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Information on EC 2.7.8.38 - archaetidylserine synthase and Organism(s) Methanothermobacter thermautotrophicus and UniProt Accession O27106

for references in articles please use BRENDA:EC2.7.8.38
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EC Tree
IUBMB Comments
Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.
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This record set is specific for:
Methanothermobacter thermautotrophicus
UNIPROT: O27106
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The taxonomic range for the selected organisms is: Methanothermobacter thermautotrophicus
The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
archaetidylserine synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine O-archaetidyltransferase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
(1)
SYSTEMATIC NAME
IUBMB Comments
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-O-(geranylgeranyl)-sn-glycerol phosphotransferase
Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phosphoserine
show the reaction diagram
149% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(oleoyl)-sn-glycero-3-phospho-L-serine
show the reaction diagram
64% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-diacylglycerol + L-serine
CMP + 1,2-diacyl-sn-glycero-3-phospho-L-serine
show the reaction diagram
fatty acids from lecithin. 199% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
CDP-2,3-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 2,3-dioleoyl-sn-glycero-1-phospho-L-serine
show the reaction diagram
280% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
86% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
the enzyme is involved in the biosynthesis of polar lipids in archaea
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
show the reaction diagram
86% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
stimulates, maximal activity in presence of 10 mM Mn2+. Mg2+ is much less effective
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Triton X-100
activity is dependent on TRiton X-100
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50 - 70
50°C: about 50% of maximal activity, 70°C: about 65% of maximal activity
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morii, H.; Koga, Y.
CDP-2,3-di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus
J. Bacteriol.
185
1181-1189
2003
Bacillus subtilis, Methanothermobacter thermautotrophicus (O27106), Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DSM 1053 (O27106)
Manually annotated by BRENDA team