Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.4.26 - isopentenyl phosphate kinase and Organism(s) Streptomyces wedmorensis and UniProt Accession Q56187

for references in articles please use BRENDA:EC2.7.4.26
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme is involved in the mevalonate pathway in Archaea . The activity has also been identified in the plant Mentha piperita (peppermint) . It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Streptomyces wedmorensis
UNIPROT: Q56187
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Streptomyces wedmorensis
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
isopentenyl phosphate kinase, mj0044, more
SYSTEMATIC NAME
IUBMB Comments
ATP:isopentenyl phosphate phosphotransferase
The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + fosfomycin
ADP + ((2R,3S)-3-methyloxiran-2-yl)phosphonic phosphoric anhydride
show the reaction diagram
i.e. [(2R,3S)-3-methyl-2-oxiranyl]phosphonic acid
-
-
?
ATP + isopentenyl phosphate
ADP + isopentenyl diphosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + isopentenyl phosphate
ADP + isopentenyl diphosphate
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
fosfomycin
competitive versus isopentenyl phosphate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q56187_STRWE
266
0
28611
TrEMBL
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mabanglo, M.F.; Serohijos, A.W.; Poulter, C.D.
The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase
Biochemistry
52
917-925
2012
Streptomyces wedmorensis (Q56187), Streptomyces wedmorensis, Thermoplasma acidophilum (Q9HLX1), Thermoplasma acidophilum
Manually annotated by BRENDA team