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Information on EC 3.1.11.7 - adenosine-5'-diphospho-5'-[DNA] diphosphatase

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IUBMB Comments
Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.1.11.8, guanosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.1.12.2, DNA-3'-diphospho-5'-guanosine diphosphatase.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
adenosine-5'-diphospho-5'-[DNA]
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phospho-5'-[DNA]
adenosine-5'-diphospho-5'-(ribonucleotide)-[DNA]
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5'-phospho-(ribonucleotide)-[DNA]
Synonyms
5'-App5'-DNA adenylate hydrolase, aprataxin, aprataxin-like protein, APTX, DNA-adenylate hydrolase, HNT3, RNA-DNA deadenylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenosine-5'-diphospho-5'-(ribonucleotide)-[DNA] + H2O = AMP + 5'-phospho-(ribonucleotide)-[DNA]
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adenosine-5'-diphospho-5'-[DNA] + H2O = AMP + phospho-5'-[DNA]
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