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Information on EC 2.4.1.283 - 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.283
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IUBMB Comments
Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose (cf. EC 2.4.1.284, 2-deoxystreptamine glucosyltransferase), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-alpha-D-glucosamine .
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The expected taxonomic range for this enzyme is: Streptomyces
Synonyms
btrM, kanF, neoD, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine = UDP + 2'-N-acetylparomamine
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