Disease on EC 3.2.2.29 - thymine-DNA glycosylase
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.
Breast Neoplasms
Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization.
Carcinogenesis
Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis.
Carcinogenesis
Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.
Carcinogenesis
Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.
Carcinoma, Hepatocellular
Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma.
Colorectal Neoplasms
Thymine DNA glycosylase is a positive regulator of wnt signaling in colorectal cancer.
Ependymoma
Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression.
Esophageal Neoplasms
Thymine DNA glycosylase-regulated TAZ promotes radioresistance by targeting nonhomologous end joining and tumor progression in esophageal cancer.
Hepatitis B
The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repair.
Infections
Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway.
Leukemia
Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
Medulloblastoma
Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression.
Neoplasms
DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells.
Neoplasms
Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53.
Stomach Neoplasms
Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system.
Stomach Neoplasms
Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer.
Stomach Neoplasms
Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.
Xeroderma Pigmentosum
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.
