Information on EC 2.1.1.16 - methylene-fatty-acyl-phospholipid synthase

for references in articles please use BRENDA:EC2.1.1.16
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The expected taxonomic range for this enzyme is: Mycolicibacterium phlei

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EC NUMBER
COMMENTARY hide
2.1.1.16
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RECOMMENDED NAME
GeneOntology No.
methylene-fatty-acyl-phospholipid synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)
The enzyme transfers a methyl group to the 10-position of a Delta-olefinic acyl chain in phosphatidylglycerol or phosphatidylinositol or, more slowly, phosphatidylethanolamine; subsequent proton transfer produces a 10-methylene group (cf. EC 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase).
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CAS REGISTRY NUMBER
COMMENTARY hide
37256-90-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
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alkylenation at the 10-carbon to give a methylene group
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?
S-adenosyl-L-methionine + phosphatidylglycerol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
alkylenation at the 10-carbon to give a methylene group
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?
S-adenosyl-L-methionine + phosphatidylinositol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
alkylenation at the 10-carbon to give a methylene group
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?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
?
show the reaction diagram
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enzymatic synthesis of tuberculostearic acid i.e. 10-methylstearic acid
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?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine
show the reaction diagram
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-
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-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
?
show the reaction diagram
-
enzymatic synthesis of tuberculostearic acid i.e. 10-methylstearic acid
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-
?
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LINKS TO OTHER DATABASES (specific for EC-Number 2.1.1.16)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)