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Information on EC 2.4.1.283 - 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.283

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IUBMB Comments

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose (cf. EC 2.4.1.284, 2-deoxystreptamine glucosyltransferase), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-α-D-glucosamine .

The enzyme appears in viruses and cellular organisms

Synonyms
btrM, kanF, neoD, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine = UDP + 2'-N-acetylparomamine
show the reaction diagram
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Highest Expressing Human Cell Lines
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