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Information on EC 3.4.21.46 - complement factor D and Organism(s) Mus musculus and UniProt Accession P03953

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.46 complement factor D
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This record set is specific for:
Mus musculus
UNIPROT: P03953 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
Synonyms
vascular endothelial growth factor, vegf-d, adipsin, factor d, pdgf-d, complement factor d, vascular endothelial growth factor d, platelet-derived growth factor d, endogenous vascular elastase, podak, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28 kDa protein, adipocyte
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-
-
-
Adipsin
alternative complement pathway component Factor D
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C3 convertase activator
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-
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C3 proactivator convertase
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-
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convertase, C3 proactivator
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-
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endogenous vascular elastase
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-
-
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esterase, properdin factor D
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-
-
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factor D
factor D (complement)
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
37213-56-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
complement component C3bB + H2O
?
show the reaction diagram
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-
-
-
?
complement factor B + H2O
?
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
complement component C3bB + H2O
?
show the reaction diagram
-
-
-
-
?
complement factor B + H2O
?
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
six week old, male, LDL receptor-deficient
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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deficiency of factor D leads to exacerbated liver injury and inflammatory cells. The absence of Factor D and lack of C3b/iC3b/C3c deposition following CCl4-induced injury is associated with more severe and prolonged liver injury
metabolism
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in humans neither MASP-1 nor MASP-3 are required for alternative pathway function. During MASP-1/-3 deficiency significant alternative pathway activity remains, indicating that mature factor D is present in the absence of MASP-1/-3
physiological function
additional information
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influence of buffer composition on the activity of the alternative pathway of complement activation in mice in the presence and the absence of the Masp1 gene products, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CFAD_MOUSE
259
0
28057
Swiss-Prot
Secretory Pathway (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
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complement factor D is a zymgen with the activation peptide QPRGR at its N-terminus. Mannose-binding lectin-associated serine protease-1 and -3 (Masp 1/3) deficient mice fail convert pro-complement factor D in its active form. Mannose-binding lectin-associated serine protease-1 converts pro-complement factor D in vitro indicating that mannose-binding lectin-associated serine protease-1 (MASP-1) is an essential protease for activating complement factor D
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
factor D gene expression is upregulated by western diet
Df-deficient mice show protection against the development of proliferative renal disease
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expressed in HEK-293T cells
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is increased during adipocyte differentiation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Elliott, M.K.; Jarmi, T.; Ruiz, P.; Xu, Y.; Holers, V.M.; Gilkeson, G.S.
Effects of complement factor D deficiency on the renal disease of MRL/lpr mice
Kidney Int.
65
129-138
2004
Mus musculus
Manually annotated by BRENDA team
Recinos, A.; Carr, B.K.; Bartos, D.B.; Boldogh, I.; Carmical, J.R.; Belalcazar, L.M.; Brasier, A.R.
Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway
Physiol. Genomics
19
131-142
2004
Mus musculus (P03953), Mus musculus
Manually annotated by BRENDA team
Takahashi, M.; Ishida, Y.; Iwaki, D.; Kanno, K.; Suzuki, T.; Endo, Y.; Homma, Y.; Fujita, T.
Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D
J. Exp. Med.
207
29-37
2010
Mus musculus
Manually annotated by BRENDA team
Degn, SE.; Jensenius, J.C.; Thiel, S.
The pro-Factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function
J. Immunol.
192
5448-5449
2014
Mus musculus
Manually annotated by BRENDA team
Cresci, G.A.; Allende, D.; McMullen, M.R.; Nagy, L.E.
Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury
Mol. Immunol.
64
9-17
2015
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
McCullough, R.L.; McMullen, M.R.; Sheehan, M.M.; Poulsen, K.L.; Roychowdhury, S.; Chiang, D.J.; Pritchard, M.T.; Caballeria, J.; Nagy, L.E.
Complement factor D protects mice from ethanol-induced inflammation and liver injury
Am. J. Physiol. Gastrointest. Liver Physiol.
315
G66-G79
2018
Mus musculus
Manually annotated by BRENDA team
Song, N.J.; Kim, S.; Jang, B.H.; Chang, S.H.; Yun, U.J.; Park, K.M.; Waki, H.; Li, D.Y.; Tontonoz, P.; Park, K.W.
Small molecule-induced complement factor D (adipsin) promotes lipid accumulation and adipocyte differentiation
PLoS ONE
11
e0162228
2016
Mus musculus (Q3UP47)
Manually annotated by BRENDA team