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Information on EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase and Organism(s) Catharanthus roseus and UniProt Accession Q42698

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IUBMB Comments
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.
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This record set is specific for:
Catharanthus roseus
UNIPROT: Q42698
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The taxonomic range for the selected organisms is: Catharanthus roseus
The enzyme appears in selected viruses and cellular organisms
Synonyms
farnesyl diphosphate synthase, farnesyl pyrophosphate synthase, fpp synthase, erg20, farnesyl pyrophosphate synthetase, hfpps, farnesyl-diphosphate synthase, fppase, fpps1, fpps3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
farnesyl-diphosphate synthase
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farnesyl pyrophosphate synthetase
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farnesyl-diphosphate synthase
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-
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farnesylpyrophosphate synthetase
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-
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geranyl transferase I
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geranyltranstransferase
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-
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prenyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkenyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.
CAS REGISTRY NUMBER
COMMENTARY hide
37277-79-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
both transient and stable overexpression of geranyl(geranyl) diphosphate synthase G(G)PPS and coexpression of G(G)PPS plus geraniol synthase GES significantly enhances the accumulation of secologanin, which in turn elevates the levels of monomeric monoterpene indole alkaloids. Transgenic plants exhibit increased levels of root alkaloid ajmalicine. The dimeric alkaloid vinblastine is enhanced only in G(G)PPS but not in G(G)PPS plus GES transgenic lines, correlating with transcript levels of peroxidase PRX1 involved in coupling of vindoline and catharanthine into 3',4'-anhydrovinblastine
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GGPPS_CATRO
357
0
38787
Swiss-Prot
Mitochondrion (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
39900
x * 39900, calculated from amino acid sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 39900, calculated from amino acid sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Thabet, I.; Guirimand, G.; Courdavault, V.; Papon, N.; Godet, S.; Dutilleul, C.; Bouzid, S.; Giglioli-Guivarch, N.; Clastre, M.; Simkin, A.
The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis
J. Plant Physiol.
168
2110-2116
2011
Catharanthus roseus (Q42698), Catharanthus roseus
Manually annotated by BRENDA team
Kumar, S.; Shilpashree, H.; Nagegowda, D.
Terpene moiety enhancement by overexpression of geranyl(geranyl) diphosphate synthase and geraniol synthase elevates monomeric and dimeric monoterpene indole alkaloids in transgenic Catharanthus roseus
Front. Plant Sci.
9
942
2018
Catharanthus roseus (Q42698)
Manually annotated by BRENDA team