We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 2.1.1.62 - mRNA (2'-O-methyladenosine-N6-)-methyltransferase for references in articles please use BRENDA:EC2.1.1.62Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
The enzyme appears in viruses and cellular organisms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
mRNA (2'-O-methyladenosine-N6-)-methyltransferase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap)
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
methyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cap-dependent 2'-O-methyltransferase
Variola sp.
-
-
messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase
-
-
-
-
mRNA cap (nucleoside-2'O)-methyltransferase
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
human, HeLa S3 cells
-
-
brenda
-
-
-
brenda
Variola sp.
vaccinia virus
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + 7MeGpppAC5
S-adenosyl-L-homocysteine + 7MeGpppA2'OMeC5
-
RNA substrate is used
-
-
?
S-adenosyl-L-methionine + G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + G(5')pppm6Am-mRNA
-
poor substrate
-
-
-
S-adenosyl-L-methionine + m7G(5')pppA-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6A-mRNA
-
-
-
-
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
S-adenosyl-L-methionine + pppA-mRNA
S-adenosyl-L-homocysteine + pppm6A-mRNA
-
-
-
-
?
additional information
?
-
-
no substrates are the oligonucleotides m7G(5')pppAm, m7G(5')pppA, m7G(5')pppAmpN, no methyl group acceptors are brome mosaic virus RNA, E. coli tRNA and rRNA and yeast tRNA
-
-
-
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
-
methyl group acceptor is methylated or unmethylated vaccinia virus RNA
mRNA containing an N6,2'-O-dimethyladenosine cap
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
-
involved in post-transcriptional modification of 5'-end of messenger-RNA
mRNA containing an N6,2'-O-dimethyladenosine cap
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
Variola sp.
-
also acts as poly(A) polymerase progressivity factor
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
-
involved in post-transcriptional modification of 5'-end of messenger-RNA
mRNA containing an N6,2'-O-dimethyladenosine cap
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-[[3-(4-methylphenyl)adamant-1-yl]carbamoyl]-L-phenylalanine
-
0.1 mM, 75% inhibition. It is suggested that the inhibitor competes with the cofactor AdoMet and presumably also the capped RNA substrate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
erythromycin
-
enzyme synthesis induced by
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0605
N-[[3-(4-methylphenyl)adamant-1-yl]carbamoyl]-L-phenylalanine
Dengue virus
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
65000
-
sucrose density gradient
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
monomer
-
1 * 65000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-70°C, 0.21 M (NH4)2SO4, stable for longer than 5 months
-
0°C, 0.21 M (NH4)2SO4, stable for 4-5 months
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ermC gene of pE194 specifies resistance to macrolide-lincosamide-streptogramin B antibiotics
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Dengue
Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Keith, J.M.; Ensinger, M.J.; Moss, B.
HeLa cell RNA (2-O-methyladenosine-N6-)-methyltransferase specific for the capped 5-end of messenger RNA
J. Biol. Chem.
253
5033-5041
1978
Homo sapiens
brenda
Shivakumar, A.G.; Dubnau, D.
Characterization of a plasmid-specified ribosome methylase associated with macrolide resistance
Nucleic Acids Res.
9
2549-2562
1981
Staphylococcus aureus
brenda
Shi, X.; Yao, P.; Jose, T.; Gershon, P.D.
Methyltransferase-specific domains within VP39, a bifunctional protein that participates in the modification of both mRNA ends
RNA
2
88-101
1996
Variola sp.
brenda
Luzhkov, V.B.; Selisko, B.; Nordqvist, A.; Peyrane, F.; Decroly, E.; Alvarez, K.; Karlen, A.; Canard, B.; Qvist, J.
Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2O)-methyltransferase
Bioorg. Med. Chem.
15
7795-7802
2007
Dengue virus
brenda
html completed