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Information on EC 3.1.4.4 - phospholipase D and Organism(s) Sicarius terrosus and UniProt Accession A0A0D4WV12

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.4 phospholipase D
IUBMB Comments
Also acts on other phosphatidyl esters.
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Select one or more organisms in this record: ?
This record set is specific for:
Sicarius terrosus
UNIPROT: A0A0D4WV12
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Word Map
The taxonomic range for the selected organisms is: Sicarius terrosus
The enzyme appears in selected viruses and cellular organisms
Synonyms
pld, phospholipase d, nape-pld, phospholipase d1, dermonecrotic toxin, phospholipase d2, pc-pld, pldalpha, rpld1, spo14, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospholipase D Beta1B1i
-
AtPLDalpha1
-
-
-
-
AtPLDalpha2
-
-
-
-
AtPLDbeta1
-
-
-
-
AtPLDbeta2
-
-
-
-
AtPLDdelta
-
-
-
-
AtPLDepsilon
-
-
-
-
AtPLDgamma1
-
-
-
-
AtPLDgamma2
-
-
-
-
AtPLDgamma3
-
-
-
-
AtPLDp1
-
-
-
-
AtPLDp2
-
-
-
-
AtPLDzeta
-
-
-
-
choline phosphatase
-
-
-
-
hPLD1
-
-
-
-
hPLD2
-
-
-
-
lecithinase D
-
-
-
-
lipophosphodiesterase II
-
-
-
-
Meiosis-specific sporulation protein SPO14
-
-
-
-
mPLD1
-
-
-
-
mPLD2
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D1
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D2
-
-
-
-
Phospholipase D1 PHOX and PX containing domain
-
-
-
-
Phospholipase D2 PHOX and PX containing domain
-
-
-
-
PLD
-
-
-
-
PLD delta
-
-
-
-
PLD epsilon
-
-
-
-
PLD zeta
-
-
-
-
PLD1C
-
-
-
-
PLDalpha
-
-
-
-
PLDalpha3
-
-
-
-
PLDbeta
-
-
-
-
PLDdelta1
-
-
-
-
PLDzeta1
-
-
-
-
PLDzeta2
-
-
-
-
rPLD1
-
-
-
-
rPLD2
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine phosphatidohydrolase
Also acts on other phosphatidyl esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-87-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine + H2O
[(4R)-2-hydroxy-2-oxido-1,3,2-dioxaphospholan-4-yl]methyl tetradecanoate + ethanolamine
show the reaction diagram
-
-
-
?
N-lauroyl-D-erythrosphingosylphosphoethanolamine + H2O
N-[(4R,5S)-2-hydroxy-2-oxido-4-[(1E)-pentadec-1-en-1-yl]-1,3,2-dioxaphosphinan-5-yl]dodecanamide + ethanolamine
show the reaction diagram
-
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BIB11_SICTE
279
0
31815
Swiss-Prot
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
strucutre at 2.1 A resolution
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E134P/G195S
mutant displays increased actiity with N-hexanoyl-D-erythrosphingosylphosphorylcholine but still prefers ethanolamine substrates over choline substrates
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lajoie, D.M.; Roberts, S.A.; Zobel-Thropp, P.A.; Delahaye, J.L.; Bandarian, V.; Binford, G.J.; Cordes, M.H.
Variable Substrate preference among phospholipase D toxins from sicariid spiders
J. Biol. Chem.
290
10994-11007
2015
Sicarius terrosus (A0A0D4WV12), Sicarius terrosus
Manually annotated by BRENDA team