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Involved in the biosynthesis of the berberine alkaloids.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
tetrahydrocolumbamine omt, more
S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine
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