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Literature summary for 2.7.1.212 extracted from
- A pentose bisphosphate pathway for nucleoside degradation in Archaea (2015), Nat. Chem. Biol., 11, 355-360.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.53 | - |
alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis |  |
| 0.53 | - |
alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 4.19 | 8.37 | ADP | depending on the presence of Ca2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 4.2 | - |
ADP | presence of Ca2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 7.3 | - |
ADP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 7.3 | - |
ADP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 12 | - |
2-deoxy-alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 12 | - |
2-deoxy-alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 19 | - |
GDP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 19 | - |
GDP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | divalent cation required, Mg2+ and Ca2+ are the most preferred. 107% of the activtiy with Mg2+ | Thermococcus kodakarensis | |
| Co2+ | 59% of the activtiy with Mg2+ | Thermococcus kodakarensis | |
| Mg2+ | divalent cation required, Mg2+ and Ca2+ are the most preferred | Thermococcus kodakarensis | |
| additional information | activities with Mn2+, Ni2+, Zn2+ and Cu2+ are all less than 20% of that with Mg2+ | Thermococcus kodakarensis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + alpha-D-ribose-1-phosphate | Thermococcus kodakarensis | - |
AMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
| alpha-D-ribose 1-phosphate + ADP | Thermococcus kodakarensis | - |
alpha-D-ribose 1,5-bisphosphate + AMP | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermococcus kodakarensis | Q5JDG9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-deoxy-alpha-D-ribose 1-phosphate + ADP | - |
Thermococcus kodakarensis | 2-deoxy-alpha-D-ribose 1,5-bisphosphate + AMP | - |
ir | |
| ADP + 2-deoxy-alpha-D-ribose-1-phosphate | - |
Thermococcus kodakarensis | AMP + 2-deoxy-alpha-D-ribose 1,5-bisphosphate | - |
? | |
| ADP + alpha-D-ribose-1-phosphate | - |
Thermococcus kodakarensis | AMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
| alpha-D-ribose 1-phosphate + ADP | - |
Thermococcus kodakarensis | alpha-D-ribose 1,5-bisphosphate + AMP | - |
ir | |
| alpha-D-ribose 1-phosphate + ADP | irreversible under physiological conditions | Thermococcus kodakarensis | alpha-D-ribose 1,5-bisphosphate + AMP | irreversible under physiological conditions | ir | |
| alpha-D-ribose 1-phosphate + GDP | irreversible under physiological conditions | Thermococcus kodakarensis | alpha-D-ribose 1,5-bisphosphate + GMP | - |
ir | |
| GDP + alpha-D-ribose-1-phosphate | 56% of the activity with ADP | Thermococcus kodakarensis | GMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
| additional information | no substrates: CDP, diphosphate | Thermococcus kodakarensis | ? | - |
? | |
| UDP + alpha-D-ribose-1-phosphate | 9% of the activity with ADP | Thermococcus kodakarensis | UMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADP-dependent ribose-1-phosphate kinase | - |
Thermococcus kodakarensis |
| TK2029 | - |
Thermococcus kodakarensis |
| TK2029 | locus name | Thermococcus kodakarensis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 85 | - |
- |
Thermococcus kodakarensis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 73 | - |
2-deoxy-alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 73 | - |
2-deoxy-alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 189 | - |
GDP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 189 | - |
GDP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 485 | - |
alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 485 | - |
alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 612 | - |
ADP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 612 | - |
ADP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 856 | 1160 | ADP | depending on the presence of Ca2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 856 | - |
ADP | presence of Ca2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | - |
Thermococcus kodakarensis |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.3 | - |
2-deoxy-alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 10.2 | - |
GDP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 83.6 | - |
ADP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 204 | - |
ADP | presence of Ca2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
| 915 | - |
alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
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Release 2023.1 (January 2023)
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