Reference on EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase and Organism(s) Escherichia coli and UniProt Accession P77488
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kuzuyama, T.; Takagi, M.; Takahashi, S.; Seto, H.
Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis
J. Bacteriol.
182
891-897
2000
Streptomyces sp., Escherichia coli (P77488), Escherichia coli
Lois, L.M.; Campos, N.; Putra, S.R.; Danielsen, K.; Rohmer, M.; Boronat, A.
Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis
Proc. Natl. Acad. Sci. USA
95
2105-2110
1998
Escherichia coli (P77488)
Querol, J.; Rodriguez-Concepcion, M.; Boronat, A.; Imperial, S.
Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid synthesis
Biochem. Biophys. Res. Commun.
289
155-160
2001
Escherichia coli (P77488), Escherichia coli
Schrmann, M.; Schrmann, M.; Sprenger, G.A.
Fructose 6-phosphate aldolase and 1-deoxy-D-xylulose 5-phosphate synthase from Escherichia coli as tools in enzymatic synthesis of 1-deoxysugars
J. Mol. Catal. B
19-20
247-252
2002
Escherichia coli
-
Querol, J.; Grosdemange-Billiard, C.; Rohmer, M.; Boronat, A.; Imperial, S.
Enzymatic synthesis of 1-deoxysugar-phosphates using E. coli 1-deoxy-D-xylulose 5-phosphate synthase
Tetrahedron Lett.
43
8265-8268
2002
Escherichia coli
-
Xiang, S.; Usunow, G.; Lange, G.; Busch, M.; Tong, L.
Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis
J. Biol. Chem.
282
2676-2682
2007
Deinococcus radiodurans, Escherichia coli
Morris, W.L.; Ducreux, L.J.; Hedden, P.; Millam, S.; Taylor, M.A.
Overexpression of a bacterial 1-deoxy-D-xylulose 5-phosphate synthase gene in potato tubers perturbs the isoprenoid metabolic network: implications for the control of the tuber life cycle
J. Exp. Bot.
57
3007-3018
2006
Escherichia coli
Cordoba, E.; Salmi, M.; Leon, P.
Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants
J. Exp. Bot.
60
2933-2943
2009
Arabidopsis thaliana (Q38854), Escherichia coli, Ginkgo biloba, Medicago truncatula (Q8L692), Medicago truncatula (Q8L693), Oryza sativa, Picea abies (A7LA00), Picea abies (A7LA01), Picea abies (A7LA02), Solanum lycopersicum, Solanum tuberosum, Zea mays
Brammer, L.A.; Meyers, C.F.
Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase
Org. Lett.
11
4748-4751
2009
Escherichia coli
Brammer, L.A.; Smith, J.M.; Wade, H.; Meyers, C.F.
1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism
J. Biol. Chem.
286
36522-36531
2011
Escherichia coli
Kirby, J.; Nishimoto, M.; Chow, R.W.; Baidoo, E.E.; Wang, G.; Martin, J.; Schackwitz, W.; Chan, R.; Fortman, J.L.; Keasling, J.D.
Enhancing terpene yield from sugars via novel routes to 1-deoxy-D-xylulose 5-phosphate
Appl. Environ. Microbiol.
81
130-138
2015
Escherichia coli (P77735), Escherichia coli, Escherichia coli MG1655 (P77735)
Morris, F.; Vierling, R.; Boucher, L.; Bosch, J.; Freel Meyers, C.L.
DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design
ChemBioChem
14
1309-1315
2013
Escherichia coli (P77488), Escherichia coli
Bartee, D.; Morris, F.; Al-Khouja, A.; Freel Meyers, C.L.
Hydroxybenzaldoximes are D-GAP-competitive inhibitors of E. coli 1-deoxy-D-xylulose-5-phosphate synthase
ChemBioChem
16
1771-1781
2015
Escherichia coli
Sanders, S.; Vierling, R.J.; Bartee, D.; DeColli, A.A.; Harrison, M.J.; Aklinski, J.L.; Koppisch, A.T.; Freel Meyers, C.L.
Challenges and hallmarks of establishing alkylacetylphosphonates as probes of bacterial 1-deoxy-D-xylulose 5-phosphate synthase
ACS Infect. Dis.
3
467-478
2017
Escherichia coli, Escherichia coli MG1655
Bartee, D.; Freel Meyers, C.L.
Targeting the unique mechanism of bacterial 1-deoxy-D-xylulose-5-phosphate synthase
Biochemistry
57
4349-4356
2018
Escherichia coli
DeColli, A.A.; Zhang, X.; Heflin, K.L.; Jordan, F.; Freel Meyers, C.L.
Active site histidines link conformational dynamics with catalysis on anti-infective target 1-deoxy-D-xylulose 5-phosphate synthase
Biochemistry
58
4970-4982
2019
Escherichia coli
Zhou, J.; Yang, L.; DeColli, A.; Freel Meyers, C.; Nemeria, N.S.; Jordan, F.
Conformational dynamics of 1-deoxy-D-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS
Proc. Natl. Acad. Sci. USA
114
9355-9360
2017
Escherichia coli (P77488), Escherichia coli
