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Information on EC 2.7.11.31 - [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
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2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinaseIUBMB Comments
The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) . Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase . GTP can act instead of ATP
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- 2.7.11.31
- metformin
- rapamycin
- peroxisome
- obesity
- aicar
- mtor
- carboxylase
-
proliferator-activated
- acetyl-coa
- endothelial
- cardiac
-
high-fat
- triglyceride
- adipocytes
- adiponectin
- glycogen
- agonist
- mellitus
-
obese
- sterol
- hypothalamic
- steatosis
- sirt1
-
antidiabetic
-
ampk-dependent
-
diet-induced
- sirtuins
- leptin
-
p-ampk
- 5-aminoimidazole-4-carboxamide
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lipogenesis
-
insulin-stimulated
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ampk-mediated
- myotubes
-
element-binding
-
hfd-induced
-
anti-obesity
- srebp-1c
- ulk1
- camkks
-
adipor1
- coactivator-1
-
palmitoyltransferase-1
- dorsomorphin
- drug development
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phospho-ampk
- epitrochlearis
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metformin-induced
- phenformin
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energy-sensing
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insulin-independent
- medicine
- industry
- pharmacology
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
adenosine monophosphate-activated protein kinase, amp-activated kinase, 5'-amp-activated protein kinase, prkaa1, snf1 kinase, adenosine 5'-monophosphate-activated protein kinase, ampkalpha1, reductase kinase, aak-2, ampk alpha2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase
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3-hydroxy-3-methylglutaryl-CoA reductase kinase
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AMP-activated protein kinase
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AMPK
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beta-hydroxy-beta-methylglutaryl-CoA reductase kinase
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hydroxymethylglutaryl coenzyme A reductase kinase
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hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating)
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reductase kinase
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[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4]
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CAS REGISTRY NUMBER
COMMENTARY
172522-01-9
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK.
Adenocarcinoma
Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase.
Adenoviridae Infections
Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.
Adrenoleukodystrophy
Loss of AMP-activated protein kinase in X-linked adrenoleukodystrophy patient-derived fibroblasts and lymphocytes.
Alzheimer Disease
AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on ?-amyloid clearance.
Amyotrophic Lateral Sclerosis
"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice.
Amyotrophic Lateral Sclerosis
Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Effects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model.
Aortic Aneurysm, Abdominal
Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms.
Aortic Valve Stenosis
Excessive training induces molecular signs of pathologic cardiac hypertrophy.
Arthritis, Rheumatoid
Compensation of Adiponectin-Induced Adenosine Monophosphate-Activated Protein Kinase and p38 Mitogen-Activated Protein Kinase Signaling in Rheumatoid Arthritis Synovial Fibroblasts.
Ataxia Telangiectasia
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Ataxia Telangiectasia
Resveratrol ameliorates high-fat diet-induced insulin resistance and fatty acid oxidation via ATM-AMPK axis in skeletal muscle.
Atherosclerosis
Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
Metformin directly suppresses atherosclerosis in normoglycemic mice via haematopoietic Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Atrial Fibrillation
Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate-activated protein kinase.
Birt-Hogg-Dube Syndrome
Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene product.
Bone Neoplasms
Activation of Adenosine Monophosphate-activated Protein Kinase Suppresses Neuroinflammation and Ameliorates Bone Cancer Pain: Involvement of Inhibition on Mitogen-activated Protein Kinase.
Brain Injuries
Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway.
Brain Ischemia
Inhibition of adenosine monophosphate-activated protein kinase reduces glial cell-mediated inflammation and induces the expression of Cx43 in astroglias after cerebral ischemia.
Brain Ischemia
Targeting Adenosine Monophosphate-Activated Protein Kinase by Metformin Adjusts Post-Ischemic Hyperemia and Extracellular Neuronal Discharge in Transient Global Cerebral Ischemia.
Brain Neoplasms
5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.
Breast Neoplasms
5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells.
Breast Neoplasms
5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors.
Breast Neoplasms
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer.
Breast Neoplasms
AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.
Breast Neoplasms
Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1.
Breast Neoplasms
Do polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review.
Breast Neoplasms
Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.
Breast Neoplasms
Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation.
Breast Neoplasms
Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism
Breast Neoplasms
Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue-Relationship between AMPK and Glycolysis.
Carcinogenesis
AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.
Carcinogenesis
Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population.
Carcinogenesis
Interaction of renin-angiotensin system and adenosine monophosphate-activated protein kinase signaling pathway in renal carcinogenesis of uninephrectomized rats.
Carcinogenesis
Involvement of NF-?B signaling pathway in the regulation of PRKAA1-mediated tumorigenesis in gastric cancer.
Carcinogenesis
Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.
Carcinogenesis
PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways.
Carcinogenesis
Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer.
Carcinoma
Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean (Phaseolus vulgaris L.).
Carcinoma
Do polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review.
Carcinoma
LINC00473/miR-497-5p Regulates Esophageal Squamous Cell Carcinoma Progression Through Targeting PRKAA1.
Carcinoma
Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.
Carcinoma
[Impact of AMPKgamma silencing on AMPK activation and intracellular lipids regulation].
Carcinoma, Hepatocellular
Activation of Adenosine Monophosphate-Activated Protein Kinase Reduces the Onset of Diet-Induced Hepatocellular Carcinoma in Mice.
Carcinoma, Non-Small-Cell Lung
Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112 (October) (2017) 81-89].
Carcinoma, Non-Small-Cell Lung
Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112, (October) (2017) 81-89].
Carcinoma, Non-Small-Cell Lung
Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway.
Carcinoma, Non-Small-Cell Lung
Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.
Carcinoma, Non-Small-Cell Lung
Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase.
Carcinoma, Non-Small-Cell Lung
Mir-451 inhibits proliferation and migration of non-small cell lung cancer cells via targeting LKB1/AMPK.
Carcinoma, Non-Small-Cell Lung
Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.
Carcinoma, Renal Cell
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Cardiomegaly
Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro.
Cardiomegaly
Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway.
Cardiomegaly
AMPK activation enhances PPAR? activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway.
Cardiomegaly
Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
Cardiomegaly
Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5'-monophosphate-activated protein kinase pathway.
Cardiomegaly
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Cardiomegaly
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy.
Cardiomegaly
Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway.
Cardiomyopathies
Eliciting ?7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling.
Cardiomyopathy, Hypertrophic
Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural history.
Cardiomyopathy, Hypertrophic
High prevalence of arrhythmic and myocardial complications in patients with cardiac glycogenosis due to PRKAG2 mutations.
Cardiotoxicity
A review on the cardioprotective mechanisms of metformin against doxorubicin.
Cardiotoxicity
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway.
Cardiovascular Diseases
Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.
Colitis
6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation.
Colonic Neoplasms
Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1 signaling.
Colonic Neoplasms
Augmented O-GlcNAcylation of AMP-activated kinase promotes the proliferation of LoVo cells, a colon cancer cell line.
Colonic Neoplasms
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Colonic Neoplasms
Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy.
Colorectal Neoplasms
Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway.
Colorectal Neoplasms
Genetic Variations in STK11, PRKAA1, and TSC1 Associated with Prognosis for Patients with Colorectal Cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Novel PRKAG2 variant presenting as liver cirrhosis: report of a family with 2 cases and review of literature.
Coronary Disease
Association between expression of AMPK pathway and adiponectin, leptin, and vascular endothelial function in rats with coronary heart disease.
Coronary Disease
[Ginseng prescription rules and molecular mechanism in treating coronary heart disease based on data mining and integrative pharmacology].
Cushing Syndrome
Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.
Cystic Fibrosis
AMPK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in CF Airway Epithelial Cells.
Cystic Fibrosis
Up-regulation of AMP-activated Kinase by Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Airway Epithelial Cells Mitigates Excessive Inflammation.
Diabetes Mellitus
Adenosine monophosphate-activated protein kinase in diabetic nephropathy.
Diabetes Mellitus
AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants.
Diabetes Mellitus
Increase in AMPK brought about by cocoa is renoprotective in experimental diabetes mellitus by reducing NOX4/TGF?-1 signaling.
Diabetes Mellitus
Liquorice flavonoid oil suppresses hyperglycaemia accompanied by skeletal muscle myocellular GLUT4 recruitment to the plasma membrane in KK-Ay mice.
Diabetes Mellitus
Metformin reduces TGF-?1-induced extracellular matrix production in nasal polyp-derived fibroblasts.
Diabetes Mellitus
The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study.
Diabetes Mellitus, Type 2
Adenosine monophosphate-activated protein kinase in diabetic nephropathy.
Diabetes Mellitus, Type 2
AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise.
Diabetes Mellitus, Type 2
AMP-activated protein kinase as regulator of P2Y6 receptor-induced insulin secretion in mouse pancreatic ?-cells.
Diabetes Mellitus, Type 2
Can patients with type 2 diabetes be treated with 5'-AMP-activated protein kinase activators?
Diabetes Mellitus, Type 2
Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways.
Diabetes Mellitus, Type 2
Liquorice flavonoid oil suppresses hyperglycaemia accompanied by skeletal muscle myocellular GLUT4 recruitment to the plasma membrane in KK-Ay mice.
Diabetes Mellitus, Type 2
Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway.
Diabetes Mellitus, Type 2
Mechanism and application of metformin in kidney diseases: An update.
Diabetes Mellitus, Type 2
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Metformin reduces TGF-?1-induced extracellular matrix production in nasal polyp-derived fibroblasts.
Diabetes Mellitus, Type 2
Nano strategies for berberine delivery, a natural alkaloid of Berberis.
Diabetes Mellitus, Type 2
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.
Diabetes Mellitus, Type 2
Role of adenosine monophosphate-activated protein kinase in the control of energy homeostasis.
Diabetes Mellitus, Type 2
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
Diabetic Cardiomyopathies
Advanced glycation end-products impair Na?/K?-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway.
Diabetic Nephropathies
Adenosine monophosphate-activated protein kinase in diabetic nephropathy.
Diabetic Nephropathies
Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPK?1?1?1 activators.
Diabetic Nephropathies
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Diabetic Nephropathies
Extracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic Nephropathy.
Diabetic Nephropathies
Renoprotective Effects of Fenofibrate via Modulation of LKB1/AMPK mRNA Expression and Endothelial Dysfunction in a Rat Model of Diabetic Nephropathy.
Diabetic Nephropathies
Thalidomide decreases high glucose-induced extracellular matrix protein synthesis in mesangial cells via the AMPK pathway.
Diabetic Nephropathies
Update on the protective renal effects of metformin in diabetic nephropathy.
Diabetic Neuropathies
Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation.
Diabetic Neuropathies
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy.
Diabetic Neuropathies
Erratum to: Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation.
ditrans,polycis-polyprenyl diphosphate synthase [(2e,6e)-farnesyl diphosphate specific] deficiency
Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway.
Dyslipidemias
Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-? and AMPK and inhibiting IL-6 and TNF-?.
Dyslipidemias
Xiexin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism.
Endometrial Neoplasms
[Effects of metformin and adiponectin on endometrial cancer cells growth].
Endometriosis
The AMPK-mTOR axis requires increased MALAT1 expression for promoting granulosa cell proliferation in endometriosis.
Endophthalmitis
5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.
Esophageal Neoplasms
PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case-control study.
Esophageal Squamous Cell Carcinoma
Do polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review.
Esophageal Squamous Cell Carcinoma
LINC00473/miR-497-5p Regulates Esophageal Squamous Cell Carcinoma Progression Through Targeting PRKAA1.
Fatty Liver
?-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway.
Fatty Liver
Amelioration of diet-induced metabolic syndrome and fatty liver with sitagliptin via regulation of adipose tissue inflammation and hepatic Adiponectin/AMPK levels in mice.
Fatty Liver
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Fatty Liver
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver.
Fatty Liver
Crude extracts from Lycium barbarum suppress SREBP-1c expression and prevent diet-induced fatty liver through AMPK activation.
Fatty Liver
Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK.
Fatty Liver
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and ?1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Fatty Liver
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Fatty Liver
Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats.
Fatty Liver
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.
Fatty Liver
Preventive Effects of (-)-Epigallocatechin Gallate on Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-db/db Mice.
Fatty Liver
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Fatty Liver
Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.
Fatty Liver
Thiazolidinediones improve hepatic fibrosis by activating the adenosine monophosphate-activated protein kinase (ampk) signaling pathway in rats with non-alcoholic steatohepatitis.
Fatty Liver
[Ginseng prescription rules and molecular mechanism in treating coronary heart disease based on data mining and integrative pharmacology].
Fetal Nutrition Disorders
Azuki bean polyphenols intake during lactation upregulate AMPK in male rat offspring exposed to fetal malnutrition.
Flavivirus Infections
Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism.
Follicular Cyst
Alterations in key metabolic sensors involved in bovine cystic ovarian disease.
Gastritis, Atrophic
TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer.
Gastroparesis
Significance of dynamic changes in gastric smooth muscle cell apoptosis, PI3K-AKT-mTOR and AMPK-mTOR signaling in a rat model of diabetic gastroparesis.
Glaucoma
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma.
Glaucoma, Open-Angle
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma.
Glioblastoma
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Glioblastoma
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.
Glioma
Activation of AMP-activated kinase modulates sensitivity of glioma cells against epidermal growth factor receptor inhibition.
Glucose Intolerance
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.
Glucose Intolerance
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Glucose Intolerance
Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus.
glucosylglycerol 3-phosphatase deficiency
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions.
Glycogen Storage Disease
High prevalence of arrhythmic and myocardial complications in patients with cardiac glycogenosis due to PRKAG2 mutations.
Glycogen Storage Disease
Novel PRKAG2 variant presenting as liver cirrhosis: report of a family with 2 cases and review of literature.
Granuloma
Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease.
Hearing Loss
Acoustic overstimulation activates 5'-AMP-activated protein kinase through a temporary decrease in ATP level in the cochlear spiral ligament prior to permanent hearing loss in mice.
Heart Block
High prevalence of arrhythmic and myocardial complications in patients with cardiac glycogenosis due to PRKAG2 mutations.
Heart Failure
AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases.
Heart Failure
Cardiac Dysfunction after Burn Injury: Role of the AMPK-SIRT1-PGC1?-NFE2L2-ARE Pathway.
Heart Failure
Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase-mediated cardiotoxicity.
Heart Failure
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Heart Failure
Direct Cardiac Actions of the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure-Overload Heart Failure.
Heart Failure
Excessive training induces molecular signs of pathologic cardiac hypertrophy.
Heart Failure
Targeting myocardial substrate metabolism in heart failure: potential for new therapies.
Hepatitis B, Chronic
Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population.
Herpes Zoster
Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes.
Herpesviridae Infections
Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase.
Hyperalgesia
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
Hyperalgesia
Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment.
Hypercholesterolemia
Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial.
Hypercholesterolemia
LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase.
Hyperemia
Targeting Adenosine Monophosphate-Activated Protein Kinase by Metformin Adjusts Post-Ischemic Hyperemia and Extracellular Neuronal Discharge in Transient Global Cerebral Ischemia.
Hyperglycemia
Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies.
Hyperglycemia
Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1.
Hyperglycemia
Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms.
Hyperlipidemias
Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies.
Hyperlipidemias
Interaction of renin-angiotensin system and adenosine monophosphate-activated protein kinase signaling pathway in renal carcinogenesis of uninephrectomized rats.
Hyperlipidemias
Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK.
Hyperlipidemias
Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet.
Hypersensitivity
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
Hypersensitivity
The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet.
Hypertension
Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways.
Hypertension, Pulmonary
Adenosine Monophosphate-Activated Protein Kinase Is Required for Pulmonary Artery Smooth Muscle Cell Survival and the Development of Hypoxic Pulmonary Hypertension.
Hypertension, Pulmonary
AMPK?2 deficiency exacerbates hypoxia-induced pulmonary hypertension by promoting pulmonary arterial smooth muscle cell proliferation.
Hypertension, Pulmonary
Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase.
Hyperthyroidism
Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart.
Hypertriglyceridemia
Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins.
Hypertriglyceridemia
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Hypertriglyceridemia
Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism.
Hypoglycemia
Estradiol regulation of hypothalamic astrocyte adenosine 5'-monophosphate-activated protein kinase activity: role of hindbrain catecholamine signaling.
Hypoglycemia
Estrogen regulates energy metabolic pathway and upstream adenosine 5'-monophosphate-activated protein kinase and phosphatase enzyme expression in dorsal vagal complex metabolosensory neurons during glucostasis and hypoglycemia.
Hypoglycemia
Hindbrain estrogen receptor-beta antagonism normalizes reproductive and counter-regulatory hormone secretion in hypoglycemic steroid-primed ovariectomized female rats.
Hypoglycemia
Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat.
Hypoglycemia
Lateral but not Medial Hypothalamic AMPK Activation Occurs at the Hypoglycemic Nadir in Insulin-injected Male Rats: Impact of Caudal Dorsomedial Hindbrain Catecholamine Signaling.
Hypoglycemia
Neuroestradiol regulation of ventromedial hypothalamic nucleus 5'-AMP-activated protein kinase activity and counterregulatory hormone secretion in hypoglycemic male versus female rats.
Hypoglycemia
Role of hindbrain adenosine 5'-monophosphate-activated protein kinase (AMPK) in hypothalamic AMPK and metabolic neuropeptide adaptation to recurring insulin-induced hypoglycemia in the male rat.
Hypoglycemia
Sex-specific acclimation of A2 noradrenergic neuron dopamine-?-hydroxylase and estrogen receptor variant protein and 5'-AMP-Activated protein kinase reactivity to recurring hypoglycemia in rat.
Hypothyroidism
The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats.
Hypoxia-Ischemia, Brain
Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.
Immune System Diseases
Suppression of adenosine monophosphate-activated protein kinase selectively triggers apoptosis in activated T cells and ameliorates immune diseases.
Infarction, Middle Cerebral Artery
Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke.
Infarction, Middle Cerebral Artery
Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury.
Infections
Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans.
Infections
Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population.
Infections
Environmental factors, seven GWAS-identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population.
Infections
Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis.
Infections
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
Infections
Impaired Cellular Energy Metabolism Contributes to Duck-Enteritis-Virus-Induced Autophagy via the AMPK-TSC2-MTOR Signaling Pathway.
Infections
Involvement of NF-?B signaling pathway in the regulation of PRKAA1-mediated tumorigenesis in gastric cancer.
Infections
Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase.
Infections
TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer.
Inflammatory Bowel Diseases
Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin.
Influenza, Human
Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways.
Insulin Resistance
A high isoflavone diet decreases 5' adenosine monophosphate-activated protein kinase activation and does not correct selenium-induced elevations in fasting blood glucose in mice.
Insulin Resistance
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.
Insulin Resistance
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.
Insulin Resistance
AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle.
Insulin Resistance
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
Insulin Resistance
AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes.
Insulin Resistance
Angiotensin II inhibits glucose uptake of skeletal muscle via the adenosine monophosphate-activated protein kinase pathway.
Insulin Resistance
Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats.
Insulin Resistance
Carnosol Increases Skeletal Muscle Cell Glucose Uptake via AMPK-Dependent GLUT4 Glucose Transporter Translocation.
Insulin Resistance
Caulerpa okamurae extract attenuates inflammatory interaction, regulates glucose metabolism and increases insulin sensitivity in 3T3-L1 adipocytes and RAW 264.7 macrophages.
Insulin Resistance
Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice.
Insulin Resistance
Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance.
Insulin Resistance
De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome.
Insulin Resistance
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Insulin Resistance
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Insulin Resistance
HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation.
Insulin Resistance
Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance.
Insulin Resistance
Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis.
Insulin Resistance
Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury.
Insulin Resistance
Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction.
Insulin Resistance
Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation.
Insulin Resistance
Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase.
Insulin Resistance
Metformin prevents LYRM1-induced insulin resistance in 3T3-L1 adipocytes via a mitochondrial-dependent mechanism.
Insulin Resistance
Metformin--mode of action and clinical implications for diabetes and cancer.
Insulin Resistance
Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons.
Insulin Resistance
Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet.
Insulin Resistance
Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities.
Insulin Resistance
Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK.
Insulin Resistance
Role of adenosine monophosphate-activated protein kinase in the control of energy homeostasis.
Insulin Resistance
Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones.
Insulin Resistance
Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK.
Insulin Resistance
Short-term calorie restriction improves glucose homeostasis in old rats: involvement of AMPK.
Insulin Resistance
Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice.
Insulin Resistance
Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-? and AMPK and inhibiting IL-6 and TNF-?.
Insulin Resistance
The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study.
Insulin Resistance
The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate-activated protein kinase activity and lipogenic gene expression in high-fat diet-fed obese mice.
Insulin Resistance
The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease.
Insulin Resistance
Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways.
Insulin Resistance
Vernonia cinerea water extract improves insulin resistance in high-fat diet-induced obese mice.
Insulin Resistance
Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats.
Insulin Resistance
[Eletroacupuncture improves lipid metabolic disorder by regulating hepatic AMPK/p38 MAPK/RRAR? signaling in rats with high-fat diet-induced insulin resistance].
Ischemic Stroke
Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke.
Ischemic Stroke
Therapeutic effects of JLX-001 on ischemic stroke by inducing autophagy via AMPK-ULK1 signaling pathway in rats.
Kidney Diseases
Selective Activation of AMPK b1-containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
Kidney Diseases, Cystic
Effect of celastrol on the progression of polycystic kidney disease in a Pkd1-deficient mouse model.
Kidney Failure, Chronic
Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease.
Kidney Failure, Chronic
Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy.
Kidney Failure, Chronic
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Leiomyomatosis
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Leukemia
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Leukemia
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Leukemia, Myeloid, Acute
AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia.
Lipodystrophy
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and ?1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Liver Cirrhosis
Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells.
Liver Cirrhosis
Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway.
Liver Cirrhosis
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Liver Diseases
AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability.
Liver Diseases
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Liver Diseases
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport.
Liver Diseases
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Liver Diseases
The 5'-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2.
Liver Diseases
Viscothionin isolated from Korean mistletoe improves nonalcoholic fatty liver disease via the activation of adenosine monophosphate-activated protein kinase.
Liver Neoplasms
Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib.
Lung Injury
The Effects of Dexmedetomidine in a Rat Model of Sepsis-Induced Lung Injury are Mediated Through the Adenosine Monophosphate-Activated Protein Kinase (AMPK)/Silent Information Regulator 1 (SIRT1) Pathway.
Lung Neoplasms
Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1?, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells.
Lung Neoplasms
Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112 (October) (2017) 81-89].
Lung Neoplasms
Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112, (October) (2017) 81-89].
Lung Neoplasms
Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway.
Lung Neoplasms
Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.
Lung Neoplasms
Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase.
Lung Neoplasms
Mir-451 inhibits proliferation and migration of non-small cell lung cancer cells via targeting LKB1/AMPK.
Lung Neoplasms
RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.
Lung Neoplasms
Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.
Lymphoma
Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells.
Lymphoma, B-Cell
Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Lymphoma, Large B-Cell, Diffuse
Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma.
Melanoma
AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival.
Melanoma
Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells.
Memory Disorders
Evaluation of the effects of metformin as adenosine monophosphate-activated protein kinase activator on spatial learning and memory in a rat model of multiple sclerosis disease.
Memory Disorders
GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-?B pathway in neuropathic pain mice.
Metabolic Diseases
Anti-Inflammatory and Anti-Obesity Properties of Food Bioactive Components: Effects on Adipose Tissue.
Metabolic Diseases
Chronic binge alcohol and ovariectomy dysregulate omental adipose tissue metaboproteome in simian immunodeficiency virus-infected female macaques.
Metabolic Diseases
Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.
Metabolic Diseases
Protectin DX prevents H2O2-mediated oxidative stress in vascular endothelial cells via an AMPK-dependent mechanism.
Metabolic Syndrome
Adenosine monophosphate-activated protein kinase in diabetic nephropathy.
Metabolic Syndrome
Amelioration of diet-induced metabolic syndrome and fatty liver with sitagliptin via regulation of adipose tissue inflammation and hepatic Adiponectin/AMPK levels in mice.
Metabolic Syndrome
AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle.
Metabolic Syndrome
AMPKalpha1 regulates the antioxidant status of vascular endothelial cells.
Metabolic Syndrome
Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase.
Metabolic Syndrome
In silico design for adenosine monophosphate-activated protein kinase agonist from traditional chinese medicine for treatment of metabolic syndromes.
Metabolic Syndrome
Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.
Metabolic Syndrome
The 5'-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2.
Multiple Myeloma
Inhibition of adenosine monophosphate-activated protein kinase induces apoptosis in multiple myeloma cells.
Multiple Myeloma
Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-?-riboside-induced apoptosis in multiple myeloma cells.
Multiple Sclerosis
Evaluation of the effects of metformin as adenosine monophosphate-activated protein kinase activator on spatial learning and memory in a rat model of multiple sclerosis disease.
Muscle Hypotonia
Metabolic studies of a patient harbouring a novel S487L mutation in the catalytic subunit of AMPK.
Muscular Atrophy
AMP-activated kinase ?2 deficiency protects mice from denervation-induced skeletal muscle atrophy.
Muscular Atrophy
Water Extract of Lotus Leaf Alleviates Dexamethasone-Induced Muscle Atrophy via Regulating Protein Metabolism-Related Pathways in Mice.
Muscular Dystrophy, Duchenne
AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy.
Mycoses
mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.
Myocardial Infarction
Effect of Yiqihuoxue prescription on myocardial energy metabolism after myocardial infarction via cross talk of liver kinase B1-dependent Notch1 and adenosine 5'-monophosphate-activated protein kinase.
Myocardial Ischemia
Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase.
Myocardial Ischemia
Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase.
Neoplasm Metastasis
Involvement of NF-?B signaling pathway in the regulation of PRKAA1-mediated tumorigenesis in gastric cancer.
Neoplasm Metastasis
SIKs suppress tumor function and regulate drug resistance in breast cancer.
Neoplasm Metastasis
SWI/SNF chromatin remodeling complex and glucose metabolism are deregulated in advanced bladder cancer.
Neoplasm Metastasis
Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer.
Neoplasm Metastasis
Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy.
Neoplasms
"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells".
Neoplasms
2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways in cancer cells: 5'-AMP-activated protein kinase (AMPK)/mTOR and PI3K/Akt/mTOR pathways.
Neoplasms
5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors.
Neoplasms
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.
Neoplasms
Acute nicotine treatment alleviates LPS-induced impairment of fear memory reconsolidation through AMPK activation and CRTC1 upregulation in hippocampus.
Neoplasms
Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction.
Neoplasms
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a Diverse Therapeutic Target: A Computational Perspective.
Neoplasms
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection.
Neoplasms
Adiponectin Antagonizes Stimulatory Effect of Tumor Necrosis Factor-{alpha} on Vascular Smooth Muscle Cell Calcification: Regulation of Growth Arrest-Specific Gene 6-Mediated Survival Pathway by Adenosine 5'-Monophosphate-Activated Protein Kinase.
Neoplasms
AICAR Attenuates TNF?-Induced Inappropriate Secretion of Monocyte Chemoattractant Protein-1 and Adiponectin in 3T3-L1 Adipocytes.
Neoplasms
AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.
Neoplasms
AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.
Neoplasms
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours.
Neoplasms
AMPK alpha-1 intrinsically regulates the function and differentiation of tumor myeloid-derived suppressor cells.
Neoplasms
AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3.
Neoplasms
AMPK?1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2.
Neoplasms
AMPK?1 Regulates Lung and Breast Cancer Progression by Regulating TLR4-Mediated TRAF6-BECN1 Signaling Axis.
Neoplasms
AMPK?2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells.
Neoplasms
Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling.
Neoplasms
Aster glehni Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPAR?-AMPK Pathway.
Neoplasms
Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling.
Neoplasms
At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation.
Neoplasms
Augmented O-GlcNAcylation of AMP-activated kinase promotes the proliferation of LoVo cells, a colon cancer cell line.
Neoplasms
Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate-Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/Protein Kinase B (PI3K/AKT) Signaling Pathways.
Neoplasms
Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model.
Neoplasms
Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer.
Neoplasms
Combination of D942 With Curcumin Protects Cardiomyocytes From Ischemic Damage Through Promoting Autophagy.
Neoplasms
Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112 (October) (2017) 81-89].
Neoplasms
Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112, (October) (2017) 81-89].
Neoplasms
Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties.
Neoplasms
Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.
Neoplasms
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.
Neoplasms
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Neoplasms
Do polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review.
Neoplasms
Down-regulation of adenosine monophosphate-activated protein kinase activity: A driver of cancer.
Neoplasms
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Neoplasms
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Neoplasms
Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14.
Neoplasms
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR? Regulation in Hyperlipidemic and Hypertensive Conditions.
Neoplasms
FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response.
Neoplasms
Galangin potentiates human breast cancer to apoptosis induced by TRAIL through activating AMPK.
Neoplasms
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Neoplasms
Genistein suppresses tumor necrosis factor ?-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor ?B and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells.
Neoplasms
Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours.
Neoplasms
GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-?B pathway in neuropathic pain mice.
Neoplasms
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Neoplasms
HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy.
Neoplasms
Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice.
Neoplasms
Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation.
Neoplasms
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Neoplasms
Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK.
Neoplasms
Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas.
Neoplasms
Involvement of NF-?B signaling pathway in the regulation of PRKAA1-mediated tumorigenesis in gastric cancer.
Neoplasms
Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation.
Neoplasms
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Neoplasms
Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells.
Neoplasms
Keratinocyte autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing.
Neoplasms
Knockdown of AMPK?2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway.
Neoplasms
LKB1/AMPK inhibits TGF-?1 production and the TGF-? signaling pathway in breast cancer cells.
Neoplasms
Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.
Neoplasms
Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway.
Neoplasms
Metformin--an adjunct antineoplastic therapy--divergently modulates tumor metabolism and proliferation, interfering with early response prediction by 18F-FDG PET imaging.
Neoplasms
MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer.
Neoplasms
N-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes.
Neoplasms
New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK.
Neoplasms
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.
Neoplasms
p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis.
Neoplasms
Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation.
Neoplasms
PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways.
Neoplasms
Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs.
Neoplasms
Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma.
Neoplasms
Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer.
Neoplasms
Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-? and AMPK and inhibiting IL-6 and TNF-?.
Neoplasms
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
Neoplasms
Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.
Neoplasms
Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib.
Neoplasms
Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer.
Neoplasms
The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria.
Neoplasms
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Neoplasms
The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins.
Neoplasms
The red pepper's spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKK?.
Neoplasms
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Neoplasms
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.
Neoplasms
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Neoplasms
Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy.
Neoplasms
Weight Gain and Metabolic Changes During Treatment with Antipsychotics and Antidepressants.
Neuralgia
Adenosine Monophosphate-activated Protein Kinase Regulates Interleukin-1? Expression and Glial Glutamate Transporter Function in Rodents with Neuropathic Pain.
Neuralgia
AMPK activation attenuates inflammatory pain through inhibiting NF-?B activation and IL-1? expression.
Neuralgia
GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-?B pathway in neuropathic pain mice.
Neuralgia
Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.
Neurodegenerative Diseases
Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3?/PP2A pathway in Parkinson's disease.
Neuroinflammatory Diseases
Activation of Adenosine Monophosphate-activated Protein Kinase Suppresses Neuroinflammation and Ameliorates Bone Cancer Pain: Involvement of Inhibition on Mitogen-activated Protein Kinase.
Neuroinflammatory Diseases
Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice.
Neuroinflammatory Diseases
Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation.
Neuroinflammatory Diseases
Erratum to: Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation.
Neuroinflammatory Diseases
Inhibition of adenosine monophosphate-activated protein kinase reduces glial cell-mediated inflammation and induces the expression of Cx43 in astroglias after cerebral ischemia.
Neuroinflammatory Diseases
miR-124 and Parkinson's disease: A biomarker with therapeutic potential.
Neuroinflammatory Diseases
Promise of metformin for preventing age-related cognitive dysfunction.
Neuroinflammatory Diseases
Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice.
Nevus
ASA Suppresses PGE2 in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma.
Non-alcoholic Fatty Liver Disease
A tRNA-derived fragment (tRF-3001b) aggravates the development of nonalcoholic fatty liver disease by inhibiting autophagy.
Non-alcoholic Fatty Liver Disease
Activation of Adenosine Monophosphate-Activated Protein Kinase Reduces the Onset of Diet-Induced Hepatocellular Carcinoma in Mice.
Non-alcoholic Fatty Liver Disease
Emerging Liver-Kidney Interactions in Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Non-alcoholic Fatty Liver Disease
MDG-1, an Ophiopogon polysaccharide, restrains process of non-alcoholic fatty liver disease via modulating the gut-liver axis.
Non-alcoholic Fatty Liver Disease
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Non-alcoholic Fatty Liver Disease
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport.
Non-alcoholic Fatty Liver Disease
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Non-alcoholic Fatty Liver Disease
The 5'-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2.
Non-alcoholic Fatty Liver Disease
The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues.
Non-alcoholic Fatty Liver Disease
Viscothionin isolated from Korean mistletoe improves nonalcoholic fatty liver disease via the activation of adenosine monophosphate-activated protein kinase.
Obesity
6'-O-acetyl mangiferin from Iris rossii Baker inhibits lipid accumulation partly via AMPK activation in adipogenesis.
Obesity
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a Diverse Therapeutic Target: A Computational Perspective.
Obesity
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Obesity
Exercise training prevents the attenuation of anesthetic pre-conditioning-mediated cardioprotection in diet-induced obese rats.
Obesity
Induction of cardiac uncoupling protein-2 expression and adenosine 5'-monophosphate-activated protein kinase phosphorylation during early states of diet-induced obesity in mice.
Obesity
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity
Metabolic fate of saturated and monounsaturated dietary fats: The Mediterranean diet revisited from epidemiological evidence to cellular mechanisms.
Obesity
Mild caloric restriction reduces blood pressure and activates endothelial AMPK-PI3K-Akt-eNOS pathway in obese Zucker rats.
Obesity
Naringin Activates AMPK Resulting in Altered Expression of SREBPs, PCSK9, and LDLR To Reduce Body Weight in Obese C57BL/6J Mice.
Obesity
Reciprocal effects of ?-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats.
Obesity
Role of adenosine monophosphate-activated protein kinase in the control of energy homeostasis.
Obesity
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
Obesity
The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate-activated protein kinase activity and lipogenic gene expression in high-fat diet-fed obese mice.
Obesity
Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review.
Obesity
Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues.
Obesity, Abdominal
Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.
Ocular Hypertension
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma.
Osteoarthritis
Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior.
Osteosarcoma
MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targeting AMP-activated protein kinase alpha 1.
Ovarian Neoplasms
Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro.
Overnutrition
Maternal overnutrition suppresses the phosphorylation of 5'-AMP-activated protein kinase in liver, but not skeletal muscle, in the fetal and neonatal sheep.
Pancreatic Neoplasms
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Peripheral Nervous System Diseases
Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes.
Pneumonia
MicroRNA-30d-5p ameliorates lipopolysaccharide-induced acute lung injury via activating AMPK?.
Polycystic Kidney Diseases
Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.
Polycystic Ovary Syndrome
Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients.
Prostatic Neoplasms
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1?-mediated metabolic switch.
Prostatic Neoplasms
Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5'-AMP-activated protein kinase (AMPK) pathway.
Prostatic Neoplasms
Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase.
Prostatic Neoplasms
Metabolic alterations and targeted therapies in prostate cancer.
Prostatic Neoplasms
Ser-486/491 phosphorylation and inhibition of AMPK? activity is positively associated with Gleason score, metastasis, and castration-resistance in prostate cancer: A retrospective clinical study.
Prostatic Neoplasms
Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer.
Proteinuria
Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro.
Pulmonary Disease, Chronic Obstructive
Bufei Jianpi Formula Improves Mitochondrial Function and Suppresses Mitophagy in Skeletal Muscle via the Adenosine Monophosphate-Activated Protein Kinase Pathway in Chronic Obstructive Pulmonary Disease.
Pulmonary Fibrosis
Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5'-Monophosphate-Activated Protein Kinase.
Pulmonary Fibrosis
Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase ?1.
Rectal Neoplasms
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Reperfusion Injury
Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia-reperfusion injury in the rat.
Rift Valley Fever
AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis.
Shock, Septic
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
Starvation
Activation of the Saccharomyces cerevisiae heat shock transcription factor under glucose starvation conditions by Snf1 protein kinase.
Starvation
AMP-activated protein kinase in the grass carp Ctenopharyngodon idellus: Molecular characterization, tissue distribution and mRNA expression in response to overwinter starvation stress.
Starvation
BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade.
Starvation
Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells.
Starvation
Expression of 5'-AMP-activated Protein Kinase with Starvation in Murine Thymocytes.
Starvation
Glucose regulates protein interactions within the yeast SNF1 protein kinase complex.
Starvation
Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation.
Starvation
Metabolic Activation of the HOG MAP Kinase Pathway by Snf1/AMPK Regulates Lipid Signaling at the Golgi.
Starvation
Methionine sulfoximine treatment and carbon starvation elicit Snf1-independent phosphorylation of the transcription activator Gln3 in Saccharomyces cerevisiae.
Starvation
Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation.
Starvation
Real-Time In-Organism NMR Metabolomics Reveals Different Roles of AMP-Activated Protein Kinase Catalytic Subunits.
Starvation
Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.
Starvation
Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation.
Status Epilepticus
Adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor gamma coactivator 1? signaling provides neuroprotection in status epilepticus in rats.
Stomach Neoplasms
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
Stomach Neoplasms
Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans.
Stomach Neoplasms
Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis.
Stomach Neoplasms
Do polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review.
Stomach Neoplasms
Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
Stomach Neoplasms
Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer.
Stomach Neoplasms
Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population.
Stomach Neoplasms
Involvement of NF-?B signaling pathway in the regulation of PRKAA1-mediated tumorigenesis in gastric cancer.
Stomach Neoplasms
LINC00152/miR-139-5p regulates gastric cancer cell aerobic glycolysis by targeting PRKAA1.
Stomach Neoplasms
PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways.
Stomach Neoplasms
Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans.
Stomach Neoplasms
TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer.
Stroke
Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke.
Stroke
Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke.
Thiamine Deficiency
Thiamine Deprivation Produces a Liver ATP Deficit and Metabolic and Genomic Effects in Mice: Findings Are Parallel to Those of Biotin Deficiency and Have Implications for Energy Disorders.
Thymoma
Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway.
Thyroid Cancer, Papillary
5'-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition.
Thyroid Neoplasms
5'-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition.
Thyroid Neoplasms
Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer.
Thyroid Neoplasms
The dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with NVP-AUY922 has a cytotoxic activity in thyroid carcinoma cells.
Trigeminal Neuralgia
Effects of Tiletamine-xylazine-tramadol Combination and its Specific Antagonist on AMPK in the Brain of Rats.
Triple Negative Breast Neoplasms
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy.
Triple Negative Breast Neoplasms
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator.
Tuberous Sclerosis
"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells".
Tuberous Sclerosis
AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.
Tuberous Sclerosis
Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease.
Tuberous Sclerosis
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Tuberous Sclerosis
Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells.
Tuberous Sclerosis
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Tuberous Sclerosis
The effects of Testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: differential effects on high androgen-responder and low-androgen responder muscle groups.
Tuberous Sclerosis
The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.
Urinary Bladder Neoplasms
Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells.
Urinary Bladder Neoplasms
Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity.
Uterine Cervical Neoplasms
Fluorescence in situ hybridization markers for prediction of cervical lymph node metastases.
Uterine Cervical Neoplasms
Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase.
Uterine Cervical Neoplasms
Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer.
Vascular Calcification
Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway.
Virus Diseases
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection.
Virus Diseases
AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis.
Virus Diseases
Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Wolff-Parkinson-White Syndrome
Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural history.
Wolff-Parkinson-White Syndrome
Mathematical simulations of the effects of altered AMP-kinase activity on I and the action potential in rat ventricle.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
glucosyl-beta-cyclodextrin binding kinetics, association and dissociation, and thermodynamics
-
additional information
additional information
glucosyl-beta-cyclodextrin binding kinetics, association and dissociation, and thermodynamics
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
the AMPK beta-subunit CBM has a beta-sandwich fold with the conserved residues Trp100, Lys126 and Trp133 (residue numbers according to beta1-CBM), classifying it under the CBM48 family
additional information
additional information
the beta-subunit exists in two isoforms (beta1 and beta2) and contains a carbohydrate-binding module (CBM) that interacts with glycogen. The two CBM isoforms (beta1- and beta2-CBM) are near identical in sequence and structure, yet show differences in carbohydrate-binding affinity. beta2-4CBM binds linear carbohydrates with -fold greater affinity than beta1-CBM and binds single alpha1,6-branched carbohydrates up to 30fold tighter
additional information
the beta-subunit exists in two isoforms (beta1 and beta2) and contains a carbohydrate-binding module (CBM) that interacts with glycogen. The two CBM isoforms (beta1- and beta2-CBM) are near identical in sequence and structure, yet show differences in carbohydrate-binding affinity. beta2-4CBM binds linear carbohydrates with -fold greater affinity than beta1-CBM and binds single alpha1,6-branched carbohydrates up to 30fold tighter
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
heterotrimer
AMPK is heterotrimer with alphabetagamma structure
additional information
additional information
the beta-subunit exists in two isoforms (beta1 and beta2) and contains a carbohydrate-binding module (CBM). The two CBM isoforms (beta1- and beta2-CBM) are near identical in sequence and structure, determination of the NMR solution structure, structure analysis
additional information
the beta-subunit exists in two isoforms (beta1 and beta2) and contains a carbohydrate-binding module (CBM). The two CBM isoforms (beta1- and beta2-CBM) are near identical in sequence and structure, determination of the NMR solution structure, structure analysis
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified subunit beta2 carbohydrate-binding module, sitting-drop vapour-diffusion method, mixing of 0.001 ml of 13 mg/ml protein in 20 mM HEPES, pH 7.0, with or without 6 mM glucosyl-beta-cyclodextrin, with 0.001 ml of reservoir solution, which contains for the unliganded enzyme 0.17 M ammonium sulfate, 15% v/v glycerol and 25.5% w/v PEG 4000, or contains 0.2 M lithium chloride, 20% w/v PEG 6000 and 0.1 M sodium HEPES, pH 7.0 for the complex with gBCD, X-ray diffraction structure determination and analysis at 1.6-2.0 A reolution, molecular replacement
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GST-tagged subunit beta1 from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography, gel filtration, anion exchange chromatography, and ultrafiltration
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene Prkab2, recombinant expression of GST-tagged subunit beta2 in Escherichia coli strain BL21(DE3)
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mobbs, J.I.; Koay, A.; Di Paolo, A.; Bieri, M.; Petrie, E.J.; Gorman, M.A.; Doughty, L.; Parker, M.W.; Stapleton, D.I.; Griffin, M.D.; Gooley, P.R.
Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
Biochem. J.
468
245-257
2015
Rattus norvegicus (P80386), Rattus norvegicus (Q9QZH4)
brenda
EXTERNAL LINKS (specific for EC-Number 2.7.11.31)
Transporter Classification Database (TCDB): 8.A.104.1.1
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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