ornithine aminotransferase feeds pyrroline-5-carboxylate exclusively into the catabolic branch of proline metabolism, which yields glutamate as an end product. Proline biosynthesis occurs predominantly or exclusively via the glutamate pathway in Arabidopsis thaliana and does not depend on glutamate produced by arginine and ornithine catabolism
ornithine aminotransferase feeds pyrroline-5-carboxylate exclusively into the catabolic branch of proline metabolism, which yields glutamate as an end product. Proline biosynthesis occurs predominantly or exclusively via the glutamate pathway in Arabidopsis thaliana and does not depend on glutamate produced by arginine and ornithine catabolism
enzyme is implicated in salt tolerance in higher plants, enzyme is implicated in proline biosynthesis and accumulation via pyrroline-5-carboxylate, OAT is essential for nitrogen recycling from arginine but not for the stress-induced proline accumulation, OAT probably links the degradation pathways for arginine and proline
deltaOAT and proline dehydrogenases (ProDH1 and ProDH2) are involved in the defence against non-host pathogens. Mutants for these genes compromise non-host resistance and show a decrease in non-host pathogen-induced reactive oxygen species
deltaOAT is involved in effector-triggered immunity (ETI) and plays a critical role in inducing early oxidative burst and other defence pathways in plants, conceivably by accumulating P5C in mitochondria
enzyme deletion mutants accumulate urea cycle intermediates when fed with arginine or ornithine and are not able to utilize nitrogen provided as arginine or ornithine. Utilisation of urea and stress induced proline accumulation are not affected in T-DNA insertion mutants with a complete loss of ornithine aminotransferase expression
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Nicotiana plumbaginifolia plants overexpressing OAT from Arabidopsis synthesize more proline than the control plants and show a higher biomass and a higher germination rate under osmotic stress conditions
genetic engineering of plants for increased production of the osmoprotectant proline, transgenic plants overexpressing OAT display enhanced tolerance to salt and drought due to increased proline content
Ornithine-delta-aminotransferase and proline dehydrogenase genes play a role in non-host disease resistance by regulating pyrroline-5-carboxylate metabolism-induced hypersensitive response