Information on EC 2.7.1.212 - alpha-D-ribose-1-phosphate 5-kinase (ADP)

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The expected taxonomic range for this enzyme is: Thermococcus kodakarensis

EC NUMBER
COMMENTARY hide
2.7.1.212
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RECOMMENDED NAME
GeneOntology No.
alpha-D-ribose-1-phosphate 5-kinase (ADP)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ADP + alpha-D-ribose 1-phosphate = AMP + alpha-D-ribose 1,5-bisphosphate
show the reaction diagram
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
nucleoside and nucleotide degradation (archaea)
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SYSTEMATIC NAME
IUBMB Comments
ADP:alpha-D-ribose-1-phosphate 5-phosphotransferase
The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in an archaeal pathway for nucleoside degradation.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-alpha-D-ribose 1-phosphate + ADP
2-deoxy-alpha-D-ribose 1,5-bisphosphate + AMP
show the reaction diagram
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-
-
ir
ADP + 2-deoxy-alpha-D-ribose-1-phosphate
AMP + 2-deoxy-alpha-D-ribose 1,5-bisphosphate
show the reaction diagram
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-
-
?
ADP + alpha-D-ribose-1-phosphate
AMP + alpha-D-ribose 1,5-bisphosphate
show the reaction diagram
-
-
-
?
alpha-D-ribose 1-phosphate + ADP
alpha-D-ribose 1,5-bisphosphate + AMP
show the reaction diagram
alpha-D-ribose 1-phosphate + GDP
alpha-D-ribose 1,5-bisphosphate + GMP
show the reaction diagram
irreversible under physiological conditions
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ir
GDP + alpha-D-ribose-1-phosphate
GMP + alpha-D-ribose 1,5-bisphosphate
show the reaction diagram
56% of the activity with ADP
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-
?
UDP + alpha-D-ribose-1-phosphate
UMP + alpha-D-ribose 1,5-bisphosphate
show the reaction diagram
9% of the activity with ADP
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-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ADP + alpha-D-ribose-1-phosphate
AMP + alpha-D-ribose 1,5-bisphosphate
show the reaction diagram
Q5JDG9
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-
-
?
alpha-D-ribose 1-phosphate + ADP
alpha-D-ribose 1,5-bisphosphate + AMP
show the reaction diagram
Q5JDG9
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-
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ir
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
divalent cation required, Mg2+ and Ca2+ are the most preferred. 107% of the activtiy with Mg2+
Co2+
59% of the activtiy with Mg2+
Mg2+
divalent cation required, Mg2+ and Ca2+ are the most preferred
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12
2-deoxy-alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
12
2-deoxy-alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
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4.19 - 8.37
ADP
0.53
alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
0.53
alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
19
GDP
presence of Mg2+, pH and temperature not specified in the publication; presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
73
2-deoxy-alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
73
2-deoxy-alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
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612 - 1160
ADP
485
alpha-D-ribose 1-phosphate
presence of Mg2+, pH and temperature not specified in the publication
485
alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
189
GDP
presence of Mg2+, pH and temperature not specified in the publication; presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.3
2-deoxy-alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
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83.6 - 204
ADP
915
alpha-D-ribose-1-phosphate
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
10.2
GDP
presence of Mg2+, pH not specified in the publication, temperature not specified in the publication
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE