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Information on EC 2.4.99.2 - beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase

for references in articles please use BRENDA:EC2.4.99.2
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IUBMB Comments
The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids . When acting on gangloside GM1a, it forms gangloside GD1a .
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Word Map
  • 2.4.99.2
  • sialylation
  • sialic
  • st6gal
  • o-glycans
  • alpha2,3-sialyltransferase
  • st6galnac
  • sialylmotifs
  • cmp-sialic
  • st8sia
  • b4galnt1
  • gm1b
  • 1,3galnac
  • alpha2,3
The enzyme appears in viruses and cellular organisms
Synonyms
st3gal-i, st3gal i, st3gal5, st3gal1, st3gal ii, st3gal2, st3galiv, hst3gal ii, sat-4, st-iv, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R = CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
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