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Information on EC 2.7.11.24 - mitogen-activated protein kinase and Organism(s) Salmo salar and UniProt Accession A9UJZ9

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EC Tree
IUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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This record set is specific for:
Salmo salar
UNIPROT: A9UJZ9
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Word Map
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The taxonomic range for the selected organisms is: Salmo salar
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide
ATP
+
a [protein]-(L-serine/L-threonine)
=
ADP
+
a [protein]-(L-serine/L-threonine) phosphate
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mapk, p38, erk1/2, p38 mapk, mitogen-activated protein kinase, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38mapk, p38 map kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
p38 mitogen-activated protein kinase
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cp38a
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-
-
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cp38b
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-
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CSAID binding protein
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-
-
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CSBP
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-
-
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Cytokine suppressive anti-inflammatory drug binding protein
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-
-
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ERK5
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-
-
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MAP kinase MXI2
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-
-
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MAP kinase p38 beta
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-
-
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MAP kinase p38 delta
-
-
-
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MAP kinase p38 gamma
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-
-
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MAP kinase p38a
-
-
-
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MAP kinase p38alpha
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-
-
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MAP kinase p38b
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-
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MAPK
-
-
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mitogen-activated protein kinase
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Mitogen-activated protein kinase p38 beta
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Mitogen-activated protein kinase p38 delta
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-
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Mitogen-activated protein kinase p38 gamma
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-
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Mitogen-activated protein kinase p38a
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Mitogen-activated protein kinase p38alpha
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-
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Mitogen-activated protein kinase p38b
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-
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p38 mitogen-activated protein kinase
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p38b
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-
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SAPK2A
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-
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stress-activated protein kinase 2a
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142243-02-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + MK2
ADP + phosphorylated MK2
show the reaction diagram
-
-
-
?
ATP + MK2
ADP + phosphorylated MK2
show the reaction diagram
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-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SB203580
blocks stress-induced phosphorlyation of MK2 in CHSE-214 cells
SB203580
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
sodium arsenite
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sodium arsenite
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additional information
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
higher expression than in the other organs
Manually annotated by BRENDA team
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A9UJZ9_SALSA
361
0
41707
TrEMBL
other Location (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
CHSE-214 cells transiently transfected with plasmid encoding p38a N-terminally Myc-tagged
CHSE-214 cells transiently transfected with plasmid encoding p38b1 N-terminally Myc-tagged
CHSE-214 cells transiently transfected with plasmid encoding p38b2 N-terminally Myc-tagged
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hansen, T.E.; Jorgensen, J.B.
Cloning and characterisation of p38 MAP kinase from Atlantic salmon A kinase important for regulating salmon TNF-2 and IL-1beta expression
Mol. Immunol.
44
3137-3146
2007
Salmo salar (A1ED58), Salmo salar (A1ED59), Salmo salar (A9UJZ9), Salmo salar, Salmo salar Aquagen standard (A1ED58), Salmo salar Aquagen standard (A1ED59), Salmo salar Aquagen standard (A9UJZ9)
Manually annotated by BRENDA team