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IUBMB Comments The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
The enzyme appears in viruses and cellular organisms
Synonyms
1-epi-valienol-7-phosphate 1-kinase, AcbU,
valC ,
vldC ,
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1-epi-valienol-7-phosphate 1-kinase
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valC
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vldC
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ATP + validone = ADP + validone 7-phosphate
(2)
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ATP + valienone = ADP + valienone 7-phosphate
(1)
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ATP:C7-cyclitol 7-phosphotransferase
The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.
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ATP + 1-epi-valienol
ADP + 1-epi-valienol 7-phosphate
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-
-
?
ATP + validone
ADP + validone 7-phosphate
ATP + valienol
ADP + valienol 7-phosphate
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-
-
?
ATP + valienone
ADP + valienone 7-phosphate
additional information
?
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ATP + validone
ADP + validone 7-phosphate
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-
-
?
ATP + validone
ADP + validone 7-phosphate
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-
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?
ATP + valienone
ADP + valienone 7-phosphate
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-
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?
ATP + valienone
ADP + valienone 7-phosphate
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-
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?
additional information
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no substrates: 1-epi-2-epi-5-epi-valiolol, 2-epi-5-epi-valiolol, 2-epi-5-epi-valiolone, 5-epi-valiolol, 1-epi-2-epi-5-epi-valiolol
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?
additional information
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ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
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?
additional information
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ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
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?
additional information
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enzyme shows glucokinase activity
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?
additional information
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enzyme shows glucokinase activity
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?
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ATP + 1-epi-valienol
ADP + 1-epi-valienol 7-phosphate
-
-
-
?
ATP + validone
ADP + validone 7-phosphate
ATP + valienol
ADP + valienol 7-phosphate
-
-
-
?
ATP + valienone
ADP + valienone 7-phosphate
additional information
?
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ATP + validone
ADP + validone 7-phosphate
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-
-
?
ATP + validone
ADP + validone 7-phosphate
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-
-
?
ATP + valienone
ADP + valienone 7-phosphate
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-
-
?
ATP + valienone
ADP + valienone 7-phosphate
-
-
-
?
additional information
?
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ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
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-
?
additional information
?
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ValC is a C7-cyclitol kinase, which phosphorylates valienone and validone, but not 2-epi-5-epi-valiolone, 5-epi-valiolone, and D-glucose, D-fructose, D-mannose, and D-mannitose, to their 7-phosphate derivatives
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?
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0.026
validone
pH 7.6, 28°C
0.019
valienone
pH 7.6, 28°C
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7.3
validone
pH 7.6, 28°C
3.5
valienone
pH 7.6, 28°C
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286
validone
pH 7.6, 28°C
180
valienone
pH 7.6, 28°C
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UniProt
brenda
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UniProt
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UniProt
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UniProt
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UniProt
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brenda
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physiological function
inactivation of valC results in mutants that lack the ability to produce validamycin A
physiological function
the ValABC gene cluster is responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis
physiological function
within the validamycin biosynthetic gene cluster, VldBC forms an operon of VldABC with VldA, the gene encoding 2-epi-5-epi-valiolone synthase
physiological function
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within the validamycin biosynthetic gene cluster, VldBC forms an operon of VldABC with VldA, the gene encoding 2-epi-5-epi-valiolone synthase
physiological function
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the ValABC gene cluster is responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis
physiological function
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inactivation of valC results in mutants that lack the ability to produce validamycin A
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VALC_STRHJ
Streptomyces hygroscopicus subsp. jinggangensis (strain 5008)
351
0
35966
Swiss-Prot
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VLDC_STRHL
351
0
35935
Swiss-Prot
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Q27GS3_ACTS5
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
492
0
54195
TrEMBL
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?
x * 40000, SDS-PAGE of recombinant His-tagged protein, x * 36750, calculated
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x * 40000, SDS-PAGE of recombinant His-tagged protein, x * 36750, calculated
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expression in Escherichia coli
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Seo, M.; Im, E.; Singh, D.; Rajkarnikar, A.; Kwon, H.; Hyun, C.; Suh, J.; Pyun, Y.; Kim, S.
Characterization of D-glucose alpha -1-phosphate uridylyltransferase (VldB) and glucokinase (VldC) involved in validamycin biosynthesis of Streptomyces hygroscopicus var. limoneus KCCM 11405
J. Microbiol. Biotechnol.
16
1311-1315
2006
Streptomyces hygroscopicus subsp. limoneus (Q15JG5), Streptomyces hygroscopicus subsp. limoneus KCCM 11405 (Q15JG5)
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brenda
Yu, Y.; Bai, L.; Minagawa, K.; Jian, X.; Li, L.; Li, J.; Chen, S.; Cao, E.; Mahmud, T.; Floss, H.G.; Zhou, X.; Deng, Z.
Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008
Appl. Environ. Microbiol.
71
5066-5076
2005
Streptomyces hygroscopicus subsp. jinggangensis (Q3T6E2), Streptomyces hygroscopicus subsp. jinggangensis 5008 (Q3T6E2)
brenda
Minagawa, K.; Zhang, Y.; Ito, T.; Bai, L.; Deng, Z.; Mahmud, T.
ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A
ChemBioChem
8
632-641
2007
Streptomyces hygroscopicus subsp. jinggangensis (Q3T6E2), Streptomyces hygroscopicus subsp. jinggangensis 5008 (Q3T6E2)
brenda
Zhang, C.S.; Podeschwa, M.; Block, O.; Altenbach, H.J.; Piepersberg, W.; Wehmeier, U.F.
Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanes sp. SE50/110
FEBS Lett.
540
53-57
2003
Actinoplanes sp. SE50/110 (Q27GS3)
brenda
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Enzyme Nomenclature
2.7.1.214 C7-cyclitol 7-kinase
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