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Information on EC 2.1.1.148 - thymidylate synthase (FAD)

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IUBMB Comments

Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH.

The enzyme appears in viruses and cellular organisms

Synonyms
flavin-dependent thymidylate synthase, thymidylate synthase thyx, thymidylate synthase x, a674r, thymidylate synthase complementing protein, flavin dependent thymidylate synthase, flavin-dependent thymidylate synthase x, flavin-dependent ts, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
pyrimidine deoxyribonucleotides de novo biosynthesis III