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Information on EC 2.3.1.252 - mycolipanoate synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.252 mycolipanoate synthase
IUBMB Comments
This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyltetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
+
3
+
6
+
6
+
holo-[mycolipanoate synthase]
=
mycolipanoyl-[mycolipanoate synthase]
+
4
+
3
+
6
+
3
Synonyms
Msl3, Pks2, pks3, polyketide beta-ketoacyl synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a long-chain acyl-CoA + 3 (R)-methylmalonyl-CoA + 6 NADPH + 6 H+ + holo-[mycolipanoate synthase] = mycolipanoyl-[mycolipanoate synthase] + 4 CoA + 3 CO2 + 6 NADP+ + 3 H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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