Literature summary for 2.3.1.252 extracted from

Dubey, V.S.; Sirakova, T.D.; Kolattukudy, P.E.
Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation (2002), Mol. Microbiol., 45, 1451-1459.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
220300	-	calculated from sequence of pks3 and pks4. The genes originally designated pks3 and pks4 in Mycobacterium tuberculosis genome jointly constitute a single gene (msl3) encoding a 220000 Da protein	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	A0A089QRB9	-	-
Mycobacterium tuberculosis H37Rv	A0A089QRB9	-	-

Synonyms

Synonyms	Comment	Organism
Msl3	gene name. The genes originally designated pks3 and pks4 in Mycobacterium tuberculosis genome jointly constitute a single gene (msl3) encoding a 220000 Da protein	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
malfunction	Msl3 is disrupted using a phage mediated delivery system. Biochemical analysis shows that the msl3 mutant does not produce mycolipanoic acids and mycolipenic (phthienoic) acids, the major constituents of polyacyl trehaloses and thus lacks this cell wall lipid, but synthesizes all of the other classes of lipids. The absence of the major acyl chains that anchor the surface-exposed acyltrehaloses causes a novel growth morphology. The cells stick to each other, most probably via the intercellular interaction between the exposed hydrophobic cell surfaces, manifesting a bead-like growth morphology without affecting the overall growth rate	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)