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alpha-D-Araf(1->3)-alpha-D-Araf-O-(CH2)7CH3 + decaprenyl phosphoryl-D-arabinose
?
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Substrates: the enzyme adds an alpha-D-Araf(1->5) to the 3-arm of the acceptor
Products: -
?
alpha-D-Araf(1->3)-alpha-D-Araf-O-(CH2)7CH3 + decaprenyl phosphoryl-D-arabinose
alpha-D-Araf(1->5)-alpha-D-Araf(1 ->3)-alpha-D-Araf-O-(CH2)7CH3 + ?
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Substrates: -
Products: -
?
alpha-D-Araf(1->5)-alpha-D-Araf-O-(CH2)7CH3 + decaprenyl phosphoryl-D-arabinose
?
-
Substrates: the enzyme adds an alpha-D-Araf(1->5) to the 3-arm of the acceptor
Products: -
?
beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan
?
lipoarabinomannan + trans,octacis-decaprenylphospho-beta-D-arabinofuranose
?
additional information
?
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Substrates: the enzyme catalyzes the addition of the first three arabinose units onto the galactan chain and associates with other arabinofuranosyltransferases, including Emb and AftC, that elongate and branch the arabinan domain
Products: -
?
beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan
?
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Substrates: the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan
Products: -
?
beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan
?
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Substrates: the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan
Products: -
?
lipoarabinomannan + trans,octacis-decaprenylphospho-beta-D-arabinofuranose
?
-
Substrates: -
Products: -
?
lipoarabinomannan + trans,octacis-decaprenylphospho-beta-D-arabinofuranose
?
-
Substrates: -
Products: -
?
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lipoarabinomannan + trans,octacis-decaprenylphospho-beta-D-arabinofuranose
?
additional information
?
-
Substrates: the enzyme catalyzes the addition of the first three arabinose units onto the galactan chain and associates with other arabinofuranosyltransferases, including Emb and AftC, that elongate and branch the arabinan domain
Products: -
?
lipoarabinomannan + trans,octacis-decaprenylphospho-beta-D-arabinofuranose
?
-
Substrates: -
Products: -
?
lipoarabinomannan + trans,octacis-decaprenylphospho-beta-D-arabinofuranose
?
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Substrates: -
Products: -
?
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Tuberculosis
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism.
Tuberculosis
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
Tuberculosis
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.
Tuberculosis
Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
Tuberculosis
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis.
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malfunction
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a deletion of the AftA gene leads to complete absence of arabinose resulting in a truncated cell wall structure possessing only a galactan core with a concomitant loss of cell wall-bound mycolates
malfunction
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a deletion of the AftA gene leads to complete absence of arabinose resulting in a truncated cell wall structure possessing only a galactan core with a concomitant loss of cell wall-bound mycolates
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metabolism
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the essential enzyme plays a role in the synthesis of the arabinan domain of lipoarabinomannan
metabolism
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the essential enzyme plays a role in the synthesis of the arabinan domain of lipoarabinomannan
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physiological function
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the enzyme is involved in cell wall arabinan biosynthesis
physiological function
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the enzyme is involved in the biosynthesis of the mycobacterial cell wall core
physiological function
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the enzyme is involved in cell wall arabinan biosynthesis
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Alderwick, L.J.; Seidel, M.; Sahm, H.; Besra, G.S.; Eggeling, L.
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis
J. Biol. Chem.
281
15653-15661
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Jankute, M.; Byng, C.V.; Alderwick, L.J.; Besra, G.S.
Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis
Glycoconj. J.
31
475-483
2014
Corynebacterium glutamicum (Q8NTW4)
brenda
Safi, H.; Lingaraju, S.; Amin, A.; Kim, S.; Jones, M.; Holmes, M.; McNeil, M.; Peterson, S.N.; Chatterjee, D.; Fleischmann, R.; Alland, D.
Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-alpha-D-arabinose biosynthetic and utilization pathway genes
Nat. Genet.
45
1190-1197
2013
Mycobacterium tuberculosis (P9WN03), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WN03)
brenda
Jankute, M.; Alderwick, L.J.; Noack, S.; Veerapen, N.; Nigou, J.; Besra, G.S.
Disruption of mycobacterial AftB results in complete loss of terminal beta(1 -> 2) arabinofuranose residues of lipoarabinomannan
ACS Chem. Biol.
12
183-190
2017
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc2155
brenda
Alderwick, L.; Birch, H.; Krumbach, K.; Bott, M.; Eggeling, L.; Besra, G.
AftD functions as an alpha1->5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core
Cell Surf.
1
2-14
2018
Corynebacterium glutamicum
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brenda
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