Information on EC 3.2.1.107 - protein-glucosylgalactosylhydroxylysine glucosidase

for references in articles please use BRENDA:EC3.2.1.107
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EC Tree
IUBMB Comments
The enzyme specifically hydrolyses glucose from alpha-D-glucosyl-(1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. Acetylation of the epsilon-amino group of the glycosylated hydroxylysine abolishes activity.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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[collagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine
+
H2O
=
D-glucose
+
[collagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
[collagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine
+
=
+
[collagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
Synonyms
2-O-alpha-D-glucopyranosyl-5-O-beta-D-galactopyranosylhydroxy-L-lysine glucohydrolase, 2-O-alpha-D-glucopyranosyl-O-beta-D-galactopyranosyl-hydroxylysine glucohydrolase, ATHL1, GGHG, glucosidase, glycosylgalactosylhydroxylysine, glycosyl-galactosyl-hydroxylysine glucosidase, glycosylgalactosylhydroxylysine glucosidase, PGGHG, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[collagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine + H2O = D-glucose + [collagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
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PATHWAY SOURCE
PATHWAYS
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