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IUBMB Comments The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
Synonyms
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ElmMIII
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S-adenosyl-L-methionine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
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MetaCyc
elloramycin biosynthesis
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S-adenosyl-L-methionine:8-demethyl-8-(2,3-di-O-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
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S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-oleandrosyl-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(4-O-methyl-alpha-L-oleandrosyl)-tetracenomycin C
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
Substrates: the enzyme is involved in the biosynthesis of the polyketide elloramycin
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S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
Substrates: the enzyme is involved in the biosynthesis of the polyketide elloramycin
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S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-oleandrosyl-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(4-O-methyl-alpha-L-oleandrosyl)-tetracenomycin C
Substrates: no activity with 8-demethyl-8-alpha-L-olivosyl tetracenomycin C or 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C
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S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-oleandrosyl-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(4-O-methyl-alpha-L-oleandrosyl)-tetracenomycin C
Substrates: no activity with 8-demethyl-8-alpha-L-olivosyl tetracenomycin C or 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C
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S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
Substrates: the enzyme is involved in the biosynthesis of the polyketide elloramycin
?
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
Substrates: the enzyme is involved in the biosynthesis of the polyketide elloramycin
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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physiological function
the enzyme is involved in the biosynthesis of the polyketide elloramycin
physiological function
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the enzyme is involved in the biosynthesis of the polyketide elloramycin
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ELMM3_STROV
261
0
29044
Swiss-Prot
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A0A2Z4AEY1_9BACT
189
0
21762
TrEMBL
-
A0A6M1YUZ0_9BACT
234
0
26853
TrEMBL
-
A0A2S6R6Y7_9PROT
304
0
34749
TrEMBL
-
A0A2S6U439_9PROT
259
0
29455
TrEMBL
-
A0A1V0RK86_9RHOB
252
0
27972
TrEMBL
-
A0A6M4GXU0_9PROT
267
0
30108
TrEMBL
-
A0A395LAI4_9HYPH
249
0
27733
TrEMBL
-
A0A2N7QZ13_9GAMM
254
0
28379
TrEMBL
-
A0A2S6R491_9PROT
270
0
31065
TrEMBL
-
A0A165LDC2_RHOFA
294
0
32462
TrEMBL
-
A0A5S9QGR2_9GAMM
276
0
30789
TrEMBL
-
A0A7Z7IM75_9MYCO
248
0
28373
TrEMBL
-
A0A2S6Q830_9PROT
250
0
28377
TrEMBL
-
A0A5E8AB22_9RHOB
252
0
27972
TrEMBL
-
A0A7U9SPL1_9FIRM
338
0
39808
TrEMBL
-
A0A8J2BMW3_9BACT
299
0
34249
TrEMBL
-
A0A5S9QYH5_9GAMM
276
0
30664
TrEMBL
-
A0A6M1ZUH1_9BACT
278
0
32210
TrEMBL
-
A0A7U9X4C2_9FIRM
378
0
42745
TrEMBL
-
A0A5E6MBQ4_9BACT
202
0
22520
TrEMBL
-
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29043
x * 29043, calculated from sequence
29044
x * 29044, calculated from sequence
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x * 29043, calculated from sequence
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x * 29044, calculated from sequence
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x * 29043, calculated from sequence
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?
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x * 29044, calculated from sequence
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expression in Escherichia coli
expression in Streptomyces albus
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Patallo, E.P.; Blanco, G.; Fischer, C.; Brana, A.F.; Rohr, J.; Mendez, C.; Salas, J.A.
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes
J. Biol. Chem.
276
18765-18774
2001
Streptomyces olivaceus (Q9AJU0), Streptomyces olivaceus, Streptomyces olivaceus Tü2353 (Q9AJU0)
brenda
Ramos, A.; Lombo, F.; Brana, A.F.; Rohr, J.; Mendez, C.; Salas, J.A.
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster
Microbiology
154
781-788
2008
Streptomyces olivaceus (Q9AJU0), Streptomyces olivaceus Tü2353 (Q9AJU0)
brenda
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