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alpha(2,3)sialyltransferase
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alpha-2,3-sialyltransferase
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alpha2,3-sialyltransferase type I
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alpha2-->3 sialyltransferase
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-
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alpha2-3-sialyltransferase 1
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multifunctional enzyme which has alpha2-6-sialyltransferase, alpha2-3-sialidase, and alpha2-3-trans-sialidase activities in addition to its major alpha2-3-sialyltransferase activity
beta-D-Gal-(1-3)-D-GalNAc alpha-(2-3)-sialyltransferase
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-
-
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beta-D-galactoside alpha2,3-sialyltransferase
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-
beta-D-galactoside alpha2->3 sialyltransferase
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beta-galactoside a-2,3-sialyltransferase
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-
beta-galactoside alpha-2,3-sialyltransferase 1
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beta-galactoside alpha-2,3-sialyltransferase
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-
-
-
beta-galactoside alpha2,3-sialyltransferase
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-
CMP-N-acetylneuraminate:beta-D-galactoside alpha2-3 sialyltransferase
-
-
-
-
CMP-Neu5Ac:Glbeta1-3GalNAc alpha2,3-sialyltransferase
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-
-
-
CMP-NeuAc:galactoside(alpha2-3)-sialyltransferase
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-
-
-
CMP-SA:Gal63GalNAc-R alpha3-sialyltransferase (SA to Gal)
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-
CMP-SA:Galbeta3GalNAc-R alpha3-sialyltransferase
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-
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CMP-sialic acid:Galbeta1-3GalNAc-R alpha3-sialyltransferase
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-
-
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Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
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-
-
-
Galbeta1,3GalNAc alpha2,3-sialyltransferase
galbeta1,3galNAcalpha2,3-sialyltransferase
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-
-
-
NeuAc alpha-2,3-sialyltransferase
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-
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sialyltransferase, cytidine monophosphoacetylneuraminate-beta-galactoside alpha2-->3-
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-
-
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2,3SiaT

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alpha3SA-T

-
-
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Galbeta1,3GalNAc alpha2,3-sialyltransferase

-
-
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Galbeta1,3GalNAc alpha2,3-sialyltransferase
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ST3Gal I

-
-
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ST3Gal III

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-
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CMP + 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-tyrosyl-[protein]
CMP-N-acetyl-beta-neuraminate + 3-O-[beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-tyrosyl-[protein]
the enzyme synthesizes CMP-NeuAc by transferring NeuAc from the alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-unit of O-glycans
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r
CMP-N-(4-pentynoyl)neuraminic acid + asialofetuin
?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
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-
-
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
?
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-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
CMP-N-acetyl-beta-neuraminate + benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + benzyl beta-D-Gal-(1->3)-alpha-D-GalNAc
CMP + benzyl alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc
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-
-
-
?
CMP-N-acetyl-beta-neuraminate + Galbeta(1->3)(GlcNAcbeta(1->6))GalNAc-OBn
CMP + ?
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-
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?
CMP-N-acetyl-beta-neuraminate + Galbeta(1->3)GalNAc-OBn
CMP + Neu5Acalpha(2->3)Galbeta(1->3)GalNAc-OBn
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-
-
?
CMP-N-acetyl-beta-neuraminate + lactose
CMP + alpha2,3-SiaLac + Neu5Ac
CMP-N-acetyl-beta-neuraminate + octyl beta-D-Gal-(1->3)-alpha-D-GalNAc
CMP + octyl alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + [antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
CMP + [antifreeze glycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
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-
?
CMP-N-acetyl-beta-neuraminate + [antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP + [antifreeze glycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP-N-acetyl-beta-neuraminate + [asialoglycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
CMP + [asialoglycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
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-
-
?
CMP-N-acetyl-beta-neuraminate + [asialoglycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP + [asialoglycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
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?
CMP-N-acetyl-beta-neuraminate + [porcine submaxillary asialo-mucin]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
CMP + [porcine submaxillary asialo-mucin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
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-
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?
CMP-N-acetyl-beta-neuraminate + [porcine submaxillary asialo-mucin]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP + [porcine submaxillary asialo-mucin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
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-
-
?
CMP-N-acetylneuraminate + 4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
CMP + 4-methylumbelliferyl alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucoside
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best substrate, about 37% conversion
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-
?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-Gal-(1->3)-alpha-D-GalNAc
CMP + 4-nitrophenyl alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc
-
-
-
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?
CMP-N-acetylneuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc
CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
best acceptor substrate
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-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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the enzyme is involved in O-linked glycosylation pathway for synthesis of core 1 and core 2 oligosaccharides
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?
CMP-N-acetylneuraminate + lactose
CMP + NeuAcalpha(2->3)Galbeta(1->4)Glc
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-
-
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?
additional information
?
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CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R

CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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-
-
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?
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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-
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?
CMP-N-acetyl-beta-neuraminate + asialofetuin

CMP + ?
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?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
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-
-
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?
CMP-N-acetyl-beta-neuraminate + lactose

CMP + alpha2,3-SiaLac + Neu5Ac
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-
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?
CMP-N-acetyl-beta-neuraminate + lactose
CMP + alpha2,3-SiaLac + Neu5Ac
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-
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?
CMP-N-acetyl-beta-neuraminate + [antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine

CMP + [antifreeze glycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
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-
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?
CMP-N-acetyl-beta-neuraminate + [antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP + [antifreeze glycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
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-
?
additional information

?
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MeO-3-Galbeta(1->3)GalNAc-OBn is a poor acceptor for the enzyme
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additional information
?
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MeO-3-Galbeta(1->3)GalNAc-OBn is a poor acceptor for the enzyme
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additional information
?
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no activity with fetuin or alpha-1-acid glycoprotein (asialoorosomucoid)
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additional information
?
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with glycoprotein and ganglioside acceptors the substrate specificity is strict, with the sequence beta-D-Gal-(1->3)-alpha-D-GalNAc serving as the exclusive acceptor. The enzyme has an equilibrium random order mechanism
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?
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CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
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-
-
?
CMP-N-acetyl-beta-neuraminate + [antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
CMP + [antifreeze glycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
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?
CMP-N-acetyl-beta-neuraminate + [antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP + [antifreeze glycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
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?
CMP-N-acetyl-beta-neuraminate + [asialoglycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
CMP + [asialoglycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
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-
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?
CMP-N-acetyl-beta-neuraminate + [asialoglycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
CMP + [asialoglycoprotein]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
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-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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the enzyme is involved in O-linked glycosylation pathway for synthesis of core 1 and core 2 oligosaccharides
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?
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R

CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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-
-
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?
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
-
-
?
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Adenocarcinoma
Expression and function of alpha 2,3-sialyl- and alpha 1,3/1,4-fucosyltransferases in colon adenocarcinoma cell lines: role in synthesis of E-selectin counter-receptors.
beta-galactoside alpha-2,3-sialyltransferase deficiency
Sialyltransferase specificity in selectin ligand formation.
Brain Neoplasms
Effect of Golgi membrane phospholipid composition on the molecular species of GM3 gangliosides synthesized by rat liver sialyltransferase.
Breast Neoplasms
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Breast Neoplasms
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Carcinoma
alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma.
Carcinoma
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Carcinoma
Enhanced sialyltransferases transcription in cervical intraepithelial neoplasia.
Carcinoma
Expression of ST3Gal, ST6Gal, ST6GalNAc and ST8Sia in human hepatic carcinoma cell lines, HepG-2 and SMMC-7721 and normal hepatic cell line, L-02.
Carcinoma, Hepatocellular
Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver.
Carcinoma, Squamous Cell
Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix.
Carcinoma, Squamous Cell
Enhanced sialyltransferases transcription in cervical intraepithelial neoplasia.
Hypertension, Pulmonary
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in peripheral blood mononuclear cells in systemic sclerosis.
Infections
Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection.
Leukemia
Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc: Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc: Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Role of aberrant sialylation of chronic myeloid leukemia granulocytes on binding and signal transduction by chemotactic peptides and colony stimulating factors.
Leukemia, Myeloid, Acute
Effect of ST3GAL 4 and FUT 7 on sialyl Lewis X synthesis and multidrug resistance in human acute myeloid leukemia.
Leukemia, Myeloid, Acute
Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc: Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
Leukocytosis
Sialyltransferase specificity in selectin ligand formation.
Neoplasms
Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo.
Neoplasms
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
Neuroblastoma
Effect of Golgi membrane phospholipid composition on the molecular species of GM3 gangliosides synthesized by rat liver sialyltransferase.
Ovarian Neoplasms
Human beta-galactoside alpha-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity.
Ovarian Neoplasms
Human GM3 Synthase Attenuates Taxol-Triggered Apoptosis Associated with Downregulation of Caspase-3 in Ovarian Cancer Cells.
Prostatic Neoplasms
Androgen-regulated transcriptional control of sialyltransferases in prostate cancer cells.
Reproductive Tract Infections
Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection.
Seizures
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
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0.54 - 1.4
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
0.02 - 1.388
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
-
0.2 - 0.21
beta-D-Gal-(1->3)-beta-D-GalNAc
0.04903
CMP-N-(4-pentynoyl)neuraminic acid
-
recombinant enzyme DELTA56ST3GalI, at pH 6.2 and 37°C
-
0.04123 - 0.876
CMP-N-acetyl-beta-neuraminate
0.18 - 0.62
CMP-N-acetylneuraminate
0.008
Galbeta(1->3)(GlcNAcbeta(1->6))GalNAc-OBn
isoform ST3Gal-I, at pH 6.0 and 25°C
0.05
Galbeta(1->3)GalNAc-OBn
isoform ST3Gal-I, at pH 6.0 and 25°C
-
0.35 - 0.39
[antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
-
0.54
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside

-
mutant enzyme E271F/R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.67
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
mutant enzyme R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.71
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
mutant enzyme E271F, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
1.4
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
wild type enzyme, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.02
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside

mutant enzyme C59S/C64S, at pH 7.4 and 37°C
-
0.026
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
wild type enzyme, at pH 7.4 and 37°C
-
0.096
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme N170A, at pH 7.4 and 37°C
-
0.105
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme S148A, at pH 7.4 and 37°C
-
0.211
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme N147S, at pH 7.4 and 37°C
-
0.352
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y230F, at pH 7.4 and 37°C
-
0.444
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y191A, at pH 7.4 and 37°C
-
0.549
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme V315Y, at pH 7.4 and 37°C
-
0.854
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y230A, at pH 7.4 and 37°C
-
1.388
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme V315A, at pH 7.4 and 37°C
-
0.2
beta-D-Gal-(1->3)-beta-D-GalNAc

pH 6.5, 37°C, enzyme form A
0.21
beta-D-Gal-(1->3)-beta-D-GalNAc
pH 6.5, 37°C, enzyme form B
0.04123
CMP-N-acetyl-beta-neuraminate

-
recombinant enzyme DELTA56ST3GalI, at pH 6.2 and 37°C
0.106
CMP-N-acetyl-beta-neuraminate
wild type enzyme, at pH 7.4 and 37°C
0.121
CMP-N-acetyl-beta-neuraminate
mutant enzyme C59S/C64S, at pH 7.4 and 37°C
0.176
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y230F, at pH 7.4 and 37°C
0.18
CMP-N-acetyl-beta-neuraminate
mutant enzyme V315A, at pH 7.4 and 37°C
0.184
CMP-N-acetyl-beta-neuraminate
mutant enzyme N170A, at pH 7.4 and 37°C
0.205
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y230A, at pH 7.4 and 37°C
0.271
CMP-N-acetyl-beta-neuraminate
mutant enzyme V315Y, at pH 7.4 and 37°C
0.481
CMP-N-acetyl-beta-neuraminate
mutant enzyme S148A, at pH 7.4 and 37°C
0.668
CMP-N-acetyl-beta-neuraminate
mutant enzyme N147S, at pH 7.4 and 37°C
0.876
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y191A, at pH 7.4 and 37°C
0.18
CMP-N-acetylneuraminate

-
mutant enzyme E271F, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.34
CMP-N-acetylneuraminate
-
mutant enzyme E271F/R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.44
CMP-N-acetylneuraminate
-
wild type enzyme, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.62
CMP-N-acetylneuraminate
-
mutant enzyme R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.35
[antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine

pH 6.5, 37°C, enzyme form A
-
0.39
[antifreeze glycoprotein]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
pH 6.5, 37°C, enzyme form B
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 - 47
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
0.2 - 3.47
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
-
0.13 - 3.65
CMP-N-acetyl-beta-neuraminate
19 - 32
CMP-N-acetylneuraminate
2 - 8
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside

-
mutant enzyme E271F, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
17
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
mutant enzyme E271F/R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
19
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
mutant enzyme R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
47
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
wild type enzyme, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.2
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside

mutant enzyme V315Y, at pH 7.4 and 37°C
-
0.47
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y191A, at pH 7.4 and 37°C
-
0.65
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme N170A, at pH 7.4 and 37°C
-
0.8
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme N147S, at pH 7.4 and 37°C
-
2.28
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme C59S/C64S, at pH 7.4 and 37°C
-
2.32
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme S148A, at pH 7.4 and 37°C
-
2.42
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme V315A, at pH 7.4 and 37°C
-
2.97
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y230A, at pH 7.4 and 37°C
-
3.15
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
wild type enzyme, at pH 7.4 and 37°C
-
3.47
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y230F, at pH 7.4 and 37°C
-
0.13
CMP-N-acetyl-beta-neuraminate

mutant enzyme V315Y, at pH 7.4 and 37°C
0.62
CMP-N-acetyl-beta-neuraminate
mutant enzyme N170A, at pH 7.4 and 37°C
0.63
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y191A, at pH 7.4 and 37°C
1.05
CMP-N-acetyl-beta-neuraminate
mutant enzyme V315A, at pH 7.4 and 37°C
1.21
CMP-N-acetyl-beta-neuraminate
mutant enzyme N147S, at pH 7.4 and 37°C
2.25
CMP-N-acetyl-beta-neuraminate
mutant enzyme C59S/C64S, at pH 7.4 and 37°C
2.5
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y230A, at pH 7.4 and 37°C
2.7
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y230F, at pH 7.4 and 37°C
3.35
CMP-N-acetyl-beta-neuraminate
wild type enzyme, at pH 7.4 and 37°C
3.65
CMP-N-acetyl-beta-neuraminate
mutant enzyme S148A, at pH 7.4 and 37°C
19
CMP-N-acetylneuraminate

-
mutant enzyme R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
23
CMP-N-acetylneuraminate
-
mutant enzyme E271F/R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
26
CMP-N-acetylneuraminate
-
mutant enzyme E271F, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
32
CMP-N-acetylneuraminate
-
wild type enzyme, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
28 - 39
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
0.37 - 121.15
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
-
0.47 - 31.6
CMP-N-acetyl-beta-neuraminate
30 - 140
CMP-N-acetylneuraminate
28
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside

-
mutant enzyme R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
32
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
mutant enzyme E271F/R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
34
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
wild type enzyme, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
39
4-methylumbelliferyl 4-O-beta-D-galactosyl-beta-D-glucoside
-
mutant enzyme E271F, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
0.37
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside

mutant enzyme V315Y, at pH 7.4 and 37°C
-
1.05
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y191A, at pH 7.4 and 37°C
-
1.75
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme V315A, at pH 7.4 and 37°C
-
3.47
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y230A, at pH 7.4 and 37°C
-
3.78
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme N147S, at pH 7.4 and 37°C
-
6.77
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme N170A, at pH 7.4 and 37°C
-
9.85
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme Y230F, at pH 7.4 and 37°C
-
22.07
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme S148A, at pH 7.4 and 37°C
-
114.17
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
mutant enzyme C59S/C64S, at pH 7.4 and 37°C
-
121.15
benzyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
wild type enzyme, at pH 7.4 and 37°C
-
0.47
CMP-N-acetyl-beta-neuraminate

mutant enzyme V315Y, at pH 7.4 and 37°C
0.72
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y191A, at pH 7.4 and 37°C
1.87
CMP-N-acetyl-beta-neuraminate
mutant enzyme N147S, at pH 7.4 and 37°C
3.35
CMP-N-acetyl-beta-neuraminate
mutant enzyme N170A, at pH 7.4 and 37°C
5.83
CMP-N-acetyl-beta-neuraminate
mutant enzyme V315A, at pH 7.4 and 37°C
7.58
CMP-N-acetyl-beta-neuraminate
mutant enzyme S148A, at pH 7.4 and 37°C
12.2
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y230A, at pH 7.4 and 37°C
15.33
CMP-N-acetyl-beta-neuraminate
mutant enzyme Y230F, at pH 7.4 and 37°C
18.6
CMP-N-acetyl-beta-neuraminate
mutant enzyme C59S/C64S, at pH 7.4 and 37°C
31.6
CMP-N-acetyl-beta-neuraminate
wild type enzyme, at pH 7.4 and 37°C
30
CMP-N-acetylneuraminate

-
mutant enzyme R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
69
CMP-N-acetylneuraminate
-
mutant enzyme E271F/R313Y, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
73
CMP-N-acetylneuraminate
-
wild type enzyme, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
140
CMP-N-acetylneuraminate
-
mutant enzyme E271F, in Tris-HCl buffer (100 mM, pH 8.5), at 37°C
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SIA4B_MOUSE
350
1
40130
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4B_PANTR
350
1
40074
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4B_RAT
350
1
40166
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4C_HUMAN
333
1
38045
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4C_MOUSE
333
1
38058
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4C_PANTR
328
1
37274
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4C_RAT
333
1
38043
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4A_CHICK
342
1
39540
Swiss-Prot
Secretory Pathway (Reliability: 3)
SIA4A_HUMAN
340
1
39075
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4A_MOUSE
337
1
39073
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4A_PANTR
340
1
39059
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4A_PIG
343
1
39769
Swiss-Prot
Secretory Pathway (Reliability: 1)
SIA4B_HUMAN
350
1
40173
Swiss-Prot
Secretory Pathway (Reliability: 1)
Q6H8N0_RAT
340
1
39349
TrEMBL
Secretory Pathway (Reliability: 1)
Q8NFD3_HUMAN
338
1
38431
TrEMBL
Secretory Pathway (Reliability: 1)
G7LI40_MEDTR
443
1
49676
TrEMBL
Secretory Pathway (Reliability: 2)
Q5ND67_ORYLA
334
1
38166
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6P9FQD0_SHEEP
333
1
38414
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2G9GZX7_9LAMI
398
1
45383
TrEMBL
Secretory Pathway (Reliability: 4)
A0A0B2NY86_GLYSO
442
1
49741
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2P6QDI0_ROSCH
430
0
49026
TrEMBL
other Location (Reliability: 4)
Q70D59_ONCMY
326
1
37384
TrEMBL
Secretory Pathway (Reliability: 2)
Q8N6A7_HUMAN
328
0
37360
TrEMBL
Secretory Pathway (Reliability: 2)
Q4JEZ1_MEDTR
421
1
48203
TrEMBL
other Location (Reliability: 3)
A0A2P6P4M4_ROSCH
437
1
49602
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2G9HZV1_9LAMI
442
1
48886
TrEMBL
Secretory Pathway (Reliability: 2)
B9SCR7_RICCO
434
1
50338
TrEMBL
other Location (Reliability: 1)
A5LHX0_PHOPO
409
0
46759
TrEMBL
-
Q15KI8_PASMD
412
0
48136
TrEMBL
-
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C59S/C64S
the mutant shows reduced activity compared to the wild type enzyme
N147S
the mutant shows strongly reduced activity compared to the wild type enzyme
N170A
the mutant shows strongly reduced activity compared to the wild type enzyme
S148A
the mutant shows strongly reduced activity compared to the wild type enzyme
V315A
the mutant shows strongly reduced activity compared to the wild type enzyme
V315Y
the mutant shows strongly reduced activity compared to the wild type enzyme
Y191A
the mutant shows strongly reduced activity compared to the wild type enzyme
Y230A
the mutant shows strongly reduced activity compared to the wild type enzyme
Y230F
the mutant shows strongly reduced activity compared to the wild type enzyme
E271F
-
the mutation does not affect alpha2-3-sialyltransferase activity
E271F/R313Y
-
the mutations do not affect alpha2-3-sialyltransferase activity
R313Y
-
the mutation does not affect alpha2-3-sialyltransferase activity
A151D
the mutant shows significantly improved properties as compared to the native enzyme. The mutant displays overall best performance in the synthesis of the GM3 trisaccharide (alpha2,3-Neu5Ac-Lac) from lactose in a one-pot, two-enzyme cascade
L387A
the mutant shows significantly improved properties as compared to the native enzyme
S359T/S360T
the mutant shows significantly improved properties as compared to the native enzyme
A151D
-
the mutant shows significantly improved properties as compared to the native enzyme. The mutant displays overall best performance in the synthesis of the GM3 trisaccharide (alpha2,3-Neu5Ac-Lac) from lactose in a one-pot, two-enzyme cascade
-
L387A
-
the mutant shows significantly improved properties as compared to the native enzyme
-
S359T/S360T
-
the mutant shows significantly improved properties as compared to the native enzyme
-
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Huang, S.; Day, T.W.; Choi, M.R.; Safa, A.R.
Human beta-galactoside alpha-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity
Mol. Cell. Biochem.
331
81-88
2009
Homo sapiens
brenda
Sugiarto, G.; Lau, K.; Li, Y.; Khedri, Z.; Yu, H.; Le, D.T.; Chen, X.
Decreasing the sialidase activity of multifunctional Pasteurella multocida alpha2-3-sialyltransferase 1 (PmST1) by site-directed mutagenesis
Mol. Biosyst.
7
3021-3027
2011
Pasteurella multocida
brenda
Perez-Garay, M.; Arteta, B.; Pages, L.; de Llorens, R.; de Bolos, C.; Vidal-Vanaclocha, F.; Peracaula, R.
alpha2,3-Sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo
PLoS ONE
5
e12524
2010
Homo sapiens
brenda
Lu, J.; Isaji, T.; Im, S.; Fukuda, T.; Kameyama, A.; Gu, J.
Expression of N-acetylglucosaminyltransferase III suppresses alpha2,3-sialylation, and its distinctive functions in cell migration are attributed to alpha2,6-sialylation levels
J. Biol. Chem.
291
5708-5720
2016
Homo sapiens
brenda
Gupta, R.; Matta, K.L.; Neelamegham, S.
A systematic analysis of acceptor specificity and reaction kinetics of five human alpha(2,3)sialyltransferases Product inhibition studies illustrate reaction mechanism for ST3Gal-I
Biochem. Biophys. Res. Commun.
469
606-612
2016
Homo sapiens (Q11201), Homo sapiens
brenda
Chandrasekaran, E.V.; Xue, J.; Xia, J.; Locke, R.D.; Matta, K.L.; Neelamegham, S.
Reversible sialylation synthesis of cytidine 5-monophospho-N-acetylneuraminic acid from cytidine 5-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products
Biochemistry
47
320-330
2008
Rattus norvegicus (Q11205)
brenda
Shigeta, S.; Winter, H.C.; Goldstein, I.J.
alpha-(2->3)- and alpha-(2->6)-Sialyltransferase activities present in three variants of Ehrlich tumor cells identification of the products derived from N-acetyllactosamine and beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->O)-Bn
Carbohydr. Res.
264
111-121
1994
Mus musculus
brenda
Sadler, J.E.; Rearick, J.I.; Paulson, J.C.; Hill, R.L.
Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands
J. Biol. Chem.
254
4434-4443
1979
Sus scrofa (Q02745)
brenda
Rearick, J.I.; Sadler, J.E.; Paulson, J.C.; Hill, R.L.
Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland
J. Biol. Chem.
254
4444-4451
1979
Sus scrofa (Q02745)
brenda
Westcott, K.R.; Hill, R.L.
Reconstitution of a porcine submaxillary gland beta-D-galactoside alpha 2-3 sialyltransferase into liposomes
J. Biol. Chem.
260
13116-13121
1985
Sus scrofa (Q02745)
brenda
Higgins, E.A.; Siminovitch, K.A.; Zhuang, D.; Brockhausen, I.; Dennis, J.W.
Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome
J. Biol. Chem.
266
6280-6290
1991
Homo sapiens
brenda
Sengupta, P.; Misra, A.K.; Suzuki, M.; Fukuda, M.; Hindsgaul, O.
Chemoenzymatic synthesis of sialylated oligosaccharides for their evaluation in a polysialyltransferase assay
Tetrahedron Lett.
44
6037-6042
2003
Rattus norvegicus
-
brenda
Fessner, W.D.; Mertsch, A.; He, N.; Yi, D.; Kickstein, M.
An alpha2,3-sialyltransferase from Photobacterium phosphoreum with broad substrate scope Controlling hydrolytic activity by directed evolution
Chem. Eur. J.
26
11614-11624
2020
Photobacterium phosphoreum (A5LHX0), Photobacterium phosphoreum JT-ISH-467 (A5LHX0)
brenda
Noel, M.; Gilormini, P.A.; Cogez, V.; Yamakawa, N.; Vicogne, D.; Lion, C.; Biot, C.; Guerardel, Y.; Harduin-Lepers, A.
Probing the CMP-sialic acid donor specificity of two human beta-D-galactoside sialyltransferases (ST3Gal I and ST6gal I) selectively acting on O- and N-glycosylproteins
ChemBioChem
18
1251-1259
2017
Homo sapiens
brenda
Wen, K.; Sung, P.; Hsieh, S.; Chou, Y.; Lee, O.; Wu, C.; Wang, P.
alpha2,3-Sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells
Oncotarget
8
29013-29027
2017
Homo sapiens
brenda
Ortiz-Soto, M.E.; Reising, S.; Schlosser, A.; Seibel, J.
Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1)
Sci. Rep.
9
17993
2019
Homo sapiens (Q11201), Homo sapiens
brenda