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Disease on EC 3.1.3.5 - 5'-nucleotidase and Organism(s) Homo sapiens and UniProt Accession Q9BXI3

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DISEASE
TITLE OF PUBLICATION
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5'-nucleotidase deficiency
A basis of the acanthocytosis in inherited and acquired disorders.
A case of hemolytic anemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency.
A family with chronic haemolysis and selective accumulation of erythrocyte CDP-choline.
A family with red cell pyrimidine 5'-nucleotidase deficiency.
About pyrimidine 5'-nucleotidase deficiency.
Adenosine 3':5'-cyclic monophosphate (cAMP)-inducible pyrimidine 5'-nucleotidase and pyrimidine nucleotide metabolism of chick embryonic erythrocytes.
CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage.
CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
CDP-choline does not inhibit erythrocyte glycolytic or pentose phosphate pathway enzyme activity.
Chromatographic analysis of human erythrocyte pyrimidine 5'-nucleotidase from five patients with pyrimidine 5'-nucleotidase deficiency.
Clinical consequences of enzyme deficiencies in the erythrocyte.
Co-Existence of Hereditary Pyrimidine 5'-Nucleotidase Deficiency and Heterozygous ?-Thalassemia: A Case Presentation.
Cytosine and uracil nucleotides in erythrocytes from two patients with pyrimidine 5'-nucleotidase deficiency.
Detection of pyrimidine 5'-nucleotidase deficiency using 1H- or 31P-nuclear magnetic resonance.
Diagnosis of pyrimidine 5'-nucleotidase deficiency suspected from a blood film.
Diagnostic and therapeutic approaches in pyrimidine 5'-nucleotidase deficiency.
Distribution of 5'-nucleotidase in human lymphoid tissues.
Distribution of erythrocyte nucleotides in pyrimidine 5'-nucleotidase deficiency.
Ecto 5'-nucleotidase deficiency in primary hypogammaglobulinaemia.
Ecto-5'-nucleotidase deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction.
Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.
Electron microscopic observation of the red pulp of the spleen in hereditary hemolytic anemia with erythrocyte pyrimidine 5'-nucleotidase deficiency: evidence for intravascular hemolysis.
Electrophoretic and kinetic studies of human erythrocytes deficient in pyrimidine 5'-nucleotidase.
Electrophoretic characterization of pyrimidine 5'-nucleotidase of human erythrocytes and its distinction from acid phosphatase.
Emergence of activated lymphocytes in CD4 and CD8 subpopulations of multiple myeloma: correlation with the expansion of suppressor T-cells (CD8+ OKM1+) and ecto-5'nucleotidase deficiency.
Enzymatic diagnosis in non-spherocytic hemolytic anemia.
Erythrocyte nucleotide pattern in two children in a Norwegian family with pyrimidine 5'-nucleotidase deficiency.
Erythrocyte pyrimidine 5'-nucleotidase deficiency. Report of 2 new cases, with a review of the literature.
Erythrocyte pyrimidine 5'-nucleotidase.
Erythrocyte pyrimidine metabolism in pyrimidine 5'-nucleotidase deficiency.
Erythrocyte-oxidized glutathione transport in pyrimidine 5'-nucleotidase deficiency.
Familial hypogammaglobulinemia with variable serum immunoglobulins. Concordance with lymphocyte ecto-5'-nucleotidase deficiency.
Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia.
Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency.
Haemolytic anaemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency. Report of the first South African family.
Hemolytic anemia in hereditary pyrimidine 5'-nucleotidase deficiency. II. Effect of pyrimidine nucleotides and their derivatives on glycolytic and pentose phosphate shunt enzyme activity.
Hemolytic anemia in hereditary pyrimidine 5'-nucleotidase deficiency: nucleotide inhibition of G6PD and the pentose phosphate shunt.
Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: A biochemical, genetic and clinical overview.
Hereditary haemolytic anaemia due to red cell pyrimidine 5'-nucleotidase deficiency in two Irish families with a note on the benefit of splenectomy.
Hereditary hemolytic anemia with erythrocyte pyrimidine 5'-nucleotidase deficiency in Spain. Clinical, biological and familial studies.
Hereditary hemolytic anemia with human erythrocyte pyrimidine 5'-nucleotidase deficiency.
Hereditary pyrimidine 5'-nucleotidase deficiency: from genetics to clinical manifestations.
Inborn errors of purine metabolism: clinical update and therapies.
Inhibition of the pentose phosphate shunt by lead: a potential mechanism for hemolysis in lead poisoning.
Kinetic and electrophoretic studies of human erythrocytes deficient in pyrimidine 5'-nucleotidase.
Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines.
Lymphocyte 5'-nucleotidase deficiency in hypogammaglobulinemia: clinical characteristics.
Lymphocyte 5'-nucleotidase deficiency: clinical and metabolic characteristics of the associated hypogammaglobulinemia.
Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia.
Lymphocyte purine metabolism -- significance of 5'-nucleotidase deficiency: a review.
Molecular basis of Japanese variants of pyrimidine 5'-nucleotidase deficiency.
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations.
Molecular characterization of six unrelated Italian patients affected by pyrimidine 5'-nucleotidase deficiency.
Multiple myeloma: ecto-5' nucleotidase deficiency of suppressor/cytotoxic (CD8) lymphocytes is a marker for the expansion of suppressor T cells.
Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.
Phosphoribosylpyrophosphate synthetase in human erythrocytes: assay and kinetic studies using high-performance liquid chromatography.
Pyrimidine 5'-nucleotidase deficiency associated to a polymalformative syndrome.
Pyrimidine 5'-nucleotidase deficiency: improved detection of carriers.
Pyrimidine 5'-nucleotidase deficiency: studies of five cases in two Japanese families.
Pyrimidine nucleoside monophosphate kinase hyperactivity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.
Pyrimidine nucleotides impair phosphoribosylpyrophosphate (PRPP) synthetase subunit aggregation by sequestering magnesium. A mechanism for the decreased PRPP synthetase activity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.
Recommended screening test for pyrimidine 5'-nucleotidase deficiency. International Committee for Standardization in Haematology.
Red cell metabolism in hereditary pyrimidine 5'-nucleotidase deficiency: effect of magnesium.
Sensitivity of leukemic human null lymphocytes to deoxynucleosides.
Splenectomy complicated by sustained extreme thrombocytosis and extensive portosplenomesenteric vein thrombosis in pyrimidine 5'-nucleotidase deficiency.
Study of a case with severe red-cell pyrimidine 5'-nucleotidase deficiency.
Syndromes with increased red cell glutathione (GSH).
Synthesis of immunoglobulin G by pokeweed mitogen- or Epstein-Barr virus-stimulated human B cells in vitro is restricted to the ecto-5'-nucleotidase positive subset.
Three cases of hereditary hemolytic anemia with pyrimidine 5'-nucleotidase deficiency in a Japanese family.
Three families with hereditary hemolytic anemia and pyrimidine 5'-nucleotidase deficiency: electrophoretic and kinetic studies.
Two cases of hereditary hemolytic anemia with pyrimidine 5'-nucleotidase deficiency.
Two new mutations of P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder.
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder.
[Congenital erythrocytic pyrimidine 5'-nucleotidase deficiency. A new type of haemolytic erythro-enzymopathy (author's transl)]
[Hemolytic anemia caused by pyrimidine 5'-nucleotidase (P5N) deficiency 15 years later. Apropos of 2 new cases of hereditary deficit and another one of lead poisoning]
[Hemolytic anemias caused by erythrocyte enzyme disorders]
[Impaired glutathione metabolism in hemolytic anemia]
[Purine ecto-5'-nucleotidase deficiency]
[Pyrimidine 5'-nucleotidase deficiency as the congenital cause of nonspherocytic hemolytic anemia]
[Pyrimidine 5'nucleotidase deficiency (P5N). Description of a new case]
Abortion, Spontaneous
[An ultrastructural and ultracytochemical study of peripheral blood thrombocytes in women with habitual spontaneous abortion]
Abortion, Threatened
[Circulating immune complexes and ribonuclease and 5'-nucleotidase activity in the blood of women with threatened abortion treated with acupuncture-reflexotherapy]
Acidosis
Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase.
Acidosis is a key regulator of osteoblast ecto-nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity.
Regulation of cardiac AMP-specific 5'-nucleotidase during ischemia mediates ATP resynthesis on reflow.
The roles of adenosine and related substances in exercise hyperaemia.
Acquired Immunodeficiency Syndrome
Enzymatic imbalance in peripheral blood mononuclear cells isolated from individuals with anti-HIV antibodies.
Laboratory aids to diagnosis--enzymes.
Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.
Acrodermatitis
Differences in the cellular zinc content and 5'-nucleotidase activity of normal and acrodermatitis enteropathica (AE) fibroblasts.
Acute Kidney Injury
Reduced activities of divalent cation activated ATP-ase and 5'-nucleotidase in glycerol induced acute renal failure.
Acute Lung Injury
Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation.
Ecto-5'-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury.
Adenocarcinoma
Demonstration of the association of the cell-surface enzyme, 5'-nucleotidase, with microvillar microfilaments by phalloidin shift on velocity sedimentation gradients.
Difference in cell surface 5'-nucleotidase activity, protein iodination and membrane properties between mouse lymphoma and rat adenocarcinoma cell variants with low and high-metastatic potential.
Effects of cytoskeletal perturbant drugs on ecto 5'-nucleotidase, a concanavalin A receptor.
Enzyme activities in human breast tumor cells and sera.
Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer.
Monoclonal antibodies against 5'-nucleotidase from a human pancreatic tumor cell line: their characterization and inhibitory capacity on tumor cell adhesion to fibronectin substratum.
Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas.
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
Adenocarcinoma of Lung
CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
Adenoma
Enzyme activities in biopsy specimens from large-bowel mucosa in colorectal adenomas and carcinomas.
adenosine deaminase deficiency
Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.
Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).
Ultra-performance liquid chromatography-tandem mass spectrometry-based multiplex enzyme assay for six enzymes associated with hereditary hemolytic anemia.
adenylate kinase deficiency
Enzymatic diagnosis in non-spherocytic hemolytic anemia.
adenylosuccinate lyase deficiency
Metabolic approaches to the treatment of autism spectrum disorders.
Agammaglobulinemia
Activity of ecto-5'-nucleotidase in lymphoblastoid cell lines derived from carriers of congenital X-linked agammaglobulinemia.
An explanation for the heterogeneity in B lymphocyte ecto-5'-nucleotidase activity in patients with hypogammaglobulinemia.
Decreased T cell ecto-5'-nucleotidase activity in agammaglobulinemia patients is not due to altered proportions of helper and suppressor T cells as defined by the monoclonal antibodies OKT4 and OKT8.
Distribution of 5'-nucleotidase in human lymphoid tissues.
Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies.
Ecto-5'-nucleotidase activities in B lymphoblastoid cell lines at various stages of maturation.
Ecto-5'-nucleotidase activities in lymphocytes and B lymphoblastoid cell lines from patients with congenital agammaglobulinemia.
Ecto-5'-nucleotidase activity in human T cell subsets. Decreased numbers of ecto-5'-nucleotidase positive cells from both OKT4+ and OKT8+ cells in patients with hypogammaglobulinemia.
Ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital X-linked agammaglobulinemia.
Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia.
Ecto-5'-nucleotidase expression during human B cell development. An explanation for the heterogeneity in B lymphocyte ecto-5'-nucleotidase activity in patients with hypogammaglobulinemia.
Familial hypogammaglobulinemia with variable serum immunoglobulins. Concordance with lymphocyte ecto-5'-nucleotidase deficiency.
Histochemical evaluation of lymphocytes in hypogammaglobulinemia. Decreased number of 5'-nucleotidase-positive cells.
Lymphocyte 5'-nucleotidase deficiency in hypogammaglobulinemia: clinical characteristics.
Lymphocyte 5'-nucleotidase deficiency: clinical and metabolic characteristics of the associated hypogammaglobulinemia.
Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia.
Normal levels of 5'-nucleotidase activity in lymphocytes from patients with X-linked agammaglobulinemia.
Normal Levels of 5'-Nucleotidase Activity in Lymphocytes from Patients with X-Linked Agammaglobulinemia.
Surface markers, 5'-nucleotidase activity, and in vitro functions of lymphocytes from patients with primary humoral immunodeficiency.
Synthesis of immunoglobulin G by pokeweed mitogen- or Epstein-Barr virus-stimulated human B cells in vitro is restricted to the ecto-5'-nucleotidase positive subset.
[Purine enzyme activities in lymphocytes from patients with impaired humoral immunity: decreased ecto-5'-nucleotidase activity in agammaglobulinemia (author's transl)]
AIDS-Related Complex
Decreased 5'-nucleotidase activity in suppressor (OKT8) T lymphocytes from homosexuals with AIDS-related complex: nonassociation with enhanced deoxynucleoside toxicity.
Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.
Alopecia
Evaluation of merbarone (NSC 336628) in disseminated malignant melanoma. A Southwest Oncology Group study.
Alzheimer Disease
Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology.
Anaplasia
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Anemia
Anemia induces 5'-nucleotidase in fibroblasts of cortical labyrinth of rat kidney.
Distribution and regulation of renal ecto-5'-nucleotidase: implications for physiological functions of adenosine.
Distribution of ecto-5'-nucleotidase in the rat liver: effect of anaemia.
Effects of low-level lead exposure on pyrimidine 5'-nucleotidase and other erythrocyte enzymes. Possible role of pyrimidine 5'-nucleotidase in the pathogenesis of lead-induced anemia.
Increased activity of 5' nucleotidase in serum of patients with sickle cell anaemia.
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
Anemia, Hemolytic
A case of hemolytic anemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency.
A new mutant erythrocyte pyrimidine 5'-nucleotidase characterized by fast electrophoretic mobility in a Chinese boy with chronic hemolytic anemia.
Adenosine 3':5'-cyclic monophosphate (cAMP)-inducible pyrimidine 5'-nucleotidase and pyrimidine nucleotide metabolism of chick embryonic erythrocytes.
CDP-choline does not inhibit erythrocyte glycolytic or pentose phosphate pathway enzyme activity.
Electrophoretic and kinetic studies of a mutant red cell pyrimidine 5'-nucleotidase.
Erythrocyte nucleotide pattern in two children in a Norwegian family with pyrimidine 5'-nucleotidase deficiency.
Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia.
Haemolytic anaemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency. Report of the first South African family.
Hemolytic anemia associated with lead poisoning from shotgun pellets and the response to Succimer treatment.
Hemolytic anemia in hereditary pyrimidine 5'-nucleotidase deficiency. II. Effect of pyrimidine nucleotides and their derivatives on glycolytic and pentose phosphate shunt enzyme activity.
Hemolytic anemia in hereditary pyrimidine 5'-nucleotidase deficiency: nucleotide inhibition of G6PD and the pentose phosphate shunt.
Hereditary haemolytic anaemia due to red cell pyrimidine 5'-nucleotidase deficiency in two Irish families with a note on the benefit of splenectomy.
Hereditary hemolytic anemia with erythrocyte pyrimidine 5'-nucleotidase deficiency in Spain. Clinical, biological and familial studies.
Hereditary pyrimidine 5'-nucleotidase deficiency: from genetics to clinical manifestations.
Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines.
Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations.
Molecular characterization of five Portuguese patients with pyrimidine 5'-nucleotidase deficient hemolytic anemia showing three new P5'N-I mutations.
Molecular characterization of six unrelated Italian patients affected by pyrimidine 5'-nucleotidase deficiency.
Proteomics reveals reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients.
Pyrimidine 5'-nucleotidase activity in normal and deficient human lymphoblastoid cells.
Red cell metabolism in hereditary pyrimidine 5'-nucleotidase deficiency: effect of magnesium.
The Enzymology of Cytosolic Pyrimidine 5'-Nucleotidases: Functional Analysis and Physiopathological Implications.
Two new mutations of P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder.
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder.
[Hemolytic anemia caused by pyrimidine 5'-nucleotidase (P5N) deficiency 15 years later. Apropos of 2 new cases of hereditary deficit and another one of lead poisoning]
[Hemolytic anemia due to abnormalities in erythrocyte nucleotide metabolism]
[Impaired glutathione metabolism in hemolytic anemia]
[Pyrimidine 5'-nucleotidase deficiency as the congenital cause of nonspherocytic hemolytic anemia]
Anemia, Hemolytic, Congenital
A family with red cell pyrimidine 5'-nucleotidase deficiency.
Electron microscopic observation of the red pulp of the spleen in hereditary hemolytic anemia with erythrocyte pyrimidine 5'-nucleotidase deficiency: evidence for intravascular hemolysis.
Electrophoretic and kinetic studies of human erythrocytes deficient in pyrimidine 5'-nucleotidase.
Hereditary hemolytic anemia with erythrocyte pyrimidine 5'-nucleotidase deficiency in Spain. Clinical, biological and familial studies.
Hereditary hemolytic anemia with human erythrocyte pyrimidine 5'-nucleotidase deficiency.
Three cases of hereditary hemolytic anemia with pyrimidine 5'-nucleotidase deficiency in a Japanese family.
Three families with hereditary hemolytic anemia and pyrimidine 5'-nucleotidase deficiency: electrophoretic and kinetic studies.
Two cases of hereditary hemolytic anemia with pyrimidine 5'-nucleotidase deficiency.
Two new mutations of P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder.
Two new mutations of the P5'N-1 gene found in Italian patients with hereditary hemolytic anemia: the molecular basis of the red cell enzyme disorder.
Anemia, Sickle Cell
Elevated ecto-5'-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease.
Increased activity of 5' nucleotidase in serum of patients with sickle cell anaemia.
Angina Pectoris
Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels.
Angina, Unstable
5'-nucleotidase and adenosine deaminase activities in blood of patients with unstable angina pectoris.
Aortic Valve Disease
Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats.
Aortic Valve Stenosis
Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats.
Simultaneous accurate quantification of HO-1, CD39, and CD73 in human calcified aortic valves using multiple enzyme digestion - filter aided sample pretreatment (MED-FASP) method and targeted proteomics.
Arteriosclerosis
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Arthritis
5'-Nucleotidase as a marker of both general and local inflammation in rheumatoid arthritis patients.
Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis.
Distribution of ecto 5'-nucleotidase on Mycoplasma species associated with arthritis.
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis]
Arthritis, Juvenile
Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
5'-Nucleotidase as a marker of both general and local inflammation in rheumatoid arthritis patients.
Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis.
Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls?
Purine enzyme levels in rheumatoid arthritis.
Reduction of monocyte 5'nucleotidase activity by gamma-interferon in multiple sclerosis and autoimmune diseases.
The activities of plasma-membrane marker enzymes in rheumatoid synovial tissues and fluids.
The importance of B-cells and ecto-5'nucleotidase in Mycoplasma fermentans infection and the relevance to rheumatoid arthritis.
Asthma
Adenosine and its role in asthma.
Asthmatic Augmentation of Airway Vagal Activity Involves Decreased Central Expression and Activity of CD73 in Rats.
Decreased expression of ectonucleotidase E-NPP1 in leukocytes from subjects with severe asthma exacerbation.
Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma.
[Enzymes of purine metabolism of lymphocytes and eosinophiles in bronchial asthma]
Astrocytoma
5'-Nucleotidase activity in human astrocytomas.
Initial studies to define the physiologic role of cN-II.
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.
On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.
Atherosclerosis
CD39 AS A CRITICAL ECTONUCLEOTIDASE DEFENSE AGAINST PATHOLOGICAL VASCULAR REMODELING.
CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation.
Extracellular Purine Metabolism in Blood Vessels (Part II): Activity of Ecto-Enzymes in Blood Vessels of Patients With Abdominal Aortic Aneurysm.
Vascular extracellular adenosine metabolism in mice correlates with susceptibility to atherosclerosis.
[Lipids of lymphocyte plasma membranes in patients with atherosclerosis and their children]
Autoimmune Diseases
Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis.
Be Aware of Aggregators in the Search for Potential Human ecto-5'-Nucleotidase Inhibitors.
Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.
Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.
Reduction of monocyte 5'nucleotidase activity by gamma-interferon in multiple sclerosis and autoimmune diseases.
The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells.
[Pathogenesis of inclusion body myositis: autoimmune or degenerative disease?].
Bacterial Infections
Lipopolysaccharide treatment modifies pH- and cation-dependent ecto-ATPase activity of endothelial cells.
beta-Thalassemia
Pyrimidine 5'-nucleotidase acquired deficiency in beta-thalassemia: involvement of enzyme-SH groups in the inactivation process.
Biliary Atresia
Serum 5'-nucleotidase in neonatal hepatitis and biliary atresia: preliminary observations.
Blast Crisis
5'nucleotidase, adenosine deaminase and purine nucleoside phosphorylase activities in acute leukaemia.
Adenosine deaminase and ecto-5'-nucleotidase activities in various leukemias with special reference to blast crisis: significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia.
Blast crisis of Philadelphia chromosome-positive chronic myelocytic leukemia (CML). Treatment results of 69 patients.
Independent expression of the surface markers 5'-nucleotidase and cALLA on leukemic cells.
The significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia.
Bone Diseases
Application of a continuous spectrophotometric assay for 5'nucleotidase activity in normal subjects and patients with liver and bone disease.
Brachydactyly
IMPAD1 mutations in two Catel-Manzke like patients.
Brain Diseases
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Brain Edema
Effects of triethyltin on different ATPases, 5'-nucleotidase and phosphodiesterases in grey and white matter of rabbit brain and their relation with brain edema.
Enzyme histochemistry of rat interfascicular oligodendroglia, with special reference to 5'-nucleotidase.
Brain Injuries
Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum.
Regional changes in ectonucleotidase activity after cortical stab injury in rat.
Regulation of ecto-5'-nucleotidase (CD73) in cultured cortical astrocytes by different inflammatory factors.
Brain Ischemia
Brain ischemia alters platelet ATP diphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats.
Focal cerebral ischemia enhances glial expression of ecto-5'-nucleotidase.
Brain Neoplasms
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.
Breast Neoplasms
5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells.
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives.
Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells.
Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo.
Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
Enzymes that hydrolyze adenine nucleotides in platelets from breast cancer patients.
Establishment of human pancreatic cancer gemcitabine?resistant cell line with ribonucleotide reductase overexpression.
Expression of ecto-5'-nucleotidase (CD73) in normal mammary gland and in breast carcinoma.
Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3?/?-catenin/cyclinD1 signaling pathway.
Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor.
Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry.
Overexpression of Ecto-5'-nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrix.
Plasma membrane enzymes in human breast carcinoma: relationship with serum hormones.
Purine salvage enzyme activities in normal and neoplastic human tissues.
RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion.
Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancer.
Serum 5'-nucleotidase of a breast cancer patient.
Serum 5'-nucleotidase: automation of a manual assay and brief observations on values in patients with breast cancer.
Serum adenosine deaminase, 5'-nucleotidase & alkaline phosphatase in breast cancer patients.
Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer.
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs.
Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells.
The cytosolic 5'-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells.
[Activity of the enzymes of DNA metabolism in the blood of patients with breast cancer]
[Use of enzyme test in chemotherapy of patients with cancer of the breast]
Burkitt Lymphoma
The importance of B-cells and ecto-5'nucleotidase in Mycoplasma fermentans infection and the relevance to rheumatoid arthritis.
Calcinosis
[Blood vessel calcinosis and histotopochemistry of 5'-nucleotidase in the blood-vessel wall]
Carcinogenesis
Alterations in the extracellular catabolism of nucleotides are involved in the antiproliferative effect of quercetin in human bladder cancer T24 cells.
Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors.
Enzyme pattern and growth rate of liver preneoplastic clones during carcinogenesis by diethylnitrosamine.
High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer.
LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3K? promoter.
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa.
[Influence of thymostimulin on the activity of certain enzymes of adenosine and AMP metabolism in lymphocytes of rats with mammary cancer]
Carcinoma
5'-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia.
Alterations in hepatic 5'-nucleotidase in the tumor-bearing rat.
Biological markers as an aid in the clinical management of patients with liver metastases.
Calcium-activated nucleotidase 1 silencing inhibits proliferation, migration, and invasion in human clear cell renal cell carcinoma.
CD73 as a novel marker for poor prognosis of oral squamous cell carcinoma.
Cytosolic 5'-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation.
Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.
Cytosolic 5'-nucleotidase/phosphotransferase of human colon carcinoma.
Differentiation of BCS-TC2 human colon adenocarcinoma cells by sodium butyrate: increase in 5'-nucleotidase activity.
Ecto-5'-nucleotidase (CD73) promotes tumor angiogenesis.
Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma.
Ecto-enzymes of mammary gland and its tumors. Lectin inhibition of 5'-nucleotidase of the 13762 rat mammary ascites carcinoma.
Enzyme histochemical analysis of lymphatic vessels in colon carcinoma: occurrence of lymphangiogenesis within the tumor.
Evaluation of 5'-nucleotidase as an enzyme marker in ovarian carcinoma.
Histochemical observations on 5'-nucleotidase activity in squamous cell carcinomas of the rat.
Immunological escape mechanism in spontaneously metastasizing mammary tumors.
Morphological analysis of lymph vessels and capillaries in gastric carcinoma.
New polyphenolic 5'-nucleotidase inhibitors isolated from the wine grape "Koshu" and their biological effects.
Nucleoside phosphotransferase activity of human colon carcinoma cytosolic 5'-nucleotidase.
Protein and enzyme content of plasma membranes derived from Walker 256 carcinoma cells grown as ascitic or solid tumours.
Purine metabolizing enzymes in lymphocytes from patients with solid tumors.
Resistance to 6-mercaptopurine. III. Deletion of a 5'-nucleotidase in a 6-mercaptopurine-resistant subline of the Ehrlich ascites carcinoma.
The Androgen-Regulated Calcium-Activated Nucleotidase 1 (CANT1) Is Commonly Overexpressed in Prostate Cancer and Is Tumor-Biologically Relevant in Vitro.
[Adenosine metabolism in lymphocytes and neurochemical stressor reactions in mice with metastatic Lewis carcinoma after surgical removal of the tumor]
[Antimetastatic action of bacterial endotoxins and changes in the activity of the enzymes of purine metabolism in macrophages]
[Effect of GMDP encapsulated into liposomes on metastatic spread of Lewis lung carcinoma]
[Preliminary study on correlation between double-contrast and serum 5'-nucleotidase of gastric carcinoma]
[Use of the study of DNA metabolism enzyme activities as a test system in the treatment of breast cancer]
Carcinoma, Ehrlich Tumor
Comparison of Ehrlich ascites tumour and mouse liver cells by analytical subcellular fractionation combined with a sensitive computational method for data analysis.
Membrane-bound 5'-nucleotidase inhibitor in Ehrlich ascites tumour cells and newborn mouse liver.
[ATPase and AMPase activity in the mitochondria of two ascitic tumors: ascites hepatoma of the rat and Ehrlich ascites tumor.]
Carcinoma, Embryonal
Ultrastructural localization of membrane phosphatases in teratocarcinoma and early embryos.
Carcinoma, Hepatocellular
A comparison of lipids from liver and hepatoma subcellular membranes.
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73).
Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Contrast manifestation of alkaline phosphatase and 5'-nucleotidase in plasma membranes isolated from rat liver and ascites hepatoma.
Ecto-5'-nucleotidase (CD73) is a potential target of hepatocellular carcinoma.
Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Efficiency of composite laboratory tests in the diagnosis of liver malignancies.
Enzymatic, biophysical and ultrastructural changes of plasma membranes in chemical-induced rat hepatoma.
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.
Isolation and characterization of the plasma membranes from rat ascites hepatomas and from normal rat livers, including newborn, regenerating, and adult livers.
Isolation and partial characterization of plasma membranes from chicken liver and from Mc-29 virus induced transplantable hepatoma.
Membrane lipids of hepatic tissue. I. Neutral lipids from subcellular fractions of liver and hepatoma 7288CTC.
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Preparation of plasma membranes from line 10 and line 1 guinea pig hepatomas.
Recycling of 5'-nucleotidase in a rat hepatoma cell line.
Serum AFU, 5'-NT and AFP as Biomarkers for Primary Hepatocellular Carcinoma Diagnosis.
Sodium selenite modulates tumour marker indices in N-nitrosodiethylamine-initiated and phenobarbital-promoted rat liver carcinogenesis.
Transport and metabolism of 5'-nucleotidase in a rat hepatoma cell line.
[ATPase and AMPase activity in the mitochondria of two ascitic tumors: ascites hepatoma of the rat and Ehrlich ascites tumor.]
[Changes in purine metabolism and in the immune response in the thymic and splenic lymphocytes of C3HA mice during chemical hepatocarcinogenesis]
[Comparison of the activity and properties of 5'-nucleotidase in the homogenates and plasma membranes of the normal liver, hepatomas and of the liver in mice with inoculated hepatomas of varying degrees of malignancy]
Carcinoma, Lewis Lung
[Effect of GMDP encapsulated into liposomes on metastatic spread of Lewis lung carcinoma]
Carcinoma, Non-Small-Cell Lung
5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer.
cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer.
Ectonucleotidase CD73 and CD39 expression in non-small cell lung cancer relates to hypoxia and immunosuppressive pathways.
The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134.
Carcinoma, Renal Cell
Calcium-activated nucleotidase 1 silencing inhibits proliferation, migration, and invasion in human clear cell renal cell carcinoma.
Ecto-5'-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells.
Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma.
Effect of dimethylsulfoxide and butyrate on 5'-nucleotidase of human renal carcinoma cells.
Carcinoma, Small Cell
Biological markers as an aid in the clinical management of patients with liver metastases.
Carcinoma, Squamous Cell
CD73 as a novel marker for poor prognosis of oral squamous cell carcinoma.
Histochemical observations on 5'-nucleotidase activity in squamous cell carcinomas of the rat.
Cardiomegaly
Changes in cardiac beta-adrenoceptor concentrations in spontaneously hypertensive and experimental renal hypertensive rats.
[The enzymatic activity of adenosine metabolism in the rat heart. The effects of cardiac hypertrophy]
Cardiomyopathies
Trypanosoma cruzi: increased 5'-nucleotidase activity associated with dysfunction of adrenergic receptors in acutely infected albino Swiss mice.
Cardiovascular Diseases
Effects of a highly palatable diet on lipid and glucose parameters, nitric oxide, and ectonucleotidases activity.
Regular exercise training reverses ectonucleotidase alterations and reduces hyperaggregation of platelets in metabolic syndrome patients.
Chemical and Drug Induced Liver Injury
[Effect of Arnica montana tincture on some hydrolytic enzyme activities of rat liver in experimental toxic hepatitis]
Cholangitis, Sclerosing
The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis.
Cholestasis
Clinical use of serum enzymes in liver disease.
Effect of antiepileptic drugs on the urinary excretion of porphyrins in non-porphyric subjects.
Quantitative changes in acid phosphatase, alkaline phosphatase and 5'-nucleotidase activity in rat liver after experimentally induced cholestasis.
Respective value of alkaline phosphatase, gamma-glutamyl transpeptidase and 5' nucleotidase serum activity in the diagnosis of cholestasis: a prospective study of 80 patients.
Serum 5'-nucleotidase and alkaline phosphatase activities after high dose chemotherapy and bone marrow transplantation in cases of malignancy in children.
[Cholestatic-type hepatitis in childhood]
[Differential diagnosis of jaundice]
[Serum 5'-nucleotidase as a diagnostic test in defining the type of cholestasis in children]
[The activity of cholestatic enzymes in viral hepatitis B]
Cholestasis, Extrahepatic
[Respective value of serum activity of alkaline phosphatase, gamma-glutamyl transpeptidase and 5'-nucleotidase in the diagnosis of intra- and extrahepatic cholestasis]
Cholestasis, Intrahepatic
[Changes in hepatobiliary enzymes and its isoenzymes in intrahepatic cholestasis in pregnancy]
Chondroma
Enzyme histochemical study on bone tumors.
Chondrosarcoma
Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation.
Enzyme histochemical study on bone tumors.
Chordoma
Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation.
Enzyme histochemical characterization of chordomas.
Cleft Palate
IMPAD1 mutations in two Catel-Manzke like patients.
Colitis
Purinergic Signaling as a Regulator of Th17 Cell Plasticity.
Colonic Neoplasms
Differentiation of BCS-TC2 human colon adenocarcinoma cells by sodium butyrate: increase in 5'-nucleotidase activity.
Ecto-5'-nucleotidase from a human colon adenocarcinoma cell line. Correlation between enzyme activity and levels in intact cells.
Enzymes in colon cancer. General information.
Quantitative analysis of lymphangiogenic markers in human colorectal cancer.
Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort.
Colorectal Neoplasms
Activities of adenosine deaminase and 5'-nucleotidase in cancerous and noncancerous human colorectal tissues.
Effects of CD73 on human colorectal cancer cell growth in vivo and in vitro.
Common Variable Immunodeficiency
Ecto-5'-nucleotidase expression during human B cell development. An explanation for the heterogeneity in B lymphocyte ecto-5'-nucleotidase activity in patients with hypogammaglobulinemia.
Surface markers, 5'-nucleotidase activity, and in vitro functions of lymphocytes from patients with primary humoral immunodeficiency.
Connective Tissue Diseases
The clinico-serological spectrum of overlap myositis.
Contracture
Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.
[Protective effects of m-nisoldipine and nisoldipine on myocardial damage in working rabbit hearts after ischemia-reperfusion]
Coronary Disease
NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease.
Coronary Occlusion
Canine DNA array as a potential tool for combining physiology and molecular biology.
Disparate effects of preconditioning and MLA on 5'-NT and adenosine levels during coronary occlusion.
Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits.
Crohn Disease
HIF-1?-induced xenobiotic transporters promote Th17 responses in Crohn's disease.
Cystic Fibrosis
P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients.
Surface enzymes in cultured fibroblasts from cystic fibrosis patients.
Cysts
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Ca2+ signaling in human ADPKD cyst epithelial cells.
Cytomegalovirus Infections
Cytomegalovirus infection increases the expression and activity of ecto-ATPase (CD39) and ecto-5'nucleotidase (CD73) on endothelial cells.
Demyelinating Diseases
Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Apyrase and 5'-nucleotidase Activities in Synaptosomes from the Cerebral Cortex of Rats Experimentally Demyelinated with Ethidium Bromide and Treated with Interferon-beta.
Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Effect of vitamin E on ectonucleotidase activities in synaptosomes and platelets and parameters of oxidative stress in rats experimentally demyelinated.
Dermatomyositis
Anti-Cytosolic 5'-Nucleotidase 1A Autoantibodies Are Absent in Juvenile Dermatomyositis.
Autoantibodies to Cytosolic 5'-Nucleotidase 1A in Primary Sjögren's Syndrome and Systemic Lupus Erythematosus.
Autoantibodies to cytosolic 5'-nucleotidase IA in inclusion body myositis.
Diabetes Mellitus
Enhanced NTPDase and 5'-nucleotidase activities in diabetes mellitus and iron-overload model.
Diabetes Mellitus, Experimental
[Characteristics of purine and nucleotide metabolism in juvenile rats with alloxan diabetes]
Diabetes Mellitus, Type 2
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies.
Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro.
Suppression of 5'nucleotidase enzymes promotes AMPK phosphorylation and metabolism in human and mouse skeletal muscle.
Diabetes, Gestational
NTPDase and 5'-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis.
Diabetic Nephropathies
The TGF-? profibrotic cascade targets ecto-5'-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease.
The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy.
Diabetic Retinopathy
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.
Digestive System Diseases
A de-sialylated isoform of serum 5'-nucleotidase: clinical and biological significance in hepatobiliary disease.
Electrophoretic fractionation of 5'-nucleotidase.
Electrophoretic separation of 5'-nucleotidase multiple forms.
Serial studies of serum alkaline phosphatase and 5'-nucleotidase levels in hepatobiliary disease.
Serum alkaline phosphatase and 5'-nucleotidase activities in patients with hepatobiliary disease.
Serum enzyme tests in diseases of the liver and biliary tree.
[Serum 5'nucleotidase activity in hepatobiliary diseases]
dihydropyrimidinase deficiency
Metabolic approaches to the treatment of autism spectrum disorders.
Dihydropyrimidine Dehydrogenase Deficiency
Metabolic approaches to the treatment of autism spectrum disorders.
Drug Resistant Epilepsy
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Encephalomyelitis
Expression of a second ecto-5'-nucleotidase variant besides the usual protein in symptomatic phase of experimental autoimmune encephalomyelitis.
Ribavirin administration alters ectonucleotidase activities in experimental autoimmune encephalomyelitis.
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Activities of 5'-nucleotidase and of deaminases in the nervous tissue of guinea pigs with experimental allergic encephalomyelitis.
Expression of a second ecto-5'-nucleotidase variant besides the usual protein in symptomatic phase of experimental autoimmune encephalomyelitis.
Ribavirin administration alters ectonucleotidase activities in experimental autoimmune encephalomyelitis.
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Endocarditis
Ecto-5'-nucleotidase: a candidate virulence factor in Streptococcus sanguinis experimental endocarditis.
Endometriosis
Purinergic Signaling in Endometriosis-Associated Pain.
Endotoxemia
Adenosine A(2A) receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes.
Enzootic Bovine Leukosis
[The content of Ca2+ and Mg2+ ions and membrane enzyme activity (AP, 5'-NT, ATPases) in the lymphocytes infected in vitro with bovine leukemia virus]
Eosinophilia
Absence of lymphocyte ecto-5'-nucleotidase in infants with reticuloendotheliosis and eosinophilia (Omenn's syndrome).
Epilepsy
5'-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain.
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats.
Epilepsy, Temporal Lobe
5'-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain.
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Erectile Dysfunction
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.
Esophageal Neoplasms
Potential role of P2X7R in esophageal squamous cell carcinoma proliferation.
Esophagitis, Peptic
The Activities of Acid DNase and 5'Nucleotidase in Erosive Reflux Esophagitis and Barrett's Epithelium.
Essential Hypertension
[Activity of pyrimidine 5'nucleotidase (py5'Nd) of erythrocytes in essential hypertension]
Fatty Liver
Adenosine signaling contributes to ethanol-induced fatty liver in mice.
Adenosine: Tipping the balance towards hepatic steatosis and fibrosis.
Fibroadenoma
Plasma membrane enzymes in human breast carcinoma: relationship with serum hormones.
Fibroma
Enzyme histochemical study on bone tumors.
Fibrosarcoma
[Hematopoiesis and changes in the RES of the spleen pulp in fibrosarcoma-bearing rats]
[Modification of splenic 5'-nucleotidase activity during proliferative processes in the spleen. Histoenzymatic study in the rat]
Gallstones
Clinical and pathological studies in cattle with hepatic disease.
The 5'-nucleotidase complex in sera from patients with gall stones--electrophoretic patterns and substrate specificity.
Gastritis
Adenosine deaminase, 5'-nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juices from patients with gastric cancer, ulcer, and atrophic gastritis.
Gastritis, Atrophic
Adenosine deaminase, 5'-nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juices from patients with gastric cancer, ulcer, and atrophic gastritis.
Enzyme activities in human gastric mucosa in gastritis and resected stomachs.
Gastroschisis
Establishment of reference values of five amniotic fluid enzymes. Analytical performances of the Hitachi 911. Application to complicated pregnancies.
Giant Cell Tumors
Enzyme histochemical study on bone tumors.
Gilbert Disease
Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II.
Glioblastoma
5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells.
Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.
Ecto-5'-nucleotidase from a human colon adenocarcinoma cell line. Correlation between enzyme activity and levels in intact cells.
Ecto-5'-nucleotidase regeneration after chemical modification of the plasma membrane.
Isolation and characterization of the ecto-5'-nucleotidase from a rat glioblastoma cell line.
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.
Methotrexate up-regulates ecto-5'-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment.
Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1.
Glioma
5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells.
A comparative study of ectonucleotidase and P2 receptor mRNA profiles in C6 cell line cultures and C6 ex vivo glioma model.
Adenosine uptake-dependent C6 cell growth inhibition.
Alpha-bisabolol Promotes Glioma Cell Death by Modulating the Adenosinergic System.
Altered extracellular ATP, ADP and AMP catabolism in glioma cell lines.
Changes of 5'-nucleotidase activity in cultured glioma cells.
Concanavalin A inhibition of ecto-5'-nucleotidase of intact cultured C6 glioma cells.
Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes.
Dexamethasone inhibits proliferation and stimulates ecto-5'-nucleotidase/CD73 activity in C6 rat glioma cell line.
Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells.
Ecto-5'-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line.
Effect of ethanol on neural cells grown in culture: interaction with plasma membrane ecto-5'-nucleotidase activity.
Gene expression for enzymes and transporters involved in regulating adenosine and inosine levels in rat forebrain neurons, astrocytes and C6 glioma cells.
Glioma sensitive or chemoresistant to temozolomide differentially modulate macrophage protumor activities.
Inactivation of Membrane Surface Ecto-5'-nucleotidase by Sodium Nitroprusside in C6 Glioma Cells.
Increased 5'-nucleotidase activity induced by dibutyryl cyclic AMP treatment of cultured glial cells.
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines.
Involvement of ecto-5'-nucleotidase/CD73 in U138MG glioma cell adhesion.
Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach.
Stimulation of rat C6 glioma ecto-5'-nucleotidase by chronic ethanol treatment.
Studies on the neuroprotective role of Piper longum in C6 glioma induced rats.
The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation.
Thyroid hormone stimulates 5'-ecto-nucleotidase of neonatal rat ventricular myocytes.
Thyroid hormone upregulates ecto-5'-nucleotidase/CD73 in C6 rat glioma cells.
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Glomerulonephritis
Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys.
Enzyme histochemistry in plastic-embedded sections of normal and diseased kidneys.
Increased expression of glomerular mesangial cell 5'-nucleotidase in membranous nephropathy.
Glomerulonephritis, IGA
Increased expression of glomerular mesangial cell 5'-nucleotidase in membranous nephropathy.
Glomerulonephritis, Membranoproliferative
Increased expression of glomerular mesangial cell 5'-nucleotidase in membranous nephropathy.
Glomerulonephritis, Membranous
Increased expression of glomerular mesangial cell 5'-nucleotidase in membranous nephropathy.
glucose-6-phosphate isomerase deficiency
Enzymatic diagnosis in non-spherocytic hemolytic anemia.
glutathione synthase deficiency
Enzymatic diagnosis in non-spherocytic hemolytic anemia.
Goiter
Localization of adenylate cyclase and 5'-nucleotidase activities in human thyroid follicular cells.
Gout
Phosphoribosylpyrophosphate synthetase in human erythrocytes: assay and kinetic studies using high-performance liquid chromatography.
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis]
Graft vs Host Disease
Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease.
Phenotype and function of engrafted maternal T cells in patients with severe combined immunodeficiency.
Serum 5'nucleotidase and alkaline phosphatase--highly predictive liver function tests for the diagnosis of graft-versus-host disease in bone marrow transplant recipients.
Serum catalase as marker of graft-vs-host disease in allogeneic bone marrow transplant recipients: pilot study.
Granuloma
Influence of hypercholesterolemia and cholesterol accumulation on rabbit carrageenan granuloma macrophage activation.
Mononuclear phagocytes from carrageenan-induce granulomas. Isolation, cultivation, and characterization.
Head and Neck Neoplasms
Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck.
Ectonucleotidase CD39 expression in regional metastases in head and neck cancer.
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer.
Heart Diseases
Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies.
Heart Failure
Activation of ecto-5'-nucleotidase in the blood and hearts of patients with chronic heart failure.
Adenosine and cardioprotection in the diseased heart.
Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction-Induced Heart Failure.
Hematologic Neoplasms
CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma.
Cytosolic 5'-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation.
IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism.
Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia.
Role of IMP-selective 5'-nucleotidase (cN-II) in hematological malignancies.
The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.
Hemophilia A
Biochemical and immunologic abnormalities in peripheral blood T lymphocytes of patients with hemophilia A.
Hemorrhagic Fever with Renal Syndrome
[Von Willebrand factor, antithrombin III and 5'-nucleotidase in the blood and the athrombogenic properties of the vascular wall in patients with hemorrhagic fever with renal syndrome]
Hepatitis
5'-Nucleotidase activities in sera and liver tissues of viral hepatitis patients.
Associated factors in modulating aflatoxin B1-albumin adduct level in three Chinese populations.
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases.
HLA-DRB1 allele and autoantibody profiles in Japanese patients with inclusion body myositis.
Serum 5'-nucleotidase in neonatal hepatitis and biliary atresia: preliminary observations.
Studies on some serum enzyme levels in various liver diseases.
[Alkaline phosphatases in human feces, intestinal mucosa and bile, and the occurrence of 5'-nucleotidase in feces (author's transl)]
[Serum haptoglobin and 5'-nucleotidase levels in patients with acute viral hepatitis with low and high bilirubin levels]
[Serum haptoglobin level, 5'-nucleotidase activity and the presence of HBs in patients with acute viral hepatitis]
[Value of measuring serum levels of haptoglobins and 5'-nucleotidase in differential diagnosis of viral hepatitis and mechanical jaundice]
Hepatitis C, Chronic
Effect of intravenous immunoglobulin therapy on anti-NT5C1A antibody-positive inclusion body myositis after successful treatment of hepatitis C: A case report.
Hepatitis E
Hepatitis E rORF2p stimulated and unstimulated peripheral expression profiling in patients with self-limiting hepatitis E infection.
Hepatitis, Alcoholic
Studies on some serum enzyme levels in various liver diseases.
Hepatitis, Chronic
5'-Nucleotidase activities in sera and liver tissues of viral hepatitis patients.
Studies on some serum enzyme levels in various liver diseases.
Hepatomegaly
Hepatic involvement in mastocytosis: clinicopathologic correlations in 41 cases.
Histiocytoma, Malignant Fibrous
Enzyme histochemical study on bone tumors.
Hodgkin Disease
Decreased adenosine deaminase (ADA) and 5'nucleotidase (5NT) activity in peripheral blood T cells in Hodgkin disease.
Red cell pyrimidine 5'-nucleotidase and glutathione in myeloproliferative and lymphoproliferative disorders.
Hydrops Fetalis
Desbuquois dysplasia type I and fetal hydrops due to novel mutations in the CANT1 gene.
Hyperalgesia
Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor ? in the Rat.
Role of a novel nociceptor autocrine mechanism in chronic pain.
Hyperargininemia
NTPDase and 5'-nucleotidase activities of synaptosomes from hippocampus of rats subjected to hyperargininemia.
Hypercholesterolemia
Effect of hyperlipoproteinemia on functional activity of peritoneal macrophages during tumor growth.
Influence of hypercholesterolemia and cholesterol accumulation on rabbit carrageenan granuloma macrophage activation.
Pravastatin restored the infarct size-limiting effect of ischemic preconditioning blunted by hypercholesterolemia in the rabbit model of myocardial infarction.
Vascular extracellular adenosine metabolism in mice correlates with susceptibility to atherosclerosis.
[Cytoplasmic membrane damage and thromboplastinemia in hypercholesterolemia]
Hyperemesis Gravidarum
Plasma 5'-nucleotidase activities increase in women with hyperemesis gravidarum.
Hyperemia
AICA riboside improves myocardial ischemia in coronary microembolization in dogs.
Hyperglycemia
Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio).
Hyperhomocysteinemia
Chronic mild hyperhomocysteinemia alters ectonucleotidase activities and gene expression of ecto-5'-nucleotidase/CD73 in rat lymphocytes.
Mild hyperhomocysteinemia alters extracellular adenine metabolism in rat brain.
[Effect of thiolactone homocysteine loading on adenosine metabolism in rats: relationship with platelet hyper-reactivity, correction of this metabolism disorders by vitamin-microelement complex]
Hypertension
Abnormal biochemistry of vascular smooth muscle plasma membrane as an important factor in the initiation and maintenance of hypertension in rats.
CD39 AS A CRITICAL ECTONUCLEOTIDASE DEFENSE AGAINST PATHOLOGICAL VASCULAR REMODELING.
Ectonucleotidase activities are altered in serum and platelets of L-NAME-treated rats.
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies.
Exercise training prevents ecto-nucleotidases alterations in platelets of hypertensive rats.
Histochemical study on 5'-nucleotidase in the cerebrovascular system in stroke-prone spontaneously hypertensive rats.
L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats.
NTPDase and 5'-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis.
Purinergic dysregulation in pulmonary hypertension.
Hyperthyroidism
5'-nucleotidase activity is altered by hypo- and hyperthyroidism in platelets from adult rats.
Effect of thyroid hormones on 5'-nucleotidase of isolated rat fat cells.
Effects of thyroid state on brain development: beta-adrenergic receptors and 5'-nucleotidase activity.
Hyperthyroidism changes nociceptive response and ecto-nucleotidase activities in synaptosomes from spinal cord of rats in different phases of development.
Hyperthyroidism increases adenosine transport and metabolism in the rat heart.
Hyperthyroidism modifies ecto-nucleotidase activities in synaptosomes from hippocampus and cerebral cortex of rats in different phases of development.
Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices.
Hypothyroidism and hyperthyroidism change ectoenzyme activity in rat platelets.
Studies on 5'-nucleotidase activity in blood serum, tissues and liver mitochondrial fraction of normal, hypo- and hyperthyroid rats.
Hypertrophy, Left Ventricular
Ecto-5'-nucleotidase deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction.
Hypotension
Metabolism of cAMP to adenosine: role in vasodilation of rat pial artery in response to hypotension.
Nucleoside composition of Heloderma venoms.
Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure.
Hypothyroidism
Changes in the activities of adenosine-metabolizing enzymes in six regions of the rat brain on chemical induction of hypothyroidism.
Enzymes involved in adenosine metabolism in rat white and brown adipocytes. Effects of streptozotocin-diabetes, hypothyroidism, age and sex differences.
Genomic-independent action of thyroid hormones on NTPDase activities in Sertoli cell cultures from congenital hypothyroid rats.
Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices.
Hypothyroidism and hyperthyroidism change ectoenzyme activity in rat platelets.
Hypothyroidism changes adenine nucleotide hydrolysis in synaptosomes from hippocampus and cerebral cortex of rats in different phases of development.
Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin.
Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
Regional effects of hypothyroidism on 5'-nucleotidase and cyclic nucleotide phosphohydrolase activities in developing rat brain.
IgA Deficiency
Familial hypogammaglobulinemia with variable serum immunoglobulins. Concordance with lymphocyte ecto-5'-nucleotidase deficiency.
Ileitis
Feed-forward inhibition of CD73 and upregulation of adenosine deaminase contribute to the loss of adenosine neuromodulation in postinflammatory ileitis.
Immune System Diseases
Structural and Modeling Studies on Ecto-5'-Nucleotidase Aiding in Inhibitor Design.
Infarction, Middle Cerebral Artery
Focal cerebral ischemia enhances glial expression of ecto-5'-nucleotidase.
Infections
5'-Nucleotidase activity in human blood granulocytes during acute infections.
Associated factors in modulating aflatoxin B1-albumin adduct level in three Chinese populations.
CD73 Inhibition Shifts Cardiac Macrophage Polarization toward a Microbicidal Phenotype and Ameliorates the Outcome of Experimental Chagas Cardiomyopathy.
Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
CrATP interferes in the promastigote-macrophage interaction in Leishmania amazonensis infection.
E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazonensis inhibits macrophage activation.
Early events after infection of Escherichia coli by bacteriophage T5. II. Control of the bacteriophage-induced 5'-nucleotidase activity.
Early events after infection of Escherichia coli by bacteriophage T5. Induction of a 5'-nucleotidase activity and excretion of free bases.
Ecto-5'-nucleotidase activities in B lymphoblastoid cell lines at various stages of maturation.
Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli.
Ecto-5'-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury.
Effect of an essential fatty acid deficient diet on experimental infection with Trypanosoma cruzi in germfree and conventional mice.
Effect of intravenous immunoglobulin therapy on anti-NT5C1A antibody-positive inclusion body myositis after successful treatment of hepatitis C: A case report.
Effect of zinc in enteropathogenic Escherichia coli infection.
Experimental infection of cattle with Listeria monocytogenes: Participation of purinergic metabolism in disease pathogenesis.
Extracellular nucleotide metabolism in Leishmania: influence of adenosine in the establishment of infection.
Impacts of Escherichia coli infection in young breeder chicks on the animal behavior and cerebral activity of purinergic and cholinergic enzymes involved in the regulation of molecules with neurotransmitter and neuromodulator function.
Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection.
Infection of Human Macrophages by
Influence of experimental Anaplasma marginale infection and splenectomy on NTPDase and 5'nucleotidase activities in platelets of cattle.
Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella.
Is a NAD pyrophosphatase activity necessary for Haemophilus influenzae type b multiplication in the blood stream?
Leishmania mexicana amazonensis: heterogeneity in 5'-nucleotidase and peroxidase activities of mononuclear phagocytes during in vivo and in vitro infection.
Macrophage activation measured by changes in 5'-nucleotidase and alkaline phosphodiesterase I activities after infection of newborn and juvenile guinea pigs with mycobacterium microti.
Melaleuca alternifolia essential oil prevents alterations to purinergic enzymes and ameliorates the innate immune response in silver catfish infected with Aeromonas hydrophila.
Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls?
Seric and hepatic NTPDase and 5' nucleotidase activities of rats experimentally infected by Fasciola hepatica.
Streptococcus suis synthesizes deoxyadenosine and adenosine by 5'-nucleotidase to dampen host immune responses.
Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients.
Suppression of macrophage lysosomal enzymes after Leishmania donovani infection.
The 5'-nucleotidase S5nA is dispensable for evasion of phagocytosis and biofilm formation in Streptococcus pyogenes.
The importance of B-cells and ecto-5'nucleotidase in Mycoplasma fermentans infection and the relevance to rheumatoid arthritis.
[Action of plant extracts on the natural immunity indices of animals]
[Analysis of the immunomodulating action of SK in mice of various strains]
[Change in the natural immunity of mice after administration of blastolysin, a glycopeptide from the Lactobacillus bulgaricus cell wall]
[Early effect of poliomyelitis virus on 5'-nucleotidase activity in HeLa cells]
[Urinary protein detection by iTRAQ® associated with renal transplant complications and its modification with therapy].
[Variation of cholostase enzymes (5'-nucleotidase and alkaline phosphatase) during a specific treatment for malaria in the Gabonese child]
Infectious Mononucleosis
Adenosine deaminase, purine nucleoside phosphorylase and 5'-nucleotidase activities in infectious mononucleosis.
Studies on the lymphocyte 5'-nucleotidase in chronic lymphocytic leukemia, infectious mononucleosis, normal subpopulations, and phytohemagglutinin-stimulated cells.
[Values of immunoglobulin classes IgG, IgM, IgA, haptoglobin and 5'nucleotidase in the blood serum in the course of infectious mononucleosis]
Inflammatory Bowel Diseases
Cell associated urokinase activity and colonic epithelial cells in health and disease.
Influenza, Human
Ecto-5'-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury.
Purification of membrane proteins in SDS and subsequent renaturation.
Insulin Resistance
Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.
Intestinal Volvulus
Parasite-specific inhibition of 5'-nucleotidase from Onchocerca volvulus and Dirofilaria immitis by the amoscanate-derivative CGP 8065.
Iron Deficiencies
Pyrimidine 5'nucleotidase and several other red cell enzyme activities in beta-thalassaemia trait.
Joint Diseases
Synovial fluid 5'-nucleotidase activity. Relationship to other purine catabolic enzymes and to arthropathies associated with calcium crystal deposition.
Joint Dislocations
IMPAD1 mutations in two Catel-Manzke like patients.
Kidney Failure, Chronic
Enzymes that hydrolyze adenine nucleotides in chronic renal failure: relationship between hemostatic defects and renal failure severity.
Kidney Neoplasms
Enzyme histochemistry in plastic-embedded sections of normal and diseased kidneys.
Kyphosis
CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage.
Laryngeal Neoplasms
Adenosine deaminase and 5'-nucleotidase activities in saliva from patients with oral and laryngeal cancer.
Leishmaniasis, Visceral
Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients.
Leptospirosis
Clinical and pathological studies in cattle with hepatic disease.
Lesch-Nyhan Syndrome
5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
Cytosolic 5'-nucleotidase hyperactivity in erythrocytes of Lesch-Nyhan syndrome patients.
Leukemia
5'-nucleotidase activity in lymphocytes from patients affected by B-cell chronic lymphocytic leukemia.
Adenosine deaminase and ecto-5'-nucleotidase activities in various leukemias with special reference to blast crisis: significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia.
Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase.
Deoxyribonucleoside triphosphate accumulation by leukemic cells.
Determination of ectoenzyme activities in leukemic cells and in established hematopoietic cell lines.
Ecto-5'-nucleotidase activity in lymphocytes from healthy and leukemia patients.
Ecto-5'-nucleotidase as a leukemia marker.
Evaluation of 5'-nucleotidase as biochemical marker in leukemias and lymphomas.
Expression of 5'-nucleotidase (CD73) related to other differentiation antigens in leukemias of B-cell lineage.
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Implications of a 5'-nucleotidase inhibitor in human leukemic cells for cellular aging and cancer.
Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.
Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.
Prognostic implication of ecto-5'-nucleotidase activity in acute lymphoblastic leukemia.
Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia.
Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia.
Significance of enzyme markers as a part of multiple marker analysis in leukemia research.
Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.
Structure-activity relationships of ?-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: Synthesis, in vitro evaluation and molecular modeling studies.
The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.
The role of 5'nucleotidase in therapy-resistance of childhood leukemia.
[Cytochemical detection of lymphocyte 5'-nucleotidase in chronic lymphatic leukemia]
Leukemia, B-Cell
Ecto 5'-nucleotidase in B-cell lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
5'-Ectonucleotidase in chronic lymphocytic leukemia.
5'-nucleotidase activity in lymphocytes from patients affected by B-cell chronic lymphocytic leukemia.
Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase.
Decreased 5'-nucleotidase activity in a T lymphocyte subpopulation from patients with B cell chronic lymphocytic leukemia.
Deoxyribonucleoside triphosphate accumulation by leukemic cells.
Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia.
Enzymological studies in chronic lymphocytic leukemia.
Expression of the human concentrative nucleotide transporter 1 (hCNT1) gene correlates with clinical response in patients affected by Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) undergoing a combination treatment with 2-chloro-2'-deoxyadenosine (2-CdA) and Rituximab.
Factors affecting bryostatin 1-enhanced 2-CdA cytotoxicity in resistant B-cell chronic lymphocytic leukemia.
Heterogeneity of 5'-nucleotidase activity in lymphocytes in chronic lymphocytic leukemia.
Lipid composition of plasma membranes from human leukemic lymphocytes.
Lymphocyte 5'-nucleotidase: absence of detectable protein in chronic lymphocytic leukemia.
Lymphocyte populations with 5'-nucleotidase in chronic lymphocytic leukemia.
Patterns of adenosine deaminase, ecto-5'-nucleotidase, poly(A)polymerase and surface light chain expression in chronic lymphocytic leukemias.
Properties of lymphocyte 5'nucleotidase in normal subjects and patients with chronic lymphocytic leukemia.
Studies on the lymphocyte 5'-nucleotidase in chronic lymphocytic leukemia, infectious mononucleosis, normal subpopulations, and phytohemagglutinin-stimulated cells.
[Cytochemical detection of lymphocyte 5'-nucleotidase in chronic lymphatic leukemia]
Leukemia, Lymphoid
Enzymes of purine metabolism in B-chronic lymphocytic leukemia.
Expression of the 5'-nucleotidase gene in the peripheral blood lymphocytes from B-chronic lymphocytic leukemia. Evaluation of mRNA.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Adenosine deaminase and ecto-5'-nucleotidase activities in various leukemias with special reference to blast crisis: significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia.
High levels of 5'-nucleotidase activity in blastic chronic myelogenous leukemia with common ALL-antigen.
The significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia.
Leukemia, Myeloid, Acute
Deoxyribonucleoside triphosphate accumulation by leukemic cells.
Enhancement of 5'-nucleotidase activity of human leukemic cells after fractionation: implications for cancer and aging.
Expression of high Km 5'-nucleotidase in leukemic blasts is an independent prognostic factor in adults with acute myeloid leukemia.
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML.
Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells.
Potential mechanisms of resistance to cytarabine in AML patients.
The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia.
Leukemia, Promyelocytic, Acute
The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.
Leukemia, T-Cell
Cytochemical markers of murine leukemias and lymphomas.
Leukemia-Lymphoma, Adult T-Cell
Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function.
Lipidoses
Clinical and pathological studies in cattle with hepatic disease.
Observations on gamma-glutamyl transferase, 5'-nucleotidase and leucine aminopeptidase activities in the plasma of the horse.
Listeriosis
Measurement of 5'-nucleotidase in mouse peritoneal macrophages in listeriosis.
Liver Abscess, Amebic
Studies on some serum enzyme levels in various liver diseases.
Liver Cirrhosis
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases.
Further studies on 5'-Nucleotidase from serum of liver cirrhotic individuals.
Kinetics of 5--nucleotidase in sera of liver cirrhotic and normal Iraqi individuals.
Liver Cirrhosis, Biliary
Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.
Kinetics of 5--nucleotidase in sera of liver cirrhotic and normal Iraqi individuals.
Liver Diseases
A correlation of serum bile acid levels with conventional biochemical parameters in the assessment of hepatobiliary dysfunctions.
Activated Hepatic Stellate Cells Upregulate Transcription of Ecto-5'-nucleotidase/CD73 via Specific SP1 and SMAD Promoter Elements.
Activation energy of serum 5'-nucleotidase as a marker for enzyme heterogeneity.
CD73 regulates hepatic stellate cells activation and proliferation through Wnt/?-catenin signaling pathway.
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases.
Efficiency of composite laboratory tests in the diagnosis of liver malignancies.
Lectin binding to serum 5'-nucleotidase and alkaline phosphatase in liver disease.
Serum 5'-nucleotidase and alkaline phosphatase activities after high dose chemotherapy and bone marrow transplantation in cases of malignancy in children.
Utilite De La ? Glutamyl Transpeptidase De La 5'Nucleotidase Et Des Isozymes De La Phosphatase Alcaline Pour Le Diagnostic Differentiel Des Affectations Hepatiques.
[Enzymatic evaluation of serum 5'nucleotidase in liver diseases]
[Ornithine carbamyl transferase, 5'nucleotidase and leucine arylamidase as diagnostic parameters in liver diseases of dogs]
[Use of gamma glutamyl transpeptidase, 5'-nucleotidase, and alkaline phosphatase isoenzymes in the differential diagnosis of liver diseases]
[Usefulness of 5'-nucleotidase in the clinical diagnosis of liver diseases]
Liver Diseases, Alcoholic
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases.
Liver Neoplasms
[Diagnostic value of 5'nucleotidase in primary and secondary neoplasms of the liver]
[Serum 5'-nucleotidase activity in patients with liver neoplasms]
Lung Injury
Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury.
Lung Neoplasms
5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer.
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Autocrine regulation of TGF-?1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells.
cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer.
Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non-small-cell Lung Cancer.
Ectonucleotidase CD73 and CD39 expression in non-small cell lung cancer relates to hypoxia and immunosuppressive pathways.
Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
Lung cancer alters the hydrolysis of nucleotides and nucleosides in platelets.
The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134.
The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene.
Lupus Erythematosus, Systemic
Autoantibodies to Cytosolic 5'-Nucleotidase 1A in Primary Sjögren's Syndrome and Systemic Lupus Erythematosus.
Comparison of some lymphocyte markers in B-cell chronic lymphocytic leukaemia and systemic lupus erythematosus (the B lymphocyte subset).
Reduced purine 5'-nucleotidase activity in lymphocytes of patients with systemic lupus erythematosus: results of a pilot study.
Lymphatic Metastasis
Activities of adenosine deaminase and 5'-nucleotidase in cancerous and noncancerous human colorectal tissues.
NT5E is associated with unfavorable prognosis and regulates cell proliferation and motility in gastric cancer.
Lymphoma
Cytochemical markers of murine leukemias and lymphomas.
Difference in cell surface 5'-nucleotidase activity, protein iodination and membrane properties between mouse lymphoma and rat adenocarcinoma cell variants with low and high-metastatic potential.
Ecto-5'-nucleotidase. I. Expression in human normal and neoplastic lymphoid cell lines representing sequential stages of B-cell differentiation.
Evaluation of 5'-nucleotidase as biochemical marker in leukemias and lymphomas.
Immunological evidence that plasma-membrane 5'-nucleotidase is a transmembrane protein.
In-situ activated macrophages are involved in host-resistance to lymphoma metastasis by production of nitric-oxide.
Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.
Lymphocyte 5'-nucleotidase activities in normal dogs and in dogs with malignant lymphoma.
Plasma membrane enzymes in BALB/c lymphomas with either T or B cell properties, I. 5'-Nucleotidase.
The redistribution of membrane surface immunoglobulin induces the rearrangement of some membrane integral proteins.
[A comparative study of the ectophosphatase activity in different subpopulations of tumor cells]
Lymphoma, B-Cell
Characteristics of red cell pyruvate kinase (PK) and pyrimidine 5'nucleotidase (P5N) abnormalities in acute leukaemia and chronic lymphoid diseases with leukaemic expression.
Ecto-5'-nucleotidase. II. Effect of 12-O-tetradecanoylphorbol 13-acetate on the expression of enzyme in normal and neoplastic B-cell lines.
Lymphoma, Follicular
The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.
Lymphoma, Non-Hodgkin
An enzyme histochemical study of non-Hodgkin's lymphoma and allied disease.
Lymphocytic ecto 5'-nucleotidase (ecto-5'NT) levels in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Red cell pyrimidine 5'-nucleotidase and glutathione in myeloproliferative and lymphoproliferative disorders.
Lymphoma, T-Cell
Cell surface antigen phenotypes and enzyme expression patterns of two murine T-cell lymphomas derived from early and/or mature thymus cells.
Lymphoma, T-Cell, Cutaneous
Purine pathway enzymes in the circulating malignant cells of patients with cutaneous T-cell lymphoma.
Lymphoproliferative Disorders
Red cell pyrimidine 5'-nucleotidase and glutathione in myeloproliferative and lymphoproliferative disorders.
Malaria
[Variation of cholostase enzymes (5'-nucleotidase and alkaline phosphatase) during a specific treatment for malaria in the Gabonese child]
Medulloblastoma
Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model.
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Melanoma
1?, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.
Absence of murine melanoma 5'-nucleotidase activity is not attributable to a detectable inhibitor.
CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.
Capillary electrophoresis-based nanoscale assays for monitoring ecto-5'-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes.
Comparison of 5'-nucleotidase activities among cultured murine melanoma cell lines.
Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells.
Ecto-5'-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells.
Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma.
Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer.
Inhibition of CD73 stimulates the migration and invasion of B16F10 melanoma cells in vitro, but results in impaired angiogenesis and reduced melanoma growth in vivo.
Isolation and characterization of a Golgi-rich fraction from the Harding-Passey mouse melanoma.
Nucleotide-metabolism and chromosome alterations in human-malignant melanoma xenografts.
The therapeutic potential of targeting CD73 and CD73-derived adenosine in melanoma.
Memory Disorders
Protective effects of anthocyanins on the ectonucleotidase activity in the impairment of memory induced by scopolamine in adult rats.
Metabolic Syndrome
Exercise Training positively modulates the Ectonucleotidase Enzymes in Lymphocytes of Metabolic Syndrome Patients.
Regular exercise training reverses ectonucleotidase alterations and reduces hyperaggregation of platelets in metabolic syndrome patients.
Mitochondrial Myopathies
Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.
Monoclonal Gammopathy of Undetermined Significance
Use of cytoplasmic 5'nucleotidase for differentiating malignant from benign monoclonal gammopathies.
Motor Neuron Disease
Anti-cytosolic 5'-nucleotidase 1A (cN1A) autoantibodies in motor neuron diseases.
Author response: Anti-cytosolic 5'-nucleotidase 1A (cN1A) autoantibodies in motor neuron diseases.
Editors' note: Anti-cytosolic 5'-nucleotidase 1A (cN1A) autoantibodies in motor neuron diseases.
Reader response: Anti-cytosolic 5'-nucleotidase 1A (cN1A) autoantibodies in motor neuron diseases.
Reduction of monocyte 5'nucleotidase activity by gamma-interferon in multiple sclerosis and autoimmune diseases.
Multiple Myeloma
5'-nucleotidase activity in myeloma cells.
Emergence of activated lymphocytes in CD4 and CD8 subpopulations of multiple myeloma: correlation with the expansion of suppressor T-cells (CD8+ OKM1+) and ecto-5'nucleotidase deficiency.
Multiple myeloma: ecto-5' nucleotidase deficiency of suppressor/cytotoxic (CD8) lymphocytes is a marker for the expansion of suppressor T cells.
Use of cytoplasmic 5'nucleotidase for differentiating malignant from benign monoclonal gammopathies.
Multiple Sclerosis
Adenosine deaminase and 5'nucleotidase activities in peripheral blood T cells of multiple sclerosis patients.
Determination of erythrocyte pyrimidine 5'-nucleotidase activity by 31P nuclear magnetic resonance: comparison of normal controls and multiple sclerosis patients.
Dys-regulation of peripheral transcript levels of ecto-5'-nucleotidase in multiple sclerosis patients.
Ecto-5'nucleotidase activity in B and T lymphocytes and monocytes of patients with multiple sclerosis.
Reduction of monocyte 5'nucleotidase activity by gamma-interferon in multiple sclerosis and autoimmune diseases.
Muscle Cramp
Cathelicidin-Related Antimicrobial Peptide Regulates CD73 Expression in Mouse Th17 Cells via p38.
Muscular Diseases
5'-nucleotidase activity in chicks, cotton rats, and lambs with nutritional myopathies.
Muscular Dystrophies
Histochemical demonstration of 5'-nucleotidase activity in inflammatory muscle disease.
Interstitial 5'-nucleotidase stain for frozen biopsy specimens of skeletal muscle. A useful adjunct in the diagnosis of polymyositis.
Muscular Dystrophy, Duchenne
5'-nucleotidase activity in Duchenne muscular dystrophy.
5'-Nucleotidase in skin fibroblasts from patients with Duchenne muscular dystrophy.
Abnormal growth kinetics and 5'-nucleotidase activities in cultured skin fibroblasts from patients with Duchenne muscular dystrophy.
Myasthenia Gravis
Deficits in Endogenous Adenosine Formation by Ecto-5'-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis.
Reduction of monocyte 5'nucleotidase activity by gamma-interferon in multiple sclerosis and autoimmune diseases.
Myelodysplastic Syndromes
Clinical significance of high-Km 5'-nucleotidase (cN-II) mRNA expression in high-risk myelodysplastic syndrome.
Myeloproliferative Disorders
[Adenosine deaminase (ADA), 5'-nucleotidase (5'N) and purine nucleoside phosphorylase (PNP) in lympho- and myeloproliferative disorders]
Myocardial Infarction
AMP deaminase, 5'-nucleotidase and adenosine deaminase in rat myocardial tissue in myocardial infarction and hypothermia.
Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model.
Extracellular Adenosine Formation by Ecto-5'-Nucleotidase (CD73) Is No Essential Trigger for Early Phase Ischemic Preconditioning.
Protecting against ischemia-reperfusion injury: antiplatelet drugs, statins, and their potential interactions.
Serial serum 5'-nucleotidase and S.G.O.T. levels in acute myocardial infarction.
[A role of magnesium: magnesium in the therapy for cardiovascular diseases]
[Activity of enzymes controlling adenosine metabolism in ischemic heart disease]
[Dynamics of 5'-nucleotidase activity in the blood plasma in experimental myocardial infarct]
Myocardial Ischemia
5'-Nucleotidase inhibition enhances postischemic myocardial performance.
Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.
Developmental differences in myocardial protection in response to 5'-nucleotidase inhibition.
EctoNucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release.
Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia.
Evaluation of the effectiveness of 5'-nucleotidase inhibitor and allopurinol in myocardial ischemia.
Ischemic preconditioning increases adenosine release and 5'-nucleotidase activity during myocardial ischemia and reperfusion in dogs. Implications for myocardial salvage.
Preservation of myocardial membrane integrity in the early phase of acute myocardial ischemia.
Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels.
Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization.
Myositis
Anti-cN1A antibodies do not correlate with specific clinical, electromyographic, or pathological findings in sporadic inclusion body myositis.
Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis.
Anti-NT5c1A Autoantibodies as Biomarkers in Inclusion Body Myositis.
Autoantibodies to Cytosolic 5'-Nucleotidase 1A in Primary Sjögren's Syndrome and Systemic Lupus Erythematosus.
Autoantibodies to cytosolic 5'-nucleotidase IA in inclusion body myositis.
Clinical utility of anti-cytosolic 5'-nucleotidase 1A antibody in idiopathic inflammatory myopathies.
Cytoplasmic 5'-nucleotidase autoantibodies in inclusion body myositis: Isotypes and diagnostic utility.
Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.
Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis.
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.
Histochemical demonstration of 5'-nucleotidase activity in inflammatory muscle disease.
Inclusion Body Myositis: Update on Pathogenesis and Treatment.
Interstitial 5'-nucleotidase stain for frozen biopsy specimens of skeletal muscle. A useful adjunct in the diagnosis of polymyositis.
Pathomechanisms of anti-cytosolic 5'-nucleotidase 1A autoantibodies in sporadic inclusion body myositis.
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
The clinico-serological spectrum of overlap myositis.
Myositis, Inclusion Body
Anti-cN1A antibodies do not correlate with specific clinical, electromyographic, or pathological findings in sporadic inclusion body myositis.
Anti-NT5c1A Autoantibodies as Biomarkers in Inclusion Body Myositis.
Autoantibodies to Cytosolic 5'-Nucleotidase 1A in Primary Sjögren's Syndrome and Systemic Lupus Erythematosus.
Autoantibodies to cytosolic 5'-nucleotidase IA in inclusion body myositis.
Cytoplasmic 5'-nucleotidase autoantibodies in inclusion body myositis: Isotypes and diagnostic utility.
Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.
Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis.
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.
Inclusion Body Myositis: Update on Pathogenesis and Treatment.
Pathomechanisms of anti-cytosolic 5'-nucleotidase 1A autoantibodies in sporadic inclusion body myositis.
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
Narcolepsy
Autoantibody targets in vaccine-associated narcolepsy.
Neoplasm Metastasis
Activities of adenosine deaminase and 5'-nucleotidase in cancerous and noncancerous human colorectal tissues.
Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients.
Can 5' nucleotidase estimation be a predictor of liver metastases?
Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses.
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases.
Ecto-5'-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells.
Ectonucleotidase CD39 expression in regional metastases in head and neck cancer.
Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration.
Efficiency of composite laboratory tests in the diagnosis of liver malignancies.
Evaluation of 5'-nucleotidase as an enzyme marker in ovarian carcinoma.
Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
In-situ activated macrophages are involved in host-resistance to lymphoma metastasis by production of nitric-oxide.
Liver scanning in short interval autopsy material of cancer patients.
Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice.
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis.
NT5E is associated with unfavorable prognosis and regulates cell proliferation and motility in gastric cancer.
Plasma membrane properties of cultured local LM cell tumors and metastases from athymic (nude) mice.
The Androgen-Regulated Calcium-Activated Nucleotidase 1 (CANT1) Is Commonly Overexpressed in Prostate Cancer and Is Tumor-Biologically Relevant in Vitro.
The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation.
The role of NK cells and CD39 in the immunological control of tumor metastases.
Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73.
Value of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver.
[Adenosine metabolism in lymphocytes and neurochemical stressor reactions in mice with metastatic Lewis carcinoma after surgical removal of the tumor]
[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis]
Neoplasms
5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells.
5'-Nucleotidase activity in human astrocytomas.
5'-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia.
?,?-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors.
A Monastrol-derived Compound, LaSOM 63, Inhibits Ecto-5'Nucleotidase/CD73 Activity and Induces Apoptotic Cell Death of Glioma Cell Lines.
A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.
A role of estrogens and insulin binding in the dietary lipid alteration of R3230AC mammary carcinoma growth in rats.
A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity.
Activities of adenosine deaminase and 5'-nucleotidase in cancerous and noncancerous human colorectal tissues.
Activity of ecto-5'-nucleotidase (NT5E/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes.
Adenosine and adenosine receptors in colorectal cancer.
Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
Adenosine triphosphatase activity of crystalline inclusions in alveolar soft part sarcoma. An ultrahistochemical study of a case.
Alterations in hepatic 5'-nucleotidase in the tumor-bearing rat.
Altered 5'-nucleotidase specific activity and distribution between two plasma membrane domains of ascites tumor cells with modified lipid composition.
Altered purinergic signaling in the tumor associated immunologic microenvironment in metastasized non-small-cell lung cancer.
An atlas of transposable element-derived alternative splicing in cancer.
An NMR-based Assay for the ex vivo Determination of Soluble CD73 Activity in Serum.
Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment.
Anti-CD73 therapy impairs tumor angiogenesis.
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Be Aware of Aggregators in the Search for Potential Human ecto-5'-Nucleotidase Inhibitors.
Biochemical composition of edge and center of malignant hamster insulinoma.
Calcium-activated nucleotidase 1 silencing inhibits proliferation, migration, and invasion in human clear cell renal cell carcinoma.
Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites?
CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.
CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma.
CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-?-mTOR-HIF-1 signaling in patients with non-small cell lung cancer.
CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors.
CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
CD73 as a novel marker for poor prognosis of oral squamous cell carcinoma.
CD73 expression in myeloid-derived suppressor cells is correlated with clinical stages in head and neck squamous cell carcinomas.
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment.
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer.
CD73 promotes resistance to HER2/ErbB2 antibody therapy.
CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers.
CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth.
Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.
Characterization and control of expression of cell surface alkaline phosphodiesterase I activity in rat mesangial glomerular cells.
Characterization of a monoclonal antibody defining a macrophage activation-specific cell surface antigen.
Chemopreventive task of capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses.
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme.
Comparison of Ehrlich ascites tumour and mouse liver cells by analytical subcellular fractionation combined with a sensitive computational method for data analysis.
Cytochemical markers of bladder carcinogenesis.
Cytochemical markers of murine leukemias and lymphomas.
Cytosolic 5'-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation.
Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.
Decreased ecto-5'nucleotidase activity of peripheral blood lymphocytes in human monoclonal gammopathies: correlation with tumor cell kinetics.
Demonstration of the association of the cell-surface enzyme, 5'-nucleotidase, with microvillar microfilaments by phalloidin shift on velocity sedimentation gradients.
Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.
Development of a fast CE method for high throughput screening of ecto-5'-nucleotidase inhibitors.
Development of a novel ectonucleotidase assay suitable for high-throughput screening.
Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.
Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma.
Differential expression of nucleotide pyrophosphatase/phosphodiesterases by Walker 256 mammary cancer cells in solid tumors and malignant ascites.
Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy.
Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles.
Ecto-5'-nucleotidase (CD73) is a potential target of hepatocellular carcinoma.
Ecto-5'-nucleotidase (CD73) promotes tumor angiogenesis.
Ecto-5'-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells.
Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma.
Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model.
Ecto-5'-nucleotidase. II. Effect of 12-O-tetradecanoylphorbol 13-acetate on the expression of enzyme in normal and neoplastic B-cell lines.
Ecto-5'-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line.
Ecto-enzymes of mammary gland and its tumors. Lectin inhibition of 5'-nucleotidase of the 13762 rat mammary ascites carcinoma.
Ectonucleotidase expression profile and activity in human cervical cancer cell lines.
Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids.
Effect of 5'-nucleotidase inhibitors on mouse immune system and experimental murine tumors.
Effect of dimethylsulfoxide and butyrate on 5'-nucleotidase of human renal carcinoma cells.
Effect of hyperlipoproteinemia on functional activity of peritoneal macrophages during tumor growth.
Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration.
Efficiency of composite laboratory tests in the diagnosis of liver malignancies.
Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses.
Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
Enhancement of 5'-nucleotidase activity of human leukemic cells after fractionation: implications for cancer and aging.
Enzyme activities controlling adenosine levels in normal and neoplastic tissues.
Enzyme activities in human breast tumor cells and sera.
Enzyme histochemical study on bone tumors.
Enzyme histochemistry and thyroid neoplasia.
Enzymes of purine metabolism in hairy cell leukemia.
Epithelioid sarcoma. Enzyme histochemical and ultrastructural study.
Evaluation of 5'-nucleotidase as an enzyme marker in ovarian carcinoma.
Evaluation of serum adenosine deaminase and 5'-nucleotidase activities as probable markers in ovarian cancer.
Expanding the clinical relevance of the 5'-nucleotidase cN-II/NT5C2.
Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity.
Generation and Function of Non-cell-bound CD73 in Inflammation.
GFI1/HDAC1-axis differentially regulates immunosuppressive CD73 in human tumor-associated FOXP3+ Th17 and inflammation-linked Th17 cells.
Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice.
High alkaline phosphatase activity of telangiectatic osteosarcoma (TOS) and its diagnostic significance.
High Expression of CD39 is Associated with Poor Prognosis and Immune Infiltrates in Clear Cell Renal Cell Carcinoma.
High expression of CD39/ENTPD1 in malignant epithelial cells of human rectal adenocarcinoma.
High-Throughput Screening Assays for Cancer Immunotherapy Targets: Ectonucleotidases CD39 and CD73.
Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death.
Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening.
Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface.
Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors.
Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line.
Immunological escape mechanism in spontaneously metastasizing mammary tumors.
Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer.
Implications of 5'-nucleotidase and its inhibitor for cellular aging and cancer.
Implications of a 5'-nucleotidase inhibitor in human leukemic cells for cellular aging and cancer.
Induction of ecto-5'-nucleotidase of rat cultured mesangial cells by interleukin-1 beta and tumour necrosis factor-alpha.
Influence of estrogen cytostatics on activity of plasma membrane enzymes 5'-nucleotidase and N+-K+-ATPase.
Inhibition of the Adenosinergic Pathway in Cancer Rejuvenates Innate and Adaptive Immunity.
Insights into Ecto-5'-Nucleotidase as a New Target for Cancer Therapy: A Medicinal Chemistry Study.
Involvement of ecto-5'-nucleotidase/CD73 in U138MG glioma cell adhesion.
Isolation and characterization of 5'-nucleotidase of a human pancreatic tumor cell line.
Isolation and characterization of the plasma membrane from Yoshida hepatoma cells.
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.
Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Liver scanning in short interval autopsy material of cancer patients.
Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice.
Malignant neuroendocrine tumor of the jejunum with osteoclast-like giant cells. Enzyme histochemistry distinguishes tumor cells from giant cells.
Membrane glycoprotein differences between normal lactating mammary tissue and the R3230 AC mammary tumor.
Membrane-bound 5'-nucleotidase inhibitor in Ehrlich ascites tumour cells and newborn mouse liver.
Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry.
Monoclonal antibodies against 5'-nucleotidase from a human pancreatic tumor cell line: their characterization and inhibitory capacity on tumor cell adhesion to fibronectin substratum.
Naringenin ameliorates renal and platelet purinergic signalling alterations in high-cholesterol fed rats through the suppression of ROS and NF-?B signaling pathways.
NT5DC2 is a novel prognostic marker in human hepatocellular carcinoma.
NT5DC2 knockdown inhibits colorectal carcinoma progression by repressing metastasis, angiogenesis and tumor-associated macrophage recruitment: A mechanism involving VEGF signaling.
NT5E is associated with unfavorable prognosis and regulates cell proliferation and motility in gastric cancer.
NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Nucleotide degrading enzymes in platelets from uterine cervical neoplasia patients treated with conization or radiotherapy.
Nucleotide metabolizing ecto-enzymes in Walker 256 tumor cells: molecular identification, kinetic characterization and biochemical properties.
Observations on gamma-glutamyl transferase, 5'-nucleotidase and leucine aminopeptidase activities in the plasma of the horse.
Overexpression of Ecto-5'-nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrix.
Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas.
Plasma membrane properties of cultured local LM cell tumors and metastases from athymic (nude) mice.
Potent antitumor and antineoplastic efficacy of baicalein on benzo(a)pyrene-induced experimental pulmonary tumorigenesis.
Preparation of plasma membranes from line 10 and line 1 guinea pig hepatomas.
Protein and enzyme content of plasma membranes derived from Walker 256 carcinoma cells grown as ascitic or solid tumours.
Purine degradative enzymes and immunological phenotypes in chronic B-lymphocytic leukaemia: indications that leukaemic immunocytoma is a separate entity.
Purine degradative enzymes in circulating malignant cells of patients with chronic B cell neoplasia.
Regulation of ecto-5'-nucleotidase (CD73) in cultured cortical astrocytes by different inflammatory factors.
Repeated Electroacupuncture Persistently Elevates Adenosine and Ameliorates Collagen-Induced Arthritis in Rats.
RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells.
Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies.
Serum 5'-nucleotidase and alkaline phosphatase activities after high dose chemotherapy and bone marrow transplantation in cases of malignancy in children.
SERUM 5'-NUCLEOTIDASE IN PATIENTS WITH CANCER.
Serum 5'-nucleotidase in patients with tumor in the liver.
Serum adenosine deaminase, 5'-nucleotidase & alkaline phosphatase in breast cancer patients.
Serum catalase as marker of graft-vs-host disease in allogeneic bone marrow transplant recipients: pilot study.
Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer.
Sodium selenite modulates tumour marker indices in N-nitrosodiethylamine-initiated and phenobarbital-promoted rat liver carcinogenesis.
Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.
Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression.
Stimulatory effects of purified macrophage colony-stimulating factor on murine resident peritoneal macrophages.
Structural and Modeling Studies on Ecto-5'-Nucleotidase Aiding in Inhibitor Design.
Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues.
Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors.
Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs.
Targeting the purinergic pathway in breast cancer and its therapeutic applications.
Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells.
The Androgen-Regulated Calcium-Activated Nucleotidase 1 (CANT1) Is Commonly Overexpressed in Prostate Cancer and Is Tumor-Biologically Relevant in Vitro.
The application of the serum gamma-glutamyl transpeptidase and the 5'-nucleotidase assay in cancer patients: a comparative study.
The cytosolic 5'-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells.
The druggability of intracellular nucleotide-degrading enzymes.
The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma.
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.
The role of NK cells and CD39 in the immunological control of tumor metastases.
The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells.
The truncated glucocorticoid receptor in the P1798 mouse lymphosarcoma is associated with resistance to glucocorticoid lysis but not to other glucocorticoid-induced functions.
Therapeutic Perspectives for CN-II in Cancer.
Three-dimensional changes in lymphatic architecture around VX2 tongue cancer--dynamic changes after administration of antiangiogenic agent.
Three-dimensional changes in lymphatic architecture around VX2 tongue cancer--dynamics of growth of cancer.
Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73.
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.
Transplantable subcutaneous hepatoma 22a affects functional activity of resident tissue macrophages in periphery.
Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma.
Tumor-Suppressive Function of miR-30d-5p in Prostate Cancer Cell Proliferation and Migration by Targeting NT5E.
Ultrastructural localization of membrane phosphatases in teratocarcinoma and early embryos.
Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State.
Value of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver.
Vascular markers for murine tumours.
Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5'-Nucleotidase Inhibitors.
Wnt and beta-catenin signaling target the expression of ecto-5'-nucleotidase and increase extracellular adenosine generation.
[5'-nucleotidase activity in the blood serum of women with malignant neoplasms of the genital organs and chronic inflammatory conditions of the adnexa uteri]
[A comparative study of the ectophosphatase activity in different subpopulations of tumor cells]
[Activity of 5'-nucleotidase from thymus and tumors upon administering bradykinin to tumor-bearing mice]
[Activity of adenosine metabolism enzymes and spontaneous chemiluminescence in macrophages in the tumor growth process]
[Age-dependent characteristics of metabolism of DNA precursors in healthy women, patients with mastopathy and breast cancer]
[ATPase and AMPase activity in the mitochondria of two ascitic tumors: ascites hepatoma of the rat and Ehrlich ascites tumor.]
[Biochemical and functional characteristics of thymus and spleen lymphocytes in C3HA mice during the growth of hepatoma 22 and after immunization with sheep erythrocytes]
[Comparison of the activity and properties of 5'-nucleotidase in the homogenates and plasma membranes of the normal liver, hepatomas and of the liver in mice with inoculated hepatomas of varying degrees of malignancy]
[Diagnostic value of 5'nucleotidase in primary and secondary neoplasms of the liver]
[Enzymes of adenosine metabolism in lymphocytes and the functional state of the sympatho-adrenal system in tumor processes]
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
[Induction of ecto-5'-nucleotidase of rat mesangial cells in culture]
[Pathologic changes of lymphatic capillaries after injection of U14 cells in rat tongue perineoplastic area]
[Preliminary study on correlation between double-contrast and serum 5'-nucleotidase of gastric carcinoma]
[The enzymatic activity of DNA metabolism of the blood in patients operated on in stomach cancer]
Nephrotic Syndrome
Lymphocyte enzyme activities in immunodeficiency syndromes with particular reference to common variable hypogammaglobulinaemia.
Nervous System Diseases
5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
Knockdown of cytosolic 5'-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells.
Neuralgia
CD73 Controls Extracellular Adenosine Generation in the Trigeminal Nociceptive Nerves.
Prostatic acid phosphatase (PAP) is the main acid phosphatase with 5'-ectonucleotidase activity in the male mouse saliva and regulates salivation.
Neuroacanthocytosis
A basis of the acanthocytosis in inherited and acquired disorders.
Neuroblastoma
Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation.
On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.
Upregulation of ecto-5'-nucleotidase in human neuroblastoma SH-SY5Y cells on differentiation by retinoic acid or phorbolester.
Neurodegenerative Diseases
Downregulation of adenosine and adenosine A1 receptor contributes to neuropathic pain in resiniferatoxin neuropathy.
Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies.
Neuroinflammatory Diseases
Complex regulation of ecto-5'-nucleotidase/CD73 and A2AR-mediated adenosine signaling at neurovascular unit: A link between acute and chronic neuroinflammation.
Oliguria
[Von Willebrand factor, antithrombin III and 5'-nucleotidase in the blood and the athrombogenic properties of the vascular wall in patients with hemorrhagic fever with renal syndrome]
Opportunistic Infections
Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.
Osteoarthritis
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis]
Osteochondrodysplasias
Expanding the clinical spectrum of B4GALT7 deficiency: homozygous p.R270C mutation with founder effect causes Larsen of Reunion Island syndrome.
Osteoporosis
Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis.
Osteosarcoma
Osteosarcoma with prominent epithelioid features.
Ovarian Neoplasms
Evaluation of serum adenosine deaminase and 5'-nucleotidase activities as probable markers in ovarian cancer.
The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27.
Pancreatic Neoplasms
Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.
Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.
Pancreatitis
[Experimental study of the hepatoprotective effect of transcranial transcutaneous electrostimulation and the synthetic analog of leu-enkephalin dalargin]
Pancreatitis, Chronic
[Serum 5'-nucleotidase activity in chronic pancreatitis]
Paralysis
Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure.
Paraproteinemias
Decreased ecto-5'nucleotidase activity of peripheral blood lymphocytes in human monoclonal gammopathies: correlation with tumor cell kinetics.
Use of cytoplasmic 5'nucleotidase for differentiating malignant from benign monoclonal gammopathies.
Parasitemia
Inhibitory effect of pyrimidine and purine nucleotides on the multiplication of Babesia gibsoni: possible cause of low parasitemia and simultaneous reticulocytosis in canine babesiosis.
Trypanosoma evansi: Activities of adenine nucleotide degradation enzymes in cerebral cortex of infected rats.
Parkinson Disease
CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling.
Peripheral Arterial Disease
Aberrant Circulating Levels of Purinergic Signaling Markers are Associated with Several Key Aspects of Peripheral Atherosclerosis and Thrombosis.
Peripheral Nerve Injuries
5'-nucleotidase positive microglia reaction in the central nervous system.
Phenylketonurias
Metabolic approaches to the treatment of autism spectrum disorders.
phosphoglycerate kinase deficiency
Enzymatic diagnosis in non-spherocytic hemolytic anemia.
Photosensitivity Disorders
Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas.
Plague
[Effect of plague microbe fraction 1 protein-polysaccharide complex and pure protein on metabolic parameters of macrophages]
Plasmacytoma
Localization of the catalytic site of 5'-nucleotidase at the inner surface of murine plasmocytoma plasma membranes.
Plasma membrane enzymes in BALB/c lymphomas with either T or B cell properties, I. 5'-Nucleotidase.
Pleurisy
The Ecto-5'-Nucleotidase/CD73 Inhibitor, ?,?-Methylene Adenosine 5'-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat.
Poliomyelitis
[Early effect of poliomyelitis virus on 5'-nucleotidase activity in HeLa cells]
Polycystic Kidney, Autosomal Dominant
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Ca2+ signaling in human ADPKD cyst epithelial cells.
Polymyositis
Autoantibodies to Cytosolic 5'-Nucleotidase 1A in Primary Sjögren's Syndrome and Systemic Lupus Erythematosus.
Autoantibodies to cytosolic 5'-nucleotidase IA in inclusion body myositis.
Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.
Histochemical demonstration of 5'-nucleotidase activity in inflammatory muscle disease.
Interstitial 5'-nucleotidase stain for frozen biopsy specimens of skeletal muscle. A useful adjunct in the diagnosis of polymyositis.
Polyuria
[Von Willebrand factor, antithrombin III and 5'-nucleotidase in the blood and the athrombogenic properties of the vascular wall in patients with hemorrhagic fever with renal syndrome]
Pre-Eclampsia
Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia.
Plasma 5'-nucleotidase activities and uric acid levels in women with pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Changes in membrane enzymes and glycosphingolipids in lymphocytes from HIV-1--infected and noninfected intravenous drug users.
Characterization of membrane vesicles circulating in the serum of patients with common acute lymphoblastic leukemia.
Deoxyribonucleoside triphosphate accumulation by leukemic cells.
Determination of ectoenzyme activities in leukemic cells and in established hematopoietic cell lines.
Diminished lymphoblast 5'-nucleotidase activity in acute lymphoblastic leukemia with T-cell characteristics.
Enzyme analysis of lymphoproliferative diseases: a useful addition to cell surface phenotyping.
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Lymphoblast purine pathway enzymes in B-cell acute lymphoblastic leukemia.
Lymphocytic ecto 5'-nucleotidase (ecto-5'NT) levels in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Prognostic implication of ecto-5'-nucleotidase activity in acute lymphoblastic leukemia.
Prognostic value of 5'nucleotidase in acute lymphoblastic leukemia with the common-ALL phenotype.
Purine pathway enzyme abnormalities in acute lymphoblastic leukemia.
Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment.
Significance of enzyme markers as a part of multiple marker analysis in leukemia research.
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.
The heterogeneity of 5'-nucleotidase activity in lymphoblasts of acute lymphoblastic leukemia, demonstrated by an improved cytochemical method.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Relation of some enzyme activities and argyrophilic proteins in childhood acute lymphoblastic leukemia.
Primary Myelofibrosis
[Modification of splenic 5'-nucleotidase activity during proliferative processes in the spleen. Histoenzymatic study in the rat]
Prostatic Hyperplasia
5'-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
The Androgen-Regulated Calcium-Activated Nucleotidase 1 (CANT1) Is Commonly Overexpressed in Prostate Cancer and Is Tumor-Biologically Relevant in Vitro.
Prostatic Neoplasms
Intracerebroventricular injection of human prostatic acid phosphatase has potent neuroprotective effects against transient focal cerebral ischemia in rats.
The Androgen-Regulated Calcium-Activated Nucleotidase 1 (CANT1) Is Commonly Overexpressed in Prostate Cancer and Is Tumor-Biologically Relevant in Vitro.
Pruritus
[Primary biliary cirrhosis]
Psoriasis
Histochemistry in psoriasis. 5'-Nucleotidase in psoriatic parakeratotic horny layer.
Pulmonary Arterial Hypertension
CD39 AS A CRITICAL ECTONUCLEOTIDASE DEFENSE AGAINST PATHOLOGICAL VASCULAR REMODELING.
Purinergic dysregulation in pulmonary hypertension.
Pulmonary Disease, Chronic Obstructive
Adenosine Metabolism in COPD: A Study on Adenosine Levels, 5'-Nucleotidase, Adenosine Deaminase and Its Isoenzymes Activity in Serum, Lymphocytes and Erythrocytes.
Altered purinergic signaling in the tumor associated immunologic microenvironment in metastasized non-small-cell lung cancer.
Reperfusion Injury
Activation of ecto-5'-nucleotidase by protein kinase C attenuates irreversible cellular injury due to hypoxia and reoxygenation in rat cardiomyocytes.
Adenosine and cardioprotection in the diseased heart.
Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model.
Ecto-5'-nucleotidase plays a role in the cardioprotective effects of heat shock protein 72 in ischemia-reperfusion injury in rat hearts.
Loss of ectonucleotidases from the coronary vascular bed after ischemia-reperfusion in isolated rat heart.
The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury.
Retinal Degeneration
[Early changes in retinal 5'-nucleotidase activity in hereditary retinal degeneration]
Retinal Perforations
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.
Retinoblastoma
LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3K? promoter.
Rhabdomyolysis
Pathological findings in 165 patients explored for malignant hyperthermia susceptibility.
ribose-phosphate diphosphokinase deficiency
Metabolic approaches to the treatment of autism spectrum disorders.
Salmonella Infections
Ecto-5'-nucleotidase (CD73) regulates host inflammatory responses and exacerbates murine salmonellosis.
Sarcoma
An enzyme histochemical study of non-Hodgkin's lymphoma and allied disease.
[Activity of 5'-nucleotidase from thymus and tumors upon administering bradykinin to tumor-bearing mice]
Sarcoma, Kaposi
Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.
Scrapie
The membrane location of scrapie infectivity.
Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice.
Seizures
Anticonvulsant effect of GMP depends on its conversion to guanosine.
Early-life hyperthermic seizures upregulate adenosine A2A receptors in the cortex and promote depressive-like behavior in adult rats.
Hyperthermia-induced seizures alter adenosine A1 and A2A receptors and 5'-nucleotidase activity in rat cerebral cortex.
Is theophylline-induced seizures in man caused by inhibition of cerebral 5'-nucleotidase activity?
Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.
Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age.
PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes.
Role of Adenosine Signaling on Pentylenetetrazole-Induced Seizures in Zebrafish.
Sepsis
Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice.
Density of muscarinic receptors in rat myocardium during early sepsis.
Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis.
Severe Combined Immunodeficiency
Phenotype and function of engrafted maternal T cells in patients with severe combined immunodeficiency.
Sezary Syndrome
Implications of a 5'-nucleotidase inhibitor in human leukemic cells for cellular aging and cancer.
Sleep Deprivation
Effect of rapid eye movement sleep deprivation on 5'-nucleotidase activity in the rat brain.
Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation.
Spinal Cord Injuries
Ecto-5'-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice.
Squamous Cell Carcinoma of Head and Neck
CD73 expression in myeloid-derived suppressor cells is correlated with clinical stages in head and neck squamous cell carcinomas.
Starvation
Role of inositol starvation on ecto-5'-nucleotidase activity during mitogen-induced lymphocyte activation.
Status Epilepticus
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Stomach Neoplasms
Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer.
Adenosine deaminase, 5'-nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juices from patients with gastric cancer, ulcer, and atrophic gastritis.
NT5E is associated with unfavorable prognosis and regulates cell proliferation and motility in gastric cancer.
Tachycardia
5'-Nucleotidase and adenosine deaminase activities in hypertrophied rat heart. The effect of tachycardia.
Teratocarcinoma
Ultrastructural localization of membrane phosphatases in teratocarcinoma and early embryos.
Thrombocytopenia
Activities of adenine nucleotide and nucleoside degradation enzymes in platelets of rats infected by Trypanosoma evansi.
Thrombocytosis
Splenectomy complicated by sustained extreme thrombocytosis and extensive portosplenomesenteric vein thrombosis in pyrimidine 5'-nucleotidase deficiency.
Thrombophilia
Purinergic signaling during intestinal inflammation.
Thrombosis
Ectonucleotidase activities are altered in serum and platelets of L-NAME-treated rats.
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.
NTPDase and 5'-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis.
Splenectomy complicated by sustained extreme thrombocytosis and extensive portosplenomesenteric vein thrombosis in pyrimidine 5'-nucleotidase deficiency.
Thymoma
Plasma membrane enzymes in BALB/c lymphomas with either T or B cell properties, I. 5'-Nucleotidase.
Thyroid Cancer, Papillary
Activity of ecto-5'-nucleotidase (NT5E/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes.
Expression of CD73 and its ecto-5'-nucleotidase activity are elevated in papillary thyroid carcinomas.
Thyroid Diseases
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Tick Infestations
Experimental vaccination of sheep and cattle against tick infestation using recombinant 5'-nucleotidase.
Tonsillitis
Divalent cation-activated-ATPase and ecto 5'-nucleotidase activities in chronic tonsillitis.
Localisation of ecto-5'-nucleotidase and divalent cation-activated ecto-ATPase in chronic tonsillitis.
Trichomonas Infections
Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis.
Tuberculosis
Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Tuberculosis, Pulmonary
[Markers of alteration of tissue structures as indicators of pulmonary tuberculosis activity]
Urinary Bladder Neoplasms
Adenosine deaminase, 5'nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human bladder tissues.
Alterations in the extracellular catabolism of nucleotides are involved in the antiproliferative effect of quercetin in human bladder cancer T24 cells.
Differential ectonucleotidase expression in human bladder cancer cell lines.
Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line.
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Uterine Cervical Neoplasms
Ectonucleotidase expression profile and activity in human cervical cancer cell lines.
Uveitis
Decreased ecto-5'-nucleotidase activity in rabbit lymphocytes during experimental lens-induced uveitis.
Ecto 5'-nucleotidase activity in lymphocytes in cases of uveitis.
Uveitis, Posterior
Ecto 5'-nucleotidase activity in lymphocytes in cases of uveitis.
Varicocele
5'-Nucleotidase activity is decreased in seminal plasma and spermatozoa from varicocele patients.
Vascular Diseases
The ratio of ADP- to ATP-ectonucleotidase activity is reduced in patients with coronary artery disease.
Vascular System Injuries
A simple assay for ecto-5'-nucleotidase using intact pulmonary artery endothelial cells. Effect of endotoxin-induced cell injury.
Alteration of purinergic signaling in diabetes: Focus on vascular function.
Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets.
Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice.
Venous Thrombosis
Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1?-driven venous thrombosis.
Vesicular Stomatitis
Changes in ecto-5'-nucleotidase activity during early stages of vesicular stomatitis virus infection. Effects of concanavalin A.
Virus Diseases
Changes in ecto-5'-nucleotidase activity during early stages of vesicular stomatitis virus infection. Effects of concanavalin A.
Heterogeneity in extracellular nucleotide hydrolysis among clinical isolates of Trichomonas vaginalis.
HLA-DRB1 allele and autoantibody profiles in Japanese patients with inclusion body myositis.
Vitamin E Deficiency
Cellular membranes and membrane-bound enzymes in vitamin E deficiency. A histochemical, cytochemical, biochemical, and morphologic study of the liver of the Pekin duckling.
Vitreous Hemorrhage
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.
Waldenstrom Macroglobulinemia
Expression of the human concentrative nucleotide transporter 1 (hCNT1) gene correlates with clinical response in patients affected by Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) undergoing a combination treatment with 2-chloro-2'-deoxyadenosine (2-CdA) and Rituximab.
Whooping Cough
Evidence for deactivation of both ectosolic and cytosolic 5'-nucleotidase by adenosine A1 receptor activation in the rat cardiomyocytes.
Role of adenosine A(1) receptors in modulating extracellular adenosine levels.
[Action of plant extracts on the natural immunity indices of animals]
[Change in the natural immunity of mice after administration of blastolysin, a glycopeptide from the Lactobacillus bulgaricus cell wall]
[Changes in 5'-nucleotidase activity in the dynamic formation of whooping cough immunity]