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Disease on EC 2.3.1.299 - sphingoid base N-stearoyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.
Ataxia
Progressive Myoclonic Epilepsy Type 8 Due to CERS1 Deficiency: A Novel Mutation with Prominent Ataxia.
Carcinoma
Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress.
Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.
Carcinoma, Squamous Cell
Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.
siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Dementia
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.
Epilepsies, Myoclonic
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.
Glioblastoma
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Glioma
Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma.
Head and Neck Neoplasms
Diverse functions of ceramide in cancer cell death and proliferation.
Heart Failure
A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle.
Inflammatory Bowel Diseases
mTNF reverse signalling induced by TNF? antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.
Insulin Resistance
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.
Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice.
Mouth Neoplasms
Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress.
Myoclonic Epilepsies, Progressive
Progressive Myoclonic Epilepsy Type 8 Due to CERS1 Deficiency: A Novel Mutation with Prominent Ataxia.
Neoplasm Metastasis
Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.
Neoplasms
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.
The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma.
Neuroblastoma
Autosomal recessive progressive myoclonus epilepsy due to impaired ceramide synthesis.
sphingoid base n-stearoyltransferase deficiency
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.
Progressive Myoclonic Epilepsy Type 8 Due to CERS1 Deficiency: A Novel Mutation with Prominent Ataxia.
Squamous Cell Carcinoma of Head and Neck
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.
Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress.