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Information on EC 2.7.8.27 - sphingomyelin synthase and Organism(s) Sus scrofa and UniProt Accession A0AAS4

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EC Tree
IUBMB Comments
The reaction can occur in both directions . This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism . Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types . Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin .
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This record set is specific for:
Sus scrofa
UNIPROT: A0AAS4
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Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
sphingomyelin synthase, sm synthase, sgms1, sphingomyelin synthase 1, sphingomyelin synthase 2, sgms2, sphingomyelin-synthase, sm synthase 1, sphingomyelin synthases 1, sphingomyelin synthase-related protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphatidylcholine:ceramide cholinephosphotransferase 1
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sphingomyelin synthase 1
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PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
ceramide:phosphatidylcholine cholinephosphotransferase
The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].
CAS REGISTRY NUMBER
COMMENTARY hide
58703-97-2
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low SMS1 expression level
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SMS1_PIG
418
6
48984
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene SMS1, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, quantitative expression analysis by real-time RT-PCR
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guillen, N.; Navarro, M.A.; Surra, J.C.; Arnal, C.; Fernandez-Juan, M.; Cebrian-Perez, J.A.; Osada, J.
Cloning, characterization, expression and comparative analysis of pig Golgi membrane sphingomyelin synthase 1
Gene
388
117-124
2007
Sus scrofa (A0AAS4), Sus scrofa
Manually annotated by BRENDA team