EC Number   |
General Information |
Reference |
|---|
    2.7.4.3 | malfunction |
adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness |
705851 |
| 2.7.4.3 | malfunction |
adenylate kinase 2 knockdown in larvae by RNA interference causes larval growth defects, including body weight decrease and development delay. Adenylate kinase 2 knockdown in larvae also decreases the number of circulating hemocytes |
721943 |
| 2.7.4.3 | malfunction |
adenylate kinase deficiency disrupts cell energetics and causes severe human diseases. Knockdown of overexpressed AK2 in human lung adenocarcinoma cells suppresses proliferation, migration, and invasion as well as induced apoptosis and autophagy |
761162 |
| 2.7.4.3 | malfunction |
although homozygous adenylate kinsase 2 mutated embryos develop without any visible defects, their growth ceases and they die before reaching the third instar larval stage |
703297 |
| 2.7.4.3 | malfunction |
depletion of adenylate kinase 2 (AK2) by RNAi impairs adiponectin secretion in 3T3-L1 adipocytes, immunoglobulin M secretion in BCL1 cells, and the induction of the unfolded protein response during differentiation of both cell types. Depletion of AK2 results in changes in adipocyte energy homeostasis, but these effects do not detectably impair key adipocyte properties such as mitochondrial biogenesis and triglyceride storage |
722732 |
| 2.7.4.3 | malfunction |
reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2 |
705850 |
| 2.7.4.3 | malfunction |
rrecombinant expression of wild-type adk gene in fucose-inducible strains rescues a growth defect, but expression of the Arg89 mutant does not. Lack of functional SpAdK causes a growth defect in vivo, SpAdK deficiency abolishes pneumococcal growth |
738250 |
| 2.7.4.3 | malfunction |
the absence of denylate kinase 6 reduces stem elongation but does not delay development |
723448 |
| 2.7.4.3 | metabolism |
adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response |
722732 |
| 2.7.4.3 | more |
activity remains essentially unchanged with change in the growth condition (maltose + peptides, maltose, maltose + peptides + sulfur S(0), maltose + sulfur S(0), peptides + sulfur S(0)) |
745202 |
