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Information on EC 2.7.4.3 - adenylate kinase and Organism(s) Drosophila melanogaster and UniProt Accession Q9U915

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EC Tree
IUBMB Comments
Inorganic triphosphate can also act as donor.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: Q9U915
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphotransferase, adenylate kinase, myokinase, adenylate kinase 1, adenylate kinase 2, nonstructural protein 4b, cinap, adenylokinase, spadk, adenylate kinase isoenzyme 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adenylate kinase isozyme 2
-
ATP:AMP phosphotransferase
-
5'-AMP-kinase
-
-
-
-
adenylic kinase
-
-
-
-
adenylokinase
-
-
-
-
kinase, adenylate (phosphorylating)
-
-
-
-
kinase, myo- (phosphorylating)
-
-
-
-
myokinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:AMP phosphotransferase
Inorganic triphosphate can also act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
9013-02-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + AMP
ADP + ADP
show the reaction diagram
-
-
-
?
ATP + AMP
2 ADP
show the reaction diagram
-
ATP and AMP are the preferred substrates
-
-
?
ATP + CMP
ADP + CDP
show the reaction diagram
-
-
-
-
?
ATP + UMP
ADP + UDP
show the reaction diagram
-
-
-
-
?
CTP + AMP
CDP + ADP
show the reaction diagram
-
-
-
-
?
GTP + AMP
GDP + ADP
show the reaction diagram
-
-
-
-
?
TTP + AMP
TDP + ADP
show the reaction diagram
-
-
-
-
?
UTP + AMP
UDP + ADP
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
localized in the mitochondrial intermembrane space
Manually annotated by BRENDA team
-
predominant nuclear localization
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
although homozygous adenylate kinsase 2 mutated embryos develop without any visible defects, their growth ceases and they die before reaching the third instar larval stage
physiological function
maternally provided adenylate kianse 2 is sufficient for embryonic development, adenylate kinase 2 plays a critical role in adenine nucleotide metabolism in the mitochondrial intermembrane space and is essential for growth in Drosophila melanogaster
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KAD2_DROME
240
0
26543
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25000
-
and 50000, gel filtration and non-reducing SDS-PAGE
27000
50000
-
and 25000, gel filtration and non-reducing SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
and monomer, 2 * 27000, SDS-PAGE
monomer
-
and dimer, 1 * 27000, SDS-PAGE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
expression in Escherichia coli and HeLa cell
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meng, G.; Zhai, R.; Liu, B.; Zheng, X.
Identification of a novel nuclear-localized adenylate kinase from Drosophila melanogaster
Biochemistry (Moscow)
73
38-43
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Fujisawa, K.; Murakami, R.; Horiguchi, T.; Noma, T.
Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster
Comp. Biochem. Physiol. B
153
29-38
2009
Drosophila melanogaster (Q9U915), Drosophila melanogaster
Manually annotated by BRENDA team