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IUBMB CommentsThe enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in an archaeal pathway for nucleoside degradation.
The enzyme appears in viruses and cellular organisms
Synonyms
adp-dependent ribose-1-phosphate kinase,
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ADP-dependent ribose-1-phosphate kinase
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TK2029
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ADP + alpha-D-ribose 1-phosphate = AMP + alpha-D-ribose 1,5-bisphosphate
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ADP:alpha-D-ribose-1-phosphate 5-phosphotransferase
The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in an archaeal pathway for nucleoside degradation.
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2-deoxy-alpha-D-ribose 1-phosphate + ADP
2-deoxy-alpha-D-ribose 1,5-bisphosphate + AMP
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-
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ir
ADP + 2-deoxy-alpha-D-ribose-1-phosphate
AMP + 2-deoxy-alpha-D-ribose 1,5-bisphosphate
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-
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?
ADP + alpha-D-ribose-1-phosphate
AMP + alpha-D-ribose 1,5-bisphosphate
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-
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?
alpha-D-ribose 1-phosphate + ADP
alpha-D-ribose 1,5-bisphosphate + AMP
alpha-D-ribose 1-phosphate + GDP
alpha-D-ribose 1,5-bisphosphate + GMP
irreversible under physiological conditions
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ir
GDP + alpha-D-ribose-1-phosphate
GMP + alpha-D-ribose 1,5-bisphosphate
56% of the activity with ADP
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?
UDP + alpha-D-ribose-1-phosphate
UMP + alpha-D-ribose 1,5-bisphosphate
9% of the activity with ADP
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?
additional information
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alpha-D-ribose 1-phosphate + ADP
alpha-D-ribose 1,5-bisphosphate + AMP
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ir
alpha-D-ribose 1-phosphate + ADP
alpha-D-ribose 1,5-bisphosphate + AMP
irreversible under physiological conditions
irreversible under physiological conditions
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ir
additional information
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no substrates: CDP, diphosphate
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additional information
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no substrates: CDP, diphosphate
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ADP + alpha-D-ribose-1-phosphate
AMP + alpha-D-ribose 1,5-bisphosphate
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alpha-D-ribose 1-phosphate + ADP
alpha-D-ribose 1,5-bisphosphate + AMP
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ir
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Ca2+
divalent cation required, Mg2+ and Ca2+ are the most preferred. 107% of the activtiy with Mg2+
Co2+
59% of the activtiy with Mg2+
Mg2+
divalent cation required, Mg2+ and Ca2+ are the most preferred
additional information
activities with Mn2+, Ni2+, Zn2+ and Cu2+ are all less than 20% of that with Mg2+
additional information
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activities with Mn2+, Ni2+, Zn2+ and Cu2+ are all less than 20% of that with Mg2+
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12
2-deoxy-alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
12
2-deoxy-alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
0.53
alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
0.53
alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
4.19 - 8.37
ADP
depending on the presence of Ca2+, pH and temperature not specified in the publication
4.2
ADP
presence of Ca2+, pH not specified in the publication, temperature not specified in the publication
7.3
ADP
presence of Mg2+, pH and temperature not specified in the publication
7.3
ADP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
19
GDP
presence of Mg2+, pH and temperature not specified in the publication
19
GDP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
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73
2-deoxy-alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
73
2-deoxy-alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
485
alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
485
alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
612
ADP
presence of Mg2+, pH and temperature not specified in the publication
612
ADP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
856 - 1160
ADP
depending on the presence of Ca2+, pH and temperature not specified in the publication
856
ADP
presence of Ca2+, pH not specified in the publication, temperature not specified in the publication
189
GDP
presence of Mg2+, pH and temperature not specified in the publication
189
GDP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
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6.3
2-deoxy-alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
915
alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
10.2
GDP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
83.6
ADP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
204
ADP
presence of Ca2+, pH not specified in the publication, temperature not specified in the publication
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Uniprot
brenda
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R1PK_THEKO
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
294
0
31915
Swiss-Prot
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A0A7G9YYC6_9EURY
94
0
9864
TrEMBL
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A0A7G9YHB1_9EURY
297
0
31095
TrEMBL
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A0A7G9YI99_9EURY
326
0
34597
TrEMBL
-
A0A7G9YKQ6_9EURY
297
0
31173
TrEMBL
-
A0A7H1KNK2_9EURY
309
0
32306
TrEMBL
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A0A7G9YMG7_9EURY
297
0
31191
TrEMBL
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A0A482D4P2_9ARCH
330
0
37227
TrEMBL
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A0A7G9YYD3_9EURY
340
0
37646
TrEMBL
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A0A7G9YD64_9EURY
333
0
34872
TrEMBL
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A0A7G9Z4X7_9EURY
311
0
33874
TrEMBL
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Aono, R.; Sato, T.; Imanaka, T.; Atomi, H.
A pentose bisphosphate pathway for nucleoside degradation in Archaea
Nat. Chem. Biol.
11
355-360
2015
Thermococcus kodakarensis (Q5JDG9), Thermococcus kodakarensis
brenda
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2.7.1.212 alpha-D-ribose-1-phosphate 5-kinase (ADP)
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