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Information on EC 2.1.1.306 - 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase and Organism(s) Streptomyces olivaceus and UniProt Accession Q9AJU1

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IUBMB Comments
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
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This record set is specific for:
Streptomyces olivaceus
UNIPROT: Q9AJU1
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The taxonomic range for the selected organisms is: Streptomyces olivaceus
The enzyme appears in selected viruses and cellular organisms
Synonyms
elmmii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:8-demethyl-8-(2-methoxy-alpga-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
show the reaction diagram
the enzyme is involved in the biosynthesis of the polyketide elloramycin
-
-
?
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-olivosyl tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(3-O-methyl-alpha-L-olivosyl)-tetracenomycin C
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(3-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C
show the reaction diagram
the enzyme is involved in the biosynthesis of the polyketide elloramycin
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in the biosynthesis of the polyketide elloramycin
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ELMM2_STROV
390
0
42836
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42835
x * 42835, calculated from sequence
42836
x * 42836, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
expression in Streptomyces albus
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Patallo, E.P.; Blanco, G.; Fischer, C.; Brana, A.F.; Rohr, J.; Mendez, C.; Salas, J.A.
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes
J. Biol. Chem.
276
18765-18774
2001
Streptomyces olivaceus (Q9AJU1), Streptomyces olivaceus, Streptomyces olivaceus T2353 (Q9AJU1)
Manually annotated by BRENDA team
Ramos, A.; Lombo, F.; Brana, A.F.; Rohr, J.; Mendez, C.; Salas, J.A.
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster
Microbiology
154
781-788
2008
Streptomyces olivaceus (Q9AJU1), Streptomyces olivaceus T2353 (Q9AJU1)
Manually annotated by BRENDA team