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Literature summary for 2.4.2.62 extracted from

  • Sethi, M.; Buettner, F.; Ashikov, A.; Krylov, V.; Takeuchi, H.; Nifantiev, N.; Haltiwanger, R.; Gerardy-Schahn, R.; Bakker, H.
    Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of Notch (2012), J. Biol. Chem., 287, 2739-2748 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.62

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine Homo sapiens
-
 UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NBI6
-
-

Purification (Commentary)

Purification (Comment) Organism
IgG-Sepharose-6 column chromatography and Superdex S200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme cannot act on a synthetic acceptor containing an alpha-linked xylose alone and has no activity with 4-nitrophenyl-alpha-D-xylose and Xyl-O-[protein with EGF-like domain] Homo sapiens ?
-
-
UDP-alpha-D-xylose + Xyl-Glc-O-[protein with EGF-like domain 16]
-
 Homo sapiens ?
-
 ?
UDP-alpha-D-xylose + Xylalpha(1->3)Xylalpha(1->3)Glcbeta-O-(CH2)3NHCOC7H15
-
 Homo sapiens ?
-
 ?
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
-
 Homo sapiens UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
-
 ?

Synonyms

Synonyms Comment Organism
C3ORF21
-
 Homo sapiens
UDP-xylose:alpha-xyloside alpha1,3-xylosyltransferase
-
 Homo sapiens
XXYLT1
-
 Homo sapiens
xyloside xylosyltransferase 1
-
 Homo sapiens