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Information on EC 3.1.3.56 - inositol-polyphosphate 5-phosphatase and Organism(s) Canis lupus familiaris and UniProt Accession Q29467

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.56 inositol-polyphosphate 5-phosphatase
IUBMB Comments
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
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This record set is specific for:
Canis lupus familiaris
UNIPROT: Q29467
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Word Map
The taxonomic range for the selected organisms is: Canis lupus familiaris
The enzyme appears in selected viruses and cellular organisms
Synonyms
inpp5k, ins(1,4,5)p3 5-phosphatase, inositol polyphosphate-5-phosphatase, inpp5a, insp 5-ptase, insp3 5-phosphatase, pip3 phosphatase, at5ptase1, 5pt13, inpp5j, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-myo-inositol 1,4,5-triphosphate 5-phosphatase
-
-
-
-
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase
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-
-
-
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase
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-
-
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inosine triphosphatase
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-
-
-
inositol 1,4,5-triphosphate 5-phosphatase
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-
-
-
inositol 1,4,5-trisphosphate 5-monophosphatase
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-
-
-
inositol 1,4,5-trisphosphate 5-phosphatase
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-
-
-
inositol 1,4,5-trisphosphate phosphatase
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-
-
-
inositol phosphate 5-phosphomonoesterase
-
-
-
-
inositol polyphosphate-5-phosphatase
-
-
-
-
inositol trisphosphate phosphomonoesterase
-
-
-
-
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase
-
-
-
-
Ins(1,4,5)P3 5-phosphatase
-
-
-
-
Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase
-
-
-
-
L-myo-inositol 1,4,5-trisphosphate-monoesterase
-
-
-
-
myo-inositol-1,4,5-trisphosphate 5-phosphatase
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-
-
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phosphatase, inosine tri-5PTASE
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
CAS REGISTRY NUMBER
COMMENTARY hide
106283-14-1
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9082-57-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
show the reaction diagram
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
show the reaction diagram
-
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
show the reaction diagram
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3-bisphosphoglycerate
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003
D-myo-Inositol 1,3,4,5-tetrakisphosphate
recombinant enzyme from E. coli
0.028
D-myo-inositol 1,4,5-trisphosphate
recombinant enzyme from E. coli
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.089
recombinant enzyme from Escherichia coli
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
sequence of clone BVCT
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
I5P1_CANLF
412
0
47683
Swiss-Prot
Secretory Pathway (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47680
calculated from DNA sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
clone BVCT expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Verjans B.; De Smedt, F.; Lecocq, R.; Vanweyenberg, V.; Moreau, C.; Erneux, C.
Cloning and expression in E. coli of dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase
Biochem. J.
300
85-90
1994
Bos taurus, Canis lupus familiaris (Q29467)
-
Manually annotated by BRENDA team