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EC Tree
IUBMB Comments L-Glutamate and L-glutamine can also act as amino donors.
The expected taxonomic range for this enzyme is: Streptomyces
Synonyms
guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase, L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase,
more
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guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase
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L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase
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1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine
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amino group transfer
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1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase
L-Glutamate and L-glutamine can also act as amino donors.
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
L-glutamate + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
5-amino-2,5-dioxopentanoic acid + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-glutamine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
alpha-ketoglutaramate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
additional information
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D-amino acids are no substrates, also catalyzes transamination between 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol and 1D-1-guanidino-1-deoxy-3-keto-scyllo inositol
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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streptomycin biosynthesis
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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streptomycin biosynthesis
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-glutamine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
alpha-ketoglutaramate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-glutamine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
alpha-ketoglutaramate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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reaction should be relatively irreversible because of cyclization or enzymic deamidation of the alpha-ketoglutaramate formed
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ir
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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streptomycin biosynthesis
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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streptomycin biosynthesis
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
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pyridoxal 5'-phosphate
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no activity in Streptomyces hygroscopicus subsp. glebosus
ATCC 14607
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brenda
ATCC 11062
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brenda
ATCC 12475
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brenda
ATCC 23265
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brenda
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inactivated by heating for 5 min
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unstable to dialysis in absence of pyridoxal 5'-phosphate, pyruvate spares the pyridoxal 5'-phosphate requirement during dialysis
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Walker, J.B.; Walker, M.S.
Streptomycin biosynthesis. Transamination reactions involving inosamines and inosadiamines
Biochemistry
8
763-770
1969
Streptomyces bikiniensis
brenda
Walker, J.B.
L-Alanine61D-1-guanidino-1-deoxy-3-deto-scyllo-inositol aminotransferase
Methods Enzymol.
43
462-465
1975
no activity in Streptomyces hygroscopicus subsp. glebosus, Streptomyces bikiniensis, Streptomyces griseus, Streptomyces ornatus
brenda
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