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Information on EC 2.7.1.72 - streptomycin 6-kinase
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2.7.1.72 streptomycin 6-kinaseIUBMB Comments
dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors.
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Word Map
- 2.7.1.72
- kanamycin
-
phosphotransferases
- geneticin
- fradiae
-
aph3\'-ia
-
aminoglycoside-modifying
- butirosin
- ribostamycin
- glaucescens
The enzyme appears in viruses and cellular organisms
Synonyms
aminoglycoside phosphotransferase, APH(6)-Id, kinase, streptidine (phosphorylating), kinase, streptomycin 6- (phosphorylating), SM 6-kinase, streptidine kinase, streptidine kinase (phosphorylating), streptomycin 6-kinase (phosphorylating), streptomycin 6-O-phosphotransferase, streptomycin 6-phosphotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
kinase, streptidine (phosphorylating)
-
-
-
-
kinase, streptomycin 6- (phosphorylating)
-
-
-
-
SM 6-kinase
-
-
-
-
streptidine kinase
-
-
-
-
streptidine kinase (phosphorylating)
-
-
-
-
streptomycin 6-kinase (phosphorylating)
-
-
-
-
streptomycin 6-O-phosphotransferase
-
-
-
-
streptomycin 6-phosphotransferase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + streptomycin = ADP + streptomycin 6-phosphate
dATP can replace ATP, dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
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SYSTEMATIC NAME
IUBMB Comments
ATP:streptomycin 6-phosphotransferase
dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors.
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CAS REGISTRY NUMBER
COMMENTARY
37278-11-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-deoxydihydrostreptomycin + ATP
ADP + 3'-deoxydihydrostreptomycin 6-phosphate
-
-
-
-
?
dihydrostreptomycin 3''-alpha-phosphate + ATP
ADP + dihydrostreptomycin 3''-alpha-phosphate 6-phosphate
-
-
-
-
?
dihydrostreptomycin 3''-phosphate + ATP
ADP + dihydrostreptomycin 3'',6-bisphosphate
-
-
-
-
?
ATP + dihydrostreptomycin
ADP + dihydrostreptomycin 6-phosphate
-
-
-
?
ATP + dihydrostreptomycin
ADP + dihydrostreptomycin 6-phosphate
-
-
-
?
ATP + dihydrostreptomycin
ADP + dihydrostreptomycin 6-phosphate
-
-
-
?
ATP + dihydrostreptomycin
ADP + dihydrostreptomycin 6-phosphate
-
-
-
?
ATP + dihydrostreptomycin
ADP + dihydrostreptomycin 6-phosphate
-
-
-
?
ATP + dihydrostreptomycin
ADP + dihydrostreptomycin 6-phosphate
-
-
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
streptomycin is secreted
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
streptomycin is secreted
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
detoxification of a potent inhibitor of protein biosynthesis
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
self-protection of streptomycin producer, because the product streptomycin 6-phosphate does not inhibit protein synthesis
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
-
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
self-protection of streptomycin producer, because the product streptomycin 6-phosphate does not inhibit protein synthesis
-
?
streptidine + ATP
streptidine 6-phosphate + ADP
-
-
O-phosphorylstreptidine + ADP
?
additional information
?
-
-
no activity with streptomycin derivatives that contain 3'-alpha-aldehyde groups
-
-
?
additional information
?
-
-
no activity with N-amidinostreptamine, N'-amidinostreptamine, N-amidinoinosamine, dTTP
-
-
?
additional information
?
-
-
no activity with GTP, CTP, UTP
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
streptomycin is secreted
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
streptomycin is secreted
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
detoxification of a potent inhibitor of protein biosynthesis
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
self-protection of streptomycin producer, because the product streptomycin 6-phosphate does not inhibit protein synthesis
-
?
ATP + streptomycin
ADP + streptomycin 6-phosphate
-
self-protection of streptomycin producer, because the product streptomycin 6-phosphate does not inhibit protein synthesis
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no inhibition by sulfhydryl reagents, formamidine disulfide, p-chloromercuribenzoate
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Actinomycosis
[Sequencing and analysis of the resistome of Streptomyces fradiae ATCC19609 in order to develop a test system for screening of new antimicrobial agents].
Astrocytoma
Stable constitutive expression of glycoprotein B (gpUL55) of human cytomegalovirus in permissive astrocytoma cells.
Foot-and-Mouth Disease
Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions.
Leukemia, Erythroblastic, Acute
The effect of doxorubicin, daunorubicin and 4'-epidoxorubicin on the exogenous c-myc promoter in mouse erythroleukemia cells.
Sarcoma
Electric field-mediated gene transfer (electroporation) into mouse Friend and human K562 erythroleukemic cells.
Teratocarcinoma
Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity.
Teratocarcinoma
Isolation of a clone of F9 teratocarcinoma cells "naturally" resistant to G418.
Tuberculosis
Cloning, expression, purification, crystallization and X-ray crystallographic analysis of Rv3168 from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Rv3168 phosphotransferase activity mediates kanamycin resistance in Mycobacterium tuberculosis.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). F2RG02_STRVP
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
298
0
32102
TrEMBL
-
A0A1L7F8X8_9PSEU
316
0
33995
TrEMBL
-
A0A6J4UV78_9CHLR
304
0
32839
TrEMBL
-
D2PUZ7_KRIFD
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
304
0
34298
TrEMBL
-
D1BUQ9_XYLCX
Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07)
312
0
33806
TrEMBL
-
D9TCR4_MICAI
Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538 / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442)
290
0
31403
TrEMBL
-
A0A2H1KGG4_9MICO
339
0
37177
TrEMBL
-
A0A1D8BXX4_9PSEU
315
0
33980
TrEMBL
-
D3Q2G9_STANL
Stackebrandtia nassauensis (strain DSM 44728 / CIP 108903 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
309
0
33653
TrEMBL
-
G2NIF0_STREK
Streptomyces sp. (strain SirexAA-E / ActE)
309
0
33164
TrEMBL
-
A0A2P9I4J2_9ACTN
318
0
33940
TrEMBL
-
A0A2H1HVL5_BRELN
339
0
37129
TrEMBL
-
A0A1B2GLC3_STRNR
308
0
33332
TrEMBL
-
C5C3S9_BEUC1
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
295
0
32378
TrEMBL
-
A0A0K3BFQ9_9PSEU
302
0
33695
TrEMBL
-
D7AUR1_NOCDD
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)
307
0
34053
TrEMBL
-
A0A2H1JEM6_9MICO
339
0
36714
TrEMBL
-
I7G2Y8_MYCS2
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
309
0
34349
TrEMBL
-
A0A1L7F9X8_9PSEU
298
0
31551
TrEMBL
-
A0QXZ6_MYCS2
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
309
0
34349
TrEMBL
-
A0A1B2GPW6_STRNR
302
0
32165
TrEMBL
-
A0A5Q5CGX1_MYCSJ
Mycobacterium sp. (strain JLS)
298
0
33439
TrEMBL
-
A1R510_PAEAT
Paenarthrobacter aurescens (strain TC1)
336
0
37080
TrEMBL
-
E6SE91_INTC7
Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP)
312
0
34106
TrEMBL
-
A0A2H1K763_9MICO
339
0
37172
TrEMBL
-
A0A1D8BZB3_9PSEU
291
0
31486
TrEMBL
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walker, J.B.; Walker, M.S.
Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate
Biochim. Biophys. Acta
148
335-341
1967
Streptomyces bikiniensis
brenda
Walker, J.B.; Skorvaga, M.
Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives
J. Biol. Chem.
248
2435-2440
1973
Streptomyces bikiniensis
brenda
Walker, J.B.
ATP:streptomycin 6-phosphotransferase
Methods Enzymol.
43
628-632
1975
Streptomyces bikiniensis, Streptomyces glebosus
brenda
Sugiyama, M.; Sakamoto, M.; Mochizuki, H.; Nimi, O.; Nomi, R.
Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin-producing micro-organism
J. Gen. Microbiol.
129
1683-1687
1983
Streptomyces griseus, Streptomyces griseus HUT 6037
brenda
Ashenafi, M.; Ammosova, T.; Nekhai, S.; Byrnes, W.M.
Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme
Mol. Cell. Biochem.
387
207-216
2014
Escherichia coli
brenda
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