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Literature summary for 3.1.2.27 extracted from
- The enzymes, regulation, and genetics of bile acid synthesis (2003), Annu. Rev. Biochem., 72, 137-174.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| PPARII | peroxisomal proliferator activated receptor-II activates the enzyme, fibrates are antagonizing the receptor activity | Mus musculus |  |
| PPARII | peroxisomal proliferator activated receptor-II activates the enzyme, fibrates are antagonizing the receptor activity | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Mus musculus | 5777 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choloyl-CoA + H2O | Mus musculus | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | cholate + CoA | - |
? | |
| choloyl-CoA + H2O | Homo sapiens | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | cholate + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choloyl-CoA + H2O | - |
Mus musculus | cholate + CoA | - |
? | |
| choloyl-CoA + H2O | - |
Homo sapiens | cholate + CoA | - |
? | |
| choloyl-CoA + H2O | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | Mus musculus | cholate + CoA | - |
? | |
| choloyl-CoA + H2O | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | Homo sapiens | cholate + CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| coenzyme A thioesterase 2 | - |
Mus musculus |
| coenzyme A thioesterase 2 | - |
Homo sapiens |
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