EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.1.11.7 | adenosine-5'-diphospho-5'-[DNA] + H2O |
- |
Homo sapiens |
AMP + phospho-5'-[DNA] |
- |
? |
| 3.1.11.7 | adenosine-5'-diphospho-5'-[DNA] + H2O |
- |
Saccharomyces cerevisiae |
AMP + phospho-5'-[DNA] |
- |
? |
| 3.1.11.7 | adenosine-5'-diphospho-5'-[DNA] + H2O |
the enzyme can use nicked and blunt substrates |
Homo sapiens |
AMP + phospho-5'-[DNA] |
- |
? |
| 3.1.11.7 | more |
substrate binding structure, overview |
Homo sapiens |
? |
- |
? |
| 3.1.11.7 | more |
aprataxin hydrolyses abnormal 5'-AMP DNA termini formed in abortive DNA ligations |
Homo sapiens |
? |
- |
? |
| 3.1.11.7 | more |
APTX-mediated DNA deadenylation activity (i.e. 5'-AMP removal) is measured in extracts of cells expressing wild-type XRCC1 or the XRCC1 phosphorylation mutant, and compared with activity in APTX-deficient and APTX-complemented human cells. APTX activity is lower in extracts from Xrcc1-/- and XRCC1 phosphorylation mutant cells compared to the robust activity in extract from wild-type XRCC1 expressing cells. And APTX-mediated DNA deadenylation activity (i.e. 5'-AMP removal) is measured in cell extracts of the XRCC1 variants, and compared with activity in patient AOA1 human fibroblasts and APTX-complemented cells |
Homo sapiens |
? |
- |
? |
| 3.1.11.7 | more |
APTX-mediated DNA deadenylation activity (i.e. 5'-AMP removal) is measured |
Homo sapiens |
? |
- |
? |
