
Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.
Neoplasms
Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells.
Neoplasms
Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer.
Neoplasms
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.
Neoplasms
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.
Neoplasms
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Neoplasms
p53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease.
Neoplasms
Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGF?1 Axis.
Neoplasms
Peripheral T cell activation in long-term renal transplant patients: concordant upregulation of adhesion molecules and cytokine gene transcription.
Neoplasms
Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer.
Neoplasms
Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.
Neoplasms
Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGF?-1.
Neoplasms
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Neoplasms
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Neoplasms
Production of gastrointestinal tumors in mice by modulating latent TGF-?1 activation.
Neoplasms
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression.
Neoplasms
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1.
Neoplasms
Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development.
Neoplasms
Quantification of thrombospondin-1 secretion and expression of alphavbeta3 and alpha3beta1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells.
Neoplasms
Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.
Neoplasms
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
Neoplasms
Reduced thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer.
Neoplasms
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Neoplasms
Regulation of tumor dormancy as a function of tumor-mediated paracrine regulation of stromal Tsp-1 and VEGF expression.
Neoplasms
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
Neoplasms
Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.
Neoplasms
Role of thrombospondin-1 and nuclear factor-kappa B signaling pathways in anti-angiogenesis of infantile hemangioma.
Neoplasms
Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis.
Neoplasms
Shift in the balance between circulating thrombospondin-1 and vascular endothelial growth factor in cancer patients: Relationship to platelet a-granule content and primary activation.
Neoplasms
Shift in the balance between circulating thrombospondin-1 and vascular endothelial growth factor in cancer patients: relationship to platelet alpha-granule content and primary activation.
Neoplasms
Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Neoplasms
Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-?B signaling pathway.
Neoplasms
Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.
Neoplasms
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.
Neoplasms
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Neoplasms
Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model.
Neoplasms
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
Neoplasms
The application of an anti-angiogenic gene (thrombospondin-1) in the treatment of human prostate cancer xenografts.
Neoplasms
The cellular basis of cardiac allograft rejection: VIII. Mechanisms underlying delayed allograft rejection in PVG C6-deficient rats.
Neoplasms
The expression levels of thrombospondin-1 in dermatofibroma and dermatofibrosarcoma protuberans.
Neoplasms
The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatment.
Neoplasms
The expression of thrombospondin-1 in benign prostatic hyperplasia and prostatic intraepithelial neoplasia is decreased in prostate cancer.
Neoplasms
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Neoplasms
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Neoplasms
The N-terminal domain of thrombospondin-1: a key for the dual effect of TSP-1 in angiogenesis and cancer progression?
Neoplasms
The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.
Neoplasms
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.
Neoplasms
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells.
Neoplasms
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells.
Neoplasms
Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2.
Neoplasms
Thrombospondin 1 mRNA as a Candidate for a Marker to Detect Thyroid-derived Fibroblasts in Fine Needle Aspiration Biopsy of the Thyroid.
Neoplasms
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Neoplasms
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Neoplasms
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-?1 (TGF-?1).
Neoplasms
Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion.
Neoplasms
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Neoplasms
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
Neoplasms
Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis.
Neoplasms
Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis.
Neoplasms
Thrombospondin-1 and transforming growth factor-beta l promote breast tumor cell invasion through up-regulation of the plasminogen/plasmin system.
Neoplasms
Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression.
Neoplasms
Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity.
Neoplasms
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Neoplasms
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Neoplasms
Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Neoplasms
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Neoplasms
Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival.
Neoplasms
Thrombospondin-1 expression in relation to p53 status and VEGF expression in human breast cancers.
Neoplasms
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Neoplasms
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Neoplasms
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Neoplasms
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Neoplasms
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Neoplasms
Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.
Neoplasms
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Neoplasms
Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.
Neoplasms
Thrombospondin-1 promotes tumor progression in cutaneous T-cell lymphoma via CD47.
Neoplasms
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation.
Neoplasms
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Neoplasms
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Neoplasms
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts.
Neoplasms
Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium.
Neoplasms
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Neoplasms
Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate.
Neoplasms
Thrombospondin-1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia.
Neoplasms
Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1.
Neoplasms
Thrombospondin-1: a unique marker to identify in vitro platelet activation when monitoring in vivo processes.
Neoplasms
Thrombospondin-2 inhibits tumor cell invasion through the modulation of MMP-9 and uPA in pancreatic cancer cells.
Neoplasms
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis.
Neoplasms
Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model.
Neoplasms
Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.
Neoplasms
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of V?9V?2 T cells in low levels of IL-2.
Neoplasms
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
Neoplasms
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Neoplasms
Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients.
Neoplasms
Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.
Neoplasms
Tumor-derived interleukin-4 reduces tumor clearance and deviates the cytokine and granzyme profile of tumor-induced CD8+ T cells.
Neoplasms
Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Neoplasms
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Neoplasms
Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes.
Neoplasms
Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells.
Neoplasms
Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer.
Neoplasms
Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
Neoplasms
Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas.
Neoplasms
[Correlation between the expression of thrombospondin-1 and the angiogenesis in mucoepidermoid carcinoma]
Neoplasms
[Inhibition of fibrosarcoma growth in mice by antibody against B cell epitope on mouse Toll-like receptor-2 extracellular domain]
Neoplasms
[Mechanism of reversion of myocardial interstitial fibrosis in diabetic cardiomyopathy by valsartan]
Neoplasms
[Relationship between changes of serum concentrations of antiangiogenic factors and disease progression in patients of pancreatic carcinoma]
Neoplasms
[Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy].
Neoplasms, Glandular and Epithelial
Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.
Nephritis
TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats.
Nephrosclerosis
Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model.
Nephrosclerosis
[Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia]
Neuroblastoma
Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma.
Neuroblastoma
Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.
Neuroblastoma
TGF?R1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells.
Neuroblastoma
Thrombospondin-1 protects against A?-induced mitochondrial fragmentation and dysfunction in hippocampal cells.
Neuroinflammatory Diseases
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Obesity
Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids.
Obesity
Serum levels of TSP-1, NF-?B and TGF-?1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation.
Obesity
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation.
Oligodendroglioma
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Osteoarthritis
CD56(+)/CD16(-) Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis.
Osteoarthritis
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis.
Osteoarthritis
Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage.
Osteoarthritis
Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis.
Osteosarcoma
Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the alpha 4 beta 1 integrin.
Osteosarcoma
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
Osteosarcoma
Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1.
Osteosarcoma
Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
Ovarian Neoplasms
Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features.
Ovarian Neoplasms
Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.
Pancreatic Neoplasms
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Pancreatic Neoplasms
Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo.
Pancreatic Neoplasms
The effect of thrombospondin-1 and TGF-beta 1 on pancreatic cancer cell invasion.
Pancreatic Neoplasms
Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.
Pancreatic Neoplasms
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Pancreatic Neoplasms
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Pancreatitis, Acute Necrotizing
Eomesodermin of atlantic salmon: an important regulator of cytolytic gene and interferon gamma expression in spleen lymphocytes.
Papillomavirus Infections
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Penile Neoplasms
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Periodontitis
Targeting TSP-1 decreased periodontitis by attenuating extracellular matrix degradation and alveolar bone destruction.
Periodontitis
Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.
Periodontitis
Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-?B Signaling Pathway.
Peripheral Arterial Disease
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.
Peripheral Arterial Disease
Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.
Peritoneal Fibrosis
Blockade of thrombospondin-1 ameliorates high glucose-induced peritoneal fibrosis through downregulation of TGF-?1/Smad3 signaling pathway.
Persistent Infection
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
Pituitary ACTH Hypersecretion
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Pituitary Neoplasms
Regulation of VEGF-A, VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line (HP75) by TGFbeta1, bFGF, and EGF.
Pituitary Neoplasms
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Pleural Effusion
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Pneumonia
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.
Pneumovirus Infections
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
Polycystic Ovary Syndrome
Serum levels of TSP-1, NF-?B and TGF-?1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation.
Polymyositis
Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis.
Pre-Eclampsia
Maternal serum thrombospondin-1 is significantly altered in cases with established preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy.
Primary Myelofibrosis
Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) - a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia.
Primary Myelofibrosis
Thrombospondin-1 is not the major activator of TGF-{beta}1 in thrombopoietin-induced myelofibrosis.
Prolactinoma
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-?1 (TGF-?1).
Prostatic Diseases
Antibody array profiling reveals serum TSP-1 as a marker to distinguish benign from malignant prostatic disease.
Prostatic Hyperplasia
Thrombospondin-1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
The expression of thrombospondin-1 in benign prostatic hyperplasia and prostatic intraepithelial neoplasia is decreased in prostate cancer.
Prostatic Neoplasms
Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.
Prostatic Neoplasms
The application of an anti-angiogenic gene (thrombospondin-1) in the treatment of human prostate cancer xenografts.
Prostatic Neoplasms
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Prostatic Neoplasms
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Prostatic Neoplasms
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Prostatic Neoplasms
Thrombospondin-1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia.
Proteinuria
Correlation of enhanced thrombospondin-1 expression, TGF-beta signalling and proteinuria in human type-2 diabetic nephropathy.
Proteinuria
[Localized expressing tendency of nuclear transcription factor kappa-B, pro-fibrosis genetic factors and fibronectin mRNA in renal tissues in proteinuria overload nephrotic young rats]
Pseudolymphoma
Expression of apoptosis associated proteins Survivin, Livin and Thrombospondin-1 in Burkitt lymphoma.
Psoriasis
Thrombospondin-1/CD47 Interaction Regulates Th17 and Treg Differentiation in Psoriasis.
Pterygium
Thrombospondin 1 polymorphism associated with decreased expression and increased risk of pterygium.
Pulmonary Arterial Hypertension
Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril.
Pulmonary Disease, Chronic Obstructive
Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Involvement of type II pneumocytes in the pathogenesis of chronic obstructive pulmonary disease.
Pulmonary Fibrosis
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Pulmonary Fibrosis
Thrombospondin-1 Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis.
Pulmonary Fibrosis
[The Role of TSP-1-CD47 in ROS-mediated Pulmonary Fibrosis Induced by Paraquat].
Pulmonary Fibrosis
[The roles of TSP-1 and its receptor CD47 in pathogenesis of paraquat-induced pulmonary fibrosis in rats].
Purpura, Thrombotic Thrombocytopenic
Postoperative thrombotic thrombocytopenic purpura in an infant: case report and literature review.
Purpura, Thrombotic Thrombocytopenic
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.
Renal Insufficiency
Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia.
Renal Insufficiency, Chronic
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction.
Renal Insufficiency, Chronic
[Role of thrombospondin-1 in the development of kidney diseases].
Retinal Degeneration
Enhanced functional integration of human photoreceptor precursors into human and rodent retina in an ex vivo retinal explant model system.
Retinal Neovascularization
[Expression and significance of thrombonspondin-1 in oxygen-induced retinopathy in mice.]
Retinoblastoma
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle.
Retinoblastoma
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Retinopathy of Prematurity
Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1.
Sarcoidosis
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Sarcoidosis, Pulmonary
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Sarcoma
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
Seizures
A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model.
Seizures
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Temporal Lobe Epilepsy Before and After Surgery.
Seizures
P2Y4/TSP-1/TGF-?1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
Sepsis
Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit.
Sepsis
Curcumin protects against lipopolysaccharide-induced vasoconstriction dysfunction via inhibition of thrombospondin-1 and transforming growth factor-?1.
Sepsis
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.
Sepsis
Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury.
Sepsis
LncRNA NEAT1 facilitates the progression of sepsis through up-regulating TSP-1 via sponging miR-370-3p.
Sepsis
Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity.
Sepsis
Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome.
Severe Combined Immunodeficiency
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Silicosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Silicosis
[Comparative analysis of serum proteomic profiles between patients with silicosis and chronic bronchitis].
Spinal Cord Injuries
Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta.
Spinal Cord Injuries
The role of thrombospondin-1 and transforming growth factor-beta after spinal cord injury in the rat.
Squamous Cell Carcinoma of Head and Neck
c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation.
Squamous Cell Carcinoma of Head and Neck
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Squamous Cell Carcinoma of Head and Neck
Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival.
ST Elevation Myocardial Infarction
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
ST Elevation Myocardial Infarction
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction.
Stomach Neoplasms
An armed oncolytic herpes simplex virus expressing thrombospondin-1 has an enhanced in vivo antitumor effect against human gastric cancer.
Stomach Neoplasms
Effect of geldanamycin on the expression of the matrix molecules and angiogenetic factors in a gastric cancer cell line.
Stomach Neoplasms
Effects of caffeic acid phenethyl ester on matrix molecules and angiogenetic and anti-angiogenetic factors in gastric cancer cells cultured on different substrates.
Stomach Neoplasms
Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer.
Stomach Neoplasms
Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma.
Stomach Neoplasms
IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.
Stomach Neoplasms
Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells.
Stomach Neoplasms
Stimulation of natural killer cells with rhCD137 ligand enhances tumor-targeting antibody efficacy in gastric cancer.
Stomach Neoplasms
Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer.
Stroke
An evaluation of the ability of thrombospondin-1 to predict stroke outcomes and mortality after ischemic stroke.
Stroke
Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1).
Stroke
Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.
Subarachnoid Hemorrhage
Elevated cerebrospinal fluid levels of thrombospondin-1 correlate with adverse clinical outcome in patients with aneurysmal subarachnoid hemorrhage.
Synovitis
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.
TDP-43 Proteinopathies
Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies.
Telangiectasia, Hereditary Hemorrhagic
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Telangiectasis
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Thrombasthenia
Association of thrombospondin-1 with the actin cytoskeleton of human thrombin-activated platelets through an alphaIIbbeta3- or CD36-independent mechanism.
Thrombocytopenia
Decreased serum thrombospondin-1 and elevation of its autoantibody are associated with multiple exacerbated clinical manifestations in systemic lupus erythematosus.
Thrombocytopenia
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Thrombosis
Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.
Thrombosis
Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation.
Thrombosis
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Thrombosis
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.
Thrombosis
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Thrombosis
Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.
Thrombosis
Towards the Therapeutic Use of Thrombospondin 1/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent.
Thrombosis
Whole-exome sequencing detects mutations in pediatric patients with atypical hemolytic uremic syndrome in Taiwan.
Thymoma
Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties.
Thyroid Cancer, Papillary
Activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion.
Thyroid Neoplasms
Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.
Thyroid Neoplasms
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells.
Thyroid Neoplasms
Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde.
Thyroid Neoplasms
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment.
Trauma, Nervous System
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Tuberculosis
Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease.
Tuberculosis
Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.
Tuberculosis
Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis.
Tuberculosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Tuberculosis, Bovine
Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers.
Tuberculosis, Pulmonary
Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis.
Typhoid Fever
Expression of intra- and extracellular granzymes in patients with typhoid fever.
Ureteral Obstruction
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction.
Ureteral Obstruction
Thrombospondin-1 Short Hairpin RNA Suppresses Tubulointerstitial Fibrosis in the Kidney of Ureteral Obstruction by Ameliorating Peritubular Capillary Injury.
Urinary Bladder Neoplasms
Effects of TSP-1-696 C/T polymorphism on bladder cancer susceptibility and clinicopathologic features.
Urinary Bladder Neoplasms
GP73 promotes invasion and metastasis of bladder cancer by regulating the epithelial-mesenchymal transition through the TGF-?1/Smad2 signalling pathway.
Urinary Bladder Neoplasms
Reduced thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer.
Urinary Bladder Neoplasms
The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer.
Urinary Bladder Neoplasms
The role of hypoxia and p53 in the regulation of angiogenesis in bladder cancer.
Urinary Bladder Neoplasms
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Urinary Bladder Neoplasms
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population.
Urologic Neoplasms
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Urticaria
Endostatin and Thrombospondin-1 levels are increased in the sera of patients with chronic spontaneous urticaria.
Uterine Cervical Neoplasms
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Uterine Cervical Neoplasms
Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis.
Uveitis
Environmental conditioning in the control of macrophage thrombospondin-1 production.
Vaccinia
Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization.
Vaccinia
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.
Vascular Diseases
Thrombospondin-5 and fluvastatin promote angiogenesis and are protective against endothelial cell apoptosis.
Vascular System Injuries
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Vascular System Injuries
Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.
Vascular System Injuries
Thrombospondins Differentially Regulate Proteins Involved in Arterial Remodeling.
Vascular System Injuries
Vascular response to intra-arterial injury in the thrombospondin-1 null mouse.
Vasculitis
Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance.
Ventricular Fibrillation
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Virus Diseases
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection.
Virus Diseases
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.
Virus Diseases
Immunosurveillance by Antiangiogenesis: Tumor Growth Arrest by T Cell-Derived Thrombospondin-1.
Virus Diseases
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
Virus Diseases
Nucleolin as the earliest target molecule of autoantibodies produced in MRL/lpr lupus-prone mice.
Vulvar Neoplasms
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Whooping Cough
Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes.
Whooping Cough
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Whooping Cough
The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration.
Wilms Tumor
Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin.
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
measurement of granzyme A activity in large intestinal mucosal extracts of rats described
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
large intestinal mucosa of rats with experimentally induced ulcerative colitis
brenda
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hirayasu, H.; Yoshikawa, Y.; Tsuzuki, S.; Fushiki, T.
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis
Biosci. Biotechnol. Biochem.
71
234-237
2007
Rattus norvegicus (Q8CJF4)
brenda
EXTERNAL LINKS (specific for EC-Number 3.4.21.78)
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Release 2023.1 (January 2023)
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