Disease on EC 2.3.1.97 - glycylpeptide N-tetradecanoyltransferase and Organism(s) Homo sapiens and UniProt Accession O60551
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Breast Neoplasms
Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.
Breast Neoplasms
N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target.
Breast Neoplasms
NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.
Candidiasis
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.
Carcinogenesis
Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma.
Carcinogenesis
Expression of N-myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines.
Carcinogenesis
Increased N-myristoyltransferase activity observed in rat and human colonic tumors.
Carcinogenesis
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.
Carcinogenesis
Requirement of N-myristoyltransferase 1 in the development of monocytic lineage.
Carcinoma
Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma.
Carcinoma
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
Carcinoma
Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model.
Colonic Neoplasms
Expression of N-myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines.
Colonic Neoplasms
Increased N-myristoyltransferase activity observed in rat and human colonic tumors.
Colonic Neoplasms
N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.
Colonic Neoplasms
N-myristoyltransferase: a potential novel diagnostic marker for colon cancer.
Colonic Neoplasms
Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review).
Colonic Neoplasms
The Potential Use of N-Myristoyltransferase as a Biomarker in the Early Diagnosis of Colon Cancer.
Common Cold
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Communicable Diseases
A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.
Communicable Diseases
In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases.
Communicable Diseases
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases.
Diabetes Mellitus
Membrane-associated N-myristoyltransferase activity is reduced in obese (fa/fa) Zucker rat liver.
Diphtheria
Naturally-occurring anti-thymocyte autoantibody which identifies a restricted CD4+CD8+CD3-/lo/int thymocyte subpopulation exhibits extensive polyspecificity.
Endodermal Sinus Tumor
A radioresistant variant cell line, NMT-1R, isolated from a radiosensitive rat yolk sac tumour cell line, NMT-1: differences of early radiation-induced morphological changes, especially apoptosis.
Endodermal Sinus Tumor
Combined effect of hyperthermia at 42 degrees C and irradiation dose of 2 Gy on two rat yolk sac tumor cell lines with different radio-thermosensitivity in vitro.
Endodermal Sinus Tumor
Establishment and characterization of a rat yolk sac tumor cell line, NMT-1, producing alpha-fetoprotein, with potential for lymphatic metastasis.
Endodermal Sinus Tumor
Potentially lethal damage repair and its inhibitory effect of caffeine in two yolk sac tumor cell lines with different radiosensitivities.
Epilepsy
Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy.
glycylpeptide n-tetradecanoyltransferase deficiency
N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation.
Hepatitis B
In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B viruses.
Infections
Down-regulation of N-myristoyl transferase expression in human T-cell line CEM by human immunodeficiency virus type-1 infection.
Infections
N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections.
Infections
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
Leishmaniasis
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.
Leishmaniasis
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.
Leishmaniasis
QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors.
Leishmaniasis
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
Leishmaniasis, Visceral
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.
Leukemia
Myristoyl-CoA:protein N-myristoyltransferase activity in cancer cells. Purification and characterization of a cytosolic isoform from the murine leukemia cell line L1210.
Leukemia
N-myristoyl-transferase activity in cancer cells. Solubilization, specificity and enzymatic inhibition of a N-myristoyl transferase from L1210 microsomes.
Leukemia, Erythroblastic, Acute
A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase.
Leukemia, Erythroblastic, Acute
Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase.
Lymphatic Metastasis
A radioresistant variant cell line, NMT-1R, isolated from a radiosensitive rat yolk sac tumour cell line, NMT-1: differences of early radiation-induced morphological changes, especially apoptosis.
Lymphatic Metastasis
Establishment and characterization of a rat yolk sac tumor cell line, NMT-1, producing alpha-fetoprotein, with potential for lymphatic metastasis.
Malaria
Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP).
Malaria
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.
Malaria
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.
Malaria
N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action.
Malaria
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.
Malaria
QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors.
Malaria
QSAR studies on benzothiophene derivatives as Plasmodium falciparum N-myristoyltransferase inhibitors: Molecular insights into affinity and selectivity.
Malaria
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Mycoses
Design, Synthesis, Antifungal Activity and Molecular Docking of Thiochroman-4-one Derivatives.
Mycoses
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.
Myositis
Autoantibodies in thymoma-associated myasthenia gravis with myositis or neuromyotonia.
Neoplasm Metastasis
Establishment and characterization of a rat yolk sac tumor cell line, NMT-1, producing alpha-fetoprotein, with potential for lymphatic metastasis.
Neoplasms
A radioresistant variant cell line, NMT-1R, isolated from a radiosensitive rat yolk sac tumour cell line, NMT-1: differences of early radiation-induced morphological changes, especially apoptosis.
Neoplasms
A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.
Neoplasms
Combined effect of hyperthermia at 42 degrees C and irradiation dose of 2 Gy on two rat yolk sac tumor cell lines with different radio-thermosensitivity in vitro.
Neoplasms
Establishment and characterization of a rat yolk sac tumor cell line, NMT-1, producing alpha-fetoprotein, with potential for lymphatic metastasis.
Neoplasms
In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases.
Neoplasms
Increased N-myristoyltransferase activity observed in rat and human colonic tumors.
Neoplasms
Myristoyl-CoA:protein N-myristoyltransferase activity in cancer cells. Purification and characterization of a cytosolic isoform from the murine leukemia cell line L1210.
Neoplasms
Myristoyl-CoA:protein N-myristoyltransferase: a novel molecular approach for cancer therapy (Review).
Neoplasms
N-myristoyl-transferase activity in cancer cells. Solubilization, specificity and enzymatic inhibition of a N-myristoyl transferase from L1210 microsomes.
Neoplasms
N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections.
Neoplasms
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.
Neoplasms
Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells.
Neoplasms
Potentially lethal damage repair and its inhibitory effect of caffeine in two yolk sac tumor cell lines with different radiosensitivities.
Neoplasms
QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors.
Neoplasms
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases.
Neoplasms
[A study on the relationship between sensitivity to CDDP and inducibility of metallothionein and glutathione of genitourinary tumors]
Neoplasms, Glandular and Epithelial
Expression of N-myristoyltransferase in human brain tumors.
Neoplasms, Glandular and Epithelial
Expression of N-myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines.
Neoplasms, Glandular and Epithelial
Increased N-myristoyltransferase activity observed in rat and human colonic tumors.
Parasitic Diseases
Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP).
Parasitic Diseases
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.
Parasitic Diseases
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.
Parkinsonian Disorders
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Pneumonia
Expression and activity of N-myristoyltransferase in lung inflammation of cattle and its role in neutrophil apoptosis.
Reperfusion Injury
QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors.
Squamous Cell Carcinoma of Head and Neck
Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma.
Trypanosomiasis, African
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Trypanosomiasis, African
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Trypanosomiasis, African
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Trypanosomiasis, African
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.
Trypanosomiasis, African
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase.
Trypanosomiasis, African
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
Trypanosomiasis, African
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.