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Information on EC 2.4.2.46 - galactan 5-O-arabinofuranosyltransferase and Organism(s) Mycobacterium tuberculosis and UniProt Accession P9WN03

for references in articles please use BRENDA:EC2.4.2.46
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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.46 galactan 5-O-arabinofuranosyltransferase
IUBMB Comments
Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria.
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This record set is specific for:
Mycobacterium tuberculosis
UNIPROT: P9WN03
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Word Map
The taxonomic range for the selected organisms is: Mycobacterium tuberculosis
The enzyme appears in selected viruses and cellular organisms
Synonyms
arabinofuranosyltransferase, rv3792, araft, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
arabinofuranosyltransferase
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arabinofuranosyltransferase A
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Rv3792
PATHWAY SOURCE
PATHWAYS
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-
SYSTEMATIC NAME
IUBMB Comments
galactofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 5-O-alpha-D-arabinofuranosyltransferase
Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan
?
show the reaction diagram
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the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan
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-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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not inhibited by ethambutol
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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a deletion of the AftA gene leads to complete absence of arabinose resulting in a truncated cell wall structure possessing only a galactan core with a concomitant loss of cell wall-bound mycolates
physiological function
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the enzyme is involved in cell wall arabinan biosynthesis
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in a Corynebacterium glutamicum AftA-deficient mutant strain and in Escherichia coli C43 (DE3) cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Alderwick, L.J.; Seidel, M.; Sahm, H.; Besra, G.S.; Eggeling, L.
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis
J. Biol. Chem.
281
15653-15661
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Safi, H.; Lingaraju, S.; Amin, A.; Kim, S.; Jones, M.; Holmes, M.; McNeil, M.; Peterson, S.N.; Chatterjee, D.; Fleischmann, R.; Alland, D.
Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-alpha-D-arabinose biosynthetic and utilization pathway genes
Nat. Genet.
45
1190-1197
2013
Mycobacterium tuberculosis (P9WN03), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WN03)
Manually annotated by BRENDA team