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Information on EC 3.2.2.26 - futalosine hydrolase and Organism(s) Streptomyces coelicolor and UniProt Accession Q9KXN0

for references in articles please use BRENDA:EC3.2.2.26
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     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.26 futalosine hydrolase
IUBMB Comments
This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.
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This record set is specific for:
Streptomyces coelicolor
UNIPROT: Q9KXN0
The taxonomic range for the selected organisms is: Streptomyces coelicolor
The enzyme appears in selected viruses and cellular organisms
Synonyms
5'-methylthioadenosine nucleosidase, futalosine hydrolase, futalosine nucleosidase, MqnB, MTAN, TTHA0556, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
futalosine hydrolase
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futalosine nucleosidase
SYSTEMATIC NAME
IUBMB Comments
futalosine ribohydrolase
This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
futalosine + H2O
dehypoxanthine futalosine + hypoxanthine
show the reaction diagram
futalosine + H2O
dehypoxanthine futalosine + hypoxanthine
show the reaction diagram
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?
additional information
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no activity with aminodeoxyfutalosine
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
futalosine + H2O
dehypoxanthine futalosine + hypoxanthine
show the reaction diagram
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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strain lacking the activity accumulates futalosine. Recombinant expression does not result in an active enzyme
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T.
An alternative menaquinone biosynthetic pathway operating in microorganisms
Science
321
1670-1673
2008
Streptomyces coelicolor (Q9KXN0), Thermus thermophilus (Q5SKT7), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SKT7)
Manually annotated by BRENDA team
Arakawa, C.; Kuratsu, M.; Furihata, K.; Hiratsuka, T.; Itoh, N.; Seto, H.; Dairi, T.
Diversity of the early step of the futalosine pathway
Antimicrob. Agents Chemother.
55
913-916
2011
Acidothermus cellulolyticus, Helicobacter pylori, Streptomyces coelicolor
Manually annotated by BRENDA team
Li, X.; Apel, D.; Gaynor, E.C.; Tanner, M.E.
5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni
J. Biol. Chem.
286
19392-19398
2011
Campylobacter jejuni, Campylobacter jejuni NCTC 11168, Streptomyces coelicolor (Q9KXN0), Thermus thermophilus (Q5SKT7)
Manually annotated by BRENDA team
Joshi, S.; Fedoseyenko, D.; Mahanta, N.; Manion, H.; Naseem, S.; Dairi, T.; Begley, T.
Novel enzymology in futalosine-dependent menaquinone biosynthesis
Curr. Opin. Chem. Biol.
47
134-141
2018
Streptomyces coelicolor
Manually annotated by BRENDA team
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