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Disease on EC 3.4.21.62 - Subtilisin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abetalipoproteinemia
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.
Acantholysis
The effect of the proteolytic enzyme savinase on human plantar skin in vitro.
Acquired Immunodeficiency Syndrome
Acute Coronary Syndrome
Comparative effects of high-dose atorvastatin versus rosuvastatin on lipid parameters, oxidized low-density lipoprotein, and proprotein convertase subtilisin kexin 9 in acute coronary syndrome.
Adenocarcinoma
A rapid and reliable enzyme immunoassay PCR-based screening method to identify EBV-carrying gastric carcinomas.
Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth.
Effect of non-tumor cell contamination on detection of p53 gene mutations in human gastric cancer cells by polymerase chain reaction single-strand conformation polymorphism analysis.
Protein Hydrolysates from Fenugreek (Trigonella foenum graecum) as Nutraceutical Molecules in Colon Cancer Treatment.
Serine protease modulation of Dependence Receptors and EMT protein expression.
Adenoma
Proteinase K Combining Two-Step Liquid-Liquid Extraction for Plasma Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics To Discover the Potential Mechanism of Colorectal Adenoma.
Alzheimer Disease
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.
Amyotrophic Lateral Sclerosis
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Anaphylaxis
Experimental sensitization to subtilisin. I. Production of immediate- and late-onset pulmonary reactions.
Scanning electron microscopic studies of the nasal mucosa in normal rabbit and rabbit exposed to alcalase.
The release of four mediators of immediate hypersensitivity from human leukemic basophils.
Anthrax
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Arenaviridae Infections
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.
Arthritis, Experimental
Selective Abrogation of BiP/GRP78 Blunts Activation of NF-{kappa}B through the ATF6 Branch of the UPR: Involvement of C/EBP{beta} and mTOR-Dependent Dephosphorylation of Akt.
Arthritis, Rheumatoid
[The expression and clinical significance of proprotein convertase subtilisin kexin 9 in rheumatoid arthritis].
Aspergillosis
Inhibition of Aspergillus serine proteinase by Streptomyces subtilisin inhibitor and high-level expression of this inhibitor in Pichia pastoris.
Asthma
Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.
Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma.
Aspergillus fumigatus-Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma.
Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
[Allergic asthma due to the detergent additive maxatase]
Asthma, Occupational
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets-A Case Study.
Atherosclerosis
New concepts in the management of dyslipidaemiaa.
Bacterial Infections
Real Time Monitoring of Layer-by-Layer Polyelectrolyte Deposition and Bacterial Enzyme Detection in Nanoporous Anodized Aluminum Oxide.
Shrimp single WAP domain (SWD)-containing protein exhibits proteinase inhibitory and antimicrobial activities.
Studies on the mode of action of bacterial AB5 toxins.
The adjacent flanking region plays a critical role in facilitating the presentation of the Listeria monocytogenes product lemA to H2 M3wt-restricted, peptide-specific murine CD8 cells.
Blister
A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts.
Brain Diseases
A comparative study of immunohistochemical methods for detecting abnormal prion protein with monoclonal and polyclonal antibodies.
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.
Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.
Detergents modify proteinase K resistance of PrP(Sc) in different transmissible spongiform encephalopathies (TSEs).
Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.
Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.
Identification and characterization of proteinase K-resistant proteins in members of the class Mollicutes.
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy.
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.
Localization of disease-related PrP in Danish patients with different subtypes of prion disease.
Measurement of altered aspartyl residues in the scrapie associated form of prion protein.
Molecular profiling and comparison of field transmissible spongiform encephalopathy cases diagnosed in Catalunya.
Synthetic human prion protein octapeptide repeat binds to the proteinase K active site.
The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.
Transmissible spongiform encephalopathy strain-associated diversity of N-terminal proteinase K cleavage sites of PrP(Sc) from scrapie-infected and bovine spongiform encephalopathy-infected mice.
Use of thermolysin in the diagnosis of prion diseases.
Brain Neoplasms
Temperature dependence of radiation-induced DNA-protein crosslinks formed under hypoxic conditions.
Breast Neoplasms
Proteinase K added to the extraction procedure markedly increases RNA yield from primary breast tumors for use in microarray studies.
Carcinoma
Cholesterol and Its Derivatives Reversibly Inhibit Proteinase K.
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Improved method for release of cell nuclei from paraffin-embedded cell material of squamous cell carcinomas.
Sensitivity of in situ detection with biotinylated probes of human papilloma virus type 16 DNA in frozen tissue sections of squamous cell carcinomas of the cervix.
[DNA extraction using Chelex resin for oncogenic amplification analysis in head and neck tumours]
Carcinoma, Ehrlich Tumor
Internucleotide protein linkers in Ehrlich ascites cell DNA.
Isolation of mitochondria from ascites tumor cells permeabilized with digitonin.
Carcinoma, Hepatocellular
Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.
Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro.
Isolation of mitochondria from ascites tumor cells permeabilized with digitonin.
Carcinoma, Squamous Cell
Improved method for release of cell nuclei from paraffin-embedded cell material of squamous cell carcinomas.
[DNA extraction using Chelex resin for oncogenic amplification analysis in head and neck tumours]
Carcinosarcoma
Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
Cardiovascular Diseases
Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224.
Quantitative pharmacokinetic evaluation of Subtilisin QK-2 after a bolus IV injection in a rat model using a novel sandwich enzyme-linked immunosorbent assay.
Charcot-Marie-Tooth Disease
Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases.
Cholera
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.
Bacterial type AB? enterotoxins--structure, function and mechanism of action.
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Studies on the mode of action of bacterial AB5 toxins.
Chondrosarcoma
Adaptation of FACE methodology for microanalysis of total hyaluronan and chondroitin sulfate composition from cartilage.
Clostridium Infections
The protease CspB is essential for initiation of cortex hydrolysis and dipicolinic acid (DPA) release during germination of spores of Clostridium perfringens type A food poisoning isolates.
Coinfection
Serum antibody response to Pseudomonas aeruginosa antigens during corneal infection.
Colonic Neoplasms
A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis.
[Extraction of RNA from paraffin embedded tissues and analysis of p53 gene expression in colonic cancer]
Colorectal Neoplasms
Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation.
Serine protease modulation of Dependence Receptors and EMT protein expression.
Communicable Diseases
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Confusion
Is the presence of abnormal prion protein in the renal glomeruli of feline species presenting with FSE authentic?
Conjunctivitis
Genetic features of Pseudomonas aeruginosa isolates associated with eye infections referred to Farabi Hospital, Tehran, Iran.
Corneal Injuries
Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model.
Coronary Artery Disease
The relationship between protein convertase subtilisin kexin type-9 levels and extent of coronary artery disease in patients with non-ST-elevation myocardial infarction.
Coronary Disease
Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk.
Protective lipid-lowering variants in healthy older individuals without coronary heart disease.
Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents.
Corticobasal Degeneration
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
COVID-19
Comparison Between a Standard and SalivaDirect RNA Extraction Protocol for Molecular Diagnosis of SARS-CoV-2 Using Nasopharyngeal Swab and Saliva Clinical Samples.
Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2.
Creutzfeldt-Jakob Syndrome
A chicken monoclonal antibody with specificity for the N-terminal of human prion protein.
A comparative study of abnormal prion protein isoforms between Gerstmann-Sträussler-Scheinker syndrome and Creutzfeldt-Jakob disease.
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Beyond PrP res type 1/type 2 dichotomy in Creutzfeldt-Jakob disease.
Beyond PrP9res) type 1/type 2 dichotomy in Creutzfeldt-Jakob disease.
Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease.
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy.
Molecular pathology of human prion diseases.
Oligomeric forms of peptide fragment PrP(214-226) in solution are preferentially recognized by PrP(Sc)-specific antibody.
Prion protein oligomers in Creutzfeldt-Jakob disease detected by gel-filtration centrifuge columns.
THE RELATIVE ABUNDANCE OF APOE AND A?1-42 ASSOCIATED WITH ABNORMAL PRION PROTEIN DIFFERS BETWEEN CREUTZFELDT-JAKOB DISEASE SUBTYPES.
Two-dimensional mapping of three phenotype-associated isoforms of the prion protein in sporadic Creutzfeldt-Jakob disease.
Cystic Fibrosis
Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa.
Gallium induces the production of virulence factors in Pseudomonas aeruginosa.
Immunoenzymometric assays for alkaline protease and exotoxin A from Pseudomonas aeruginosa: development and use in detecting exoproteins in clinical isolates from patients with cystic fibrosis.
Longitudinal study of immune response to Pseudomonas aeruginosa antigens in cystic fibrosis.
Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa.
Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis.
Proteases of Pseudomonas aeruginosa in patients with cystic fibrosis.
Quantitation and enzymatic activity of the alkaline protease from Pseudomonas aeruginosa in culture supernatants from clinical strains.
Relation between antibody response to Pseudomonas aeruginosa exoproteins and colonization/infection in patients with cystic fibrosis.
[Alginate, elastase and alkaline protease production of Pseudomonas aeruginosa strains isolated from various body sites]
[Production of elastase, exotoxin A and alkaline protease during bronchopulmonary exacerbations in patients with mucoviscidosis chronically infected by Pseudomonas aeruginosa]
Cysts
Analysis of Giardia lamblia Interactions with Polymer Surfaces Using a Microarray Approach.
Carbohydrate analysis of Acanthamoeba castellanii.
Detection of Giardia cysts with a cDNA probe and applications to water samples.
First Report of Soybean Cyst Nematode (Heterodera glycines) on Tobacco in Henan, Central China.
Resistance of Acanthamoeba to classic DNA extraction methods used for the diagnosis of corneal infections.
Sensitivity of Vermamoeba (Hartmannella) vermiformis cysts to conventional disinfectants and protease.
Deglutition Disorders
A novel soft surimi gel with functionality prepared using alcalase for people suffering from dysphagia.
Dehydration
Can conformational changes be responsible for solvent and excipient effects on the catalytic behavior of subtilisin Carlsberg in organic solvents?
High salt- and SDS-stable DNA binding protein complexes with ATPase and protein kinase activity retained in chromatin-depleted nuclei.
Transition state stabilization of subtilisins in organic media.
Dementia
Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?
Demyelinating Diseases
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.
Dengue
Cellular proteins bind to the 3' and 5' untranslated regions of dengue 2 virus genome.
Dermatitis
Occupational enzyme dermatitis. Results of patch testing with Alcalase.
Dermatitis, Atopic
Mutations in the SASPase Gene (ASPRV1) Are Not Associated with Atopic Eczema or Clinically Dry Skin.
Diabetes Mellitus
Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk.
Diphtheria
Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics.
Topology of diphtheria toxin in lipid vesicle membranes: a proteolysis study.
Dyslipidemias
AMCP Partnership Forum: Driving New Advances in Dyslipidemia Management.
Expression of LDLRs (Low-Density Lipoprotein Receptors), Dyslipidemia Severity, and Response to PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Homozygous Familial Hypercholesterolemia: Connecting the Dots.
Genetics for the Identification of Lipid Targets Beyond PCSK9.
Lipid Management in Diabetes with a Focus on Emerging Therapies.
New compounds able to control hepatic cholesterol metabolism: Is it possible to avoid statin treatment in aged people?
Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015).
[PCSK9 inhibitors in hypercholesterolemia : New hope for patients with diabetes mellitus?]
Encephalopathy, Bovine Spongiform
A comparative study of immunohistochemical methods for detecting abnormal prion protein with monoclonal and polyclonal antibodies.
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.
Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.
The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.
Use of thermolysin in the diagnosis of prion diseases.
Endemic Diseases
Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21.
Eosinophilia
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Epidermal Cyst
Molecular evidence supporting the neoplastic nature of some epidermoid cysts of the testis.
Eye Burns
[Necrolytic properties of alkaline protease in the treatment of severe eye burns]
Fibrosarcoma
Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro.
Foodborne Diseases
The protease CspB is essential for initiation of cortex hydrolysis and dipicolinic acid (DPA) release during germination of spores of Clostridium perfringens type A food poisoning isolates.
Frontotemporal Dementia
Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating.
Gastrointestinal Diseases
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Genetic Diseases, Inborn
[Homozygous hypercholesterolemia - new therapeutic options in cases with complete lack of LDL- receptor].
Glomerulonephritis
Nutritionally induced necrotizing glomerulonephritis and polyarteritis nodosa in pigs.
Granuloma
In vivo activity of proteases of Pseudomonas aeruginosa in a rat model.
Hemolytic-Uremic Syndrome
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli.
Combined Action of Shiga Toxin Type 2 and Subtilase Cytotoxin in the Pathogenesis of Hemolytic Uremic Syndrome.
Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak.
Hemorrhagic Fever, Crimean
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.
Hepatitis
HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".
The spectrum of complement-fixing antinuclear antibodies in patients with hepatocellular carcinoma.
Hepatitis C
Detection of hepatitis "C" virus in formalin-fixed liver tissue by nested polymerase chain reaction.
Hepatitis C: description of a highly sensitive method for clinical detection of viral RNA.
Localization of hepatitis C virus RNA in human liver biopsies by in situ hybridization using thymine-thymine dimerized oligo DNA probes: improved method.
Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay.
Herpes Zoster
Evidence for a role of the major glycoprotein in the structural maintenance of the pig zona pellucida.
Polarization of blastomeres in the cleaving rabbit embryo.
Homozygous Familial Hypercholesterolemia
Expression of LDLRs (Low-Density Lipoprotein Receptors), Dyslipidemia Severity, and Response to PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Homozygous Familial Hypercholesterolemia: Connecting the Dots.
Hypercholesterolemia
Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing.
Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients.
Efficacy and Safety of PCSK9 Inhibitors in Hypercholesterolemia Associated With Refractory Nephrotic Syndrome.
Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia.
Endothelial function improvement in patients with familial hypercholesterolemia receiving PCSK-9 inhibitors on top of maximally tolerated lipid lowering therapy.
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.
OSLER and ODYSSEY LONG TERM: PCSK9 inhibitors on the right track of reducing cardiovascular events.
Proprotein Convertase Subtilisin Kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies.
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia: Effect on stroke risk.
Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia.
Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents.
The therapeutic potential of PCSK9 inhibition in primary dyslipidemia, the example from SAR236553/REGN727 McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase Subtilisin/Kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012. [Epub ahead of print].
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.
[Homozygous hypercholesterolemia - new therapeutic options in cases with complete lack of LDL- receptor].
Hyperglycemia
Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.
Hyperlipidemias
Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice.
Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential.
Hyperlipoproteinemia Type II
Consensus statement of professional associations on prescribing of PCSK9-inhibitors.
Correction to: Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients.
Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia.
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.
Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia.
Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents.
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.
Hypersensitivity
Antigenic and allergenic characterization of the enzymes alcalase and savinase by crossed immunoelectrophoresis and crossed radioimmunoelectrophoresis.
Distinct human T cell repertoires mediate immediate and delayed-type hypersensitivity to the Trichophyton antigen, Tri r 2.
Experimental sensitization to subtilisin. I. Production of immediate- and late-onset pulmonary reactions.
HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN'-induced hypersensitivity.
Phosphorylation and Enzymatic Hydrolysis with Alcalase and Papain Effectively Reduce Allergic Reactions to Gliadins in Normal Mice.
Scanning electron microscopic studies of the nasal mucosa in normal rabbit and rabbit exposed to alcalase.
[Occupational allergies to cellulases]
Hypersensitivity, Delayed
An alkaline protease in the delayed hypersensitivity skin lesions in the guinea-pigs.
Hypersensitivity, Immediate
Experimental periodontal disease. Immediate hypersensitivity.
Hypertension
ACE inhibitory activity of pangasius catfish (Pangasius sutchi) skin and bone gelatin hydrolysate.
Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates.
In vitro Angiotesin-1-converting enzyme, ?-amylase and ?-glucosidase inhibitory and antioxidant activities of Luffa cylindrical (L.) M. Roem seed protein hydrolysate.
Proteolytic activities in hypertensive cardiomyopathy of rats.
Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein.
Hypobetalipoproteinemias
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.
Infections
A genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarrays.
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.
A neutral protease from Bacillus nematocida, another potential virulence factor in the infection against nematodes.
A smooth-type, phage-resistant Klebsiella pneumoniae mutant strain reveals OmpC is indispensable for GH-K3 infection.
Aaprb1, a subtilsin-like protease, required for autophagy and virulence of the tangerine pathotype of Alternaria alternata.
Alkaline protease-deficient mutants of Pseudomonas aeruginosa are virulent in the eye.
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6.
Application of in situ hybridization to tissue sections for identification of molds causing invasive fungal infection.
Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.
Characterization of subtilase protease in Cryptosporidium parvum and C. hominis.
Cloning of and genetic variation in protease VCP1 from the nematophagous fungus Pochonia chlamydosporia.
Cloning, expression and deletion of the cuticle-degrading protease BLG4 from nematophagous bacterium Brevibacillus laterosporus G4.
Comparative proteomic analysis of the sweetpotato provides insights into response mechanisms to Fusarium oxysporum f. sp. batatas.
Conditioned Medium from Enterohemorrhagic Escherichia coli-Infected T84 Cells Inhibits Signal Transducer and Activator of Transcription 1 Activation by Gamma Interferon.
Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations.
Development of a high-efficiency gene knockout system for Pochonia chlamydosporia.
Differential gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus during infection.
Diverse effects of Galleria mellonella infection with entomopathogenic and clinical strains of Pseudomonas aeruginosa.
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo.
Entry of mouse hepatitis virus into cells by endosomal and nonendosomal pathways.
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Expression of Exogenous Human Hepatic Nuclear Factor-1? by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2.
Expression of pathogenesis-related genes in Metarhizium anisopliae when infecting Spodoptera exigua
Failure to induce formation of proteinase K resistant fibrils in pigeons through experimental infection with paramyxovirus type 1.
Functional identification of the gene bace16 from nematophagous bacterium Bacillus nematocida.
Fusion of Semliki Forest virus infected Aedes albopictus cells at low pH is a fusion from within.
Genetics of natural resistance to Sendai virus infection in mice.
Identification of a Highly Antigenic Region of Subtilisin-Like Serine Protease 1 for Serodiagnosis of Neospora caninum Infection.
In situ cleavage of the baculovirus occlusion derived virus receptor binding protein P74 in the peroral infectivity complex.
In vivo activity of proteases of Pseudomonas aeruginosa in a rat model.
In vivo bacterial protease production during Pseudomonas aeruginosa corneal infection.
In vivo characterization of host and bacterial protease expression during Pseudomonas aeruginosa corneal infections in naive and immunized mice.
Influence of Leishmania infection on blood-meal digestion in the sandflies Phlebotomus papatasi and P. langeroni.
Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model.
Lipopolysaccharide from nonvirulent Ara+ Burkholderia pseudomallei isolates is immunologically indistinguishable from lipopolysaccharide from virulent Ara- clinical isolates.
Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
Optimization of DNA Extraction from Field-Collected Mammalian Whole Blood on Filter Paper for Trypanosoma cruzi (Chagas Disease) Detection.
Plasmodium berghei PIMMS2 promotes ookinete invasion of the Anopheles gambiae mosquito midgut.
Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut.
Pseudomonas aeruginosa proteases and corneal virulence.
Recent Findings in Onychomycosis and Their Application for Appropriate Treatment.
Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro.
Role of elastase as a virulence factor in experimental Pseudomonas aeruginosa infection in mice.
Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein.
Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.
Strain-dependent differences in beta-sheet conformations of abnormal prion protein.
Subtilisin-like proteases in plant-pathogen recognition and immune priming: a perspective.
Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition.
Testing plasma subtilisin inhibitory activity as a selective marker for dermo resistance in eastern oysters.
The Pochonia chlamydosporia serine protease gene vcp1 is subject to regulation by carbon, nitrogen and pH: implications for nematode biocontrol.
Toll-Like Receptor 2 recognizes Orientia tsutsugamushi and increases susceptibility to murine experimental scrub typhus.
Transcriptome of an entomophthoralean fungus (Pandora formicae) shows molecular machinery adjusted for successful host exploitation and transmission.
[Significance of Pseudomonas aeruginosa virulence factors for acute and chronic Pseudomonas aeruginosa infections]
[Significance of Pseudomonas aeruginosa virulence factors in acute and chronic Pseudomonas aeruginosa infections]
Influenza, Human
Allantoic fluid protease activity during influenza virus infection.
Comparative Evaluation of Three Preprocessing Methods for Extraction and Detection of Influenza A Virus Nucleic Acids from Sputum.
Expression of influenza B virus hemagglutinin containing multibasic residue cleavage sites.
Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools.
Inhibition of subtilisin by influenza virus infected allantoic fluids.
Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers.
Insomnia, Fatal Familial
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Invasive Pulmonary Aspergillosis
The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis.
Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis.
Ischemic Stroke
PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Hyperglycemic Mice Increases the Risk of Hemorrhagic Transformation of Ischemic Stroke.
Keratitis
Corneal virulence of Pseudomonas aeruginosa elastase B and alkaline protease produced by Pseudomonas putida.
Degradation of uniquely glycosylated secretory immunoglobulin a in tears from patients with Pseudomonas aeruginosa keratitis.
Detection of virulence factors in Serratia strains isolated from contact lens-associated corneal ulcers.
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Genetic features of Pseudomonas aeruginosa isolates associated with eye infections referred to Farabi Hospital, Tehran, Iran.
Inhibitory effects of ovomacroglobulin on bacterial keratitis in rabbits.
Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.
Kuru
Wernicke encephalopathy-like symptoms as an early manifestation of Creutzfeldt-Jakob disease in a chronic alcoholic.
Leukemia-Lymphoma, Adult T-Cell
Development of ultra-super sensitive immunohistochemistry and its application to the etiological study of adult T-cell leukemia/lymphoma.
Lewy Body Disease
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.
Liver Cirrhosis
Decreased activity of hepatic alkaline protease in rats with carbon tetrachloride-induced liver cirrhosis.
Lung Diseases
Equinins in equine neutrophils: quantification in tracheobronchial secretions as an aid in the diagnosis of chronic pulmonary disease.
Lupus Erythematosus, Systemic
Proprotein convertase subtilisin kexin 9 is associated with disease activity and is implicated in immune activation in systemic lupus erythematosus.
Lymphocytic Choriomeningitis
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P.
Lymphoma
Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation.
The role of multivalency in antibody mediated liposome targeting.
[Effect of microwave pretreatment on the detection of Epstein-Barr virus EBER RNA's using in situ hybridization]
Malaria
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.
A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase.
Expression of Exogenous Human Hepatic Nuclear Factor-1? by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2.
Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease.
Molecular Determinants of Binding to the Plasmodium Subtilisin-like Protease 1.
Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Mastitis
Identification of pathogens in mastitis milk samples with fluorescent in situ hybridization.
Melanoma
Invasion of melanoma cells by Mycoplasma hyorhinis: enhancement by protease treatment.
Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein.
Memory Disorders
Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
Metabolic Syndrome
Pilot-scale produced fermented lentil protects against t-BHP-triggered oxidative stress by activation of Nrf2 dependent on SAPK/JNK phosphorylation.
Metrorrhagia
Detection of Plasmodium falciparum using a cloned DNA probe: a simple procedure suitable for field application.
Radioactive and enzymatic cloned cDNA probes for bovine enteric coronavirus detection by molecular hybridization.
Multiple System Atrophy
Biochemical characterization of the core structure of alpha-synuclein filaments.
Muscular Atrophy
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Muscular Dystrophies
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Mycoses
Crystal structure of a fungal protease inhibitor from Antheraea mylitta.
Neoplasms
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.
Carcinosarcoma of the breast: molecular-biological study for analysis of histogenesis.
Cellular distribution of endothelin-1 mRNA in human brain by in situ RT-PCR.
Clinicopathological Characterization of TSH-Producing Adenomas: Special Reference to TSH-immunoreactive but Clinically Non-functioning Adenomas.
Dense distribution of nuclear alkaline protease to nucleoli with increase in rapidly growing cells in rats.
Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells.
Effect of Different Proteinase K Digest Protocols and Deparaffinization Methods on Yield and Integrity of DNA Extracted From Formalin-fixed, Paraffin-embedded Tissue.
Evaluation of a novel subtilisin inhibitor gene and mutant derivatives for the expression and secretion of mouse tumor necrosis factor alpha by Streptomyces lividans.
Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics.
Glucagon, glicentin, proglucagon, PYY, PP and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells.
GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy.
Immunomodulatory properties of the milk whey products obtained by enzymatic and microbial hydrolysis
Improved DNA content histograms from formalin-fixed, paraffin-embedded liver tissue by proteinase K digestion.
Inhibition of tumor necrosis factor-alpha-induced RANTES secretion by alkaline protease in A549 cells.
Internucleotide protein linkers in Ehrlich ascites cell DNA.
Interwoven MOF-Coated Janus Cells as a Novel Carrier of Toxic Proteins.
Isolation of mitochondria from ascites tumor cells permeabilized with digitonin.
Low-molecular-weight fractions of Alcalase hydrolyzed egg ovomucin extract exert anti-inflammatory activity in human dermal fibroblasts through the inhibition of tumor necrosis factor-mediated nuclear factor ?B pathway.
Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro.
Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy.
Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications.
On telomere shortening in soft-tissue tumors.
Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis.
Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population.
Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells.
pspA overexpression in Streptomyces lividans improves both Sec- and Tat-dependent protein secretion.
Radiation-induced DNA damage in tumors and normal tissues. I. Feasibility of estimating the hypoxic fraction.
Radiation-induced DNA damage in tumors and normal tissues: IV. Influence of proliferation status and cell type on the formation of oxygen-dependent DNA damage in cultured cells.
Secretagogue activities in cod (Gadus morhua) and shrimp (Penaeus aztecus) extracts and alcalase hydrolysates determined in AR4-2J pancreatic tumour cells.
Serine protease modulation of Dependence Receptors and EMT protein expression.
Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.
Squid gelatin hydrolysates with antihypertensive, anticancer and antioxidant activity
Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.
Tumor-induced sensitivity to apoptosis in T cells from patients with renal cell carcinoma: role of nuclear factor-kappaB suppression.
[Alterations of c-Myc and c-erbB-2 genes in ovarian tumours]
[Apoptosis of HL-60 cells induced by crystal proteins from Bacillus thuringiensis Bt9875]
Nephrotic Syndrome
Efficacy and Safety of PCSK9 Inhibitors in Hypercholesterolemia Associated With Refractory Nephrotic Syndrome.
Neuritis
Proteinase induced demyelination. An electrophysiological and histological study.
Neuritis, Autoimmune, Experimental
Proteinase induced demyelination. An electrophysiological and histological study.
Neuroblastoma
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line.
Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis.
Quantitation and characterisation of poly(A)-containing messenger RNAs from mouse neuroblastoma cells.
Neurodegenerative Diseases
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
Detection of proteinase K resistant proteins in the urine of patients with Creutzfeldt-Jakob and other neurodegenerative diseases.
Neuromuscular Diseases
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Non-alcoholic Fatty Liver Disease
Interrogation of selected genes influencing serum LDL-Cholesterol levels in patients with well characterized NAFLD.
The Role of PCSK9 in the Pathogenesis of Non-alcoholic Fatty Liver Disease and the Effect of PCSK9 Inhibitors.
Non-ST Elevated Myocardial Infarction
The relationship between protein convertase subtilisin kexin type-9 levels and extent of coronary artery disease in patients with non-ST-elevation myocardial infarction.
Onychomycosis
Detection of Trichophyton rubrum and Trichophyton interdigitale in onychomycosis using monoclonal antibodies against Sub6 (Tri r 2).
Determination of terbinafine in nail samples during systemic treatment for onychomycoses.
Osteosarcoma
Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.
Paralysis
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Parkinson Disease
Distinct ?-synuclein strains differentially promote tau inclusions in neurons.
Parkinsonian Disorders
The aggregation state of ?-synuclein deposits in dermal nerve fibers of patients with Parkinson's disease resembles that in the brain.
Periodontal Pocket
Inhibitory effect of serum globulins on the adhesion of Prevotella nigrescens to hydroxyapatite.
Photosensitivity Disorders
Hematoporphyrin photosensitization of serum albumin and subtilisin BPN'.
Photosensitization tissue model.
Pick Disease of the Brain
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Pneumonia
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
[Changes of the activity of blood serum alkaline protease in young children with acute pneumonia]
Polycystic Kidney Diseases
Molecular analysis of the gene encoding a novel chitin-binding protease from Alteromonas sp. strain O-7 and its role in the chitinolytic system.
Polyneuropathies
Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases.
Prion Diseases
A pitfall in diagnosis of human prion diseases using detection of protease-resistant prion protein in urine. Contamination with bacterial outer membrane proteins.
Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions.
Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.
Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
Could immunomodulation be used to prevent prion diseases?
Detergents modify proteinase K resistance of PrP(Sc) in different transmissible spongiform encephalopathies (TSEs).
Development of oligomeric prion-protein aggregates in a mouse model of prion disease.
Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.
Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy.
Genetic influence on the structural variations of the abnormal prion protein.
Genetic prion disease: no role for the immune system in disease pathogenesis?
Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA.
Identification and characterization of proteinase K-resistant proteins in members of the class Mollicutes.
Identification and Structural Characterization of the Precursor Conformation of the Prion Protein which Directly Initiates Misfolding and Oligomerization.
Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy.
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.
Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid.
Localization of disease-related PrP in Danish patients with different subtypes of prion disease.
Measurement of altered aspartyl residues in the scrapie associated form of prion protein.
Molecular pathogenesis of prion diseases.
Molecular profiling and comparison of field transmissible spongiform encephalopathy cases diagnosed in Catalunya.
Molecular Subtyping of PrP(res) in Human Sporadic CJD Brain Tissue.
Overexpression of nonconvertible PrPc delta114-121 in scrapie-infected mouse neuroblastoma cells leads to trans-dominant inhibition of wild-type PrP(Sc) accumulation.
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein.
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
Proteinase K enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2A11.
Proteomic analysis of prion diseases: creating clarity or causing confusion?
PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection.
Transmissible spongiform encephalopathy strain-associated diversity of N-terminal proteinase K cleavage sites of PrP(Sc) from scrapie-infected and bovine spongiform encephalopathy-infected mice.
Use of a new immunoassay to measure PrP Sc levels in scrapie-infected sheep brains reveals PrP genotype-specific differences.
Use of thermolysin in the diagnosis of prion diseases.
Prostatic Neoplasms
Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells.
Proteinuria
Mass spectrometry-based proteomic exploration of the small urinary extracellular vesicles in ANCA-associated vasculitis in comparison with total urine.
Pseudomonas Infections
Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa.
Pulmonary Aspergillosis
Polymerase chain reaction amplification of Asp f I and alkaline protease genes from fungus balls: clinical application in pulmonary aspergillosis.
Rabies
A simple method for detection of rabies viral sequences in 16-year old archival brain specimens with one-week fixation in formalin.
Renal Insufficiency, Chronic
Preparation, characterization and physicochemical properties of novel low-phosphorus egg yolk protein.
Respiratory Hypersensitivity
A fungal protease allergen provokes airway hyper-responsiveness in asthma.
Retinoblastoma
Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization.
Sarcoma, Avian
Engineering proteases with altered specificity.
Scabies
Contribution of cutinase serine 42 side chain to the stabilization of the oxyanion transition state.
Scrapie
A Distinct Proteinase K Resistant Prion Protein Fragment in Goats with No Signs of Disease in a Classical Scrapie Outbreak.
A modified host protein model of scrapie.
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones.
Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents.
Biochemical properties of protease resistant prion protein PrPsc in natural sheep scrapie.
Biological and biochemical characterization of sheep scrapie in Japan.
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.
Characteristics of 263K scrapie agent in multiple hamster species.
Characterization of proteinase K-resistant N- and C-terminally truncated PrP in Nor98 atypical scrapie.
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
Conformational change in hamster scrapie prion protein (PrP27-30) associated with proteinase K resistance and prion infectivity.
Detection and discrimination of PrPSc by multi-spectral ultraviolet fluorescence.
Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion.
Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations.
Detection of ultra-low levels of pathologic prion protein in scrapie infected hamster brain homogenates using real-time immuno-PCR.
Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.
Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein.
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.
Evaluation of a combinatorial approach to prion inactivation using an oxidizing agent, SDS, and proteinase K.
Generation of a Persistently Infected MDBK Cell Line with Natural Bovine Spongiform Encephalopathy (BSE).
Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus.
Identification of putative atypical scrapie in sheep in Portugal.
Immunological characterization of abnormal prion protein from atypical scrapie cases in sheep using a panel of monoclonal antibodies.
Influence of guanidine on proteinase K resistance in vitro and infectivity of scrapie prion protein PrP(Sc).
Infrared microspectroscopy detects protein misfolding cyclic amplification (PMCA)-induced conformational alterations in hamster scrapie progeny seeds.
Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins.
Involvement of protein in scrapie agent infectivity.
Isolation and structural studies of the intact scrapie agent protein.
Molecular analysis of the abnormal prion protein during coinfection of mice by bovine spongiform encephalopathy and a scrapie agent.
Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer.
Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells.
Overexpression of active Syrian golden hamster prion protein PrPc as a glutathione S-transferase fusion in heterologous systems.
Partitioning of TSE infectivity during ethanol fractionation of human plasma.
Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity.
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions.
Purification and partial characterization of the normal cellular homologue of the scrapie agent protein.
Purification of the scrapie agent by density gradient centrifugation.
Rapid expression of polymorphic ovine prion proteins and studies on their protease sensitivity.
Rapid typing of transmissible spongiform encephalopathy strains with differential ELISA.
Recombinant alkaline serine protease II degrades scrapie isoform of prion protein.
Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance.
Recombinant prion protein rPrP27-30 from Syrian golden hamster reveals proteinase K sensitivity.
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases.
Reversibility of scrapie inactivation is enhanced by copper.
Scrapie agent contains a hydrophobic protein.
Scrapie associated fibril detection on decomposed and fixed ovine brain material.
Scrapie infectivity is independent of amyloid staining properties of the N-terminally truncated prion protein.
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis.
Scrapie-infected cells, isolated prions, and recombinant prion protein: a comparative study.
Strain-specific proteolytic processing of the prion protein in prion diseases of ruminants transmitted in ovine transgenic mice.
The effects of prion protein proteolysis and disaggregation on the strain properties of hamster scrapie.
The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.
Use of a new immunoassay to measure PrP Sc levels in scrapie-infected sheep brains reveals PrP genotype-specific differences.
Use of thermolysin in the diagnosis of prion diseases.
Using small molecule reagents to selectively modify epitopes based on their conformation.
Viroids and prions.
Scrub Typhus
Toll-Like Receptor 2 recognizes Orientia tsutsugamushi and increases susceptibility to murine experimental scrub typhus.
Sepsis
Effect of passive immunotherapy on murine gut-derived sepsis caused by Pseudomonas aeruginosa.
Efficacies of alkaline protease, elastase and exotoxin A toxoid vaccines against gut-derived Pseudomonas aeruginosa sepsis in mice.
Skin Diseases
Low-molecular-weight fractions of Alcalase hydrolyzed egg ovomucin extract exert anti-inflammatory activity in human dermal fibroblasts through the inhibition of tumor necrosis factor-mediated nuclear factor ?B pathway.
T cell stimulating stratum corneum antigens: characterization by chromatography and electrophoresis indicates limited diversity.
Sleep Initiation and Maintenance Disorders
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Spinal Dysraphism
Allergic and latex-specific sensitization: route, frequency, and amount of exposure that are required to initiate IgE production.
Squamous Cell Carcinoma of Head and Neck
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
[DNA extraction using Chelex resin for oncogenic amplification analysis in head and neck tumours]
Starvation
Changes in the starvation response through covalent cell attachment.
Functional analysis of a subtilisin-like serine protease gene from biocontrol fungus Trichoderma harzianum.
Selective inhibition of calcium-stimulated cation-induced pinocytosis by starvation and inhibitors of protein synthesis in Amoeba proteus.
Stroke
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia: Effect on stroke risk.
subtilisin deficiency
Alkaline protease deficiency in the cr-1 (crisp) mutant of Neurospora crassa.
Supranuclear Palsy, Progressive
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Tetanus
Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin.
X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin.
Thrombosis
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli.
High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters.
Improvement of the acid resistance, catalytic efficiency, and thermostability of nattokinase by multisite-directed mutagenesis.
Molecular analysis of a fibrin-degrading enzyme from Bacillus subtilis K2 isolated from the Indonesian soybean-based fermented food moromi.
Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis.
Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli.
Subtilisin QK-2: secretory expression in Lactococcus lactis and surface display onto gram-positive enhancer matrix (GEM) particles.
Thrombolytic effect of Subtilisin QK on carrageenan induced thrombosis model in mice.
Tissue factor–dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli.
[Evaluating thrombolytic efficacy and thrombus targetability of RGDS-liposomes encapsulating subtilisin FS33 in vivo]
Tinea
Assessment of the subtilisin gene profile in Trichophyton verrucosum isolated from human and animal dermatophytoses in two-stage multiplex PCR.
Detection of subtilisin 3 and 6 in skin biopsies of cattle with clinically manifested bovine ringworm.
Tuberculosis
Development of antigen detection assay for diagnosis of tuberculosis using sputum samples.
Human CD4-CD8- alpha beta + T-cell receptor T cells recognize different mycobacteria strains in the context of CD1b.
Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis.
Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
Tuberculosis, Pleural
Modified TB rapid test by proteinase K for rapid diagnosis of pleural tuberculosis.
Urinary Tract Infections
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Uterine Cervical Neoplasms
Characterization of the anti-cancer-cell parasporal proteins of a Bacillus thuringiensis isolate.
Purification and identification of novel cytotoxic oligopeptides from soft coral Sarcophyton glaucum.
Vaccinia
3'-modified oligonucleotides by reverse DNA synthesis.
Evidence for an alkaline protease in vaccinia virus.
Vascular Diseases
Efficacy and Safety of PCSK9 Inhibitors in Hypercholesterolemia Associated With Refractory Nephrotic Syndrome.
PCSK9 inhibition: ready for prime time in CKD?
Vesicular Stomatitis
Endocytosis in Saccharomyces cerevisiae: internalization of enveloped viruses into spheroplasts.
Vibrio Infections
Cloning and expression of the gene encoding an extracellular alkaline serine protease from Vibrio alginolyticus strain HY9901, the causative agent of vibriosis in Lutjanus erythopterus (Bloch).
Role of alkaline serine protease, asp, in vibrio alginolyticus virulence and regulation of its expression by luxO-luxR regulatory system.
Warts
Human papillomavirus DNA from warts for typing by endonuclease restriction patterns: purification by alkaline plasmid methods.
Wasting Disease, Chronic
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Generation of a Persistently Infected MDBK Cell Line with Natural Bovine Spongiform Encephalopathy (BSE).
Wasting Syndrome
Myofibrillar protease activity in muscle tissue from patients in catabolic conditions.
Whooping Cough
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.
Bacterial type AB? enterotoxins--structure, function and mechanism of action.
Dissociation of catalytic and invasive activities of Bordetella pertussis adenylate cyclase.
Dynamic Duo-The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin.
Major outbreak of pertussis in northern Alberta, Canada: analysis of discrepant direct fluorescent-antibody and culture results by using polymerase chain reaction methodology.
Surface anchoring of bacterial subtilisin important for maturation function.
The Major Leukocyte Chemotactic and Activating Factors in the Mouse Gut Lumen Are Not N-Formylpeptide Receptor 1 Agonists.
Wilms Tumor
Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications.