Information on EC 188.8.131.52 - 1,3,6,8-tetrahydroxynaphthalene synthasefor references in articles please use BRENDA:EC184.108.40.206
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Isolated from the fungus Colletotrichum lagenarium , and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius . It only uses malonyl-CoA, without invovement of acetyl-CoA.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
1,3,6,8-tetrahydroxynaphthalene synthase, PhlD, PKS, PKS III, PKS1, RppA, SCO1206, THN synthase, THNS, type III polyketide synthase,
5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O
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