Ligand 1D-myo-inositol 1,3,4,5-tetrakisphosphate

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Basic Ligand Information

Molecular Structure
Picture of 1D-myo-inositol 1,3,4,5-tetrakisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H16O18P4
1D-myo-inositol 1,3,4,5-tetrakisphosphate
CIPFCGZLFXVXBG-XCMZKKERSA-N
Synonyms:
1D-myo-inositol-1,3,4,5-tetrakisphosphate, 1D-myo-inositol 1,2,4,6-tetrakisphosphate, 1D-myo-inositol 1,3,4,5-tetrasphosphate, D-myo-Inositol 1,3,4,5-tetrakisphosphate, inositol (1,3,4,5)-tetrakisphosphate, Inositol-1,3,4,5-tetrakisphosphate, Inositol 1,3,4,5-tetrakisphosphate, inositol tetraphosphate, myo-inositol-1,3,4,5-tetrakisphosphate, myo-inositol 1,3,4,5-tetrakisphosphate, myoinositol 1,3,4,5-tetrakisphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1D-myo-inositol 1,4,6-trisphosphate + ATP = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + myo-inositol 1,3,4,5-tetrakisphosphate = ADP + myo-inositol-1,3,4,5,6-pentakisphosphate
show the reaction diagram
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ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
show the reaction diagram
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D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
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inositol 1,3,4,5-tetrakisphosphate + H2O = inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
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inositol 1,3,4,5-tetrakisphosphate + H2O = inositol 1,3,5-trisphosphate + phosphate
show the reaction diagram
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inositol tetraphosphate + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + myo-inositol 1,4,5-trisphosphate = ADP + myo-inositol-1,3,4,5-tetrakisphosphate
show the reaction diagram
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1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate
show the reaction diagram
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1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
recombinant, catalytically active fragment of isoform C, allosteric product activation in the absence of Ca2+/calmodulin, which per se activates enzyme and abolishes the allosteric effect
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activates, maximal 58.6fold activation
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
-
IC50 for inositol hexakisphosphate kinase activity is 0.061 mM, IC50 for ATP synthase activity is 0.0325 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (24 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00013
-
pH 7.2, 37°C
0.028
-
-
0.0989
-
-
2
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Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.009
-
pH 7.2, 37°C
0.003
0.004
pH 7.2, 37°C, versus 1D-myo-inositol-1,3,4-trisphosphate
0.00012
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.013
-
product inhibition, IC50 is 0.013 mM

References & Links

Links to other databases for 1D-myo-inositol 1,3,4,5-tetrakisphosphate

ChEBI
PubChem
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PubChem