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Information on EC 3.2.2.26 - futalosine hydrolase and Organism(s) Streptomyces coelicolor and UniProt Accession Q9KXN0

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EC Tree
     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.26 futalosine hydrolase
IUBMB Comments
This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.
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This record set is specific for:
Streptomyces coelicolor
UNIPROT: Q9KXN0
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The taxonomic range for the selected organisms is: Streptomyces coelicolor
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
ttha0556, futalosine hydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
futalosine nucleosidase
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futalosine hydrolase
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-
-
-
futalosine nucleosidase
SYSTEMATIC NAME
IUBMB Comments
futalosine ribohydrolase
This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
futalosine + H2O
dehypoxanthine futalosine + hypoxanthine
show the reaction diagram
-
-
-
?
futalosine + H2O
dehypoxanthine futalosine + hypoxanthine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no activity with aminodeoxyfutalosine
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
futalosine + H2O
dehypoxanthine futalosine + hypoxanthine
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
strain lacking the activity accumulates futalosine. Recombinant expression does not result in an active enzyme
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T.
An alternative menaquinone biosynthetic pathway operating in microorganisms
Science
321
1670-1673
2008
Streptomyces coelicolor (Q9KXN0), Thermus thermophilus (Q5SKT7), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SKT7)
Manually annotated by BRENDA team
Arakawa, C.; Kuratsu, M.; Furihata, K.; Hiratsuka, T.; Itoh, N.; Seto, H.; Dairi, T.
Diversity of the early step of the futalosine pathway
Antimicrob. Agents Chemother.
55
913-916
2011
Acidothermus cellulolyticus, Helicobacter pylori, Streptomyces coelicolor
Manually annotated by BRENDA team
Li, X.; Apel, D.; Gaynor, E.C.; Tanner, M.E.
5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni
J. Biol. Chem.
286
19392-19398
2011
Campylobacter jejuni, Campylobacter jejuni NCTC 11168, Streptomyces coelicolor (Q9KXN0), Thermus thermophilus (Q5SKT7)
Manually annotated by BRENDA team
Joshi, S.; Fedoseyenko, D.; Mahanta, N.; Manion, H.; Naseem, S.; Dairi, T.; Begley, T.
Novel enzymology in futalosine-dependent menaquinone biosynthesis
Curr. Opin. Chem. Biol.
47
134-141
2018
Streptomyces coelicolor
Manually annotated by BRENDA team