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Disease on EC 2.8.2.1 - aryl sulfotransferase and Organism(s) Homo sapiens and UniProt Accession O75897

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DISEASE
TITLE OF PUBLICATION
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Aberrant Crypt Foci
Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases.
Acquired Immunodeficiency Syndrome
Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation.
Acute Kidney Injury
Suppressed Hepatic Production of Indoxyl Sulfate Attenuates Cisplatin-Induced Acute Kidney Injury in Sulfotransferase 1a1-Deficient Mice.
Adenocarcinoma
Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function.
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture.
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Regulation of SULT1E1 expression in Ishikawa adenocarcinoma cells by tibolone.
Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cells.
Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study.
Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells.
Transcriptional Regulation of Human Cytosolic Sulfotransferase 1C3 by Peroxisome Proliferator-Activated Receptor ? in LS180 Human Colorectal Adenocarcinoma Cells.
Adenoma
Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas.
Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.
Adenomyosis
Adenomyosis: genetics of estrogen metabolism.
Alopecia
Characterization of follicular minoxidil sulfotransferase activity in a cohort of pattern hair loss patients from the Indian Subcontinent.
Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss.
SULT1A1 (Minoxidil Sulfotransferase) enzyme booster significantly improves response to topical minoxidil for hair regrowth.
Alzheimer Disease
Reduced sulfotransferase SULT2A1 activity in patients with Alzheimer's disease.
aryl sulfotransferase deficiency
A cerebroside sulphotransferase deficiency in a human disorder of myelin.
A Cerebroside Sulphotransferase Deficiency in a Human Disorder of Myelin.
Asthma
SULT 1A3 single-nucleotide polymorphism and the single dose pharmacokinetics of inhaled salbutamol enantiomers: Are some athletes at risk of higher urine levels?
Atherosclerosis
Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
Peculiarities of Immune Regulation in Men of Perm Region with Atherosclerosis Related to Polymorphism of Candidate Genes.
Brain Neoplasms
Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors.
Breast Diseases
Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.
Breast Neoplasms
Acute Effect of High-dose Isoflavones from Pueraria lobata (Willd.) Ohwi on Lipid and Bone Metabolism in Ovariectomized Mice.
Adrenal androgen concentrations in breast tumours and in normal breast tissue. The relationship to oestradiol metabolism.
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Altered expression of the hormone- and xenobiotic-metabolizing sulfotransferase enzymes 1A2 and 1C1 in malignant breast tissue.
Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy.
Association between SULT1A1 Arg213His (rs9282861) Polymorphism and Risk of Breast Cancer: A Systematic Review and Meta-Analysis.
Association of sulfotransferase SULT1A1 with breast cancer risk: a meta-analysis of case-control studies with subgroups of ethnic and menopausal statue.
Association of SULT1A1 Arg²¹³His polymorphism with male breast cancer risk: results from a multicenter study in Italy.
Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer.
Bacterial expression and kinetic characterization of the human monoamine-sulfating form of phenol sulfotransferase.
Bilateral adrenalectomy for metastatic breast carcinoma.
Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.
Biotransformation of melatonin in human breast cancer cell lines: role of sulfotransferase 1A1.
Cancer and molecular biomarkers of phase 2.
Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk.
Characterization of Formononetin Sulfonation in SULT1A3 Overexpressing HKE293 Cells: Involvement of Multidrug Resistance-Associated Protein 4 in Excretion of Sulfate.
Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.
CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer.
Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?
Effect of interferon-?2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes.
Effects of SULT1A1 Copy Number Variation on Estrogen Concentration and Tamoxifen-Associated Adverse Drug Reactions in Premenopausal Thai Breast Cancer Patients: A Preliminary Study.
Epigenetic silencing of the sulfotransferase 1A1 gene by hypermethylation in breast tissue.
Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study.
Estrogen sulfotransferases in breast and endometrial cancers.
Estrogen-related genes and their contribution to racial differences in breast cancer risk.
Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.
Expression of hydroxysteroid sulphotransferase is related to estrogen receptor status in human mammary cancer.
Genetic polymorphism of estrogen metabolizing enzymes in siberian women with breast cancer.
Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.
Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer.
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer.
Genetic variants of the sulfotransferase 1A1 and breast cancer risk.
Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients.
Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy.
Identification and characterization of cytosolic sulfotransferase activities in MCF-7 human breast carcinoma cells.
Identification and targeting of selective vulnerability rendered by tamoxifen resistance.
Immunohistochemical localisation of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study.
Indoxylsulfate, a Metabolite of the Microbiome, Has Cytostatic Effects in Breast Cancer via Activation of AHR and PXR Receptors and Induction of Oxidative Stress.
Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk.
Investigation of prognostic value of polymorphisms within estrogen metabolizing genes in Lithuanian breast cancer patients.
Metabolism of resveratrol in breast cancer cell lines: Impact of sulfotransferase 1A1 expression on cell growth inhibition.
Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones.
Need for clarification of results in the recent meta-analysis about SULT1A1 codon 213 polymorphism and breast cancer risk.
Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology.
Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer.
Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Possible Risk Modification by Polymorphisms of Estrogen Metabolizing Genes in Familial Breast Cancer Susceptibility in an Indian Population.
Properties of estrogen and hydroxysteroid sulphotransferases in human mammary cancer.
Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients.
Steroid sulphotransferase activity in human hormone-independent MDA-MB-468 mammary cancer cells.
Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin.
Sulfation through the looking glass--recent advances in sulfotransferase research for the curious.
Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites.
Sulfotransferase 1A1 (SULT1A1) gene expression is regulated by members of the NFI transcription factors in human breast cancer cells.
Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women.
Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study.
Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women.
Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk.
Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer.
Sulfotransferase SULT1A1 Arg213His polymorphism with cancer risk: a meta-analysis of 53 case-control studies.
SULT1A1 Arg213His Polymorphism, Smoked Meat, and Breast Cancer Risk: A Case-Control Study and Meta-Analysis.
SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells.
SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study.
SULT1A1 polymorphism and esophageal cancer in males.
SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls.
SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?
SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen.
SULT1E1 and ID2 genes as candidates for inherited predisposition to breast and ovarian cancer in Jewish women.
SULT1E1 inhibits cell proliferation and invasion by activating PPAR? in breast cancer.
The association of SULT1A1 codon 213 polymorphism and breast cancer susceptibility: meta-analysis from 16 studies involving 23,445 subjects.
[A case-control study on association of SULT1A1 polymorphism, smoked meat intake with breast cancer risk].
[Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women]
[Study on the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) and susceptibility to breast cancer in Chinese women]
[The association of sulfotransferase1A1 His allele and breast cancer in Han ethnic Chinese women]
Breast Neoplasms, Male
Association of SULT1A1 Arg²¹³His polymorphism with male breast cancer risk: results from a multicenter study in Italy.
SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures?
Carcinogenesis
Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism.
Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver.
Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.
Epigenetic silencing of the sulfotransferase 1A1 gene by hypermethylation in breast tissue.
Examination of human tissue cytosols for expression of sulfotransferase isoform 1A2 (SULT1A2) using a SULT1A2-specific antibody.
Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population.
Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice.
Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.
Sulfotransferase 1A1 as a Biomarker for Susceptibility to Carcinogenesis: From Molecular Genetics to the Role of Dietary Flavonoids.
Sulfotransferase SULT1A1 Arg213His polymorphism with cancer risk: a meta-analysis of 53 case-control studies.
The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis.
Transcriptomic-based toxicological investigations of ethanol to human umbilical vein endothelial cells.
[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]
Carcinoma
A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.
Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells.
Combined effects of GSTO1 and SULT1A1 polymorphisms and cigarette smoking on urothelial carcinoma risk in a Taiwanese population.
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
Genotypes of CYP1A1,?SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case-control study from Kashmir, India.
Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant.
Immunohistochemical localisation of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study.
Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2.
Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma.
Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma.
Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese.
SULT1A1 polymorphism and esophageal cancer in males.
Carcinoma, Hepatocellular
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Gel-based proteomics of liver cancer progression in rat.
Generation and release of nitrotyrosine O-sulfate by HepG2 human hepatoma cells upon SIN-1 stimulation: identification of SULT1A3 as the enzyme responsible.
Induction of human sulfotransferase 1A3 (SULT1A3) by glucocorticoids.
Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells.
Manganese-dependent Dopa/tyrosine sulfation in HepG2 human hepatoma cells: novel Dopa/tyrosine sulfotransferase activities associated with the human monoamine-form phenol sulfotransferase.
Overexpression of SULT2B1b Promotes Angiogenesis in Human Gastric Cancer.
Substrate specificity of human monoamine (M)-form phenol sulfotransferase: preparation and analysis of Dopa 3-O-sulfate and Dopa 4-O-sulfate.
Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.
Transcriptional profiling reveals a role for ROR{alpha} in regulating gene expression in obesity-associated inflammation and hepatic steatosis.
Carcinoma, Non-Small-Cell Lung
Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.
Carcinoma, Squamous Cell
A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
Genotypes of CYP1A1,?SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case-control study from Kashmir, India.
Carcinoma, Transitional Cell
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Chemical and Drug Induced Liver Injury
ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models.
Cholangitis, Sclerosing
Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR.
Cholestasis
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Bile salt sulphation in man. Liver bile salt sulphotransferase activity in patients with primary biliary cirrhosis.
Bile salt sulphotransferase activity in the liver of cholestatic infants.
Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1.
Enzymatic sulphation of bile salts in man. Bile salt sulphotransferase activity in percutaneous liver biopsy specimens from patients with liver disease.
Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction.
Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.
Colonic Neoplasms
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Alterations of O-glycan biosynthesis in human colon cancer tissues.
Colorectal Neoplasms
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.
Association of the SULT1A1 R213H polymorphism with colorectal cancer.
Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer.
Lack of association of SULT1A1 R213H polymorphism with colorectal cancer: a meta-analysis.
Metabolic differences and their impact on human disease Sulfotransferase and colorectal cancer.
Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer.
Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival.
Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer.
Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
SULT1A1 genotype and susceptibility to colorectal cancer.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]
Corneal Dystrophies, Hereditary
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.
Coronary Artery Disease
Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2).
Crohn Disease
Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn's Disease Patients with Active Mucosal Lesions.
Cystic Fibrosis
Elevated hepatic SULT1E1 activity in mouse models of cystic fibrosis alters the regulation of estrogen responsive proteins.
Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis.
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
Regulation of hepatic sulfotransferase (SULT) 1E1 expression and effects on estrogenic activity in cystic fibrosis (CF).
Dementia
Evaluation of factors of importance for clinical dementia diagnosis.
Diabetes Mellitus, Type 2
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
Drug-Related Side Effects and Adverse Reactions
Effects of SULT1A1 Copy Number Variation on Estrogen Concentration and Tamoxifen-Associated Adverse Drug Reactions in Premenopausal Thai Breast Cancer Patients: A Preliminary Study.
Endometrial Neoplasms
CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk.
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT.
Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk.
The relationship between oestradiol metabolism and adrenal steroids in the endometrium of postmenopausal women with and without endometrial cancer.
Endometriosis
Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells.
Endotoxemia
ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models.
Ependymoma
Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics.
Epilepsy
Platelet 3H-imipramine binding and sulphotransferase activity in primary headache.
Esophageal Neoplasms
SULT1A1 polymorphism and esophageal cancer in males.
Esophageal Squamous Cell Carcinoma
SULT1A1 polymorphism and esophageal cancer in males.
Fatty Liver
Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.
Hepatic oestrone sulphotransferase activity and plasma levels of oestrone sulphate, oestrone and oestradiol in male guinea pigs with fatty liver.
Genital Diseases, Female
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.
Glioma
Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling.
Goiter, Nodular
Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens.
Head and Neck Neoplasms
A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.
Hepatitis B, Chronic
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Herpes Simplex
Transcriptomic-based toxicological investigations of ethanol to human umbilical vein endothelial cells.
Herpes Zoster
Alteration of the steroidogenesis in boys with autism spectrum disorders.
Development of adrenal cortical zonation and expression of key elements of adrenal androgen production in the chimpanzee (Pan troglodytes) from birth to adulthood.
Hypersensitivity
Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.
Hypotension
Induction of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by triamcinolone acetonide: impact on minoxidil-mediated hypotension.
Infections
Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages.
Influenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice.
Transcriptomic-based toxicological investigations of ethanol to human umbilical vein endothelial cells.
Intestinal Diseases
Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis.
Leukemia
Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380.
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia.
Leukemia, Myeloid, Acute
Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities.
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia.
Liver Cirrhosis, Alcoholic
Downregulation of sulfotransferase expression and activity in diseased human livers.
Liver Cirrhosis, Biliary
Bile salt sulphation in man. Liver bile salt sulphotransferase activity in patients with primary biliary cirrhosis.
Liver Diseases
Bile salt sulphation in man. Liver bile salt sulphotransferase activity in patients with primary biliary cirrhosis.
Conjugation pathways in liver disease.
Elevated hepatic SULT1E1 activity in mouse models of cystic fibrosis alters the regulation of estrogen responsive proteins.
Enzymatic sulphation of bile salts in man. Bile salt sulphotransferase activity in percutaneous liver biopsy specimens from patients with liver disease.
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver.
Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Toxicogenomics directory of chemically exposed human hepatocytes.
Liver Neoplasms
Gel-based proteomics of liver cancer progression in rat.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Lung Neoplasms
A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population.
Association between Cancer Risk and Drug Metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Japanese Cases of Lung Cancer.
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population.
Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population.
Impact of polymorphism in sulfotransferase gene on the risk of lung cancer.
Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer.
Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.
Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis.
SULT1A1 Arg213His polymorphism and lung cancer risk: a meta-analysis.
Lymphatic Metastasis
Genetic variants of the sulfotransferase 1A1 and breast cancer risk.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Metabolic Diseases
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
Migraine Disorders
Platelet 3H-imipramine binding and sulphotransferase activity in primary headache.
Platelet sulphotransferase activity, plasma sulphate levels and sulphation capacity in patients with migraine and tension headache.
[Platelet phenol sulfotransferase activities: a migraine marker?]
Migraine without Aura
Platelet 3H-imipramine binding and sulphotransferase activity in primary headache.
Mouth Neoplasms
Polymorphic variants of drug-metabolizing enzymes alter the risk and survival of oral cancer patients.
SULT1A1 genetic polymorphisms and the association between smoking and oral cancer in a case-control study in Brazil.
Moyamoya Disease
Probing Estrogen Sulfotransferase-Mediated Inflammation with [11C]-PiB in the Living Human Brain.
Mucopolysaccharidosis III
Brain glycosaminoglycans and glycosaminoglycan sulphotransferase in Sanfilippo syndrome.
Nasal Polyps
Phenol sulfotransferase activities and localization in human nasal polyp epithelium.
Neoplasm Metastasis
Genetic variants of the sulfotransferase 1A1 and breast cancer risk.
Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.
Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells.
Polymorphic variants of drug-metabolizing enzymes alter the risk and survival of oral cancer patients.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Neoplasms
Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3.
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Alterations of O-glycan biosynthesis in human colon cancer tissues.
Altered expression of the hormone- and xenobiotic-metabolizing sulfotransferase enzymes 1A2 and 1C1 in malignant breast tissue.
Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer.
An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population.
Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities.
Association between Cancer Risk and Drug Metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Japanese Cases of Lung Cancer.
Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population.
Association of SULT1A1 Arg²¹³His polymorphism with male breast cancer risk: results from a multicenter study in Italy.
Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk.
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer.
Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia.
Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor.
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Double adenomas with different pathological and hormonal features in the left adrenal gland of a patient with Cushing's syndrome.
Down-regulation of dehydroepiandrosterone sulfotransferase gene in human hepatocellular carcinoma.
Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.
Epigenetic silencing of the sulfotransferase 1A1 gene by hypermethylation in breast tissue.
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors.
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.
Expression and prognostic value of SULT1A2 in bladder cancer.
Expression of glutathione S-transferase and phenol sulfotransferase, but not of UDP-glucuronosyltransferase, in the human lung tumor cell lines NCI-H322 and NCI-H358.
Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380.
Expression of sulfotransferases and sulfatases in human breast cancer: Impact on resveratrol metabolism.
Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population.
Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer.
Genetic polymorphism of estrogen metabolizing enzymes in siberian women with breast cancer.
Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population.
Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.
Genetic variants of the sulfotransferase 1A1 and breast cancer risk.
Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.
Human cytosolic sulfotransferase SULT1A1.
Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan.
Identification and targeting of selective vulnerability rendered by tamoxifen resistance.
Impact of p53 function on the sulfotransferase-mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1-hydroxymethylpyrene in vitro.
Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers.
Inhibition of phenolsulphotransferase by salicylic acid: a possible mechanism by which aspirin may reduce carcinogenesis.
Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases.
LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine.
Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?
Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.
Metabolism of the oral contraceptive steroids ethynylestradiol and norgestimate by normal (Huma 7) and malignant (MCF-7 and ZR-75-1) human breast cells in culture.
Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues.
Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma.
Pharmacogenetics of soluble sulfotransferases (SULTs).
Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Steroid hormones and human breast cancer. An hypothesis.
Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.
Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition.
Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study.
Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors.
Sulfotransferase 1A1 as a Biomarker for Susceptibility to Carcinogenesis: From Molecular Genetics to the Role of Dietary Flavonoids.
Sulfotransferase genetic variation: from cancer risk to treatment response.
Sulfotransferase SULT1A1 Arg213His polymorphism with cancer risk: a meta-analysis of 53 case-control studies.
SULT1A1 Arg213His polymorphism and susceptibility of environment-related cancers: a meta analysis of 5,915 cases and 7,900 controls.
SULT1A1 copy number variation: ethnic distribution analysis in an Indian population.
SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen.
SULT1E1 inhibits cell proliferation and invasion by activating PPAR? in breast cancer.
Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms.
The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis.
The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese.
The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.
UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients.
Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells.
[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]
[Justifying genetic and immune markers of efficiency and sensitivity under combined exposure to risk factors in mining industry workers].
Neoplasms, Multiple Primary
Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk.
Neuroblastoma
Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells.
Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.
SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
[Sulfurtransferase activity in cultured neuronal clone cells]
Neurodegenerative Diseases
Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling.
Phosphorylation/dephosphorylation of human SULT4A1: Role of Erk1 and PP2A.
Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2.
Neuroinflammatory Diseases
Transcript analysis of laser capture microdissected white matter astrocytes and higher phenol sulfotransferase 1A1 expression during autoimmune neuroinflammation.
Neuronal Ceroid-Lipofuscinoses
Analysis of Batten disease candidate genes STP and STM.
Mapping of two phenol sulphotransferase genes, STP and STM, to 16p: candidate genes for Batten disease.
Phenol sulfotransferases: candidate genes for Batten disease.
Non-alcoholic Fatty Liver Disease
A case-control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease.
Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver.
Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.
Obesity
Coding Variants are Relevant to the Expression of Obesity-Related Genes for Pediatric Adiposity.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Pharmacogenetics of soluble sulfotransferases (SULTs).
Osteoporosis
A Nucleotide-Gated Molecular Pore Selects Sulfotransferase Substrates.
Osteosarcoma
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities.
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors.
Proteomic profiling of osteosarcoma cells identifies ALDOA and SULT1A3 as negative survival markers of human osteosarcoma.
Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells.
Ovarian Neoplasms
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer.
SULT1E1 and ID2 genes as candidates for inherited predisposition to breast and ovarian cancer in Jewish women.
Pancreatic Neoplasms
Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture.
Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells.
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Pheochromocytoma
Human pheochromocytoma phenol sulfotransferase: biochemical properties and activities of thermolabile and thermostable forms.
Polycystic Kidney Diseases
Decreased sulfotransferase SULT1C2 gene expression in DPT-induced polycystic kidney.
Polycystic Ovary Syndrome
Variants in SULT2A1 Affect the DHEA Sulphate to DHEA Ratio in Patients With Polycystic Ovary Syndrome But Not the Hyperandrogenic Phenotype.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia.
Primary Ovarian Insufficiency
The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.
Prolactinoma
Erythrocyte catechol-O-methyltransferase, platelet monoamine oxidase, and platelet phenol sulfotransferase activities in patients with prolactin-secreting pituitary adenomas.
Prostatic Neoplasms
Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians.
Association of SULT2A1 allelic variants with plasma adrenal androgens and prostate cancer in African American men.
Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population.
Inherited Variants in SULT1E1 and Response to Abiraterone Acetate by Men with Metastatic Castration Refractory Prostate Cancer.
Phenol sulphotransferase SULT1A1 polymorphism in prostate cancer: lack of association.
Sulfotransferase 1A1 Arg(213)His polymorphism and prostate cancer risk.
Transfection of human prostate cancer CA-HPV-10 cells with cytosolic sulfotransferase SULT1E1 affects estrogen signaling and gene transcription.
Pulmonary Disease, Chronic Obstructive
Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer.
Pulmonary Edema
The proteome of Hypobaric Induced Hypoxic Lung: Insights from Temporal Proteomic Profiling for Biomarker Discovery.
Rectal Neoplasms
[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]
Reperfusion Injury
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of human sulfotransferases in the bioactivation of nitro- and aminotoluenes.
Sarcoma
Studies of the decrease of tyrosine-O-sulphated proteins in Rous sarcoma-virus-transformed rat embryo fibroblasts, line 3Y1. Examination of the sulphate activation and tyrosyl-protein sulphotransferase systems.
Sarcoma, Ewing
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors.
Sepsis
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
Sjogren's Syndrome
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients.
Squamous Cell Carcinoma of Head and Neck
A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.
Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese.
Stomach Neoplasms
Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population.
Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Stroke
Probing Estrogen Sulfotransferase-Mediated Inflammation with [11C]-PiB in the Living Human Brain.
Tension-Type Headache
Platelet 3H-imipramine binding and sulphotransferase activity in primary headache.
Platelet sulphotransferase activity, plasma sulphate levels and sulphation capacity in patients with migraine and tension headache.
Thrombosis
Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice.
Thyroid Diseases
Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens.
Urinary Bladder Neoplasms
Association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer: a meta-analysis.
Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population.
Bladder cancer risk from the perspective of genetic polymorphisms in the carcinogen metabolizing enzymes.
Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.
Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses.
Expression and prognostic value of SULT1A2 in bladder cancer.
Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer.
GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population.
Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study.
SULT1A1 Arg213His polymorphism is associated with bladder cancer risk: a meta-analysis.
[Steroid and xenobiotic receptor (SXR), multidrug resistance gene (MDR1) and GSTs, SULTs and CYP polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors]
Urogenital Neoplasms
Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk.
Vaccinia
PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers.
Xeroderma Pigmentosum
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.