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Information on EC 2.4.2.62 - xylosyl alpha-1,3-xylosyltransferase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.62 xylosyl alpha-1,3-xylosyltransferase
IUBMB Comments
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
=
+
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Synonyms
C3ORF21, UDP-xylose:alpha-xyloside alpha1,3-xylosyltransferase, XXYLT1, xyloside alpha-1,3-xylosyltransferase, xyloside alpha1-3 xylosyltransferase, xyloside xylosyltransferase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
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PATHWAY SOURCE
PATHWAYS
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