We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 2.7.1.214 - C7-cyclitol 7-kinase for references in articles please use BRENDA:EC2.7.1.214
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
The enzyme appears in viruses and cellular organisms
Synonyms
1-epi-valienol-7-phosphate 1-kinase, AcbU, valC, vldC,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-epi-valienol-7-phosphate 1-kinase
Q27GS3
-
valC
-
-
gene name
-
vldC
-
-
gene name
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + validone = ADP + validone 7-phosphate
(2)
-
-
-
ATP + valienone = ADP + valienone 7-phosphate
(1)
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP:C7-cyclitol 7-phosphotransferase
The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-epi-valienol
ADP + 1-epi-valienol 7-phosphate
Q27GS3
-
-
-
?
ATP + validone
ADP + validone 7-phosphate
ATP + valienol
ADP + valienol 7-phosphate
Q27GS3
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
additional information
?
-
ATP + validone
ADP + validone 7-phosphate
-
-
-
-
?
ATP + validone
ADP + validone 7-phosphate
-
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
-
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
-
-
-
-
?
additional information
?
-
Q27GS3
no substrates: 1-epi-2-epi-5-epi-valiolol, 2-epi-5-epi-valiolol, 2-epi-5-epi-valiolone, 5-epi-valiolol, 1-epi-2-epi-5-epi-valiolol
-
-
-
additional information
?
-
-
ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
-
-
-
additional information
?
-
-
ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
-
-
-
additional information
?
-
enzyme shows glucokinase activity
-
-
-
additional information
?
-
enzyme shows glucokinase activity
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-epi-valienol
ADP + 1-epi-valienol 7-phosphate
Q27GS3
-
-
-
?
ATP + validone
ADP + validone 7-phosphate
ATP + valienol
ADP + valienol 7-phosphate
Q27GS3
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
additional information
?
-
ATP + validone
ADP + validone 7-phosphate
-
-
-
-
?
ATP + validone
ADP + validone 7-phosphate
-
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
-
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
-
-
-
-
?
additional information
?
-
-
ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
-
-
-
additional information
?
-
-
ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.026
validone
-
pH 7.6, 28°C
0.019
valienone
-
pH 7.6, 28°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7.3
validone
-
pH 7.6, 28°C
3.5
valienone
-
pH 7.6, 28°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
286
validone
-
pH 7.6, 28°C
180
valienone
-
pH 7.6, 28°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
Q27GS3
UniProt
brenda
-
UniProt
brenda
-
UniProt
brenda
-
UniProt
brenda
-
UniProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Q27GS3
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
within the validamycin biosynthetic gene cluster, VldBC forms an operon of VldABC with VldA, the gene encoding 2-epi-5-epi-valiolone synthase
physiological function
-
the ValABC gene cluster is responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis
physiological function
-
inactivation of valC results in mutants that lack the ability to produce validamycin A
physiological function
-
inactivation of valC results in mutants that lack the ability to produce validamycin A; the ValABC gene cluster is responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis
-
physiological function
-
within the validamycin biosynthetic gene cluster, VldBC forms an operon of VldABC with VldA, the gene encoding 2-epi-5-epi-valiolone synthase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
VALC_STRHJ
Streptomyces hygroscopicus subsp. jinggangensis (strain 5008)
351
0
35966
Swiss-Prot
VLDC_STRHL
351
0
35935
Swiss-Prot
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
?
-
x * 40000, SDS-PAGE of recombinant His-tagged protein, x * 36750, calculated
?
-
x * 40000, SDS-PAGE of recombinant His-tagged protein, x * 36750, calculated
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Seo, M.; Im, E.; Singh, D.; Rajkarnikar, A.; Kwon, H.; Hyun, C.; Suh, J.; Pyun, Y.; Kim, S.
Characterization of D-glucose alpha -1-phosphate uridylyltransferase (VldB) and glucokinase (VldC) involved in validamycin biosynthesis of Streptomyces hygroscopicus var. limoneus KCCM 11405
J. Microbiol. Biotechnol.
16
1311-1315
2006
Streptomyces hygroscopicus subsp. limoneus (Q15JG5), Streptomyces hygroscopicus subsp. limoneus KCCM 11405 (Q15JG5)
-
brenda
Yu, Y.; Bai, L.; Minagawa, K.; Jian, X.; Li, L.; Li, J.; Chen, S.; Cao, E.; Mahmud, T.; Floss, H.G.; Zhou, X.; Deng, Z.
Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008
Appl. Environ. Microbiol.
71
5066-5076
2005
Streptomyces hygroscopicus subsp. jinggangensis (Q3T6E2), Streptomyces hygroscopicus subsp. jinggangensis 5008 (Q3T6E2)
brenda
Minagawa, K.; Zhang, Y.; Ito, T.; Bai, L.; Deng, Z.; Mahmud, T.
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A
ChemBioChem
8
632-641
2007
Streptomyces hygroscopicus subsp. jinggangensis (Q3T6E2), Streptomyces hygroscopicus subsp. jinggangensis 5008 (Q3T6E2)
brenda
Zhang, C.S.; Podeschwa, M.; Block, O.; Altenbach, H.J.; Piepersberg, W.; Wehmeier, U.F.
Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanes sp. SE50/110
FEBS Lett.
540
53-57
2003
Actinoplanes sp. SE50/110 (Q27GS3)
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
2.7.1.214 C7-cyclitol 7-kinase
more
top
Information
