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Information on EC 3.1.2.27 - choloyl-CoA hydrolase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.2 Thioester hydrolases
                3.1.2.27 choloyl-CoA hydrolase
IUBMB Comments
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
acyl-CoA thioesterase, bile acid-CoA thioesterase, chenodeoxycholic acid-CoA thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, choloyl-coenzyme A thioesterase, coenzyme A thioesterase 2, peroxisomal acyl-coA thioesterase, PTE-2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
choloyl-CoA + H2O = cholate + CoA
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PATHWAY SOURCE
PATHWAYS
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